| MeSH term | MeSH ID | Detail |
|---|---|---|
| Actinobacillus Infections | D000189 | 4 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Anal Gland Neoplasms | D000694 | 1 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Ascariasis | D001196 | 3 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Blister | D001768 | 16 associated lipids |
| Blood Platelet Disorders | D001791 | 12 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Brain Damage, Chronic | D001925 | 6 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Carcinoma, Renal Cell | D002292 | 12 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Reddy RC and Standiford TJ | Nrf2 and PPAR{gamma}: PPARtnering against oxidant-induced lung injury. | 2010 | Am. J. Respir. Crit. Care Med. | pmid:20634499 |
| Suzuki R and Freed AN | Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11779726 |
| Krawiec ME et al. | Persistent wheezing in very young children is associated with lower respiratory inflammation. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11371398 |
| Kowalski ML et al. | Differential metabolism of arachidonic acid in nasal polyp epithelial cells cultured from aspirin-sensitive and aspirin-tolerant patients. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10673176 |
| Cho HY et al. | Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice. | 2010 | Am. J. Respir. Crit. Care Med. | pmid:20224069 |
| Hanks BC et al. | Evaluation of anti-inflammatory and chondroprotective effects of peroxisome proliferator-activated receptor gamma agonists in cartilage and synovial explants from dogs. | 2010 | Am. J. Vet. Res. | pmid:20919899 |
| Beasley R et al. | Cholinergic-mediated bronchoconstriction induced by prostaglandin D2, its initial metabolite 9 alpha,11 beta-PGF2, and PGF2 alpha in asthma. | 1987 | Am. Rev. Respir. Dis. | pmid:2960256 |
| Liu MC et al. | Evidence for elevated levels of histamine, prostaglandin D2, and other bronchoconstricting prostaglandins in the airways of subjects with mild asthma. | 1990 | Am. Rev. Respir. Dis. | pmid:2368958 |
| Ingenito EP et al. | Bronchoalveolar lavage cell and mediator responses to hyperpnea-induced bronchoconstriction in the guinea pig. | 1990 | Am. Rev. Respir. Dis. | pmid:2339838 |
| Naclerio RM et al. | Mediator release after nasal airway challenge with allergen. | 1983 | Am. Rev. Respir. Dis. | pmid:6354022 |
| Cohan VL et al. | Dexamethasone does not inhibit the release of mediators from human mast cells residing in airway, intestine, or skin. | 1989 | Am. Rev. Respir. Dis. | pmid:2478059 |
| Picado C et al. | Release of peptide leukotriene into nasal secretions after local instillation of aspirin in aspirin-sensitive asthmatic patients. | 1992 | Am. Rev. Respir. Dis. | pmid:1309968 |
| Wang D et al. | Aminophylline reduces air-flow-induced constriction in the canine lung periphery. | 1988 | Am. Rev. Respir. Dis. | pmid:3422143 |
| Schleimer RP et al. | Characterization of inflammatory mediator release from purified human lung mast cells. | 1986 | Am. Rev. Respir. Dis. | pmid:3485946 |
| Gray PR et al. | The role of cyclooxygenase products in the acute airway obstruction and airway hyperreactivity of ponies with heaves. | 1989 | Am. Rev. Respir. Dis. | pmid:2502051 |
| Eggleston PA et al. | Disassociation of the release of histamine and arachidonic acid metabolites from osmotically activated basophils and human lung mast cells. | 1990 | Am. Rev. Respir. Dis. | pmid:1691604 |
| Jongejan RC et al. | Effects of inflammatory mediators on the responsiveness of isolated human airways to methacholine. | 1990 | Am. Rev. Respir. Dis. | pmid:2240835 |
| Holgate ST | Contribution of inflammatory mediators to the immediate asthmatic reaction. | 1987 | Am. Rev. Respir. Dis. | pmid:3473955 |
| Fuller RW et al. | Prostaglandin D2 potentiates airway responsiveness to histamine and methacholine. | 1986 | Am. Rev. Respir. Dis. | pmid:3511806 |
| Gundel RH et al. | Antigen-induced mediator release in primates. | 1991 | Am. Rev. Respir. Dis. | pmid:1648317 |
| Wang D et al. | Terbutaline acts at multiple sites to inhibit bronchoconstriction induced by dry air in canine peripheral airways. | 1992 | Am. Rev. Respir. Dis. | pmid:1595994 |
| Broide DH et al. | Airway levels of mast cell-derived mediators in exercise-induced asthma. | 1990 | Am. Rev. Respir. Dis. | pmid:1689974 |
| Kleeberger SR et al. | The role of mediators in the response of the canine peripheral lung to 1 ppm ozone. | 1988 | Am. Rev. Respir. Dis. | pmid:2829670 |
| Fernández PL | [Stress and inflammatory bowell disease (I.B.D). Therapeutic strategies]. | 2006 | An R Acad Nac Med (Madr) | pmid:17172222 |
| Koyama J et al. | Simultaneous determination of histamine and prostaglandin D2 using an LC-ESI-MS/MS method with positive/negative ion-switching ionization modes: application to the study of anti-allergic flavonoids on the degranulation of KU812 cells. | 2011 | Anal Bioanal Chem | pmid:21725829 |
| Hirano A et al. | Arachidonic acid-induced channel- and carrier-type ion transport across planar bilayer lipid membranes. | 2003 | Anal Sci | pmid:12608744 |
| Chen Q et al. | A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonist. | 2004 | Anal. Biochem. | pmid:15556564 |
| Zorrilla S et al. | Selective binding of the fluorescent dye 1-anilinonaphthalene-8-sulfonic acid to peroxisome proliferator-activated receptor gamma allows ligand identification and characterization. | 2010 | Anal. Biochem. | pmid:20025845 |
| Cao H et al. | An improved LC-MS/MS method for the quantification of prostaglandins E(2) and D(2) production in biological fluids. | 2008 | Anal. Biochem. | pmid:17976507 |
| Welter H et al. | Partial loss of contractile marker proteins in human testicular peritubular cells in infertility patients. | 2013 | Andrology | pmid:23413143 |
| Araki M et al. | Isoflurane modulates phorbol myristate acetate-, prostaglandin D2-, and prostaglandin E2-induced alterations in hepatic flow and metabolism in the perfused liver in fasted rats. | 1994 | Anesth. Analg. | pmid:7639362 |
| Stellato C et al. | Human basophil/mast cell releasability. IX. Heterogeneity of the effects of opioids on mediator release. | 1992 | Anesthesiology | pmid:1280014 |
| Kashani IA et al. | Effects of prostaglandins on the pulmonary vascular bed of newborn rats with chronic hypoxia. | 1986 | Angiology | pmid:3511774 |
| Cichocka-Jarosz E et al. | Impact of Hymenoptera venom allergy and the effects of specific venom immunotherapy on mast cell metabolites in sensitized children. | 2014 | Ann Agric Environ Med | pmid:24959779 |
| Campbell AM et al. | Conjunctival provocation tests with codeine phosphate. Effect of disodium cromoglycate. | 1993 | Ann Allergy | pmid:7687104 |
| Naclerio RM | Effects of antihistamines on inflammatory mediators. | 1993 | Ann Allergy | pmid:7690526 |
| Campbell AM et al. | In vitro activation of bronchoalveolar lavage cells by house dust mite allergens. | 1992 | Ann Allergy | pmid:1371209 |
| Wasserman SI | Basic mechanisms in asthma. | 1988 | Ann Allergy | pmid:3163472 |
| Small P et al. | Effects of intensity of early response to allergen on the late phase of both the nose and skin. | 1994 | Ann Allergy | pmid:8092561 |
| Orfan N et al. | Systemic cold urticaria in a five-year-old boy. | 1991 | Ann Allergy | pmid:1867452 |
| Marone G et al. | Mechanisms of activation of human mast cells and basophils by general anesthetic drugs. | 1993 | Ann Fr Anesth Reanim | pmid:7690200 |
| Fujishima H et al. | Chemotactic responses of peripheral blood eosinophils to prostaglandin D2 in atopic keratoconjunctivitis. | 2013 | Ann. Allergy Asthma Immunol. | pmid:23886231 |
| Small P and Barrett D | Evaluation of dust and dust mite nasal provocation. | 1995 | Ann. Allergy Asthma Immunol. | pmid:8603280 |
| Rank MA et al. | Systemic reactions to allergen immunotherapy: a role for measuring a PGD2 metabolite? | 2013 | Ann. Allergy Asthma Immunol. | pmid:23244662 |
| Chiba T et al. | The opposing role of two prostaglandin D2 receptors, DP and CRTH2, in human eosinophil migration. | 2011 | Ann. Allergy Asthma Immunol. | pmid:21624751 |
| Leynadier F | [Mast cells and basophils in asthma]. | 1989 | Ann. Biol. Clin. (Paris) | pmid:2675683 |
| Liu JJ et al. | Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro. | 2007 | Ann. Hematol. | pmid:17089125 |
| Polosa R et al. | [Mast cell mediator release after endobronchial challenge with adenosine 5'-monophosphate in asthmatic subjects]. | 1994 Apr-Jun | Ann. Ital. Med. Int. | pmid:7522500 |
| Barrett KE | Effect of histamine and other mast cell mediators on T84 epithelial cells. | 1992 | Ann. N. Y. Acad. Sci. | pmid:1456653 |
| Kim EH et al. | Upregulation of VEGF by 15-deoxy-Delta12,14-prostaglandin J2 via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cells. | 2006 | Ann. N. Y. Acad. Sci. | pmid:17384282 |