PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sasaguri T et al. | Prostaglandins A and J arrest the cell cycle of cultured vascular smooth muscle cells without suppression of c-myc expression. | 1992 | Exp. Cell Res. | pmid:1572402 |
| Kuchinke W et al. | A lung type prostaglandin F synthase is expressed in bovine liver: cDNA sequence and expression in E. coli. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1339268 |
| Ninomiya H et al. | Endothelin-1 induces stimulation of prostaglandin synthesis in cells obtained from canine airways by bronchoalveolar lavage. | 1992 | Prostaglandins | pmid:1584994 |
| Krueger JM et al. | Prostaglandins E2 and D2 have little effect on rabbit sleep. | 1992 | Physiol. Behav. | pmid:1523224 |
| Naclerio RM | Additional properties of cetirizine, a new H1 antagonist. | 1991 May-Jun | Allergy Proc | pmid:1680095 |
| Lundin-Schiller S and Mitchell MD | Prostaglandin production by human chorion laeve cells in response to inflammatory mediators. | 1991 Jul-Aug | Placenta | pmid:1946245 |
| Conde B et al. | Modulation of cell growth and differentiation induced by prostaglandin D2 in the glioma cell line C6. | 1991 Jan-Feb | Anticancer Res. | pmid:1902073 |
| Giles H et al. | A comparative study of the prostanoid receptor profile of 9 alpha 11 beta-prostaglandin F2 and prostaglandin D2. | 1991 | Br. J. Pharmacol. | pmid:1665742 |
| Georgitis JW et al. | Nasal inflammatory mediator release in ragweed allergic rhinitis: correlation with cellular influx into nasal secretions. | 1991 | Int. Arch. Allergy Appl. Immunol. | pmid:1666629 |
| Takayanagi I et al. | Effects of aging on alpha 2-adrenoceptor mechanisms in isolated guinea-pig tracheal preparations. | 1991 | Eur. J. Pharmacol. | pmid:1674919 |
| Goerg KJ et al. | Antisecretory effect of prostaglandin D2 in rat colon in vitro: action sites. | 1991 | Am. J. Physiol. | pmid:1676243 |
| Fox CC et al. | Modulation of mediator release from human intestinal mast cells by sulfasalazine and 5-aminosalicylic acid. | 1991 | Dig. Dis. Sci. | pmid:1703070 |
| Keenan CM and Rangachari PK | Contrasting effects of PGE2 and PGD2: ion transport in the canine proximal colon. | 1991 | Am. J. Physiol. | pmid:2003610 |
| Roberts LJ and Oates JA | Biochemical diagnosis of systemic mast cell disorders. | 1991 | J. Invest. Dermatol. | pmid:16799604 |
| Massey WA et al. | Profile of prostanoid release following antigen challenge in vivo in the skin of man. | 1991 | Br. J. Dermatol. | pmid:1760357 |
| Shikada K et al. | NIP-121 and cromakalim, potassium channel openers, preferentially suppress prostanoid-induced contraction of the guinea-pig isolated trachea. | 1991 | Eur. J. Pharmacol. | pmid:1814761 |
| Gaetani P et al. | Effect of high-dose methylprednisolone and U74006F on eicosanoid synthesis after subarachnoid hemorrhage in rats. | 1991 | Stroke | pmid:1900645 |
| Brodsky L et al. | Arachidonic acid metabolites in middle ear effusions of children. | 1991 | Ann. Otol. Rhinol. Laryngol. | pmid:1648326 |
| Weiler H et al. | Studies on the effects of aminopterin and methotrexate on the release of prostaglandin PGE2, PGD2, and PGI2 from small intestine in the rat in vivo. | 1991 | Clin. Chim. Acta | pmid:1769112 |
| Watanabe T et al. | Characterization of prostaglandin and thromboxane receptors expressed on a megakaryoblastic leukemia cell line, MEG-01s. | 1991 | Blood | pmid:1718495 |
| Minc-Golomb D et al. | Gene dosage of CuZnSOD and Down's syndrome: diminished prostaglandin synthesis in human trisomy 21, transfected cells and transgenic mice. | 1991 | EMBO J. | pmid:1829676 |
| Tasaki Y et al. | Prostaglandin D2 metabolite stimulates collagen synthesis by human osteoblasts during calcification. | 1991 | Prostaglandins | pmid:1871375 |
| Vesin MF et al. | Preferential synthesis of prostaglandin D2 by neurons and prostaglandin E2 by fibroblasts and nonneuronal cells in chick dorsal root ganglia. | 1991 | J. Neurochem. | pmid:2051162 |
| Ramis I et al. | In vivo release of 15-HETE and other arachidonic acid metabolites in nasal secretions during early allergic reactions. | 1991 | Prostaglandins | pmid:1662405 |
| Fukushima M | [Prostaglandins and cell proliferation]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:2024021 |
| Hori T et al. | Prostaglandins antagonize fibroblast proliferation stimulated by tumor necrosis factor. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1993070 |
| White MV et al. | Hydrocortisone inhibits rat basophilic leukemia cell mediator release induced by neutrophil-derived histamine releasing activity as well as by anti-IgE. | 1991 | J. Immunol. | pmid:1712816 |
| Stellato C et al. | General anaesthetics induce only histamine release selectively from human mast cells. | 1991 | Br J Anaesth | pmid:1722691 |
| Walmrath D et al. | Intravascular anti-IgE challenge in perfused lungs: mediator release and vascular pressor response. | 1991 | J. Appl. Physiol. | pmid:1723406 |
| Vesin MF and Droz B | Biosynthesis of prostaglandins D2 and E2 in chick dorsal root ganglion during development. | 1991 | J. Neurochem. | pmid:1904909 |
| Misawa M and Kanai Y | Effect of the new antiallergic drug epinastine on chemical mediator induced bronchoconstrictions in guinea pigs. | 1991 | Arzneimittelforschung | pmid:1725697 |
| Abman SH and Accurso FJ | Sustained fetal pulmonary vasodilation with prolonged atrial natriuretic factor and GMP infusions. | 1991 | Am. J. Physiol. | pmid:1847014 |
| Sladek K et al. | Formation of PGD2 after allergen inhalation in atopic asthmatics. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1847781 |
| King LS et al. | Pulmonary vascular effects of prostaglandin D2, but not its systemic vascular or airway effects, are mediated through thromboxane receptor activation. | 1991 | Circ. Res. | pmid:1825033 |
| Arzubiaga C et al. | Neuropeptide Y, a putative cotransmitter in noradrenergic neurons, induces mast cell degranulation but not prostaglandin D2 release. | 1991 | J. Allergy Clin. Immunol. | pmid:1825102 |
| Koshihara Y et al. | Prostaglandin D2 stimulates calcification by human osteoblastic cells. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825424 |
| Atsmon J et al. | Modulation of the antiproliferative activity of 9-deoxy-delta 9,delta 12(E)-PGD2 by conjugation with intracellular glutathione. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825432 |
| Hayaishi O | Molecular mechanisms of sleep-wake regulation: roles of prostaglandins D2 and E2. | 1991 | FASEB J. | pmid:1907936 |
| Koizumi K et al. | Induction of 31,000 protein by PGD2-treated vascular endothelial cells. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825433 |
| Morrow JD et al. | A stable isotope dilution mass spectrometric assay for the major urinary metabolite of PGD2. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825560 |
| Howarth P et al. | The comparative nasal effects of prostaglandin D2 in normal and rhinitic subjects. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825579 |
| Gundel RH et al. | The effects of a 5-lipoxygenase inhibitor on antigen-induced mediator release, late-phase bronchoconstriction and cellular infiltrates in primates. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825582 |
| Watanabe K et al. | The structure and function of prostaglandin F synthase. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825592 |
| Gebicke-Haerter PJ et al. | Regulation and glucocorticoid-independent induction of lipocortin I in cultured astrocytes. | 1991 | J. Neurochem. | pmid:1828830 |
| Francis HP et al. | The thromboxane receptor antagonist BAY u3405 reverses prostaglandin D2 (PGD2)-induced bronchoconstriction in the anaesthetised guinea pig. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1835329 |
| Kobayashi Y et al. | Syntheses of 2,6-dideoxy-6-fluoro-2-[(3R and 3S)-3- hydroxytetradecanamido]-3-O-[(3R)-3-(tetradecanoyloxy)tetra decanoyl]-D- glucopyranose 4-(dihydrogen phosphate) and 2-deoxy-2-[(3R and 3S)-3- hydroxytetradecanamido]-3-O-[(3R)-3-(tetradecanoyloxy)tetra decanoyl]- alpha-D-glucopyranosyl fluoride 4-(dihydrogen phosphate): fluorosugar analogues of GLA-60. | 1991 | Carbohydr. Res. | pmid:1813114 |
| Murakami M et al. | Eicosanoid generation from antigen-primed mast cells by extracellular mammalian 14-kDa group II phospholipase A2. | 1991 | FEBS Lett. | pmid:1756867 |
| McMahon TJ et al. | Influence of SQ 30741 on thromboxane receptor-mediated responses in the feline pulmonary vascular bed. | 1991 | J. Appl. Physiol. | pmid:1837015 |
| Ney P and Schrör K | PGD2 and its mimetic ZK 110.841 are potent inhibitors of receptor-mediated activation of human neutrophils. | 1991 | Eicosanoids | pmid:1647806 |
| Smith GS et al. | Adaptive cytoprotection against alcohol injury in the rat stomach is not due to increased prostanoid synthesis. | 1991 | Prostaglandins | pmid:1906621 |