PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Maurin AC et al. | Expression of PPARgamma and beta/delta in human primary osteoblastic cells: influence of polyunsaturated fatty acids. | 2005 | Calcif. Tissue Int. | pmid:15868283 |
| Yoshida M et al. | Methotrexate suppresses inflammatory agonist induced interleukin 6 synthesis in osteoblasts. | 2005 | J. Rheumatol. | pmid:15868610 |
| Li X et al. | Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes. | 2005 | J. Rheumatol. | pmid:15868626 |
| De Oliveira C et al. | Insulin alters nuclear factor-lambdaB and peroxisome proliferator-activated receptor-gamma protein expression induced by glycated bovine serum albumin in vascular smooth-muscle cells. | 2005 | J. Lab. Clin. Med. | pmid:15871306 |
| Planagumà A et al. | The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARgamma activation. | 2005 | FASEB J. | pmid:15876570 |
| Kim HY et al. | Upregulation of LPS-induced chemokine KC expression by 15-deoxy-delta12,14-prostaglandin J2 in mouse peritoneal macrophages. | 2005 | Immunol. Cell Biol. | pmid:15877607 |
| Blanco M et al. | Increased plasma levels of 15-deoxyDelta prostaglandin J2 are associated with good outcome in acute atherothrombotic ischemic stroke. | 2005 | Stroke | pmid:15879329 |
| Hashimoto Y et al. | Prostaglandin D2 inhibits IgE-mediated scratching by suppressing histamine release from mast cells. | 2005 | J. Pharmacol. Sci. | pmid:15879676 |
| Raible DG et al. | Mast cell mediators prostaglandin-D2 and histamine activate human eosinophils. | 1992 | J. Immunol. | pmid:1588043 |
| Marchini C et al. | Aspirin modulates LPS-induced nitric oxide release in rat glial cells. | 2005 Jun 10-17 | Neurosci. Lett. | pmid:15882795 |
| MartÃn AR et al. | The COX-2 inhibitor, rofecoxib, ameliorates dextran sulphate sodium induced colitis in mice. | 2005 | Inflamm. Res. | pmid:15883736 |
| Artwohl M et al. | Thiazolidinediones inhibit apoptosis and heat shock protein 60 expression in human vascular endothelial cells. | 2005 | Thromb. Haemost. | pmid:15886792 |
| Malki S et al. | Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation. | 2005 | EMBO J. | pmid:15889150 |
| Capobianco E et al. | 15-Deoxy-Delta12,14-prostaglandin J2 and peroxisome proliferator-activated receptor gamma (PPARgamma) levels in term placental tissues from control and diabetic rats: modulatory effects of a PPARgamma agonist on nitridergic and lipid placental metabolism. | 2005 | Reprod. Fertil. Dev. | pmid:15899154 |
| Avis I et al. | Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition. | 2005 | Cancer Res. | pmid:15899809 |
| Wang Z and Figueiredo-Pereira ME | Inhibition of sequestosome 1/p62 up-regulation prevents aggregation of ubiquitinated proteins induced by prostaglandin J2 without reducing its neurotoxicity. | 2005 | Mol. Cell. Neurosci. | pmid:15911346 |
| Ishida A et al. | Characterization of cAMP-dependent proteolysis of GATA-6. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15913546 |
| Hennersdorf F et al. | Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation. | 2005 | Cell Res. | pmid:15916720 |
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| D'Onofrio C et al. | Comparative anti-viral and anti-proliferative activity of PGA1 and PGJ2 against HTLV-I-infected MT-2 cells. | 1992 | Int. J. Cancer | pmid:1592539 |
| Kunkel SL et al. | Suppression of immune complex vasculitis in rats by prostaglandin. | 1979 | J. Clin. Invest. | pmid:159314 |
| Tomita H et al. | Troglitazone and 15-deoxy-delta(12,14)-prostaglandin J2 inhibit shear-induced coupling factor 6 release in endothelial cells. | 2005 | Cardiovasc. Res. | pmid:15949477 |
| Wang D et al. | Terbutaline acts at multiple sites to inhibit bronchoconstriction induced by dry air in canine peripheral airways. | 1992 | Am. Rev. Respir. Dis. | pmid:1595994 |
| Ibabe A et al. | Modulation of peroxisome proliferator-activated receptors (PPARs) by PPAR(alpha)- and PPAR(gamma)-specific ligands and by 17beta-estradiol in isolated zebrafish hepatocytes. | 2005 | Toxicol In Vitro | pmid:15964169 |
| Hogaboam CM et al. | Platelet-activating factor synthesis by peritoneal mast cells and its inhibition by two quinoline-based compounds. | 1992 | Br. J. Pharmacol. | pmid:1596692 |
| Núñez NP et al. | PPAR-gamma ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells. | 2006 | Cancer Lett. | pmid:15979236 |
| Kaplan JM et al. | 15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock. | 2005 | Shock | pmid:15988322 |
| Costello DA et al. | Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro. | 2005 | Neuropharmacology | pmid:15993441 |
| Patel KM et al. | Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma). | 2005 | Cell. Signal. | pmid:15993751 |
| Zurich MG et al. | Unusual astrocyte reactivity caused by the food mycotoxin ochratoxin A in aggregating rat brain cell cultures. | 2005 | Neuroscience | pmid:15994020 |
| Chacón P et al. | Induction of cyclooxygenase-2 expression by allergens in lymphocytes from allergic patients. | 2005 | Eur. J. Immunol. | pmid:15997464 |
| Honma Y et al. | Prostaglandin D2 and prostaglandin E2 accelerate the recovery of cutaneous barrier disruption induced by mechanical scratching in mice. | 2005 | Eur. J. Pharmacol. | pmid:16000196 |
| Kim HJ et al. | 15-Deoxy-delta12,14-PGJ2 inhibits IL-6-induced Stat3 phosphorylation in lymphocytes. | 2005 | Exp. Mol. Med. | pmid:16000871 |
| Pande V and Ramos MJ | Molecular recognition of 15-deoxy-delta(12,14)-prostaglandin J2 by nuclear factor-kappa B and other cellular proteins. | 2005 | Bioorg. Med. Chem. Lett. | pmid:16006125 |
| Eggler AL et al. | Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16006525 |
| Matsuzaki Y et al. | 15-deoxy-Delta12, 14-prostaglandin J2 activates the expression of p15INK4b gene, a cyclin-dependent kinase inhibitor. | 2005 | Int. J. Oncol. | pmid:16010433 |
| Polikandriotis JA et al. | Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:16020752 |
| Kim J et al. | Suppression of prostate tumor cell growth by stromal cell prostaglandin D synthase-derived products. | 2005 | Cancer Res. | pmid:16024620 |
| Hata AN et al. | Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2. | 2005 | J. Biol. Chem. | pmid:16030019 |
| Pereira MP et al. | Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms. | 2006 | J. Cereb. Blood Flow Metab. | pmid:16034372 |
| Mouihate A et al. | Fever suppression in near-term pregnant rats is dissociated from LPS-activated signaling pathways. | 2005 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:16037126 |
| Nakae K et al. | Functional role of prostacyclin receptor in rat dorsal root ganglion neurons. | 2005 | Neurosci. Lett. | pmid:16039053 |
| Gelir E et al. | Effect of rapid-eye-movement sleep deprivation on rat hypothalamic prostaglandins. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16039105 |
| Masini E et al. | Reduction of antigen-induced respiratory abnormalities and airway inflammation in sensitized guinea pigs by a superoxide dismutase mimetic. | 2005 | Free Radic. Biol. Med. | pmid:16043023 |
| Muñoz U et al. | The cyclopentenone 15-deoxy-delta(12,14)-prostaglandin J2 inhibits G1/S transition and retinoblastoma protein phosphorylation in immortalized lymphocytes from Alzheimer's disease patients. | 2005 | Exp. Neurol. | pmid:16061222 |
| Chen ZY and Tseng CC | 15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signal transduction pathway in HT-29 colon cancer cells. | 2005 | Mol. Pharmacol. | pmid:16077033 |
| Chevalier E et al. | Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment. | 2005 | J. Immunol. | pmid:16081770 |
| Kim KA et al. | 15d-Deoxy-Delta12,14-prostaglandin J2 modulates collagen type I synthesis in human hepatic stellate cells by inducing oxidative stress. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16098720 |
| Chen C and Bazan NG | Lipid signaling: sleep, synaptic plasticity, and neuroprotection. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099392 |
| Stahlschmidt J et al. | Urothelial differentiation in chronically urine-deprived bladders of patients with end-stage renal disease. | 2005 | Kidney Int. | pmid:16105033 |