Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Tsuji T et al. | Reduction of nuclear peroxisome proliferator-activated receptor gamma expression in methamphetamine-induced neurotoxicity and neuroprotective effects of ibuprofen. | 2009 | Neurochem. Res. | pmid:18946735 |
Bruck R et al. | Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor. | 2009 | Dig. Dis. Sci. | pmid:18594976 |
Gressner OA et al. | Elevated concentrations of 15-deoxy-Delta12,14-prostaglandin J2 in chronic liver disease propose therapeutic trials with peroxisome proliferator activated receptor gamma-inducing drugs. | 2009 | Liver Int. | pmid:19018984 |
Mickleborough TD et al. | Eicosapentaenoic acid is more effective than docosahexaenoic acid in inhibiting proinflammatory mediator production and transcription from LPS-induced human asthmatic alveolar macrophage cells. | 2009 | Clin Nutr | pmid:19054597 |
Yamamura K et al. | Intracellular protein phosphorylation in eosinophils and the functional relevance in cytokine production. | 2009 | Int. Arch. Allergy Immunol. | pmid:19494504 |
Chiba T et al. | 15-Deoxy-Delta(12,14)-prostaglandin J2 induces IL-8 and GM-CSF in a human airway epithelial cell line (NCI-H292). | 2009 | Int. Arch. Allergy Immunol. | pmid:19494510 |
Csányi G et al. | Effects of 3-aminopyridine-induced seizures on platelet eicosanoid synthesis. | 2008 May-Jun | Pharmacol Rep | pmid:18622059 |
Kalogeromitros D et al. | A quercetin containing supplement reduces niacin-induced flush in humans. | 2008 Jul-Sep | Int J Immunopathol Pharmacol | pmid:18831918 |
Papageorgiou E et al. | Rosiglitazone attenuates insulin-like growth factor 1 receptor survival signaling in PC-3 cells. | 2008 Jul-Aug | Mol. Med. | pmid:18475308 |
Pettipher R and Hansel TT | Antagonists of the prostaglandin D2 receptor CRTH2. | 2008 Jul-Aug | Drug News Perspect. | pmid:18836589 |
Takahashi N et al. | Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators. | 2008 Jul-Aug | Channels (Austin) | pmid:18769139 |
Tokuda H et al. | Function of Rho-kinase in prostaglandin D2-induced interleukin-6 synthesis in osteoblasts. | 2008 Jul-Aug | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18771907 |
Yasui K et al. | Contribution of prostaglandin D2 via prostanoid DP receptor to nasal hyperresponsiveness in guinea pigs repeatedly exposed to antigen. | 2008 | Eur. J. Pharmacol. | pmid:17927976 |
Napimoga MH et al. | 15d-prostaglandin J2 inhibits inflammatory hypernociception: involvement of peripheral opioid receptor. | 2008 | J. Pharmacol. Exp. Ther. | pmid:17928570 |
Caito S et al. | Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, PPARgamma agonists, differentially regulate cigarette smoke-mediated pro-inflammatory cytokine release in monocytes/macrophages. | 2008 | Antioxid. Redox Signal. | pmid:17970647 |
Cao H et al. | An improved LC-MS/MS method for the quantification of prostaglandins E(2) and D(2) production in biological fluids. | 2008 | Anal. Biochem. | pmid:17976507 |
Farias SE et al. | Formation of eicosanoids, E2/D2 isoprostanes, and docosanoids following decapitation-induced ischemia, measured in high-energy-microwaved rat brain. | 2008 | J. Lipid Res. | pmid:18503030 |
Zhao W et al. | TGF-beta1 attenuates mediator release and de novo Kit expression by human skin mast cells through a Smad-dependent pathway. | 2008 | J. Immunol. | pmid:18981148 |
Cruz-Orengo L et al. | Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1. | 2008 | Mol Pain | pmid:18671867 |
Zayed N et al. | Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2. | 2008 | Arthritis Rheum. | pmid:18975308 |
Telleria-Diaz A et al. | Different effects of spinally applied prostaglandin D2 on responses of dorsal horn neurons with knee input in normal rats and in rats with acute knee inflammation. | 2008 | Neuroscience | pmid:18678231 |
Niwa Y et al. | Opposite effects of PU.1 on mast cell stimulation. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18680724 |
Arima M and Fukuda T | Prostaglandin D2 receptors DP and CRTH2 in the pathogenesis of asthma. | 2008 | Curr. Mol. Med. | pmid:18691063 |
Oku H and Umino T | Molecular characterization of peroxisome proliferator-activated receptors (PPARs) and their gene expression in the differentiating adipocytes of red sea bream Pagrus major. | 2008 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:18691667 |
Ryan AJ et al. | 15-deoxy-Delta12,14-prostaglandin J2 impairs phosphatidylcholine synthesis and induces nuclear accumulation of thiol-modified cytidylyltransferase. | 2008 | J. Biol. Chem. | pmid:18614529 |
Ulivi V et al. | 15-deoxy-delta 12,14-prostaglandin J(2) inhibits the synthesis of the acute phase protein SIP24 in cartilage: Involvement of COX-2 in resolution of inflammation. | 2008 | J. Cell. Physiol. | pmid:18615580 |
Gressner OA et al. | Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways. | 2008 | J. Hepatol. | pmid:18486259 |
Lee JH et al. | The 15-deoxy-delta 12,14-prostaglandin J2 suppresses monocyte chemoattractant protein-1 expression in IFN-gamma-stimulated astrocytes through induction of MAPK phosphatase-1. | 2008 | J. Immunol. | pmid:19050284 |
Lian TW et al. | Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages. | 2008 | Biochim. Biophys. Acta | pmid:18662803 |
Satarug S et al. | Prostaglandin D2 induces heme oxygenase-1 mRNA expression through the DP2 receptor. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18957281 |
Jozkowicz A et al. | 15d-PGJ2 upregulates synthesis of IL-8 in endothelial cells through induction of oxidative stress. | 2008 | Antioxid. Redox Signal. | pmid:18665800 |
Huang W et al. | PPARalpha and PPARgamma effectively protect against HIV-induced inflammatory responses in brain endothelial cells. | 2008 | J. Neurochem. | pmid:18710415 |
You Q et al. | Mechanism of T cell tolerance induction by murine hepatic Kupffer cells. | 2008 | Hepatology | pmid:18712788 |
Boisvert M et al. | PGJ2 antagonizes NF-kappaB-induced HIV-1 LTR activation in colonic epithelial cells. | 2008 | Virology | pmid:18755491 |
O'Brien JJ et al. | 15-deoxy-delta12,14-PGJ2 enhances platelet production from megakaryocytes. | 2008 | Blood | pmid:18755987 |
Shiraishi Y et al. | Cyclooxygenase-2/prostaglandin D2/CRTH2 pathway mediates double-stranded RNA-induced enhancement of allergic airway inflammation. | 2008 | J. Immunol. | pmid:18097056 |
Yang JH et al. | Anti-allergic activity of an ethanol extract from Salviae miltiorrhiza. | 2008 | Arch. Pharm. Res. | pmid:19099230 |
Napimoga MH et al. | Peroxisome proliferator-activated receptor-gamma ligand, 15-deoxy-Delta12,14-prostaglandin J2, reduces neutrophil migration via a nitric oxide pathway. | 2008 | J. Immunol. | pmid:18097063 |
Lutzow YS et al. | 15-Deoxy-Delta12,14-prostaglandin J2 induces chemokine expression, oxidative stress and microfilament reorganization in bovine mammary epithelial cells. | 2008 | J. Dairy Res. | pmid:18226310 |
Torres D et al. | Prostaglandin D2 inhibits the production of IFN-gamma by invariant NK T cells: consequences in the control of B16 melanoma. | 2008 | J. Immunol. | pmid:18178816 |
Zhao H et al. | Met-Arg-Trp derived from Rubisco lowers blood pressure via prostaglandin D(2)-dependent vasorelaxation in spontaneously hypertensive rats. | 2008 | Peptides | pmid:18180074 |
Feltenmark S et al. | Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18184802 |
Kerr BJ et al. | The protective effects of 15-deoxy-delta-(12,14)-prostaglandin J2 in spinal cord injury. | 2008 | Glia | pmid:18205174 |
Taketa K et al. | Oxidized low density lipoprotein activates peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARgamma through MAPK-dependent COX-2 expression in macrophages. | 2008 | J. Biol. Chem. | pmid:18208815 |
Jin YR et al. | Antiplatelet activity of epigallocatechin gallate is mediated by the inhibition of PLCgamma2 phosphorylation, elevation of PGD2 production, and maintaining calcium-ATPase activity. | 2008 | J. Cardiovasc. Pharmacol. | pmid:18209568 |
Choi IK et al. | PPAR-gamma ligand promotes the growth of APC-mutated HT-29 human colon cancer cells in vitro and in vivo. | 2008 | Invest New Drugs | pmid:18161004 |
Urade Y | [Structure and function of prostaglandin D synthase]. | 2008 | Tanpakushitsu Kakusan Koso | pmid:18326294 |
Terao A et al. | Gene expression in the rat brain during prostaglandin D2 and adenosinergically-induced sleep. | 2008 | J. Neurochem. | pmid:18331290 |
Inagaki S et al. | Human liver dihydrodiol dehydrogenase 1-catalyzed reaction generating 9alpha,11beta-prostaglandin F2 from prostaglandin D2 followed by micellar electrokinetic chromatography. | 2008 | J Sep Sci | pmid:18307166 |
Paolini JF et al. | Effects of laropiprant on nicotinic acid-induced flushing in patients with dyslipidemia. | 2008 | Am. J. Cardiol. | pmid:18308010 |