PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Inflammation D007249 119 associated lipids
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Brain Ischemia D002545 89 associated lipids
Seizures D012640 87 associated lipids
Arteriosclerosis D001161 86 associated lipids
Atherosclerosis D050197 85 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Alzheimer Disease D000544 76 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

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Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Frölich JC et al. Advances in the analysis of eicosanoids by ELISA and GC/MS/MS. 1986 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2949561
Nordlund JJ et al. Prostaglandin E2 and D2 but not MSH stimulate the proliferation of pigment cells in the pinnal epidermis of the DBA/2 mouse. 1986 J. Invest. Dermatol. pmid:3528310
Burrall B and Ziboh VA Increased biosynthesis of lipoxygenase products by UVB-irradiated guinea pig epidermis: evidence of a cyclooxygenase inhibitor. 1986 J. Invest. Dermatol. pmid:3086462
Hattori Y and Levi R Effect of PGD2 on cardiac contractility: a negative inotropism secondary to coronary vasoconstriction conceals a primary positive inotropic action. 1986 J. Pharmacol. Exp. Ther. pmid:3012066
Tsao CJ et al. In-vitro effects of antineoplastic prostaglandins on human leukemic cell growth and normal myelopoiesis. 1986 Leuk. Res. pmid:3012210
Halenda SP et al. Effects of thrombin, phorbol myristate acetate and prostaglandin D2 on 40-41 kDa protein that is ADP ribosylated by pertussis toxin in platelets. 1986 FEBS Lett. pmid:3015684
Todo S et al. Cell kinetic studies of PGD2 cytotoxicity on the in vitro growth of human neuroblastoma. 1986 Prostaglandins Leukot Med pmid:3016753
Bhattacharya SK The antinociceptive effect of intracerebroventricularly administered prostaglandin D2 in the rat. 1986 Psychopharmacology (Berl.) pmid:3016786
Hamid-Bloomfield S and Whittle BJ Prostaglandin D2 interacts at thromboxane receptor-sites on guinea-pig platelets. 1986 Br. J. Pharmacol. pmid:3017497
Shalit M et al. New role for heparan sulfate: regulator of leukotriene generation in mouse E-mast cells. 1986 Life Sci. pmid:3018403
Kuno S et al. Prostaglandin E2, a seminal constituent, facilitates the replication of acquired immune deficiency syndrome virus in vitro. 1986 Proc. Natl. Acad. Sci. U.S.A. pmid:3010301
Eling TE et al. Oxidation of glutathione to its thiyl free radical metabolite by prostaglandin H synthase. A potential endogenous substrate for the hydroperoxidase. 1986 J. Biol. Chem. pmid:3007487
Narumiya S and Fukushima M Site and mechanism of growth inhibition by prostaglandins. I. Active transport and intracellular accumulation of cyclopentenone prostaglandins, a reaction leading to growth inhibition. 1986 J. Pharmacol. Exp. Ther. pmid:3772804
Narumiya S et al. Site and mechanism of growth inhibition by prostaglandins. II. Temperature-dependent transfer of a cyclopentenone prostaglandin to nuclei. 1986 J. Pharmacol. Exp. Ther. pmid:3772805
Bregman MD et al. Inhibition of human melanoma growth by prostaglandin A, D, and J analogues. 1986 Cancer Res. pmid:3698005
Zavoico GB et al. Regulation of intracellular pH in human platelets. Effects of thrombin, A23187, and ionomycin and evidence for activation of Na+/H+ exchange and its inhibition by amiloride analogs. 1986 J. Biol. Chem. pmid:3020026
Schleimer RP et al. Characterization of inflammatory mediator release from purified human lung mast cells. 1986 Am. Rev. Respir. Dis. pmid:3485946
Peters SP et al. The pharmacologic control of mediator release from human basophils and mast cells. 1986 Respiration pmid:3494282
Bhuyan BK et al. Cell cycle effects of prostaglandins A1, A2, and D2 in human and murine melanoma cells in culture. 1986 Cancer Res. pmid:3456266
Brooks DP et al. Role of brain prostaglandins in the control of vasopressin secretion in the conscious rat. 1986 Endocrinology pmid:3456303
Watanabe K et al. Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase. 1986 Proc. Natl. Acad. Sci. U.S.A. pmid:3456602
Maclouf J et al. Development of a radioimmunoassay for prostaglandin D2 using an antiserum against 11-methoxime prostaglandin D2. 1986 Prostaglandins pmid:3456623
Barnes VF and Heavey DJ Effect of prostaglandin D2 on histamine-induced weals in human skin. 1986 Br. J. Pharmacol. pmid:3456816
Gaetani P et al. Prostaglandin D2 monitoring in human CSF after subarachnoid hemorrhage: the possible role of prostaglandin D2 in the genesis of cerebral vasospasm. 1986 Ital J Neurol Sci pmid:3456998
Sugiyama T et al. Platelet prostaglandin D2 dehydrogenase in patients with myeloproliferative disorders. 1986 Prostaglandins Leukot Med pmid:3457389
Kikuchi Y et al. Inhibition of human ovarian cancer cell growth in vitro and in nude mice by prostaglandin D2. 1986 Cancer Res. pmid:3458525
Ruzicka T et al. Skin levels of arachidonic acid-derived inflammatory mediators and histamine in atopic dermatitis and psoriasis. 1986 J. Invest. Dermatol. pmid:3018086
Kuno S et al. Prostaglandin E2 administered via anus causes immunosuppression in male but not female rats: a possible pathogenesis of acquired immune deficiency syndrome in homosexual males. 1986 Proc. Natl. Acad. Sci. U.S.A. pmid:3458226
Hardy CC et al. Evidence against the formation of 13,14-dihydro-15-keto-prostaglandin F2 alpha following inhalation of prostaglandin D2 in man. 1986 Br. J. Pharmacol. pmid:3467804
Makhoul RG and Gewertz BL Renal prostaglandins. 1986 J. Surg. Res. pmid:3511324
Inoué S Multifactorial humoral regulation of sleep. 1986 Clin Neuropharmacol pmid:3471328
Bhuyan BK et al. Cytotoxicity of combinations of prostaglandin D2 (PGD2) and antitumor drugs for B16 melanoma cells in culture. 1986 Invest New Drugs pmid:3473056
Lumsden MA et al. Changes in the concentration of prostaglandins in preovulatory human follicles after administration of hCG. 1986 J. Reprod. Fertil. pmid:3459888
Watanabe Y et al. Modulation by prostaglandin D2 of mitral cell responses to odor stimulation in rabbit olfactory bulb. 1986 Brain Res. pmid:2873871
Haxhiu MA et al. [Bronchial response to prostaglandins (F2 alpha and D2) and leukotrienes in patients with bronchial asthma]. 1986 Jan-Mar Plucne Bolesti pmid:3466189
Seibert K et al. 9 alpha, 11 beta-prostaglandin F2: formation and metabolism by human lung and contractile effects on human bronchial smooth muscle. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2959045
Roberts LJ et al. PGD2 is transformed by human coronary arteries to 9 alpha, 11 beta-PGF2, which contracts human coronary artery rings. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2959090
Watanabe K et al. Stereospecific conversion of prostaglandin D2 to 9 alpha, 11 beta-prostaglandin F2 and prostaglandin H2 to prostaglandin F2 alpha by PGF synthetase. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2959094
Jacobsen S et al. Synergism between thapsigargin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate on the release of [14C]arachidonic acid and histamine from rat peritoneal mast cells. 1987 Biochem. Pharmacol. pmid:2435291
Kawabe H et al. Differential calcium effects on prostaglandin D2 generation and histamine release from isolated rat peritoneal mast cells. 1987 Biochem. Biophys. Res. Commun. pmid:2436614
Watanabe Y et al. Synthesis of 11C-labeled prostaglandins and positron emission tomography studies using the rhesus monkey. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960207
Hayaishi O et al. Prostaglandin D2 induces sleep when infused into the cerebral ventricle of conscious monkeys. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960208
Narumiya S and Fukushima M Active transport and cellular accumulation of cyclopentenone prostaglandins: a mechanism of prostaglandin-induced growth inhibition. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960214
Ruzicka T and Auböck J Arachidonic acid metabolism in guinea pig Langerhans cells: studies on cyclooxygenase and lipoxygenase pathways. 1987 J. Immunol. pmid:3098849
Ono K et al. Suppressive effects of various antitumor prostaglandin derivatives on the activity levels of DNA polymerases in human cultured tumor cells. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960215
Beasley R et al. Cholinergic-mediated bronchoconstriction induced by prostaglandin D2, its initial metabolite 9 alpha,11 beta-PGF2, and PGF2 alpha in asthma. 1987 Am. Rev. Respir. Dis. pmid:2960256
Saito R et al. The effect of neurotransmitters on cataleptic behavior induced by PG D2 in rats. 1987 Pharmacol. Biochem. Behav. pmid:2883669
Westcott JY et al. Eicosanoids in human ventricular cerebrospinal fluid following severe brain injury. 1987 Prostaglandins pmid:2835791
Brown MS et al. Arachidonic acid metabolites during nasal challenge. 1987 Arch. Otolaryngol. Head Neck Surg. pmid:3099812
Chiabrando C et al. Prostaglandin and thromboxane synthesis by M5076 ovarian reticulosarcoma during growth: effects of a thromboxane synthetase inhibitor. 1987 Cancer Res. pmid:3100032
Bhattacharya SK and Parmar SS Prostaglandin D2 inhibits pentylenetetrazole-induced convulsions in rats by a serotonin-mediated mechanism. 1987 Pharm. Res. pmid:2977646
Anton RF and Randall CL Central nervous system prostaglandins and ethanol. 1987 Alcohol. Clin. Exp. Res. pmid:3105343
Santoro MG et al. PGJ2, a new antiviral prostaglandin: inhibition of Sendai virus replication and alteration of virus protein synthesis. 1987 J. Gen. Virol. pmid:3033130
Levi-Schaffer F et al. Mouse bone marrow-derived mast cells cocultured with fibroblasts. Morphology and stimulation-induced release of histamine, leukotriene B4, leukotriene C4, and prostaglandin D2. 1987 J. Immunol. pmid:2445814
Kozuka T et al. Prostaglandin D2 release by guinea pig skin during in vitro anaphylaxis induced by antigen and compound 48/80. 1987 J. Invest. Dermatol. pmid:2433354
Church MK and Hiroi J Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by anti-allergic drugs and salbutamol. 1987 Br. J. Pharmacol. pmid:2435353
Pearce FL et al. Some studies on human pulmonary mast cells obtained by bronchoalveolar lavage and by enzymic dissociation of whole lung tissue. 1987 Int. Arch. Allergy Appl. Immunol. pmid:2437052
Weinreich D and Undem BJ Immunological regulation of synaptic transmission in isolated guinea pig autonomic ganglia. 1987 J. Clin. Invest. pmid:2437156
Abdel-Malek ZA et al. In vitro modulation of proliferation and melanization of S91 melanoma cells by prostaglandins. 1987 Cancer Res. pmid:2438034
Bushfield M et al. Effects of protein kinase C activation on human platelet cyclic AMP metabolism. 1987 FEBS Lett. pmid:2820806
Williams KA et al. Effects of activation of protein kinase C on the agonist-induced stimulation and inhibition of cyclic AMP formation in intact human platelets. 1987 Biochem. J. pmid:2444206
Lawrence ID et al. Purification and characterization of human skin mast cells. Evidence for human mast cell heterogeneity. 1987 J. Immunol. pmid:2444649
Benyon RC et al. Prostaglandin D2 release from human skin mast cells in response to ionophore A23187. 1987 Br. J. Pharmacol. pmid:2447989
Underwood DC et al. Blockade of thromboxane responses in the airway of the cat by SQ 29,548. 1987 J. Appl. Physiol. pmid:2440845
Levi-Schaffer F et al. Co-culture of human lung-derived mast cells with mouse 3T3 fibroblasts: morphology and IgE-mediated release of histamine, prostaglandin D2, and leukotrienes. 1987 J. Immunol. pmid:2439587
Leung KB et al. Some further properties of human pulmonary mast cells recovered by bronchoalveolar lavage and enzymic dispersion of lung tissue. 1987 Agents Actions pmid:2440274
Church MK et al. Non-IgE-dependent bacteria-induced histamine release from human lung and tonsillar mast cells. 1987 Clin. Allergy pmid:2441900
Kosaka Y et al. Oxatomide inhibits the release of bronchoconstrictor arachidonic acid metabolites (iLTC4 and PGD2) from rat mast cells and guinea-pig lung. 1987 Agents Actions pmid:2442981
Pipkorn U et al. Effect of short-term systemic glucocorticoid treatment on human nasal mediator release after antigen challenge. 1987 J. Clin. Invest. pmid:2443539
Rodriguez R et al. Effect of nimodipine on arachidonic acid metabolites after subarachnoid hemorrhage. 1987 Acta Neurol. Scand. pmid:3120489
Namima M and Okamoto K Modulatory action of prostaglandin D2 on the release of 3H-norepinephrine from rat cerebellar slices. 1987 Jpn. J. Pharmacol. pmid:2883337
Omini C et al. Prostaglandin D2 and the cholinergic system in guinea pig airways. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2823557
Viganò T et al. Adenosine and eicosanoid release from immunologically challenged human lung fragments. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2823581
Tilden SJ et al. Effects of OKY 1581 on bronchoconstrictor responses to arachidonic acid and PGH2. 1987 J. Appl. Physiol. pmid:2954941
Shimizu Y et al. Selective synthesis and retention of 66k protein in a human neuroblastoma cell line (NCG) treated with a cytotoxic dosage of delta 12-prostaglandin J2. 1987 Prostaglandins pmid:3449899
Suzuki F et al. Methyl ester of prostaglandin D2 as a delivery system of prostaglandin D2 into brain. 1987 Biochim. Biophys. Acta pmid:3467795
Richelsen B Relationship between binding and action of different prostaglandins in rat adipocytes with special reference to PGE2 and PGI2. 1987 Biochem. Pharmacol. pmid:2825710
Hayashi H et al. Metabolism of prostaglandin D2 in isolated rat lung: the stereospecific formation of 9 alpha,11 beta-prostaglandin F2 from prostaglandin D2. 1987 Biochim. Biophys. Acta pmid:3467796
Dieter P et al. Prostaglandin release but not superoxide production by rat Kupffer cells stimulated in vitro depends on Na+/H+ exchange. 1987 Eur. J. Biochem. pmid:2826152
Drummond WH and Carter RL Cardiac depressant and circulatory effects of prostaglandin D2 in developing lambs. 1987 Am. J. Physiol. pmid:3468806
Burgess JR et al. Enzymatic transformation of PGH2 to PGF2 alpha catalyzed by glutathione S-transferases. 1987 Biochem. Biophys. Res. Commun. pmid:3468949
Beasley CR et al. 9 alpha,11 beta-prostaglandin F2, a novel metabolite of prostaglandin D2 is a potent contractile agonist of human and guinea pig airways. 1987 J. Clin. Invest. pmid:3469218
Greaves MW et al. [New pharmacologic developments in physical urticaria--therapeutic consequences]. 1987 Z. Hautkr. pmid:3472418
Goto H [Quantitative determination of prostaglandin D2 in the rat gastric mucosa by high performance liquid chromatography]. 1987 Nihon Shokakibyo Gakkai Zasshi pmid:3473244
Kariya T et al. Platelet abnormality with no response to PGD2 in a patient with metastatic pancreas carcinoma and myeloproliferative disorder. 1987 Nippon Ketsueki Gakkai Zasshi pmid:3473883
Holgate ST Contribution of inflammatory mediators to the immediate asthmatic reaction. 1987 Am. Rev. Respir. Dis. pmid:3473955
Tran-Thi TA et al. Studies on synthesis and degradation of eicosanoids by rat hepatocytes in primary culture. 1987 J. Hepatol. pmid:2828463
Amano N [Effects of anesthesia and various types of stress on prostaglandin D2 (PGD2) contents in brain and plasma levels of stress hormones in rats]. 1987 Masui pmid:3480360
Brunelli G et al. PGD2 induces pulmonary hyperresponsiveness to acetylcholine in vivo in the guinea-pig. 1987 J Auton Pharmacol pmid:3480891
Weinreich D and Wonderlin WF Inhibition of calcium-dependent spike after-hyperpolarization increases excitability of rabbit visceral sensory neurones. 1987 J. Physiol. (Lond.) pmid:3481834
Nakamura M et al. In vivo effects of prostaglandins on human retinoblastoma cells in nude mice. 1987 Jpn. J. Ophthalmol. pmid:3482290
Hanasaki K et al. Beta 2-adrenergic regulation of prostaglandin D2 receptor in rabbit platelets. 1987 Biochim. Biophys. Acta pmid:2880608
Holgate ST et al. Primary and secondary effector cells in the pathogenesis of bronchial asthma. 1987 Int. Arch. Allergy Appl. Immunol. pmid:3553030
Rao PS et al. Dose-dependent effects of prostaglandin D2 on hemodynamics, renal function, and blood gas analyses. 1987 Am. J. Obstet. Gynecol. pmid:3555078
Kinoshita T et al. Predominance of prostaglandin D2 and I2 in the rat gastric mucosa--analysis by high-performance liquid chromatography. 1987 Biochem. Int. pmid:3555501
Matsuura H and Imaya H [Effect of prostaglandin (delta 12-PGJ2) on host immunity--an experimental study]. 1987 Gan To Kagaku Ryoho pmid:3592721
Yamamoto N et al. Mechanism of inhibition of herpes simplex virus replication by delta 7-prostaglandin A1 and delta 12-prostaglandin J2. 1987 Biochem. Biophys. Res. Commun. pmid:3040001
Bhattacharya SK and Rao PJ Prostaglandin D2-induced catalepsy in rats: role of 5-hydroxytryptamine. 1987 J. Pharm. Pharmacol. pmid:2890744
Tamaoki J et al. Cholinergic neuromodulation by prostaglandin D2 in canine airway smooth muscle. 1987 J. Appl. Physiol. pmid:2891674
Shimojima T et al. [Effects of prostaglandins on superoxide production by human polymorphonuclear leukocytes]. 1987 Nihon Shishubyo Gakkai Kaishi pmid:2851629