PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Actinobacillus Infections D000189 4 associated lipids
Adenocarcinoma D000230 166 associated lipids
Alzheimer Disease D000544 76 associated lipids
Anal Gland Neoplasms D000694 1 associated lipids
Anaphylaxis D000707 35 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Ascariasis D001196 3 associated lipids
Asthma D001249 52 associated lipids
Astrocytoma D001254 15 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Blister D001768 16 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
Body Weight D001835 333 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Bronchial Spasm D001986 18 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Carcinoma, Renal Cell D002292 12 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

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Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Moriai M et al. Down-regulation of hTERT expression plays an important role in 15-deoxy-Delta12,14-prostaglandin J2-induced apoptosis in cancer cells. 2009 Int. J. Oncol. pmid:19360348
Hayashi N et al. Antitumor effects of peroxisome proliferator activate receptor gamma ligands on anaplastic thyroid carcinoma. 2004 Int. J. Oncol. pmid:14654945
Matsuzaki Y et al. 15-deoxy-Delta12, 14-prostaglandin J2 activates the expression of p15INK4b gene, a cyclin-dependent kinase inhibitor. 2005 Int. J. Oncol. pmid:16010433
Morosetti R et al. The PPARgamma ligands PGJ2 and rosiglitazone show a differential ability to inhibit proliferation and to induce apoptosis and differentiation of human glioblastoma cell lines. 2004 Int. J. Oncol. pmid:15254749
Shim J et al. The peroxisome proliferator-activated receptor gamma ligands, pioglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2), have antineoplastic effects against hepatitis B virus-associated hepatocellular carcinoma cells. 2010 Int. J. Oncol. pmid:19956851
Cekanova M et al. Gene alterations by peroxisome proliferator-activated receptor gamma agonists in human colorectal cancer cells. 2008 Int. J. Oncol. pmid:18360708
Takashima T et al. PPAR-gamma ligands inhibit growth of human esophageal adenocarcinoma cells through induction of apoptosis, cell cycle arrest and reduction of ornithine decarboxylase activity. 2001 Int. J. Oncol. pmid:11494023
Tsujimoto S et al. Nimesulide, a cyclooxygenase-2 selective inhibitor, suppresses obesity-related non-alcoholic fatty liver disease and hepatic insulin resistance through the regulation of peroxisome proliferator-activated receptor γ. 2016 Int. J. Mol. Med. pmid:27431935
Li H and Narahara H 15-Deoxy-Δ(12,14)-prostaglandin J(2) induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer cell lines. 2013 Int. J. Mol. Med. pmid:23403520
Joos H et al. Single impact trauma in human early-stage osteoarthritic cartilage: implication of prostaglandin D2 but no additive effect of IL-1β on cell survival. 2011 Int. J. Mol. Med. pmid:21567074
Kase K et al. Inhibitory action of roxithromycin on histamine release and prostaglandin D2 production from beta-defensin 2-stimulated mast cells. 2009 Int. J. Mol. Med. pmid:19212651
Jung WK et al. The 15-deoxy-δ12,14-prostaglandin J2 inhibits LPS‑stimulated inflammation via enhancement of the platelet‑activating factor acetylhydrolase activity in human retinal pigment epithelial cells. 2014 Int. J. Mol. Med. pmid:24337644
Yoshimura R et al. The effect of peroxisome proliferator-activated receptor-gamma ligand on urological cancer cells. 2003 Int. J. Mol. Med. pmid:14612958
Okano H et al. The PPARgamma ligand, 15-Deoxy-Delta12,14-PGJ2, regulates apoptosis-related protein expression in cholangio cell carcinoma cells. 2003 Int. J. Mol. Med. pmid:14612959
Hogrefe C et al. Single impact cartilage trauma and TNF-α: interactive effects do not increase early cell death and indicate the need for bi-/multidirectional therapeutic approaches. 2012 Int. J. Mol. Med. pmid:22922824
Franzese O et al. Functional antagonism between IL-2 and PGA1 or PGJ2 in the control of proliferation of human cord blood-derived mononuclear cells. 1996 Int. J. Immunopharmacol. pmid:9089005
Ikai K and Imamura S Prostaglandin D2 in the skin. 1988 Int. J. Dermatol. pmid:3286543
Shah S et al. Efficacy and safety of extended-release niacin/laropiprant plus statin vs. doubling the dose of statin in patients with primary hypercholesterolaemia or mixed dyslipidaemia. 2010 Int. J. Clin. Pract. pmid:20518948
Radziszewski W et al. Nitric oxide donors induce extrusion of cyclic GMP from isolated human blood platelets by a mechanism which may be modulated by prostaglandins. 1995 Int. J. Cardiol. pmid:8586470
Koyani CN et al. 15-deoxy-Δ¹²,¹⁴-PGJ₂ promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis. 2014 Int. J. Cardiol. pmid:24698234
Fukuoka T et al. Prostaglandin D synthase is a potential novel therapeutic agent for the treatment of gastric carcinomas expressing PPARγ. 2015 Int. J. Cancer pmid:25516376
Higashida H et al. Cytotoxic action of prostaglandin D2 on mouse neuroblastoma cells. 1983 Int. J. Cancer pmid:6574994
Winnett G et al. Prostaglandin J2 metabolites inhibit aromatase activity by redox-sensitive mechanisms: potential implications for breast cancer therapy. 2003 Int. J. Cancer pmid:12494466
Badawi AF and Badr MZ Expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma and levels of prostaglandin E2 and 15-deoxy-delta12,14-prostaglandin J2 in human breast cancer and metastasis. 2003 Int. J. Cancer pmid:12455057
D'Onofrio C et al. Comparative anti-viral and anti-proliferative activity of PGA1 and PGJ2 against HTLV-I-infected MT-2 cells. 1992 Int. J. Cancer pmid:1592539
Castellani ML et al. Rat basophilic leukemia cells (RBL-2H3) generate prostaglandin D2 (PGD2) after regulated upon activation, normal T-cell expressed and secreted (RANTES) activation. 2006 Oct-Dec Int. J. Biol. Markers pmid:17177158
Chou YH et al. The possible role of heat shock factor-1 in the negative regulation of heme oxygenase-1. 2005 Int. J. Biochem. Cell Biol. pmid:15618017
Yu JH et al. SOCS 3 and PPAR-gamma ligands inhibit the expression of IL-6 and TGF-beta1 by regulating JAK2/STAT3 signaling in pancreas. 2008 Int. J. Biochem. Cell Biol. pmid:18035585
Baudouin-Legros M et al. Long-term CFTR inhibition modulates 15d-prostaglandin J2 in human pulmonary cells. 2012 Int. J. Biochem. Cell Biol. pmid:22481026
Kristensen DM et al. Paracetamol (acetaminophen), aspirin (acetylsalicylic acid) and indomethacin are anti-androgenic in the rat foetal testis. 2012 Int. J. Androl. pmid:22612476
Wang XS et al. Functional characterization of human mast cells cultured from adult peripheral blood. 2006 Int. Immunopharmacol. pmid:16546715
Zhang M et al. Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats by activation of peroxisome proliferator-activated receptor gamma. 2006 Int. Immunopharmacol. pmid:16782535
El-Shazly AE et al. IFN-γ and TNF-α potentiate prostaglandin D2-induced human eosinophil chemotaxis through up-regulation of CRTH2 surface receptor. 2011 Int. Immunopharmacol. pmid:21835268
Kumar S et al. Phaseolin: a 47.5kDa protein of red kidney bean (Phaseolus vulgaris L.) plays a pivotal role in hypersensitivity induction. 2014 Int. Immunopharmacol. pmid:24468678
Motilva V et al. COX expression and PGE(2) and PGD(2) production in experimental acute and chronic gastric lesions. 2005 Int. Immunopharmacol. pmid:15652766
Napimoga MH et al. Low doses of 15d-PGJ2 induce osteoblast activity in a PPAR-gamma independent manner. 2013 Int. Immunopharmacol. pmid:23597428
Villegas I et al. A new flavonoid derivative, dosmalfate, attenuates the development of dextran sulphate sodium-induced colitis in mice. 2003 Int. Immunopharmacol. pmid:14636824
El-Shazly AE et al. Tyrosine kinase inhibition is an important factor for gene expression of CRTH2 in human eosinophils and lymphocytes: A novel mechanism for explaining eosinophils recruitment by the neuro-immune axis in allergic rhinitis. 2017 Int. Immunopharmacol. pmid:28222358
Kanunfre CC et al. Ciglitizone and 15d PGJ2 induce apoptosis in Jurkat and Raji cells. 2004 Int. Immunopharmacol. pmid:15251113
Wu P et al. Inflammation pro-resolving potential of 3,4-dihydroxyacetophenone through 15-deoxy-delta12,14-prostaglandin J2 in murine macrophages. 2007 Int. Immunopharmacol. pmid:17761349
Azuma Y et al. 15-Deoxy-delta(12,14)-prostaglandin J2 is a negative regulator of macrophage functions. 2001 Int. Immunopharmacol. pmid:11710539
Boehme SA et al. Murine bone marrow-derived mast cells express chemoattractant receptor-homologous molecule expressed on T-helper class 2 cells (CRTh2). 2009 Int. Immunol. pmid:19346259
Boehme SA et al. A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation. 2009 Int. Immunol. pmid:19066314
Boehme SA et al. Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanisms. 2009 Int. Immunol. pmid:19066315
Takeshita K et al. CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation. 2004 Int. Immunol. pmid:15173122
Georgitis JW et al. Chronic sinusitis: characterization of cellular influx and inflammatory mediators in sinus lavage fluid. 1995 Int. Arch. Allergy Immunol. pmid:7719157
Genovese A et al. Protein Fv produced during viral hepatitis is an endogenous immunoglobulin superantigen activating human heart mast cells. 2003 Int. Arch. Allergy Immunol. pmid:14707465
al-Laith M and Pearce FL On the mechanism of action of sodium orthovanadate in inducing histamine release from rat peritoneal mast cells. 1993 Int. Arch. Allergy Immunol. pmid:7689004
Genovese A et al. Role of mast cells, basophils and their mediators in adverse reactions to general anesthetics and radiocontrast media. 1996 Int. Arch. Allergy Immunol. pmid:8645973
Itabashi S et al. Late asthmatic response causes peripheral airway hyperresponsiveness in dogs treated with metopirone. 1993 Int. Arch. Allergy Immunol. pmid:8508057
Patella V et al. Oxatomide inhibits the release of proinflammatory mediators from human basophils and mast cells. 1996 Int. Arch. Allergy Immunol. pmid:8753840
Abraha D et al. (S,S)-formoterol increases the production of IL-4 in mast cells and the airways of a murine asthma model. 2004 Int. Arch. Allergy Immunol. pmid:15031612
Okayama Y and Church MK Comparison of the modulatory effect of ketotifen, sodium cromoglycate, procaterol and salbutamol in human skin, lung and tonsil mast cells. 1992 Int. Arch. Allergy Immunol. pmid:1375203
Yamamoto M et al. Expression and characterization of PGD2 receptors in chronic rhinosinusitis: modulation of DP and CRTH2 by PGD2. 2009 Int. Arch. Allergy Immunol. pmid:18802357
Ueki S et al. Anti- and proinflammatory effects of 15-deoxy-delta-prostaglandin J2(15d-PGJ2) on human eosinophil functions. 2007 Int. Arch. Allergy Immunol. pmid:17541271
Chiba T et al. Possible novel receptor for PGD2 on human bronchial epithelial cells. 2007 Int. Arch. Allergy Immunol. pmid:17541272
Butterfield JH and Weiler CR Prevention of mast cell activation disorder-associated clinical sequelae of excessive prostaglandin D(2) production. 2008 Int. Arch. Allergy Immunol. pmid:18622141
Hartmann K et al. Effect of CC chemokines on mediator release from human skin mast cells and basophils. 1995 Int. Arch. Allergy Immunol. pmid:7580286
Yamamura K et al. Intracellular protein phosphorylation in eosinophils and the functional relevance in cytokine production. 2009 Int. Arch. Allergy Immunol. pmid:19494504
Chiba T et al. 15-Deoxy-Delta(12,14)-prostaglandin J2 induces IL-8 and GM-CSF in a human airway epithelial cell line (NCI-H292). 2009 Int. Arch. Allergy Immunol. pmid:19494510
Imaizumi T et al. 15-deoxy-delta(12,14)-prostaglandin J2 inhibits IFN-gamma-induced galectin-9 expression in cultured human umbilical vein endothelial cells. 2003 Int. Arch. Allergy Immunol. pmid:12759491
Tudorić N et al. Phosphoramidon augments contraction of guinea pig tracheal smooth muscle induced by histamine and leukotriene-D4. 1994 Int. Arch. Allergy Immunol. pmid:8111247
Chiba T et al. Prostaglandin D2 induces IL-8 and GM-CSF by bronchial epithelial cells in a CRTH2-independent pathway. 2006 Int. Arch. Allergy Immunol. pmid:16940740
Shefler I et al. Inhibition of basic secretagogue-induced signaling in mast cells by cell permeable G alpha i-derived peptides. 2008 Int. Arch. Allergy Immunol. pmid:17848806
Takahashi G et al. The potential role of prostaglandin D2 in nasal congestion observed in a guinea pig model of allergic rhinitis. 2012 Int. Arch. Allergy Immunol. pmid:22472859
Marone G et al. Human heart mast cells in anaphylaxis and cardiovascular disease. 1995 May-Jun Int. Arch. Allergy Immunol. pmid:7542106
Georgitis JW et al. Nasal inflammatory mediator release in ragweed allergic rhinitis: correlation with cellular influx into nasal secretions. 1991 Int. Arch. Allergy Appl. Immunol. pmid:1666629
Petrini B et al. Modulation of lymphocyte and monocyte responses in vitro by 9-deoxy-delta 9-prostaglandin D2 and 9-deoxy-delta 9-delta 12-prostaglandin D2. 1988 Int. Arch. Allergy Appl. Immunol. pmid:3229858
Pearce FL et al. Some studies on human pulmonary mast cells obtained by bronchoalveolar lavage and by enzymic dissociation of whole lung tissue. 1987 Int. Arch. Allergy Appl. Immunol. pmid:2437052
Lewis RA et al. Pharmacologic regulation of mediator generation and release from the murine bone marrow derived mast cell. 1985 Int. Arch. Allergy Appl. Immunol. pmid:2409010
Norman PS et al. Mediator release after allergic and physical nasal challenges. 1985 Int. Arch. Allergy Appl. Immunol. pmid:2409027
Triggiani M et al. Inhibition of histamine and prostaglandin D2 release from human lung mast cells by ciclosporin A. 1989 Int. Arch. Allergy Appl. Immunol. pmid:2468619
Charlesworth EN et al. Cells and secretagogues involved in the human late-phase response. 1989 Int. Arch. Allergy Appl. Immunol. pmid:2468620
Church MK et al. Interaction of neuropeptides with human mast cells. 1989 Int. Arch. Allergy Appl. Immunol. pmid:2468622
Levi-Schaffer F and Shalit M Differential release of histamine and prostaglandin D2 in rat peritoneal mast cells activated with peptides. 1989 Int. Arch. Allergy Appl. Immunol. pmid:2482257
Ennis M et al. Action of 3-isobutyl-1-methylxanthine and prostaglandins D2 and E1 on histamine release from rat and guinea pig mast cells. 1983 Int. Arch. Allergy Appl. Immunol. pmid:6196300
Holgate ST et al. Primary and secondary effector cells in the pathogenesis of bronchial asthma. 1987 Int. Arch. Allergy Appl. Immunol. pmid:3553030
Virtue S et al. Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans. 2015 Int J Obes (Lond) pmid:25801691
Abbasi S et al. Elimination of the biphasic pharmacodynamics of 15d-PGJ2 by controlling its release from a nanoemulsion. 2016 Int J Nanomedicine pmid:27354798
Oh YC et al. Anti-allergic activity of a platycodon root ethanol extract. 2010 Int J Mol Sci pmid:20717534
Fujita M et al. Cytotoxicity of 15-deoxy-Δ(12,14)-prostaglandin J(2) through PPARγ-independent pathway and the involvement of the JNK and Akt pathway in renal cell carcinoma. 2012 Int J Med Sci pmid:22991494
Kalogeromitros D et al. A quercetin containing supplement reduces niacin-induced flush in humans. 2008 Jul-Sep Int J Immunopathol Pharmacol pmid:18831918
Hashimoto K et al. Peroxisome proliferator-activated receptor gamma ligand inhibits cell growth and invasion of human pancreatic cancer cells. 2002 Int J Gastrointest Cancer pmid:12630765
Tzanakakis GN et al. The preventive effect of ketoconazole on experimental metastasis from a human pancreatic carcinoma may be related to its effect on prostaglandin synthesis. 2002 Int J Gastrointest Cancer pmid:12630766
Büyükgüzel K et al. Prostaglandin biosynthesis by midgut tissue isolated from the tobacco hornworm, Manduca sexta. 2002 Insect Biochem. Mol. Biol. pmid:11886778
Tunaz H et al. Prostaglandin biosynthesis by fat body from true armyworms, Pseudaletia unipuncta. 2001 Insect Biochem. Mol. Biol. pmid:11222953
Kaplan J et al. Pioglitazone reduces inflammation through inhibition of NF-κB in polymicrobial sepsis. 2014 Innate Immun pmid:24029145
Mor A et al. Inhibitory effect of farnesylthiosalicylic acid on mediators release by mast cells: preferential inhibition of prostaglandin D(2) and tumor necrosis factor-α release. 2011 Inflammation pmid:20706780
Fernandez-Bustamante A et al. Early increase in alveolar macrophage prostaglandin 15d-PGJ2 precedes neutrophil recruitment into lungs of cytokine-insufflated rats. 2013 Inflammation pmid:23616184
Johansson S et al. CC16 inhibits the migration of eosinophils towards the formyl peptide fMLF but not towards PGD2. 2009 Inflammation pmid:19132521
Petersen LJ and Skov PS The effect of salmeterol and salbutamol on mediator release and skin responses in immediate and late phase allergic cutaneous reactions. 1999 Inflamm. Res. pmid:10563469
Ayoub SS et al. Cyclooxygenase expression and prostaglandin levels in central nervous system tissues during the course of chronic relapsing experimental autoimmune encephalomyelitis (EAE). 2011 Inflamm. Res. pmid:21667309
Lau HY and Chan CL Modulation of intracellular cyclic AMP in immunologically activated rat peritoneal mast cells by prostaglandin D2. 2001 Inflamm. Res. pmid:11411605
Chan CL and Lau HY Effects of prostanoid receptor agonists on immunologically-activated rat peritoneal mast cells. 1998 Inflamm. Res. pmid:9561397
Lau HY and Stenton GR Effects of non-steroidal anti-inflammatory drugs and cyclooxygenase-2 specific inhibitors on mediator release from rat peritoneal mast cells. 1998 Inflamm. Res. pmid:9561398
Yuan ZB et al. Temporal expression of cyclooxygenase-2 in peritoneal macrophages of rats and effects of panax notoginseng saponins. 2009 Inflamm. Res. pmid:19184357
Whelan CJ Evidence that 13-14 di-hydro, 15-keto prostaglandin D(2)-induced airway eosinophilia in guinea-pigs is independent of interleukin-5. 2009 Inflamm. Res. pmid:19184361
Martín AR et al. The COX-2 inhibitor, rofecoxib, ameliorates dextran sulphate sodium induced colitis in mice. 2005 Inflamm. Res. pmid:15883736
Chan CL and Lau HY Prostanoid DP receptor activation inhibits anti-IgE induced histamine release from rat peritoneal mast cells. 1999 Inflamm. Res. pmid:10350148
Sánchez-Gómez FJ et al. Modulation of GSTP1-1 oligomerization by electrophilic inflammatory mediators and reactive drugs. 2013 Inflamm Allergy Drug Targets pmid:23596995