Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Xie S et al. | 15 deoxy delta12,14 PGJ2 induces procoagulant activity in cultured human endothelial cells. | 2002 | Thromb. Haemost. | pmid:11916086 |
Eligini S et al. | 15-deoxy-delta12,14-Prostaglandin J2 inhibits tissue factor expression in human macrophages and endothelial cells: evidence for ERK1/2 signaling pathway blockade. | 2002 | Thromb. Haemost. | pmid:12353085 |
Bertelé V et al. | SQ 22536, an adenylate-cyclase inhibitor, prevents the antiplatelet effect of dazoxiben, a thromboxane-synthetase inhibitor. | 1984 | Thromb. Haemost. | pmid:6326343 |
Artwohl M et al. | Thiazolidinediones inhibit apoptosis and heat shock protein 60 expression in human vascular endothelial cells. | 2005 | Thromb. Haemost. | pmid:15886792 |
Blockmans D et al. | Heparin-induced thrombocytopenia platelet aggregation studies in the presence of heparin fractions or semi-synthetic analogues of various molecular weights and anticoagulant activities. | 1986 | Thromb. Haemost. | pmid:3518134 |
Sampson SE et al. | Effect of inhaled prostaglandin D2 in normal and atopic subjects, and of pretreatment with leukotriene D4. | 1997 | Thorax | pmid:9227716 |
Brugha RE et al. | Carbon in airway macrophages from children with asthma. | 2014 | Thorax | pmid:24567296 |
Dahlén SE and Kumlin M | Monitoring mast cell activation by prostaglandin D2 in vivo. | 2004 | Thorax | pmid:15170020 |
Bochenek G et al. | Plasma 9alpha,11beta-PGF2, a PGD2 metabolite, as a sensitive marker of mast cell activation by allergen in bronchial asthma. | 2004 | Thorax | pmid:15170023 |
O'Sullivan S et al. | Exposure of healthy volunteers to swine house dust increases formation of leukotrienes, prostaglandin D2, and bronchial responsiveness to methacholine. | 1998 | Thorax | pmid:10195076 |