Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Mutalithas K et al. | CRTH2 expression on T cells in asthma. | 2010 | Clin. Exp. Immunol. | pmid:20491797 |
Koharudin LM et al. | Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20231490 |
Norman P | DP(2) receptor antagonists in development. | 2010 | Expert Opin Investig Drugs | pmid:20615077 |
Pedersen PJ et al. | Prostaglandin phospholipid conjugates with unusual biophysical and cytotoxic properties. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20591667 |
Bai YJ et al. | A LC-MS-based method for quantification of biomarkers from serum of allergic rats. | 2010 | Molecules | pmid:20657485 |
Reddy RC and Standiford TJ | Nrf2 and PPAR{gamma}: PPARtnering against oxidant-induced lung injury. | 2010 | Am. J. Respir. Crit. Care Med. | pmid:20634499 |
Ahmad AS et al. | Prostaglandin D2 DP1 receptor is beneficial in ischemic stroke and in acute exicitotoxicity in young and old mice. | 2010 | Age (Dordr) | pmid:20640551 |
Shah S et al. | Efficacy and safety of extended-release niacin/laropiprant plus statin vs. doubling the dose of statin in patients with primary hypercholesterolaemia or mixed dyslipidaemia. | 2010 | Int. J. Clin. Pract. | pmid:20518948 |
Genovese A et al. | Human cardiac mast cells in anaphylaxis. | 2010 | Chem Immunol Allergy | pmid:20519884 |
Diers AR et al. | Modulation of mammary cancer cell migration by 15-deoxy-delta(12,14)-prostaglandin J(2): implications for anti-metastatic therapy. | 2010 | Biochem. J. | pmid:20536428 |
Vong L et al. | A pro-resolution mediator, prostaglandin D(2), is specifically up-regulated in individuals in long-term remission from ulcerative colitis. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20547854 |
Lehmann GM et al. | Novel anti-adipogenic activity produced by human fibroblasts. | 2010 | Am. J. Physiol., Cell Physiol. | pmid:20554910 |
Schuligoi R et al. | CRTH2 and D-type prostanoid receptor antagonists as novel therapeutic agents for inflammatory diseases. | 2010 | Pharmacology | pmid:20559016 |
Kaur S et al. | Induction of prostaglandin D2 through the p38 MAPK pathway is responsible for the antipruritic activity of sertaconazole nitrate. | 2010 | J. Invest. Dermatol. | pmid:20505747 |
Rodrigues WF et al. | 15d-PGJ(2) modulates acute immune responses to Trypanosoma cruzi infection. | 2010 | Mem. Inst. Oswaldo Cruz | pmid:20428671 |
Blancou P and Anegon I | Editorial: Heme oxygenase-1 and dendritic cells: what else? | 2010 | J. Leukoc. Biol. | pmid:20123679 |
Nørregaard R et al. | Urinary tract obstruction induces transient accumulation of COX-2-derived prostanoids in kidney tissue. | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20147610 |
Zhang HX et al. | Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-Delta(12,14)-prostaglandin J(2). | 2010 | Exp. Neurol. | pmid:20083106 |
Katura T et al. | 15-Deoxy-delta 12,14-prostaglandin J2 biphasically regulates the proliferation of mouse hippocampal neural progenitor cells by modulating the redox state. | 2010 | Mol. Pharmacol. | pmid:20086036 |
Buga GM et al. | L-4F alters hyperlipidemic (but not healthy) mouse plasma to reduce platelet aggregation. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:19965777 |
Roy SJ et al. | Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: identification of a recycling motif. | 2010 | Eur. J. Pharmacol. | pmid:20035740 |
Lin TY and London CA | Characterization and modulation of canine mast cell derived eicosanoids. | 2010 | Vet. Immunol. Immunopathol. | pmid:20036014 |
Byrns MC et al. | Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:20036328 |
Templeton DJ et al. | Purification of reversibly oxidized proteins (PROP) reveals a redox switch controlling p38 MAP kinase activity. | 2010 | PLoS ONE | pmid:21085594 |
Moraes LA et al. | Non-genomic effects of PPARgamma ligands: inhibition of GPVI-stimulated platelet activation. | 2010 | J. Thromb. Haemost. | pmid:20040043 |
Subra C et al. | Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins. | 2010 | J. Lipid Res. | pmid:20424270 |
Hatanaka M et al. | 15d-prostaglandin J2 enhancement of nerve growth factor-induced neurite outgrowth is blocked by the chemoattractant receptor- homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist CAY10471 in PC12 cells. | 2010 | J. Pharmacol. Sci. | pmid:20424389 |
Zhang F et al. | Peroxisome proliferator-activated receptor-gamma agonists suppress iNOS expression induced by LPS in rat primary Schwann cells. | 2010 | J. Neuroimmunol. | pmid:19942298 |
Zorrilla S et al. | Selective binding of the fluorescent dye 1-anilinonaphthalene-8-sulfonic acid to peroxisome proliferator-activated receptor gamma allows ligand identification and characterization. | 2010 | Anal. Biochem. | pmid:20025845 |
Maggiora M et al. | Involvement of PPARα and PPARγ in apoptosis and proliferation of human hepatocarcinoma HepG2 cells. | 2010 | Cell Biochem. Funct. | pmid:20862655 |
Uehara Y | [Prostaglandin D2 and related substances]. | 2010 | Nippon Rinsho | pmid:20960740 |
Hanks BC et al. | Evaluation of anti-inflammatory and chondroprotective effects of peroxisome proliferator-activated receptor gamma agonists in cartilage and synovial explants from dogs. | 2010 | Am. J. Vet. Res. | pmid:20919899 |
Kim NJ et al. | Concise and enantioselective total synthesis of 15-deoxy-Δ-(12,14)-prostaglandin J(2). | 2010 | J. Org. Chem. | pmid:20929274 |
Pérez-Nievas BG et al. | Chronic immobilisation stress ameliorates clinical score and neuroinflammation in a MOG-induced EAE in Dark Agouti rats: mechanisms implicated. | 2010 | J Neuroinflammation | pmid:20929574 |
Bancos S et al. | Induction of heme oxygenase-1 in normal and malignant B lymphocytes by 15-deoxy-Delta(12,14)-prostaglandin J(2) requires Nrf2. | 2010 | Cell. Immunol. | pmid:20064636 |
Oh YC et al. | Anti-allergic activity of a platycodon root ethanol extract. | 2010 | Int J Mol Sci | pmid:20717534 |
Cerrato S et al. | Effects of palmitoylethanolamide on immunologically induced histamine, PGD2 and TNFalpha release from canine skin mast cells. | 2010 | Vet. Immunol. Immunopathol. | pmid:19625089 |
Pérez-Novo CA et al. | CRTH2 mediates the activation of human Th2 cells in response to PGD(2) released from IgE/anti-IgE treated nasal polyp tissue. | 2010 | Allergy | pmid:19839971 |
Mo C et al. | PPARgamma regulates LIF-induced growth and self-renewal of mouse ES cells through Tyk2-Stat3 pathway. | 2010 | Cell. Signal. | pmid:19922793 |
Kanda N et al. | Prostaglandin D2 induces the production of human beta-defensin-3 in human keratinocytes. | 2010 | Biochem. Pharmacol. | pmid:19925780 |
Biburger M et al. | Pivotal Advance: Heme oxygenase 1 expression by human CD4+ T cells is not sufficient for their development of immunoregulatory capacity. | 2010 | J. Leukoc. Biol. | pmid:19797297 |
Toaldo C et al. | PPARgamma ligands inhibit telomerase activity and hTERT expression through modulation of the Myc/Mad/Max network in colon cancer cells. | 2010 | J. Cell. Mol. Med. | pmid:19912441 |
Diers AR et al. | Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanisms. | 2010 | Biochem. J. | pmid:19916962 |
Morgenweck J et al. | Activation of peroxisome proliferator-activated receptor gamma in brain inhibits inflammatory pain, dorsal horn expression of Fos, and local edema. | 2010 | Neuropharmacology | pmid:19891980 |
Liu JY et al. | Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model. | 2010 | Biochem. Pharmacol. | pmid:19896470 |
Shimura C et al. | Dendritic cells express hematopoietic prostaglandin D synthase and function as a source of prostaglandin D2 in the skin. | 2010 | Am. J. Pathol. | pmid:20008150 |
Yamaguchi S et al. | Delta12-prostaglandin J2 as a product and ligand of human serum albumin: formation of an unusual covalent adduct at His146. | 2010 | J. Am. Chem. Soc. | pmid:20014793 |
Lin TH et al. | Upregulation of heme oxygenase-1 inhibits the maturation and mineralization of osteoblasts. | 2010 | J. Cell. Physiol. | pmid:20020468 |
Guo N et al. | Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease. | 2010 | J. Biol. Chem. | pmid:20308056 |
Poncin S et al. | N-acetylcysteine and 15 deoxy-{delta}12,14-prostaglandin J2 exert a protective effect against autoimmune thyroid destruction in vivo but not against interleukin-1{alpha}/interferon {gamma}-induced inhibitory effects in thyrocytes in vitro. | 2010 | Am. J. Pathol. | pmid:20489149 |
Kolaczkowska E et al. | Resident peritoneal macrophages and mast cells are important cellular sites of COX-1 and COX-2 activity during acute peritoneal inflammation. | 2009 Nov-Dec | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:19885646 |
Moreira V et al. | Effects of Bothrops asper snake venom on the expression of cyclooxygenases and production of prostaglandins by peritoneal leukocytes in vivo, and by isolated neutrophils and macrophages in vitro. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19155166 |
Hayden RE et al. | Treatment of primary CLL cells with bezafibrate and medroxyprogesterone acetate induces apoptosis and represses the pro-proliferative signal of CD40-ligand, in part through increased 15dDelta12,14,PGJ2. | 2009 | Leukemia | pmid:18923439 |
Csanky E et al. | Lipid metabolite levels of prostaglandin D2 and eicosapentaenoic acid recovered from bronchoalveolar lavage fluid correlate with lung function of chronic obstructive pulmonary disease patients and controls. | 2009 | Electrophoresis | pmid:19294692 |
Wang Y et al. | Peroxisome proliferator-activated receptor gamma agonists enhance lung maturation in a neonatal rat model. | 2009 | Pediatr. Res. | pmid:19262292 |
Yamamoto M et al. | Expression and characterization of PGD2 receptors in chronic rhinosinusitis: modulation of DP and CRTH2 by PGD2. | 2009 | Int. Arch. Allergy Immunol. | pmid:18802357 |
Pirianov G et al. | The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J(2) delays lipopolysaccharide-induced preterm delivery and reduces mortality in the newborn mouse. | 2009 | Endocrinology | pmid:18845626 |
Tsuji T et al. | Reduction of nuclear peroxisome proliferator-activated receptor gamma expression in methamphetamine-induced neurotoxicity and neuroprotective effects of ibuprofen. | 2009 | Neurochem. Res. | pmid:18946735 |
Waku T et al. | Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids. | 2009 | J. Mol. Biol. | pmid:18977231 |
Bruck R et al. | Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor. | 2009 | Dig. Dis. Sci. | pmid:18594976 |
O'Brien JJ et al. | 15-deoxy-Delta12,14 prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis. | 2009 | J. Thromb. Haemost. | pmid:18983509 |
Hokari R et al. | Increased expression and cellular localization of lipocalin-type prostaglandin D synthase in Helicobacter pylori-induced gastritis. | 2009 | J. Pathol. | pmid:19768745 |
Urade Y | [Molecular mechanisms of insomnia]. | 2009 | Nippon Rinsho | pmid:19768929 |
Ma XM et al. | Peroxisome proliferator-activated receptor-gamma is essential in the pathogenesis of gastric carcinoma. | 2009 | World J. Gastroenterol. | pmid:19701967 |
Levy JH | Biomarkers in the diagnosis of anaphylaxis: making nature disclose her mysteries. | 2009 | Clin. Exp. Allergy | pmid:19032357 |
Boehme SA et al. | A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation. | 2009 | Int. Immunol. | pmid:19066314 |
Boehme SA et al. | Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanisms. | 2009 | Int. Immunol. | pmid:19066315 |
Ding Q et al. | Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes. | 2009 | Endocrinology | pmid:19074584 |
Schröder R et al. | The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation. | 2009 | J. Biol. Chem. | pmid:19010788 |
Eichele K et al. | R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway. | 2009 | Pharm. Res. | pmid:19015962 |
Gressner OA et al. | Elevated concentrations of 15-deoxy-Delta12,14-prostaglandin J2 in chronic liver disease propose therapeutic trials with peroxisome proliferator activated receptor gamma-inducing drugs. | 2009 | Liver Int. | pmid:19018984 |
Kobayashi M et al. | The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds. | 2009 | Mol. Cell. Biol. | pmid:19001094 |
Irikura D et al. | Biochemical, functional, and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase. | 2009 | J. Biol. Chem. | pmid:19131342 |
Kar R et al. | A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells. | 2009 | Oncogene | pmid:19448671 |
Zhang GY et al. | Activation of peroxisome proliferator-activated receptor-gamma inhibits transforming growth factor-beta1 induction of connective tissue growth factor and extracellular matrix in hypertrophic scar fibroblasts in vitro. | 2009 | Arch. Dermatol. Res. | pmid:19466435 |
Ulbrich SE et al. | Quantitative characterization of prostaglandins in the uterus of early pregnant cattle. | 2009 | Reproduction | pmid:19470711 |
Shichijo M et al. | A prostaglandin D2 receptor antagonist modifies experimental asthma in sheep. | 2009 | Clin. Exp. Allergy | pmid:19486034 |
Wang X et al. | Potential effects of peroxisome proliferator-activated receptor activator on LPS-induced lung injury in rats. | 2009 | Pulm Pharmacol Ther | pmid:19489131 |
Tokudome S et al. | Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis. | 2009 | J. Clin. Invest. | pmid:19451694 |
Mickleborough TD et al. | Eicosapentaenoic acid is more effective than docosahexaenoic acid in inhibiting proinflammatory mediator production and transcription from LPS-induced human asthmatic alveolar macrophage cells. | 2009 | Clin Nutr | pmid:19054597 |
Arnaud LT et al. | Proteasome-caspase-cathepsin sequence leading to tau pathology induced by prostaglandin J2 in neuronal cells. | 2009 | J. Neurochem. | pmid:19457109 |
Olmos G et al. | 15-Deoxy-Delta(12,14)-prostaglandin-J(2) reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1alpha degradation. | 2009 | Cell. Mol. Life Sci. | pmid:19458911 |
Brechbuhl HM et al. | Select cyclopentenone prostaglandins trigger glutathione efflux and the role of ABCG2 transport. | 2009 | Free Radic. Biol. Med. | pmid:19520157 |
Ramji DP | Growth hormone-releasing peptides, CD36, and stimulation of cholesterol efflux: cyclooxygenase-2 is the link. | 2009 | Cardiovasc. Res. | pmid:19520704 |
Xue L et al. | Novel function of CRTH2 in preventing apoptosis of human Th2 cells through activation of the phosphatidylinositol 3-kinase pathway. | 2009 | J. Immunol. | pmid:19494281 |
Yamamura K et al. | Intracellular protein phosphorylation in eosinophils and the functional relevance in cytokine production. | 2009 | Int. Arch. Allergy Immunol. | pmid:19494504 |
Chiba T et al. | 15-Deoxy-Delta(12,14)-prostaglandin J2 induces IL-8 and GM-CSF in a human airway epithelial cell line (NCI-H292). | 2009 | Int. Arch. Allergy Immunol. | pmid:19494510 |
Niki E | Lipid peroxidation: physiological levels and dual biological effects. | 2009 | Free Radic. Biol. Med. | pmid:19500666 |
Moniot B et al. | The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation. | 2009 | Development | pmid:19429785 |
Relic B et al. | Genistein induces adipogenesis but inhibits leptin induction in human synovial fibroblasts. | 2009 | Lab. Invest. | pmid:19434061 |
Jung WK et al. | The 15-deoxy-Delta12,14-prostaglandin J2 inhibits LPS-stimulated AKT and NF-kappaB activation and suppresses interleukin-6 in osteoblast-like cells MC3T3E-1. | 2009 | Life Sci. | pmid:19409914 |
Strakhova MI et al. | In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties. | 2009 | Br. J. Pharmacol. | pmid:19413570 |
Bujold K et al. | CD36-mediated cholesterol efflux is associated with PPARgamma activation via a MAPK-dependent COX-2 pathway in macrophages. | 2009 | Cardiovasc. Res. | pmid:19377069 |
Mrabet-Dahbi S et al. | Murine mast cells secrete a unique profile of cytokines and prostaglandins in response to distinct TLR2 ligands. | 2009 | Exp. Dermatol. | pmid:19382314 |
Li H and Pauza CD | Effects of 15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) and rosiglitazone on human gammadelta2 T cells. | 2009 | PLoS ONE | pmid:19888466 |
Landrier JF et al. | Adiponectin expression is induced by vitamin E via a peroxisome proliferator-activated receptor gamma-dependent mechanism. | 2009 | Endocrinology | pmid:19833717 |
Lauring B et al. | Laropiprant in combination with extended-release niacin does not alter urine 11-dehydrothromboxane B2, a marker of in vivo platelet function, in healthy, hypercholesterolemic, and diabetic subjects. | 2009 | J Clin Pharmacol | pmid:19833861 |
Khanim FL et al. | Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia. | 2009 | PLoS ONE | pmid:19997560 |
Pustovrh MC et al. | MMP/ TIMP balance is modulated in vitro by 15dPGJ(2) in fetuses and placentas from diabetic rats. | 2009 | Eur. J. Clin. Invest. | pmid:19811527 |
Piprek RP | Genetic mechanisms underlying male sex determination in mammals. | 2009 | J. Appl. Genet. | pmid:19875885 |