Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hall TJ et al. | Decreased natural killer cell activity in atopic eczema. | 1985 | Immunology | pmid:3876984 |
Watanabe K et al. | Biosynthesis of prostaglandin F2 alpha from prostaglandins H2 and D2 by an apparently homogeneous enzyme. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936081 |
Liston TE et al. | Prostaglandin D2 is metabolized in humans to 9 alpha,11 beta-prostaglandin F2, a novel biologically active prostaglandin. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936123 |
Kimura H et al. | Modulatory effects of prostaglandin D2, E2 and F2 alpha on the postsynaptic actions of inhibitory and excitatory amino acids in cerebellar Purkinje cell dendrites in vitro. | 1985 | Brain Res. | pmid:2859088 |
Toda N et al. | Neuroeffector actions of prostaglandins on isolated arteries. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936153 |
Ueno R et al. | Prostaglandin D2: a cerebral sleep-regulating substance in rats. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936173 |
Wong P et al. | Diminished sensitivity of platelet aggregation to prostaglandin D2 in patients with myeloproliferative disorders and in patients with acute leukemia. | 1985 | Nippon Ketsueki Gakkai Zasshi | pmid:3890456 |
Cutler LS et al. | Cytochemical localization of adenylate cyclase in the dense tubule system of human blood platelets stimulated by forskolin, prostacyclin and prostaglandin D2. | 1985 | Biochim. Biophys. Acta | pmid:3890960 |
Siegl PK and Wenger HC | Cardiovascular responses to an isosterically modified prostaglandin analog in the anesthetized dog. | 1985 | Eur. J. Pharmacol. | pmid:3899681 |
Regulatory control and standardization of allergenic extracts. Clinical studies with "standardized" extracts. | 1985 | Arb Paul Ehrlich Inst Georg Speyer Haus Ferdinand Blum Inst Frankf A M | pmid:3901924 | |
Kiyomiya K and Oh-ishi S | Involvement of arachidonic acid metabolites in acute inflammation: detection of 6-keto-PGF1 alpha, thromboxane B2 and PGD2 in rat pleurisy induced by phorbol myristate acetate. | 1985 | Jpn. J. Pharmacol. | pmid:3936958 |
Majewska MD and Chuang DM | Benzodiazepines enhance the muscimol-dependent activation of phospholipase A2 in glioma C6 cells. | 1985 | J. Pharmacol. Exp. Ther. | pmid:2857784 |
Baud L et al. | Lipoxygenase products mediate the attachment of rat macrophages to glomeruli in vitro. | 1985 | Kidney Int. | pmid:3927056 |
Westcott JY and Murphy RC | Effect of alcohols on arachidonic acid metabolism in murine mastocytoma cells and human polymorphonuclear leukocytes. | 1985 | Biochim. Biophys. Acta | pmid:2982416 |
Spannhake EW et al. | Influence of mediators of anaphylaxis on collateral ventilation and the lung periphery of the dog. | 1985 | J. Pharmacol. Exp. Ther. | pmid:3860642 |
Liston TE and Roberts LJ | Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3862115 |
Tanaka H et al. | The effects of PGD2 and 9-deoxy-delta 9-PGD2 on colony formation of murine osteosarcoma cells. | 1985 | Prostaglandins | pmid:3863195 |
Liston TE and Roberts LJ | Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer. | 1985 | J. Biol. Chem. | pmid:3863815 |
Roberts LJ and Sweetman BJ | Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosis. | 1985 | Prostaglandins | pmid:3864190 |
Rajtar G et al. | Prostaglandins and human platelet aggregation. Implications for the anti-aggregating activity of thromboxane-synthase inhibitors. | 1985 | Biochem. Pharmacol. | pmid:3918536 |
Mendieta CF et al. | Biosynthesis of prostaglandins in gingiva of patients with chronic periodontitis. | 1985 | J. Periodontol. | pmid:3919173 |
Robinson C and Holgate ST | Mast cell-dependent inflammatory mediators and their putative role in bronchial asthma. | 1985 | Clin. Sci. | pmid:2981650 |
Pugliese G et al. | Hepatic transformation of prostaglandin D2 to a new prostanoid, 9 alpha,11 beta-prostaglandin F2, that inhibits platelet aggregation and constricts blood vessels. | 1985 | J. Biol. Chem. | pmid:3863819 |
Bhattacharya SK and Parmar SS | Prostaglandin D2-induced potentiation of hexobarbitone hypnosis in rats: role of 5-hydroxytryptamine. | 1985 | J. Pharm. Pharmacol. | pmid:2868104 |
Whittle BJ et al. | Specificity between the anti-aggregatory actions of prostacyclin, prostaglandin E1 and D2 on platelets. | 1985 | Adv. Exp. Med. Biol. | pmid:2871707 |
Gay SW and Kosher RA | Prostaglandin synthesis during the course of limb cartilage differentiation in vitro. | 1985 | J Embryol Exp Morphol | pmid:3867724 |
Hollingsworth EB and Patrick GA | Involvement of the serotonergic system in the prolongation of pentobarbital sleeping time produced by prostaglandin D2. | 1985 | Pharmacol. Biochem. Behav. | pmid:2859604 |
Shimatsu A et al. | Prostaglandin D2 stimulates vasoactive intestinal polypeptide release into rat hypophysial portal blood. | 1984 Mar-Apr | Peptides | pmid:6591147 |
Bito LZ | Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds. | 1984 | Exp. Eye Res. | pmid:6370708 |
Peters SP et al. | Arachidonic acid metabolism in purified human lung mast cells. | 1984 | J. Immunol. | pmid:6199420 |
Tynan SS et al. | On the multiplicity of platelet prostaglandin receptors. II. The use of N-0164 for distinguishing the loci of action for PGI2, PGD2, PGE2 and hydantoin analogs. | 1984 | Prostaglandins | pmid:6087417 |
Rao PS et al. | Prostaglandin D2 in canine endotoxic shock. Hemodynamic, hematologic, biochemical, and blood gas analyses. | 1984 | Am. J. Obstet. Gynecol. | pmid:6424477 |
Schick B et al. | Activation of rat serosal mast cells by chymase, an endogenous secretory granule protease. | 1984 | J. Immunol. | pmid:6425408 |
Dembinska-Kieć A et al. | Formation of leukotriene C4-like material by rat brain tissue. | 1984 | Eur. J. Pharmacol. | pmid:6426980 |
Kawamura M and Koshihara Y | Prostaglandin D2 lowers nuclear DNA polymerase activity in cultured mastocytoma cells. | 1984 | Prostaglandins | pmid:6427850 |
Imanishi J et al. | [Inhibition of the multiplication of human herpes virus I by prostaglandin D2 and the synergistic effect of human leukocyte interferon]. | 1984 | C. R. Seances Soc. Biol. Fil. | pmid:6100083 |
Mitsuma T and Nogimori T | Effects of substance P, angiotensin II, oxotremorine and prostaglandin D2 on thyrotropin secretion in rats. | 1984 | Horm. Res. | pmid:6201427 |
Ennis M et al. | Prostaglandin and histamine release from stimulated rat peritoneal mast cells. | 1984 | Agents Actions | pmid:6203356 |
Inoué S et al. | Differential sleep-promoting effects of five sleep substances nocturnally infused in unrestrained rats. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6592612 |
Inoué S et al. | Little sleep-promoting effect of three sleep substances diurnally infused in unrestrained rats. | 1984 | Neurosci. Lett. | pmid:6593603 |
Peters SP et al. | Effect of prostaglandin D2 in modulating histamine release from human basophils. | 1984 | J. Pharmacol. Exp. Ther. | pmid:6198512 |
Marsden KA et al. | The effect of prostaglandin D2 (PGD2) on circulating eosinophils. | 1984 | Prostaglandins Leukot Med | pmid:6593748 |
Uemura S et al. | Inotropic effects of prostaglandin D2 and E1 on the newborn rabbit heart. | 1984 | Pediatr. Res. | pmid:6596550 |
Heavey DJ et al. | Effects of intravenous infusions of prostaglandin D2 in man. | 1984 | Prostaglandins | pmid:6596653 |
Abramovich DR et al. | The effect of prostaglandin D2 on the blood vessels of the perfused isolated cotyledon of the human placenta. | 1984 | Br. J. Pharmacol. | pmid:6584189 |
Kikawa Y et al. | 9-Deoxy-delta 9, delta 12-13,14-dihydroprostaglandin D2, a metabolite of prostaglandin D2 formed in human plasma. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6584883 |
Sakai T et al. | Prostaglandin D2 inhibits the proliferation of human malignant tumor cells. | 1984 | Prostaglandins | pmid:6584941 |
Imashuku S et al. | [Differentiation induction and potentiation of chemotherapy by PGE1 infusion in patients with neuroblastoma--effect of PGE1 on metastatic potential of neuroblastoma]. | 1984 | Gan To Kagaku Ryoho | pmid:6585182 |
Nakajima M and Toda N | Neuroeffector actions of prostaglandin D2 on isolated dog mesenteric arteries. | 1984 | Prostaglandins | pmid:6587438 |
Andersen NH and Hartzell CJ | High-field 1H NMR studies of prostaglandin H2 and its decomposition pathways. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6587849 |