Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Church MK et al. | Non-IgE-dependent bacteria-induced histamine release from human lung and tonsillar mast cells. | 1987 | Clin. Allergy | pmid:2441900 |
Kosaka Y et al. | Oxatomide inhibits the release of bronchoconstrictor arachidonic acid metabolites (iLTC4 and PGD2) from rat mast cells and guinea-pig lung. | 1987 | Agents Actions | pmid:2442981 |
Pipkorn U et al. | Effect of short-term systemic glucocorticoid treatment on human nasal mediator release after antigen challenge. | 1987 | J. Clin. Invest. | pmid:2443539 |
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pmid:24456221 | ||||
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pmid:24471457 | ||||
Benyon RC et al. | Prostaglandin D2 release from human skin mast cells in response to ionophore A23187. | 1987 | Br. J. Pharmacol. | pmid:2447989 |
Schulman ES et al. | Differential effects of the complement peptides, C5a and C5a des Arg on human basophil and lung mast cell histamine release. | 1988 | J. Clin. Invest. | pmid:2449462 |
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Robinson C et al. | The immunoglobulin E- and calcium-dependent release of histamine and eicosanoids from human dispersed mastocytosis spleen cells. | 1988 | J. Invest. Dermatol. | pmid:2450144 |
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pmid:24565634 | ||||
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pmid:24568186 | ||||
pmid:24571868 | ||||
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Ormerod AD et al. | Prostaglandin D2 and histamine release in cold urticaria unaccompanied by evidence of platelet activation. | 1988 | J. Allergy Clin. Immunol. | pmid:2459177 |
Undem BJ et al. | Isoproterenol-induced inhibition of immunoglobulin E-mediated release of histamine and arachidonic acid metabolites from the human lung mast cell. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2459368 |
Keery RJ and Lumley P | AH6809, a prostaglandin DP-receptor blocking drug on human platelets. | 1988 | Br. J. Pharmacol. | pmid:2460179 |
Barr RM et al. | The release of prostaglandin D2 from human skin in vivo and in vitro during immediate allergic reactions. | 1988 | Br. J. Pharmacol. | pmid:2460180 |
Michel L et al. | Prostaglandin D2 generation in mouse bone marrow-derived mast cells exposed to dexamethasone is associated with endogenous peroxidase activity. | 1988 | Lab. Invest. | pmid:2460694 |
Lebel B et al. | Correlation between symptoms and the threshold for release of mediators in nasal secretions during nasal challenge with grass-pollen grains. | 1988 | J. Allergy Clin. Immunol. | pmid:2461405 |
Bousquet J et al. | Antiallergic activity of H1-receptor antagonists assessed by nasal challenge. | 1988 | J. Allergy Clin. Immunol. | pmid:2461406 |
Church MM et al. | The mediator and cellular basis of the allergic response. | 1988 | Allergy | pmid:2462372 |
Takei M et al. | Role of cyclic AMP during histamine release. Histamine release is not directly related to increase in cyclic AMP levels in rat mast cells activated by concanavalin A, anti-IgE, antigen, prostaglandin D2 and isoproterenol. | 1988 | Biol. Chem. Hoppe-Seyler | pmid:2463844 |
pmid:24639050 | ||||
Jeon KI et al. | Inhibitory effects of PPARγ ligands on TGF-β1-induced corneal myofibroblast transformation. | 2014 | Am. J. Pathol. | pmid:24650561 |
Marone G | Control mechanisms of mediator release in human basophils and mast cells. | 1988 Nov-Dec | Immunol. Invest. | pmid:2465995 |
Miadonna A et al. | Mediators and allergic inflammation of human airways. | 1988 | Respiration | pmid:2466314 |
Trist DG et al. | The antagonism by BW A868C of PGD2 and BW245C activation of human platelet adenylate cyclase. | 1989 | Br. J. Pharmacol. | pmid:2466517 |
pmid:24680891 | ||||
Lebel B et al. | Spontaneous and non-specific release of histamine and PGD2 by bronchoalveolar lavage cells from asthmatic and normal subjects: effect of nedocromil sodium. | 1988 | Clin. Allergy | pmid:2468432 |
Carrier EJ et al. | Levuglandin forms adducts with histone h4 in a cyclooxygenase-2-dependent manner, altering its interaction with DNA. | 2014 | Biochemistry | pmid:24684440 |
Triggiani M et al. | Inhibition of histamine and prostaglandin D2 release from human lung mast cells by ciclosporin A. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468619 |
Charlesworth EN et al. | Cells and secretagogues involved in the human late-phase response. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468620 |
Church MK et al. | Interaction of neuropeptides with human mast cells. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468622 |
Charlesworth EN et al. | Cutaneous late-phase response to allergen. Mediator release and inflammatory cell infiltration. | 1989 | J. Clin. Invest. | pmid:2468688 |
Ohuchi K et al. | Stimulation of histamine release and arachidonic acid metabolism in rat peritoneal mast cells by thapsigargin, a non-TPA-type tumor promoter. | 1989 | Biochim. Biophys. Acta | pmid:2469475 |
Charlesworth EN et al. | Effect of cetirizine on mast cell-mediator release and cellular traffic during the cutaneous late-phase reaction. | 1989 | J. Allergy Clin. Immunol. | pmid:2469708 |
Koyani CN et al. | 15-deoxy-Δ¹²,¹â´-PGJâ‚‚ promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis. | 2014 | Int. J. Cardiol. | pmid:24698234 |
Tippin BL et al. | Intestinal tumor suppression in ApcMin/+ mice by prostaglandin D2 receptor PTGDR. | 2014 | Cancer Med | pmid:24729479 |
Tang J et al. | Aspirin treatment improved mesenchymal stem cell immunomodulatory properties via the 15d-PGJ2/PPARγ/TGF-β1 pathway. | 2014 | Stem Cells Dev. | pmid:24730450 |
Church MK et al. | Mast cells, neuropeptides and inflammation. | 1989 | Agents Actions | pmid:2473641 |
van Overveld FJ | Mediator release from human lung mast cell subtypes in chronic bronchitis and emphysema. | 1989 | Agents Actions | pmid:2473645 |
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Benyon RC et al. | Differential release of histamine and eicosanoids from human skin mast cells activated by IgE-dependent and non-immunological stimuli. | 1989 | Br. J. Pharmacol. | pmid:2474353 |
Ikai K et al. | Inhibitory effect of tranilast on prostaglandin D synthetase. | 1989 | Biochem. Pharmacol. | pmid:2475113 |
pmid:24755408 | ||||
Morrow JD et al. | Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid. | 1989 | Prostaglandins | pmid:2475889 |
Dubertret L et al. | Biological and cellular responses to grass pollen in sensitive patients. | 1989 | Dermatologica | pmid:2476344 |
pmid:24767875 | ||||
Wachs M et al. | Observations on the pathogenesis of nasal priming. | 1989 | J. Allergy Clin. Immunol. | pmid:2477429 |
Stürzebecher S et al. | Effects of PGD2, PGE1, and PGI2-analogues on PGDF-release and aggregation of human gelfiltered platelets. | 1989 | Prog. Clin. Biol. Res. | pmid:2477855 |
Cohan VL et al. | Dexamethasone does not inhibit the release of mediators from human mast cells residing in airway, intestine, or skin. | 1989 | Am. Rev. Respir. Dis. | pmid:2478059 |
Reshef A et al. | The pattern and kinetics in human skin of erythema and mediators during the acute and late-phase response (LPR). | 1989 | J. Allergy Clin. Immunol. | pmid:2478604 |
Marone G et al. | Human basophil/mast cell releasability. VII. Heterogeneity of the effect of adenosine on mediator secretion. | 1989 | Life Sci. | pmid:2480501 |
Kuroyanagi G et al. | Suppression by resveratrol of prostaglandin D2-stimulated osteoprotegerin synthesis in osteoblasts. | 2014 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24813642 |
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Reiss TF et al. | Local mediator release after antigen challenge of a bronchial segment in allergic dogs. | 1989 | Am. J. Physiol. | pmid:2481982 |
pmid:24820432 | ||||
Levi-Schaffer F and Shalit M | Differential release of histamine and prostaglandin D2 in rat peritoneal mast cells activated with peptides. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2482257 |
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Mantel A et al. | Aldo-keto reductase 1C3 is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism. | 2014 | Exp. Dermatol. | pmid:24917395 |
Pradhan A and Olsson PE | Juvenile ovary to testis transition in zebrafish involves inhibition of ptges. | 2014 | Biol. Reprod. | pmid:24920039 |
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Asbóth G et al. | The relation between thromboxane and prostaglandin synthesis in human decidua tissue: a comparison of eicosanoid synthesis in minced tissue with that in a cell-free preparation. | 1989 | Biochim. Biophys. Acta | pmid:2493805 |
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Froissart P et al. | Modulation by phorbol 12-myristate 13-acetate of arachidonic acid release from rat basophilic leukemia cells stimulated with A23187. | 1989 | Biochim. Biophys. Acta | pmid:2496761 |
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pmid:24975423 | ||||
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pmid:24985010 | ||||
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Lapointe DS and Olson MS | Platelet-activating factor-stimulated hepatic glycogenolysis is not mediated through cyclooxygenase-derived metabolites of arachidonic acid. | 1989 | J. Biol. Chem. | pmid:2501299 |
pmid:25016088 | ||||
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Robinson C et al. | The IgE- and calcium-dependent release of eicosanoids and histamine from human purified cutaneous mast cells. | 1989 | J. Invest. Dermatol. | pmid:2504819 |
Ikai K et al. | Prostaglandin D2, a mediator in both immediate and delayed-type immune reactions in the skin. | 1989 | Dermatologica | pmid:2506083 |
pmid:25072357 | ||||
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