PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Sarcoidosis D012507 13 associated lipids
Pleurisy D010998 20 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cataract D002386 34 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Sarcoma 180 D012510 21 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Precancerous Conditions D011230 48 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Hypotension D007022 41 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Coronary Disease D003327 70 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Rhinitis D012220 10 associated lipids
Melanoma D008545 69 associated lipids
Asthma D001249 52 associated lipids
Hyperemia D006940 25 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Leukemia P388 D007941 43 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Myocardial Infarction D009203 21 associated lipids
Peritonitis D010538 38 associated lipids
Urticaria Pigmentosa D014582 4 associated lipids
Alzheimer Disease D000544 76 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Arteriosclerosis D001161 86 associated lipids
Leukemia D007938 74 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Hematoma D006406 5 associated lipids
Myeloproliferative Disorders D009196 5 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Fibrosis D005355 23 associated lipids
Ascariasis D001196 3 associated lipids
Thyroid Diseases D013959 8 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Carcinoma, Renal Cell D002292 12 associated lipids
Fetal Weight D020567 12 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Stroke D020521 32 associated lipids
Leukodystrophy, Globoid Cell D007965 6 associated lipids
Liver Cirrhosis, Biliary D008105 12 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hyperlipoproteinemia Type IV D006953 6 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Brain Ischemia D002545 89 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Seizures D012640 87 associated lipids
Nerve Degeneration D009410 53 associated lipids
Peptic Ulcer D010437 19 associated lipids
Leukemia, Basophilic, Acute D015471 9 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Astrocytoma D001254 15 associated lipids
Carotid Artery Thrombosis D002341 7 associated lipids
Nasal Polyps D009298 26 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Erythema D004890 22 associated lipids
Hyperalgesia D006930 42 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Fever D005334 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Thrombocytopenia D013921 15 associated lipids
Bronchial Spasm D001986 18 associated lipids
Hyperlipidemias D006949 73 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Cough D003371 19 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Kim YI et al. Effects of 15-deoxy-∆¹²,¹⁴-prostaglandin J₂ on the production of IL-8 and the expression of Toll-like receptor 2 in human primary keratinocytes stimulated with lipopolysaccharide. 2011 Mol. Biol. Rep. pmid:20174873
Tsujita T et al. Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system: a study using green fluorescent protein transgenic zebrafish. 2011 Genes Cells pmid:21143560
Neri T et al. Role of NF-kappaB and PPAR-gamma in lung inflammation induced by monocyte-derived microparticles. 2011 Eur. Respir. J. pmid:21148223
Kumar VB et al. Angiogenic effect of laminin involves modulation of cyclooxygenase-2 and prostaglandin levels. 2011 Exp. Biol. Med. (Maywood) pmid:21148739
Higuchi S et al. IL-4 mediates dicloxacillin-induced liver injury in mice. 2011 Toxicol. Lett. pmid:21094227
Afrin LB Polycythemia from mast cell activation syndrome: lessons learned. 2011 Am. J. Med. Sci. pmid:21642812
Kajiwara D et al. Role of hematopoietic prostaglandin D synthase in biphasic nasal obstruction in guinea pig model of experimental allergic rhinitis. 2011 Eur. J. Pharmacol. pmid:21645503
Erttmann SF et al. PGD2 and PGE2 regulate gene expression of Prx 6 in primary macrophages via Nrf2. 2011 Free Radic. Biol. Med. pmid:21651978
Chiba T et al. The opposing role of two prostaglandin D2 receptors, DP and CRTH2, in human eosinophil migration. 2011 Ann. Allergy Asthma Immunol. pmid:21624751
Liu TY et al. [Advances in the study of histaminergic systems and sleep-wake regulation]. 2011 Yao Xue Xue Bao pmid:21626776
Zhang Y et al. Simultaneous and high-throughput quantitation of urinary tetranor PGDM and tetranor PGEM by online SPE-LC-MS/MS as inflammatory biomarkers. 2011 J Mass Spectrom pmid:21706677
Ugajin T et al. FcεRI, but not FcγR, signals induce prostaglandin D2 and E2 production from basophils. 2011 Am. J. Pathol. pmid:21712025
Tobiasova Z et al. Peroxisome proliferator-activated receptor-γ agonists prevent in vivo remodeling of human artery induced by alloreactive T cells. 2011 Circulation pmid:21690493
Menon R et al. Amniotic fluid eicosanoids in preterm and term births: effects of risk factors for spontaneous preterm labor. 2011 Obstet Gynecol pmid:21691170
Chowdhury AA et al. 15-Deoxy-Δ(12,14)-prostaglandin J(2) interferes inducible synthesis of prostaglandins E(2) and F(2α) that suppress subsequent adipogenesis program in cultured preadipocytes. 2011 Prostaglandins Other Lipid Mediat. pmid:21699992
Yamamoto Y et al. Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2. 2011 Am. J. Pathol. pmid:21703412
Ebersberger A et al. Effects of prostaglandin D2 on tetrodotoxin-resistant Na+ currents in DRG neurons of adult rat. 2011 Pain pmid:21345590
Ulivi V et al. Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an anti-inflammatory cyclooxygenase-2 (COX-2) pathway. 2011 Arthritis Res. Ther. pmid:21682897
Farhat A et al. Hematopoietic-Prostaglandin D2 synthase through PGD2 production is involved in the adult ovarian physiology. 2011 J Ovarian Res pmid:21352547
Yamamoto Y et al. 15-Deoxy-Δ12,14-prostaglandin J2 enhanced the anti-tumor activity of camptothecin against renal cell carcinoma independently of topoisomerase-II and PPARγ pathways. 2011 Biochem. Biophys. Res. Commun. pmid:21683069
Luker T et al. Zwitterionic CRTh2 antagonists. 2011 J. Med. Chem. pmid:21355602
Ayoub SS et al. Cyclooxygenase expression and prostaglandin levels in central nervous system tissues during the course of chronic relapsing experimental autoimmune encephalomyelitis (EAE). 2011 Inflamm. Res. pmid:21667309
Matsumoto T et al. Lipocalin-type prostaglandin D synthase is associated with coronary vasospasm and vasomotor reactivity in response to acetylcholine. 2011 Circ. J. pmid:21325722
Wang P et al. Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-Δ(12,14)-PGJ2. 2011 PLoS ONE pmid:22096605
Varma D et al. Comparison of UHPLC and HPLC methods for the assay of prostanoids: "are the methods equivalent in terms of accuracy and precision?". 2011 Bioanalysis pmid:21510759
Raman P et al. 15-Deoxy-delta12,14-prostaglandin J2-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor gamma. 2011 Mol. Pharmacol. pmid:21511917
Lin TH et al. 15-deoxy-Δ(12,14) -prostaglandin-J2 and ciglitazone inhibit TNF-α-induced matrix metalloproteinase 13 production via the antagonism of NF-κB activation in human synovial fibroblasts. 2011 J. Cell. Physiol. pmid:21344384
Zheng S et al. Novel biphasic role of LipoxinA(4) on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts. 2011 Mediators Inflamm. pmid:21765620
Lalier L et al. Prostaglandins antagonistically control Bax activation during apoptosis. 2011 Cell Death Differ. pmid:20966963
Hernandez JM and Janssen LJ Thromboxane prostanoid receptor activation amplifies airway stretch-activated contractions assessed in perfused intact bovine bronchial segments. 2011 J. Pharmacol. Exp. Ther. pmid:21768224
Sharma I et al. In vitro effects of peroxisome proliferator-activated receptor-γ ligands on gene expression in lipopolysaccharide-induced endometrial and endometriotic stromal cells. 2011 Fertil. Steril. pmid:20970133
Tanaka A et al. Mast cells function as an alternative modulator of adipogenesis through 15-deoxy-delta-12, 14-prostaglandin J2. 2011 Am. J. Physiol., Cell Physiol. pmid:21865589
Larsson AK et al. Prostaglandin Dâ‚‚ induces contractions through activation of TP receptors in peripheral lung tissue from the guinea pig. 2011 Eur. J. Pharmacol. pmid:21872585
Degousee N et al. Group V phospholipase A2 in bone marrow-derived myeloid cells and bronchial epithelial cells promotes bacterial clearance after Escherichia coli pneumonia. 2011 J. Biol. Chem. pmid:21849511
Mesquita-Santos FP et al. Co-operative signalling through DP(1) and DP(2) prostanoid receptors is required to enhance leukotriene C(4) synthesis induced by prostaglandin D(2) in eosinophils. 2011 Br. J. Pharmacol. pmid:20973774
Wienecke T et al. Discrepancy between strong cephalic arterial dilatation and mild headache caused by prostaglandin Dâ‚‚ (PGDâ‚‚). 2011 Cephalalgia pmid:20974593
El-Shazly AE et al. IFN-γ and TNF-α potentiate prostaglandin D2-induced human eosinophil chemotaxis through up-regulation of CRTH2 surface receptor. 2011 Int. Immunopharmacol. pmid:21835268
Kuehn HS et al. Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release. 2011 J. Biol. Chem. pmid:20980255
Surh YJ et al. 15-Deoxy-Δ¹²,¹⁴-prostaglandin J₂, an electrophilic lipid mediator of anti-inflammatory and pro-resolving signaling. 2011 Biochem. Pharmacol. pmid:21843512
Bräutigam K et al. Combined treatment with TRAIL and PPARγ ligands overcomes chemoresistance of ovarian cancer cell lines. 2011 J. Cancer Res. Clin. Oncol. pmid:20878528
Alves C et al. Effects of 15d-PGJâ‚‚-loaded poly(D,L-lactide-co-glycolide) nanocapsules on inflammation. 2011 Br. J. Pharmacol. pmid:20883476
Lu Y et al. Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation. 2011 Biochem. Pharmacol. pmid:21907188
Kanda N et al. The antimycotic drugs itraconazole and terbinafine hydrochloride induce the production of human β-defensin-3 in human keratinocytes. 2011 Immunobiology pmid:20875690
Burke SJ and Collier JJ The gene encoding cyclooxygenase-2 is regulated by IL-1β and prostaglandins in 832/13 rat insulinoma cells. 2011 Cell. Immunol. pmid:21885043
Liu H et al. Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury. 2011 Neurobiol. Dis. pmid:20933087
Crosignani S et al. Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases. 2011 J. Med. Chem. pmid:21916510
Moniot B et al. Hematopoietic prostaglandin D synthase (H-Pgds) is expressed in the early embryonic gonad and participates to the initial nuclear translocation of the SOX9 protein. 2011 Dev. Dyn. pmid:21887724
Hewson CA et al. A differential role for ceramide kinase in antigen/FcɛRI-mediated mast cell activation and function. 2011 Clin. Exp. Allergy pmid:21255156
Kanai Y et al. Identification of novel oxidized levuglandin D2 in marine red alga and mouse tissue. 2011 J. Lipid Res. pmid:21893678
Tao H and Hajri T Very low density lipoprotein receptor promotes adipocyte differentiation and mediates the proadipogenic effect of peroxisome proliferator-activated receptor gamma agonists. 2011 Biochem. Pharmacol. pmid:21924248
De Nuccio C et al. Peroxisome proliferator-activated receptor γ agonists accelerate oligodendrocyte maturation and influence mitochondrial functions and oscillatory Ca(2+) waves. 2011 J. Neuropathol. Exp. Neurol. pmid:21937914
Choi YH et al. The extracellular signal-regulated kinase mitogen-activated protein kinase/ribosomal S6 protein kinase 1 cascade phosphorylates cAMP response element-binding protein to induce MUC5B gene expression via D-prostanoid receptor signaling. 2011 J. Biol. Chem. pmid:21832046
Ji Y et al. Nutrient-induced inflammation in the intestine. 2011 Curr Opin Clin Nutr Metab Care pmid:21587069
Jakob S and Lovell-Badge R Sex determination and the control of Sox9 expression in mammals. 2011 FEBS J. pmid:21281448
Hardy KD et al. Nonenzymatic free radical-catalyzed generation of 15-deoxy-Δ(12,14)-prostaglandin J₂-like compounds (deoxy-J₂-isoprostanes) in vivo. 2011 J. Lipid Res. pmid:20944061
Wang JJ and Mak OT Induction of apoptosis in non-small cell lung carcinoma A549 cells by PGDâ‚‚ metabolite, 15d-PGJâ‚‚. 2011 Cell Biol. Int. pmid:21999315
Seno T et al. 15-Deoxy-Δ¹²,¹⁴ prostaglandin J₂ reduces the formation of atherosclerotic lesions in apolipoprotein E knockout mice. 2011 PLoS ONE pmid:22003398
Birbian N et al. No association of PTGDR -441C/T polymorphism with asthma in a North Indian population. 2011 Dis. Markers pmid:22182808
Ahmed SR et al. Prostaglandin D2 regulates CD4+ memory T cell trafficking across blood vascular endothelium and primes these cells for clearance across lymphatic endothelium. 2011 J. Immunol. pmid:21715691
Yu R et al. Competitive enzymatic interactions determine the relative amounts of prostaglandins E2 and D2. 2011 J. Pharmacol. Exp. Ther. pmid:21865441
Koyama J et al. Simultaneous determination of histamine and prostaglandin D2 using an LC-ESI-MS/MS method with positive/negative ion-switching ionization modes: application to the study of anti-allergic flavonoids on the degranulation of KU812 cells. 2011 Anal Bioanal Chem pmid:21725829
Galvão Nascimento N et al. Contribution of mast cells to the oedema induced by Bothrops moojeni snake venom and a pharmacological assessment of the inflammatory mediators involved. 2010 Feb-Mar Toxicon pmid:19703484
Mutalithas K et al. CRTH2 expression on T cells in asthma. 2010 Clin. Exp. Immunol. pmid:20491797
Koharudin LM et al. Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20231490
Lou HQ et al. [CRTH2 antagonist ameliorates airway inflammation in rats with asthma]. 2010 Zhejiang Da Xue Xue Bao Yi Xue Ban pmid:20175238
He R et al. The prostaglandin Dâ‚‚ receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge. 2010 J. Allergy Clin. Immunol. pmid:20713302
Schell C et al. 15-Deoxy-delta 12-14-prostaglandin-J2 induces hypertrophy and loss of contractility in human testicular peritubular cells: implications for human male fertility. 2010 Endocrinology pmid:20133451
Poncin S et al. Oxidative stress: a required condition for thyroid cell proliferation. 2010 Am. J. Pathol. pmid:20093493
Wang Y et al. Role of cyclooxygenase-2 signaling pathway dysfunction in unexplained recurrent spontaneous abortion. 2010 Chin. Med. J. pmid:20819509
Xiao Y et al. 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-gamma-dependent and mediated by the caspase-3-dependent apoptotic pathway. 2010 FEBS J. pmid:20050918
van den Brule S et al. The D prostanoid receptor agonist BW245C [(4S)-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidineheptanoic acid] inhibits fibroblast proliferation and bleomycin-induced lung fibrosis in mice. 2010 J. Pharmacol. Exp. Ther. pmid:20719937
Watanabe K et al. 15-deoxy-delta 12,14-prostaglandin J2 prevents inflammatory response and endothelial cell damage in rats with acute obstructive cholangitis. 2010 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:20056897
Kar R et al. Mitochondrial remodeling following fission inhibition by 15d-PGJ2 involves molecular changes in mitochondrial fusion protein OPA1. 2010 Biochem. Biophys. Res. Commun. pmid:20678484
Satoh T et al. Indomethacin-induced reduction in CRTH2 in eosinophilic pustular folliculitis (Ofuji's disease): a proposed mechanism of action. 2010 Acta Derm. Venereol. pmid:20107720
Akin C et al. Mast cell activation syndrome: Proposed diagnostic criteria. 2010 J. Allergy Clin. Immunol. pmid:21035176
Veliça P et al. Prostaglandin D2 inhibits C2C12 myogenesis. 2010 Mol. Cell. Endocrinol. pmid:20109525
Gallant MA et al. Increased concentrations of prostaglandin D2 during post-fracture bone remodeling. 2010 J. Rheumatol. pmid:20080921
Zhang HX et al. Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-Delta(12,14)-prostaglandin J(2). 2010 Exp. Neurol. pmid:20083106
Katura T et al. 15-Deoxy-delta 12,14-prostaglandin J2 biphasically regulates the proliferation of mouse hippocampal neural progenitor cells by modulating the redox state. 2010 Mol. Pharmacol. pmid:20086036
Buga GM et al. L-4F alters hyperlipidemic (but not healthy) mouse plasma to reduce platelet aggregation. 2010 Arterioscler. Thromb. Vasc. Biol. pmid:19965777
Roy SJ et al. Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: identification of a recycling motif. 2010 Eur. J. Pharmacol. pmid:20035740
Lin TY and London CA Characterization and modulation of canine mast cell derived eicosanoids. 2010 Vet. Immunol. Immunopathol. pmid:20036014
Byrns MC et al. Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer. 2010 J. Steroid Biochem. Mol. Biol. pmid:20036328
Kim SH et al. Toluene diisocyanate (TDI) regulates haem oxygenase-1/ferritin expression: implications for toluene diisocyanate-induced asthma. 2010 Clin. Exp. Immunol. pmid:20345975
Zimmer M et al. The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. 2010 Cancer Res. pmid:20354189
Koyama M et al. Histone deacetylase inhibitors and 15-deoxy-Delta12,14-prostaglandin J2 synergistically induce apoptosis. 2010 Clin. Cancer Res. pmid:20371690
Kim DH et al. 15-Deoxy-Delta(12,14)-prostaglandin J(2) stabilizes, but functionally inactivates p53 by binding to the cysteine 277 residue. 2010 Oncogene pmid:20208557
Cho HY et al. Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice. 2010 Am. J. Respir. Crit. Care Med. pmid:20224069
Krall CM et al. Food deprivation alters thermoregulatory responses to lipopolysaccharide by enhancing cryogenic inflammatory signaling via prostaglandin D2. 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20393159
Lee JJ et al. The protective effects of paclitaxel on platelet aggregation through the inhibition of thromboxane A2 synthase. 2010 Arch. Pharm. Res. pmid:20361303
Pérez-Novo CA et al. CRTH2 mediates the activation of human Th2 cells in response to PGD(2) released from IgE/anti-IgE treated nasal polyp tissue. 2010 Allergy pmid:19839971
Bach-Ngohou K et al. Enteric glia modulate epithelial cell proliferation and differentiation through 15-deoxy-12,14-prostaglandin J2. 2010 J. Physiol. (Lond.) pmid:20478974
Masoodi M et al. Prostaglandin D production in FM55 melanoma cells is regulated by alpha-melanocyte-stimulating hormone and is not related to melanin production. 2010 Exp. Dermatol. pmid:20482620
Hilliard M et al. The anti-inflammatory prostaglandin 15-deoxy-delta(12,14)-PGJ2 inhibits CRM1-dependent nuclear protein export. 2010 J. Biol. Chem. pmid:20457605
Yokoyama Y et al. 15-Deoxy-Delta12,14-prostaglandin J2 inhibits angiotensin II-induced fibronectin expression via hepatocyte growth factor induction in human peritoneal mesothelial cells. 2010 Ther Apher Dial pmid:20438519
Romanovsky AA and Garami A Prostaglandin riddles in energy metabolism: E is for excess, D is for depletion. Focus on "Food deprivation alters thermoregulatory responses to lipopolysaccharide by enhancing cryogenic inflammatory signaling via prostaglandin D2". 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20410482
Shiraya K et al. A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules. 2010 J. Biol. Chem. pmid:20448048
Mishra N et al. Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-Delta(12,14)-prostaglandin J2. 2010 Biochem. Biophys. Res. Commun. pmid:20307494
Guo N et al. Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease. 2010 J. Biol. Chem. pmid:20308056
Poncin S et al. N-acetylcysteine and 15 deoxy-{delta}12,14-prostaglandin J2 exert a protective effect against autoimmune thyroid destruction in vivo but not against interleukin-1{alpha}/interferon {gamma}-induced inhibitory effects in thyrocytes in vitro. 2010 Am. J. Pathol. pmid:20489149