Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Steinbrink K et al. | Induction of dendritic cell maturation and modulation of dendritic cell-induced immune responses by prostaglandins. | 2000 | Arch. Dermatol. Res. | pmid:11000287 |
Miwa Y et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) induces G(1) arrest and differentiation marker expression in vascular smooth muscle cells. | 2000 | Mol. Pharmacol. | pmid:10999955 |
Uchida K | Induction of glutathione S-transferase by prostaglandins. | 2000 | Mech. Ageing Dev. | pmid:10996013 |
Heneka MT et al. | Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo. | 2000 | J. Neurosci. | pmid:10995830 |
Soler M et al. | Human vascular smooth muscle cells but not endothelial cells express prostaglandin E synthase. | 2000 | Circ. Res. | pmid:10988243 |
Vanaja DK et al. | Tumor prevention and antitumor immunity with heat shock protein 70 induced by 15-deoxy-delta12,14-prostaglandin J2 in transgenic adenocarcinoma of mouse prostate cells. | 2000 | Cancer Res. | pmid:10987274 |
Nishio T et al. | Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10973807 |
Miyahara T et al. | Peroxisome proliferator-activated receptors and hepatic stellate cell activation. | 2000 | J. Biol. Chem. | pmid:10969082 |
Saarinen JV et al. | Release of histamine and leukotriene C4 in immediate allergic wheal reaction as measured with the microdialysis technique. | 2000 | Arch. Dermatol. Res. | pmid:10966057 |
Woodward DF et al. | Replacement of the carboxylic acid group of prostaglandin f(2alpha) with a hydroxyl or methoxy substituent provides biologically unique compounds. | 2000 | Br. J. Pharmacol. | pmid:10952685 |
Davis TL and Sharif NA | Pharmacological characterization of [(3)H]-prostaglandin E(2) binding to the cloned human EP(4) prostanoid receptor. | 2000 | Br. J. Pharmacol. | pmid:10952683 |
Bernardo A et al. | Role of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and its natural ligand 15-deoxy-Delta12, 14-prostaglandin J2 in the regulation of microglial functions. | 2000 | Eur. J. Neurosci. | pmid:10947800 |
Yokoyama Y et al. | Synergistic antiproliferative effect of delta 12-prostaglandin J2 (delta 12-PGJ2) and hyperthermia on human esophageal cancer cell lines. | 2000 | Hum. Cell | pmid:10937344 |
Mc Clay EF | The effects of Delta(12)-PGJ(2) on malignant cells. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10936416 |
Clay CE et al. | 15-deoxy-Delta(12,14)PGJ(2) induces diverse biological responses via PPARgamma activation in cancer cells. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10936413 |
Maxey KM et al. | The nature and composition of 15-deoxy-Delta(12,14)PGJ(2). | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10936412 |
Hartert TV et al. | Prostaglandin E(2) decreases allergen-stimulated release of prostaglandin D(2) in airways of subjects with asthma. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10934099 |
Kozak KR et al. | Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2. | 2000 | J. Biol. Chem. | pmid:10931854 |
Ikeda Y et al. | Suppression of rat thromboxane synthase gene transcription by peroxisome proliferator-activated receptor gamma in macrophages via an interaction with NRF2. | 2000 | J. Biol. Chem. | pmid:10930400 |
Marra F et al. | Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells. | 2000 | Gastroenterology | pmid:10930382 |