Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Madhu C et al. | Penetration of natural prostaglandins and their ester prodrugs and analogs across human ocular tissues in vitro. | 1998 | J Ocul Pharmacol Ther | pmid:9811228 |
Arakida Y et al. | In vitro pharmacologic profile of YM158, a new dual antagonist for LTD4 and TXA2 receptors. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9808690 |
Ma H et al. | Estrogen-induced production of a peroxisome proliferator-activated receptor (PPAR) ligand in a PPARgamma-expressing tissue. | 1998 | J. Biol. Chem. | pmid:9804768 |
Matsushita N et al. | Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antiasthmatic effects. | 1998 | Jpn. J. Pharmacol. | pmid:9804057 |
Huszár E et al. | Elevated circulating adenosine level potentiates antigen-induced immediate bronchospasm and bronchoconstrictor mediator release in sensitized guinea pigs. | 1998 | J. Allergy Clin. Immunol. | pmid:9802380 |
Tada K et al. | Induction of cyclooxygenase-2 by secretory phospholipases A2 in nerve growth factor-stimulated rat serosal mast cells is facilitated by interaction with fibroblasts and mediated by a mechanism independent of their enzymatic functions. | 1998 | J. Immunol. | pmid:9794438 |
Ohtani-Fujita N et al. | p53-Independent activation of the gadd45 promoter by Delta12-prostaglandin J2. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9792828 |
Szczeklik A et al. | Salmeterol prevents aspirin-induced attacks of asthma and interferes with eicosanoid metabolism. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9769277 |
Crider JY et al. | Use of a semi-automated, robotic radioimmunoassay to measure cAMP generated by activation of DP-, EP2-, and IP-prostaglandin receptors in human ocular and other cell types. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758211 |
Kilunga Kubata B et al. | Plasmodium falciparum produces prostaglandins that are pyrogenic, somnogenic, and immunosuppressive substances in humans. | 1998 | J. Exp. Med. | pmid:9743538 |
Csala M et al. | Prostaglandin-independent stimulation of interleukin-6 production by fibrinogen degradation product D in perfused murine liver. | 1998 | Scand. J. Immunol. | pmid:9743211 |
Takahashi S et al. | Localization of a cyclopentenone prostaglandin to the endoplasmic reticulum and induction of BiP mRNA. | 1998 | Biochem. J. | pmid:9742210 |
Christman BW | Lipid mediator dysregulation in primary pulmonary hypertension. | 1998 | Chest | pmid:9741570 |
Rosenbaum SE and Greenberg AS | The short- and long-term effects of tumor necrosis factor-alpha and BRL 49653 on peroxisome proliferator-activated receptor (PPAR)gamma2 gene expression and other adipocyte genes. | 1998 | Mol. Endocrinol. | pmid:9717841 |
Terao A et al. | Interleukin-1 induces slow-wave sleep at the prostaglandin D2-sensitive sleep-promoting zone in the rat brain. | 1998 | J. Neurosci. | pmid:9698346 |
Yoshida T et al. | Inhibitory effects of prostaglandin D2 against the proliferation of human colon cancer cell lines and hepatic metastasis from colorectal cancer. | 1998 | Surg. Today | pmid:9697269 |
Palea S et al. | Pharmacological characterization of thromboxane and prostanoid receptors in human isolated urinary bladder. | 1998 | Br. J. Pharmacol. | pmid:9692770 |
Colville-Nash PR et al. | Inhibition of inducible nitric oxide synthase by peroxisome proliferator-activated receptor agonists: correlation with induction of heme oxygenase 1. | 1998 | J. Immunol. | pmid:9670978 |
Seckl J | Mechanisms of fetal origins of health problems in adults need to be investigated. | 1998 | BMJ | pmid:9665923 |
Marx N et al. | Macrophages in human atheroma contain PPARgamma: differentiation-dependent peroxisomal proliferator-activated receptor gamma(PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro. | 1998 | Am. J. Pathol. | pmid:9665460 |