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Cyclooxygenation of the arachidonoyl side chain of 1-arachidonoylglycerol and related compounds block their ability to prevent anandamide and 2-oleoylglycerol metabolism by rat brain in vitro. |
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PPAR-gamma agonists inhibit toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-kappaB pathways. |
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Chem Immunol Allergy |
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The anti-inflammatory prostaglandin 15d-PGJ2 decreases oxidative/nitrosative mediators in brain after acute stress in rats. |
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Psychopharmacology (Berl.) |
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Aromatase inhibition by 15-deoxy-prostaglandin J(2) (15-dPGJ(2)) and N-(4-hydroxyphenyl)-retinamide (4HPR) is associated with enhanced ceramide production. |
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The cyclopentenone prostaglandin 15-deoxydelta(12,14)-prostaglandin J2 attenuates the development of zymosan-induced shock. |
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Intensive Care Med |
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Increased plasma levels of 15-deoxyDelta prostaglandin J2 are associated with good outcome in acute atherothrombotic ischemic stroke. |
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In vivo effects of isatin on rat platelet eicosanoids. |
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Modulation of peroxisome proliferator-activated receptors (PPARs) by PPAR(alpha)- and PPAR(gamma)-specific ligands and by 17beta-estradiol in isolated zebrafish hepatocytes. |
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Toxicol In Vitro |
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Molecular recognition of 15-deoxy-delta(12,14)-prostaglandin J2 by nuclear factor-kappa B and other cellular proteins. |
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Bioorg. Med. Chem. Lett. |
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Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. |
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15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock. |
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Shock |
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Troglitazone and 15-deoxy-delta(12,14)-prostaglandin J2 inhibit shear-induced coupling factor 6 release in endothelial cells. |
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Cardiovasc. Res. |
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Expression of PPARgamma and beta/delta in human primary osteoblastic cells: influence of polyunsaturated fatty acids. |
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Calcif. Tissue Int. |
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Effects of salmeterol xinafoate and fluticasone propionate on immunological activation of human cultured mast cells. |
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Allergol Int |
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Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea. |
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Allergol Int |
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Endogenous 15-deoxy-Delta(12,14)-prostaglandin J(2) synthesized by adipocytes during maturation phase contributes to upregulation of fat storage. |
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FEBS Lett. |
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[The peroxisome-proliferator-activated gamma receptor and chronic inflammatory bowel disease (PPARgamma and IBD)]. |
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Prostaglandin J2 reduces catechol-O-methyltransferase activity and enhances dopamine toxicity in neuronal cells. |
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Neurobiol. Dis. |
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Effects of indomethacin and dexamethasone on mechanical scratching-induced cutaneous barrier disruption in mice. |
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Exp. Dermatol. |
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Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation. |
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15d-prostaglandin J2 protects brain from ischemia-reperfusion injury. |
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ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin. |
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2006 |
Mol. Carcinog. |
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Cytoskeleton/endoplasmic reticulum collapse induced by prostaglandin J2 parallels centrosomal deposition of ubiquitinated protein aggregates. |
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Am. J. Physiol. Heart Circ. Physiol. |
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Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats by activation of peroxisome proliferator-activated receptor gamma. |
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A role of PPAR-gamma in androstenediol-mediated salutary effects on cardiac function following trauma-hemorrhage. |
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Gestational age-dependent up-regulation of prostaglandin D synthase (PGDS) and production of PGDS-derived antiinflammatory prostaglandins in human placenta. |
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Systemic inflammation induces COX-2 mediated prostaglandin D2 biosynthesis in mice spinal cord. |
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Neuropharmacology |
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Identification of novel protein targets for modification by 15-deoxy-Delta12,14-prostaglandin J2 in mesangial cells reveals multiple interactions with the cytoskeleton. |
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J. Am. Soc. Nephrol. |
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15d-Prostaglandin J2 activates peroxisome proliferator-activated receptor-gamma, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats. |
2006 |
J. Cereb. Blood Flow Metab. |
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Differentiation and growth inhibition mediated via the RXR:PPARgamma heterodimer in colon cancer. |
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Chem Asian J |
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Prostaglandin D2 and J2-series (PGJ2, Delta12-PGJ2) prostaglandins stimulate IL-6 and MCP-1, but inhibit leptin, expression and secretion by 3T3-L1 adipocytes. |
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Pflugers Arch. |
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Peroxisome proliferator-activated receptor-gamma ligands inhibit proliferation and induce apoptosis in mantle cell lymphoma. |
2006 |
Anticancer Drugs |
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Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor. |
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J. Immunol. |
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COX-1 inhibition enhances scratching behaviour in NC/Nga mice with atopic dermatitis. |
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Exp. Dermatol. |
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Depot-specific prostaglandin synthesis in human adipose tissue: a novel possible mechanism of adipogenesis. |
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Gene |
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PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Delta12,14-prostaglandin J2. |
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15-Deoxy-12,14-prostaglandin J2 inhibits interferon gamma induced MHC class II but not class I expression on ARPE cells through a PPAR gamma independent mechanism. |
2006 |
Prostaglandins Other Lipid Mediat. |
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Prostaglandin D2 induces the phosphorylation of HSP27 in osteoblasts: function of the MAP kinase superfamily. |
2006 |
Prostaglandins Leukot. Essent. Fatty Acids |
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Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. |
2006 |
Shock |
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Effect of peroxisome proliferator activated receptor (PPAR)gamma agonists on prostaglandins cascade in joint cells. |
2006 |
Biorheology |
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Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators. |
2006 |
Shock |
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