PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Huang ZL et al. | Prostaglandins and adenosine in the regulation of sleep and wakefulness. | 2007 | Curr Opin Pharmacol | pmid:17129762 |
| Kim HY and Kim HS | Upregulation of MIP-2 (CXCL2) expression by 15-deoxy-Delta(12,14)-prostaglandin J(2) in mouse peritoneal macrophages. | 2007 | Immunol. Cell Biol. | pmid:17130903 |
| Tanaka Y et al. | Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice. | 2007 | Mol. Pharmacol. | pmid:17151289 |
| Suwaki N et al. | Expression and potential role of peroxisome proliferator-activated receptor gamma in the placenta of diabetic pregnancy. | 2007 | Placenta | pmid:16753211 |
| Nitta N et al. | Quantitative analysis of eosinophil chemotaxis tracked using a novel optical device -- TAXIScan. | 2007 | J. Immunol. Methods | pmid:17289072 |
| Reyes-Martin P et al. | Cyclooxygenase-independent inhibition of H2O2-induced cell death by S-ketoprofen in renal cells. | 2007 | Pharmacol. Res. | pmid:17291778 |
| Aldini G et al. | Identification of actin as a 15-deoxy-Delta12,14-prostaglandin J2 target in neuroblastoma cells: mass spectrometric, computational, and functional approaches to investigate the effect on cytoskeletal derangement. | 2007 | Biochemistry | pmid:17297918 |
| Pettipher R et al. | Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases. | 2007 | Nat Rev Drug Discov | pmid:17396136 |
| Gayarre J et al. | Modification of proteins by cyclopentenone prostaglandins is differentially modulated by GSH in vitro. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17405918 |
| Hagens WI et al. | Targeting 15d-prostaglandin J2 to hepatic stellate cells: two options evaluated. | 2007 | Pharm. Res. | pmid:17245650 |
| Sugimoto M et al. | Putative mechanism of the itch-scratch circle: repeated scratching decreases the cutaneous level of prostaglandin D2, a mediator that inhibits itching. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17250998 |
| Monroy MA et al. | THE PPARgamma ligand 15d-PGJ2 modulates macrophage activation after injury in a murine trauma model. | 2007 | Shock | pmid:17510607 |
| Zingarelli B et al. | Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt. | 2007 | Shock | pmid:17589386 |
| Vunta H et al. | The anti-inflammatory effects of selenium are mediated through 15-deoxy-Delta12,14-prostaglandin J2 in macrophages. | 2007 | J. Biol. Chem. | pmid:17439952 |
| Taniguchi H et al. | Prostaglandin D2 protects neonatal mouse brain from hypoxic ischemic injury. | 2007 | J. Neurosci. | pmid:17442814 |
| Zhang XC et al. | Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17483291 |
| Ponferrada A et al. | The role of PPARgamma on restoration of colonic homeostasis after experimental stress-induced inflammation and dysfunction. | 2007 | Gastroenterology | pmid:17484875 |
| Fulzele SV et al. | 15-Deoxy-Delta12,14-prostaglandin J2 enhances docetaxel anti-tumor activity against A549 and H460 non-small-cell lung cancer cell lines and xenograft tumors. | 2007 | Anticancer Drugs | pmid:17159504 |
| Fournier T et al. | Involvement of PPARgamma in human trophoblast invasion. | 2007 | Placenta | pmid:17321592 |
| Rajakariar R et al. | Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyDelta12 14 PGJ2. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18077391 |
| Moulin D et al. | Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cells. | 2007 | Cytokine | pmid:18023358 |
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| Rollins MD et al. | Anti-inflammatory effects of PPAR-gamma agonists directly correlate with PPAR-gamma expression during acute pancreatitis. | 2006 Sep-Oct | J. Gastrointest. Surg. | pmid:16966031 |
| Goya K et al. | The thiazolidinedione drug troglitazone up-regulates nitric oxide synthase expression in vascular endothelial cells. | 2006 Sep-Oct | J. Diabetes Complicat. | pmid:16949522 |
| Castellani ML et al. | Rat basophilic leukemia cells (RBL-2H3) generate prostaglandin D2 (PGD2) after regulated upon activation, normal T-cell expressed and secreted (RANTES) activation. | 2006 Oct-Dec | Int. J. Biol. Markers | pmid:17177158 |
| Lappas M et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) and troglitazone regulation of the release of phospholipid metabolites, inflammatory cytokines and proteases from human gestational tissues. | 2006 Nov-Dec | Placenta | pmid:16434095 |
| Urade Y | Twenty-fifth anniversary of the discovery of somnogenic activity of prostaglandin D2: sleep research directed by Osamu Hayaishi. | 2006 May-Jun | IUBMB Life | pmid:16754308 |
| Okano M et al. | Presence and characterization of prostaglandin D2-related molecules in nasal mucosa of patients with allergic rhinitis. | 2006 May-Jun | Am J Rhinol | pmid:16871941 |
| Guyer BJ et al. | Mast cell inhibitor R112 is well tolerated and affects prostaglandin D2 but not other mediators, symptoms, or nasal volumes in a nasal challenge model of allergic rhinitis. | 2006 May-Jun | Allergy Asthma Proc | pmid:16913263 |
| Kim SJ et al. | Effects of methyl gallate on arachidonic acid metabolizing enzymes: Cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. | 2006 | Arch. Pharm. Res. | pmid:17121182 |
| Berruyer C et al. | Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity. | 2006 | J. Exp. Med. | pmid:17145956 |
| Kang DS et al. | 15-deoxy-Delta12,14-prostaglandin J2 induces renal epithelial cell death through NF-kappaB-dependent and MAPK-independent mechanism. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16890972 |
| Nakata S et al. | 15-Deoxy-Delta12,14-prostaglandin J(2) induces death receptor 5 expression through mRNA stabilization independently of PPARgamma and potentiates TRAIL-induced apoptosis. | 2006 | Mol. Cancer Ther. | pmid:16891469 |
| Wang XS and Lau HY | Beta-adrenoceptor-mediated inhibition of mediator release from human peripheral blood-derived mast cells. | 2006 | Clin. Exp. Pharmacol. Physiol. | pmid:16895550 |
| Zhang A et al. | Prostaglandin D2 inhibits TGF-beta1-induced epithelial-to-mesenchymal transition in MDCK cells. | 2006 | Am. J. Physiol. Renal Physiol. | pmid:16896186 |
| Chaffer CL et al. | PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma. | 2006 | BMC Cancer | pmid:16519808 |
| Pérez S et al. | The 2-series prostaglandins suppress VLDL secretion in an inflammatory condition-dependent manner in primary rat hepatocytes. | 2006 | Biochim. Biophys. Acta | pmid:16545597 |
| Wise H | Lack of interaction between prostaglandin E2 receptor subtypes in regulating adenylyl cyclase activity in cultured rat dorsal root ganglion cells. | 2006 | Eur. J. Pharmacol. | pmid:16545798 |
| Wang XS et al. | Functional characterization of human mast cells cultured from adult peripheral blood. | 2006 | Int. Immunopharmacol. | pmid:16546715 |
| Sawai H et al. | Activation of peroxisome proliferator-activated receptor-gamma decreases pancreatic cancer cell invasion through modulation of the plasminogen activator system. | 2006 | Mol. Cancer Res. | pmid:16547153 |
| Fu YG et al. | Inhibition of gastric cancer cells associated angiogenesis by 15d-prostaglandin J2 through the downregulation of angiopoietin-1. | 2006 | Cancer Lett. | pmid:16412567 |
| Wung BS et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) suppresses IL-6-induced STAT3 phosphorylation via electrophilic reactivity in endothelial cells. | 2006 | Life Sci. | pmid:16413037 |
| Mathiesen JM et al. | On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2. | 2006 | Mol. Pharmacol. | pmid:16418339 |
| Barreto EO et al. | High levels of filamentous actin and apoptosis correlate with mast cell refractoriness under alloxan-evoked diabetes. | 2006 | Life Sci. | pmid:16647092 |
| Funovics P et al. | Effects of 15d-PGJ(2) on VEGF-induced angiogenic activities and expression of VEGF receptors in endothelial cells. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16647637 |
| Jin MH et al. | Anti-inflammatory activity of Ailanthus altissima in ovalbumin-induced lung inflammation. | 2006 | Biol. Pharm. Bull. | pmid:16651713 |
| Mohri I et al. | Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher. | 2006 | J. Neurosci. | pmid:16624958 |
| Hauser B et al. | Effects of 15-deoxy-Delta12,14-prostaglandin-J2 during hyperdynamic porcine endotoxemia. | 2006 | Intensive Care Med | pmid:16534570 |
| Shimizu T et al. | A role of PPAR-gamma in androstenediol-mediated salutary effects on cardiac function following trauma-hemorrhage. | 2006 | Ann. Surg. | pmid:16794398 |
| Chen Y et al. | Effects of PPARgamma agonists on cell survival and focal adhesions in a Chinese thyroid carcinoma cell line. | 2006 | J. Cell. Biochem. | pmid:16795079 |
| Yucel-Lindberg T et al. | Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts. | 2006 | Cell. Signal. | pmid:16766159 |
| Relic B et al. | Peroxisome proliferator-activated receptor-gamma1 is dephosphorylated and degraded during BAY 11-7085-induced synovial fibroblast apoptosis. | 2006 | J. Biol. Chem. | pmid:16766531 |
| Sugimoto M et al. | Role of COX-1 and COX-2 on skin PGs biosynthesis by mechanical scratching in mice. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16815697 |
| Schwartz MS et al. | Determination of a prostaglandin D2 antagonist and its acyl glucuronide metabolite in human plasma by high performance liquid chromatography with tandem mass spectrometric detection--a lack of MS/MS selectivity between a glucuronide conjugate and a phase I metabolite. | 2006 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16716772 |
| Na HK and Surh YJ | Transcriptional regulation via cysteine thiol modification: a novel molecular strategy for chemoprevention and cytoprotection. | 2006 | Mol. Carcinog. | pmid:16673384 |
| BrazÃs P et al. | Dermal microdialysis in the dog: in vivo assessment of the effect of cyclosporin A on cutaneous histamine and prostaglandin D2 release. | 2006 | Vet. Dermatol. | pmid:16674731 |
| Hickson-Bick DL et al. | The response of neonatal rat ventricular myocytes to lipopolysaccharide-induced stress. | 2006 | Shock | pmid:16680021 |
| Son MJ et al. | Naturally occurring biflavonoid, ochnaflavone, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. | 2006 | Arch. Pharm. Res. | pmid:16681032 |
| Wang WM et al. | [Effects of peroxisome proliferators-activated receptor gamma agonists on transforming growth factor-beta1 and Smads signal pathway: experiment with rat renal fibroblasts]. | 2006 | Zhonghua Yi Xue Za Zhi | pmid:16681946 |
| Sun K et al. | PPAR gamma inhibits growth of rat hepatic stellate cells and TGF beta-induced connective tissue growth factor expression. | 2006 | Acta Pharmacol. Sin. | pmid:16723090 |
| Ou Z et al. | Neuronal expression of peroxisome proliferator-activated receptor-gamma (PPARgamma) and 15d-prostaglandin J2--mediated protection of brain after experimental cerebral ischemia in rat. | 2006 | Brain Res. | pmid:16725118 |
| Lee S et al. | Rosiglitazone ameliorates cisplatin-induced renal injury in mice. | 2006 | Nephrol. Dial. Transplant. | pmid:16728429 |
| Rajasingh J and Bright JJ | 15-Deoxy-delta12,14-prostaglandin J2 regulates leukemia inhibitory factor signaling through JAK-STAT pathway in mouse embryonic stem cells. | 2006 | Exp. Cell Res. | pmid:16737695 |
| Wang Z et al. | Prostaglandin J2 alters pro-survival and pro-death gene expression patterns and 26 S proteasome assembly in human neuroblastoma cells. | 2006 | J. Biol. Chem. | pmid:16737963 |
| Yasugi E et al. | Peroxisome proliferator-activated receptor gamma ligands stimulate myeloid differentiation and lipogenensis in human leukemia NB4 cells. | 2006 | Dev. Growth Differ. | pmid:16573735 |
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| Garg TK and Chang JY | Methylmercury causes oxidative stress and cytotoxicity in microglia: attenuation by 15-deoxy-delta 12, 14-prostaglandin J2. | 2006 | J. Neuroimmunol. | pmid:16225932 |
| Shiraki T et al. | Spectroscopic analyses of the binding kinetics of 15d-PGJ2 to the PPARgamma ligand-binding domain by multi-wavelength global fitting. | 2006 | Biochem. J. | pmid:16236024 |
| Benkirane K et al. | PPAR-gamma inhibits ANG II-induced cell growth via SHIP2 and 4E-BP1. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16155101 |
| Zhang YF et al. | Peroxisome proliferator-activated receptor-gamma is expressed by rat peritoneal mesothelial cells: its potential role in peritoneal cavity local defense. | 2006 | Am. J. Nephrol. | pmid:17183189 |
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| Millán O et al. | Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis. | 2006 | Carcinogenesis | pmid:16113051 |
| Núñez NP et al. | PPAR-gamma ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells. | 2006 | Cancer Lett. | pmid:15979236 |
| Willermain F et al. | 15-Deoxy-12,14-prostaglandin J2 inhibits interferon gamma induced MHC class II but not class I expression on ARPE cells through a PPAR gamma independent mechanism. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16939878 |
| Lim HJ et al. | PPARgamma activation induces CD36 expression and stimulates foam cell like changes in rVSMCs. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16939881 |
| Chiba T et al. | Prostaglandin D2 induces IL-8 and GM-CSF by bronchial epithelial cells in a CRTH2-independent pathway. | 2006 | Int. Arch. Allergy Immunol. | pmid:16940740 |
| Yu X et al. | Nrf2-mediated induction of cytoprotective enzymes by 15-deoxy-Delta12,14-prostaglandin J2 is attenuated by alkenal/one oxidoreductase. | 2006 | J. Biol. Chem. | pmid:16857669 |
| Chen ZH et al. | Induction of adaptive response and enhancement of PC12 cell tolerance by 7-hydroxycholesterol and 15-deoxy-delta(12,14)-prostaglandin J2 through up-regulation of cellular glutathione via different mechanisms. | 2006 | J. Biol. Chem. | pmid:16565077 |
| Horiguchi T et al. | Cyclooxygenase-2 mediates the development of cortical spreading depression-induced tolerance to transient focal cerebral ischemia in rats. | 2006 | Neuroscience | pmid:16567054 |
| Siddhivarn C et al. | Prostaglandin D2 pathway and peroxisome proliferator-activated receptor gamma-1 expression are induced by mechanical loading in an osteoblastic cell line. | 2006 | J. Periodont. Res. | pmid:16499711 |
| Coyle AT and Kinsella BT | Synthetic peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone suppress transcription by promoter 3 of the human thromboxane A2 receptor gene in human erythroleukemia cells. | 2006 | Biochem. Pharmacol. | pmid:16499875 |
| Makino N et al. | Peroxisome proliferator-activated receptor-gamma ligands attenuate brain natriuretic peptide production and affect remodeling in cardiac fibroblasts in reoxygenation after hypoxia. | 2006 | Cell Biochem. Biophys. | pmid:16456235 |
| Figarella K et al. | Prostaglandin-induced programmed cell death in Trypanosoma brucei involves oxidative stress. | 2006 | Cell Death Differ. | pmid:16456581 |
| Belvisi MG et al. | Peroxisome proliferator-activated receptor gamma agonists as therapy for chronic airway inflammation. | 2006 | Eur. J. Pharmacol. | pmid:16458290 |
| Rolin S et al. | Prostanoids as pharmacological targets in COPD and asthma. | 2006 | Eur. J. Pharmacol. | pmid:16458293 |
| Masuda H et al. | 15-deoxy-Delta12,14-prostaglandin J2 attenuates development of cyclophosphamide-induced cystitis in rats. | 2006 | Urology | pmid:16461118 |
| Lee E et al. | Anti-asthmatic activity of an ethanol extract from Saururus chinensis. | 2006 | Biol. Pharm. Bull. | pmid:16462020 |
| Raetz CR et al. | Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. | 2006 | J. Lipid Res. | pmid:16479018 |
| Nakahata Y et al. | The in vitro real-time oscillation monitoring system identifies potential entrainment factors for circadian clocks. | 2006 | BMC Mol. Biol. | pmid:16483373 |
| Ye F et al. | Quantitative characterization of 15-deoxy-delta(12,14)-prostaglandin J2 in regulating EGFPSmad2 translocation in CHO cells through PPARgamma/TGFbeta/Smad2 pathway. | 2006 | Cell. Physiol. Biochem. | pmid:16914899 |
| Lee JJ et al. | Antiplatelet activity of carnosol is mediated by the inhibition of TXA2 receptor and cytosolic calcium mobilization. | 2006 | Vascul. Pharmacol. | pmid:16916624 |
| Ulven T and Kostenis E | Targeting the prostaglandin D2 receptors DP and CRTH2 for treatment of inflammation. | 2006 | Curr Top Med Chem | pmid:16918458 |
| Theiner G et al. | The mast cell mediator PGD2 suppresses IL-12 release by dendritic cells leading to Th2 polarized immune responses in vivo. | 2006 | Immunobiology | pmid:16920486 |
| Urade Y and Mohri I | [Sleep and brain function]. | 2006 | No To Hattatsu | pmid:16986732 |
| Kim EH and Surh YJ | 15-deoxy-Delta12,14-prostaglandin J2 as a potential endogenous regulator of redox-sensitive transcription factors. | 2006 | Biochem. Pharmacol. | pmid:16987499 |
| Diaz BL et al. | Group V secretory phospholipase A2 amplifies the induction of cyclooxygenase 2 and delayed prostaglandin D2 generation in mouse bone marrow culture-derived mast cells in a strain-dependent manner. | 2006 | Biochim. Biophys. Acta | pmid:17064958 |
| Qin S et al. | Protection of RPE cells from oxidative injury by 15-deoxy-delta12,14-prostaglandin J2 by augmenting GSH and activating MAPK. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:17065531 |
| Gyles SL et al. | A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatants. | 2006 | Immunology | pmid:17067313 |