PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
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| Nishizawa EE et al. | Prostaglandin d2 as a potential antithrombotic agent. | 1975 | Prostaglandins | pmid:806102 |
| Kunkel SL et al. | Suppression of immune complex vasculitis in rats by prostaglandin. | 1979 | J. Clin. Invest. | pmid:159314 |
| Cooper B | Diminished platelet adenylate cyclase activation by prostaglandin D2 in acute thrombosis. | 1979 | Blood | pmid:380688 |
| Wendling MG and DuCharme DW | Cardiovascular effects of prostaglandin D3 and D2 in anesthetized dogs. | 1981 | Prostaglandins | pmid:6945633 |
| Spannhake EW et al. | Bronchoactive metabolites of arachidonic acid and their role in airway function. | 1981 | Prostaglandins | pmid:6801729 |
| Stenson WF et al. | Metabolism of exogenous arachidonic acid by murine macrophage-like tumor cell lines. | 1981 | Prostaglandins | pmid:6803301 |
| Claeys M et al. | Lack of prostacyclin biosynthesis by aortic tissue of the chicken. | 1981 | Prostaglandins | pmid:6803304 |
| Gerritsen ME and Printz MP | Prostaglandin D synthase in microvessels from the rat cerebral cortex. | 1981 | Prostaglandins | pmid:6119739 |
| Lagarde M et al. | Refractoriness of diabetic platelets to inhibitory prostaglandins. | 1981 | Prostaglandins Med | pmid:6273957 |
| Smith JB | Prostaglandins and platelet aggregation. | 1981 | Acta Med. Scand. Suppl. | pmid:7034481 |
| Nakagawa S et al. | Evaluation of prostaglandin D2 (PGD2) as an anticoagulative agent for haemodialysis in comparison with prostaglandin E1 (PGE1). | 1981 | Proc Eur Dial Transplant Assoc | pmid:7036145 |
| McRea JC et al. | Prostaglandin releasing polymers - stability and efficacy. | 1981 | Trans Am Soc Artif Intern Organs | pmid:7036503 |
| Harris DN et al. | 9 alpha-homo-9,11-epoxy-5,13-prostadienoic acid analogues: specific stable agonist (SQ 26, 538) and antagonist (SQ 26, 536) of the human platelet thromboxane receptor. | 1981 | Prostaglandins | pmid:6270744 |
| Hemker DP and Aiken JW | Effects of prostaglandins on autonomic function in vivo, with special emphasis on PGD2 and PGD3. | 1981 | Prog. Lipid Res. | pmid:6952267 |
| Poynard T et al. | Secretory diarrhea and prostaglandin D2 overproduction in systemic mastocytosis. | 1982 | N. Engl. J. Med. | pmid:6953312 |
| Fukushima M et al. | Prostaglandin D2, a potential antineoplastic agent. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6953969 |
| Watanabe T et al. | NADP-linked 15-hydroxyprostaglandin dehydrogenase for prostaglandin D in human blood platelets. | 1982 | Arch. Biochem. Biophys. | pmid:6954879 |
| Sirén AL | Central cardiovascular and thermal effects of prostaglandin D2 in rats. | 1982 | Prostaglandins Leukot Med | pmid:6955803 |
| Mitchell MD et al. | The human placenta: a major source of prostaglandin D2. | 1982 | Prostaglandins Leukot Med | pmid:6955806 |
| Gualde N et al. | Stimulation of prostaglandin synthesis by the serum factor (FTS). | 1982 | Cell. Immunol. | pmid:6957270 |
| Tokumoto H et al. | An NADP-linked 15-hydroxyprostaglandin dehydrogenase specific for prostaglandin D2 from swine brain. | 1982 | J. Biol. Chem. | pmid:6958674 |
| Narumiya S et al. | Prostaglandin D2 in rat brain, spinal cord and pituitary: basal level and regional distribution. | 1982 | Life Sci. | pmid:6960222 |
| Ueno R et al. | Prostaglandin D2 induces sleep when microinjected into the preoptic area of conscious rats. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6960896 |
| Fukushima M et al. | 9-deoxy-delta 9-prostaglandin D2, a prostaglandin D2 derivative with potent antineoplastic and weak smooth muscle-contracting activities. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6961920 |
| Ishizawa M and Minowa T | Effects of PGD2 and PGF2 alpha on longitudinal and circular muscles of guinea-pig isolated proximal colon. | 1982 | Prostaglandins | pmid:6962973 |
| Peters SP et al. | The role of prostaglandin D2 in IgE-mediated reactions in man. | 1982 | Trans. Assoc. Am. Physicians | pmid:6963831 |
| Kennedy I et al. | Studies on the characterisation of prostanoid receptors: a proposed classification. | 1982 | Prostaglandins | pmid:6131499 |
| Watanabe T et al. | Characterization of the biosynthetic pathway of prostaglandin D2 in human platelet-rich plasma. | 1982 | J. Biol. Chem. | pmid:6816798 |
| Qureshi Z and Cagen LM | Prostaglandins F2 alpha produced by rabbit renal slices is not a metabolite of prostaglandins E2. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6803799 |
| Lewis RA et al. | Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE. | 1982 | J. Immunol. | pmid:6809826 |
| Karniguian A et al. | Prostaglandins: specific inhibition of platelet adhesion to collagen and relationship with cAMP level. | 1982 | Prostaglandins | pmid:6287536 |
| Shimizu T et al. | Specific binding of prostaglandin D2 to rat brain synaptic membrane. Occurrence, properties, and distribution. | 1982 | J. Biol. Chem. | pmid:6292197 |
| Ruzicka T and Printz MP | Arachidonic acid metabolism in guinea pig skin. | 1982 | Biochim. Biophys. Acta | pmid:6809055 |
| Kinoshita F et al. | Suppressive effect of prostaglandin (PG)D2 on pulsatile luteinizing hormone release in conscious castrated rats. | 1982 | Endocrinology | pmid:6951712 |
| Okamatsu S and Lefer AM | Cardiac effects of prostaglandins during global ischemia in isolated perfused cat hearts. | 1982 | Prostaglandins Leukot Med | pmid:6952273 |