PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Pulmonary Aspergillosis D055732 1 associated lipids
Persistent Fetal Circulation Syndrome D010547 1 associated lipids
Zollinger-Ellison Syndrome D015043 1 associated lipids
Anal Gland Neoplasms D000694 1 associated lipids
Mastocytosis, Systemic D034721 1 associated lipids
Trigeminal Neuralgia D014277 1 associated lipids
Epilepsy, Tonic-Clonic D004830 2 associated lipids
Cryptorchidism D003456 2 associated lipids
Decapitation D049248 2 associated lipids
Cystitis, Interstitial D018856 2 associated lipids
Asthma, Aspirin-Induced D055963 2 associated lipids
Choroid Diseases D015862 2 associated lipids
Optic Neuropathy, Ischemic D018917 2 associated lipids
Angioedemas, Hereditary D054179 2 associated lipids
Respiratory Sounds D012135 3 associated lipids
HTLV-I Infections D015490 3 associated lipids
Ascariasis D001196 3 associated lipids
Sleep Disorders, Circadian Rhythm D020178 3 associated lipids
Wounds, Stab D014951 3 associated lipids
Cryptococcosis D003453 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Peters SP et al. The role of prostaglandin D2 in IgE-mediated reactions in man. 1982 Trans. Assoc. Am. Physicians pmid:6963831
Fukushima M et al. [Antineoplastic action of prostaglandin D2--effect of PGD2 on proliferation of L1210 leukemic cells in culture]. 1982 Gan To Kagaku Ryoho pmid:6964030
Ueno R et al. Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide. 1982 Proc. Natl. Acad. Sci. U.S.A. pmid:6964402
Toda N Different responsiveness of a variety of isolated dog arteries to prostaglandin D2. 1982 Prostaglandins pmid:6950464
Kennedy I et al. Studies on the characterisation of prostanoid receptors: a proposed classification. 1982 Prostaglandins pmid:6131499
Watanabe T et al. Characterization of the biosynthetic pathway of prostaglandin D2 in human platelet-rich plasma. 1982 J. Biol. Chem. pmid:6816798
Qureshi Z and Cagen LM Prostaglandins F2 alpha produced by rabbit renal slices is not a metabolite of prostaglandins E2. 1982 Biochem. Biophys. Res. Commun. pmid:6803799
Ruzicka T and Printz MP Arachidonic acid metabolism in guinea pig skin. 1982 Biochim. Biophys. Acta pmid:6809055
Kinoshita F et al. Suppressive effect of prostaglandin (PG)D2 on pulsatile luteinizing hormone release in conscious castrated rats. 1982 Endocrinology pmid:6951712
Wendling MG and DuCharme DW Cardiovascular effects of prostaglandin D3 and D2 in anesthetized dogs. 1981 Prostaglandins pmid:6945633
Spannhake EW et al. Bronchoactive metabolites of arachidonic acid and their role in airway function. 1981 Prostaglandins pmid:6801729
Stenson WF et al. Metabolism of exogenous arachidonic acid by murine macrophage-like tumor cell lines. 1981 Prostaglandins pmid:6803301
Claeys M et al. Lack of prostacyclin biosynthesis by aortic tissue of the chicken. 1981 Prostaglandins pmid:6803304
Gerritsen ME and Printz MP Prostaglandin D synthase in microvessels from the rat cerebral cortex. 1981 Prostaglandins pmid:6119739
Lagarde M et al. Refractoriness of diabetic platelets to inhibitory prostaglandins. 1981 Prostaglandins Med pmid:6273957
Smith JB Prostaglandins and platelet aggregation. 1981 Acta Med. Scand. Suppl. pmid:7034481
Nakagawa S et al. Evaluation of prostaglandin D2 (PGD2) as an anticoagulative agent for haemodialysis in comparison with prostaglandin E1 (PGE1). 1981 Proc Eur Dial Transplant Assoc pmid:7036145
McRea JC et al. Prostaglandin releasing polymers - stability and efficacy. 1981 Trans Am Soc Artif Intern Organs pmid:7036503
Harris DN et al. 9 alpha-homo-9,11-epoxy-5,13-prostadienoic acid analogues: specific stable agonist (SQ 26, 538) and antagonist (SQ 26, 536) of the human platelet thromboxane receptor. 1981 Prostaglandins pmid:6270744
Hemker DP and Aiken JW Effects of prostaglandins on autonomic function in vivo, with special emphasis on PGD2 and PGD3. 1981 Prog. Lipid Res. pmid:6952267
Kunkel SL et al. Suppression of immune complex vasculitis in rats by prostaglandin. 1979 J. Clin. Invest. pmid:159314
Cooper B Diminished platelet adenylate cyclase activation by prostaglandin D2 in acute thrombosis. 1979 Blood pmid:380688
Nishizawa EE et al. Prostaglandin d2 as a potential antithrombotic agent. 1975 Prostaglandins pmid:806102
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