PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Imaizumi T et al. | 15-Deoxy-D12,14-prostaglandin J2 inhibits CX3CL1/fractalkine expression in human endothelial cells. | 2002 | Immunol. Cell Biol. | pmid:12406386 |
| Kim SY et al. | Effects of tanshinone I isolated from Salvia miltiorrhiza bunge on arachidonic acid metabolism and in vivo inflammatory responses. | 2002 | Phytother Res | pmid:12410540 |
| Jawerbaum A et al. | Modulation of nitric oxide concentration and lipid metabolism by 15-deoxy Delta12,14prostaglandin J2 in embryos from control and diabetic rats during early organogenesis. | 2002 | Reproduction | pmid:12417000 |
| Kubata BK et al. | A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi. | 2002 | J. Exp. Med. | pmid:12417633 |
| Shahbazian A et al. | Differential peristaltic motor effects of prostanoid (DP, EP, IP, TP) and leukotriene receptor agonists in the guinea-pig isolated small intestine. | 2002 | Br. J. Pharmacol. | pmid:12429577 |
| Fahmi H et al. | 15d-PGJ(2) is acting as a 'dual agent' on the regulation of COX-2 expression in human osteoarthritic chondrocytes. | 2002 | Osteoarthr. Cartil. | pmid:12435328 |
| Yang X et al. | Hypoxic induction of cox-2 regulates proliferation of human pulmonary artery smooth muscle cells. | 2002 | Am. J. Respir. Cell Mol. Biol. | pmid:12444028 |
| Nikitakis NG et al. | 15-PGJ2, but not thiazolidinediones, inhibits cell growth, induces apoptosis, and causes downregulation of Stat3 in human oral SCCa cells. | 2002 | Br. J. Cancer | pmid:12454768 |
| Badawi AF and Badr MZ | Expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma and levels of prostaglandin E2 and 15-deoxy-delta12,14-prostaglandin J2 in human breast cancer and metastasis. | 2003 | Int. J. Cancer | pmid:12455057 |
| Gueck T et al. | Influence of vitamin E on mast cell mediator release. | 2002 | Vet. Dermatol. | pmid:12464062 |
| Kalla R et al. | Loss of microglial ramification in microglia-astrocyte cocultures: involvement of adenylate cyclase, calcium, phosphatase, and Gi-protein systems. | 2003 | Glia | pmid:12465045 |
| Sawyer N et al. | Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. | 2002 | Br. J. Pharmacol. | pmid:12466225 |
| Satoh T and Watanabe Y | [Cyclopentenone prostaglandin derivatives as neuroprotective compounds]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:12486935 |
| Larsen P et al. | Calcium-stimulated short-circuit currents in the canine proximal colonic epithelium: effects of DK-PGD2, a metabolite of prostaglandin D2. | 2002 | Can. J. Physiol. Pharmacol. | pmid:12489928 |
| Monneret G et al. | 15R-methyl-prostaglandin D2 is a potent and selective CRTH2/DP2 receptor agonist in human eosinophils. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12490611 |
| Satoh T | [Neurotrophin-like low molecular weight compounds]. | 2002 | Nippon Yakurigaku Zasshi | pmid:12491808 |
| Li L et al. | RasGRP4 regulates the expression of prostaglandin D2 in human and rat mast cell lines. | 2003 | J. Biol. Chem. | pmid:12493770 |
| Winnett G et al. | Prostaglandin J2 metabolites inhibit aromatase activity by redox-sensitive mechanisms: potential implications for breast cancer therapy. | 2003 | Int. J. Cancer | pmid:12494466 |
| Nithipatikom K et al. | Requirement of cyclooxygenase-2 expression and prostaglandins for human prostate cancer cell invasion. | 2002 | Clin. Exp. Metastasis | pmid:12498388 |
| Arici M et al. | Stimulation of proximal tubular cell apoptosis by albumin-bound fatty acids mediated by peroxisome proliferator activated receptor-gamma. | 2003 | J. Am. Soc. Nephrol. | pmid:12506134 |
| Weber SM et al. | Inhibition of IFN-gamma -induced STAT1 activation by 15- deoxy-Delta 12,14-prostaglandin J2. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12517740 |
| Pang L et al. | Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors. | 2003 | J. Immunol. | pmid:12517972 |
| Neuschäfer-Rube F et al. | Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor. | 2003 | Biochem. J. | pmid:12519077 |
| Calnek DS et al. | Peroxisome proliferator-activated receptor gamma ligands increase release of nitric oxide from endothelial cells. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12524224 |
| Li LH and Ku BS | [Regulation of SWS by hormones and cytokines]. | 2000 | Sheng Li Ke Xue Jin Zhan | pmid:12532764 |
| Farrow B and Evers BM | Activation of PPARgamma increases PTEN expression in pancreatic cancer cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12535639 |
| Desmond JC et al. | The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs. | 2003 | Cancer Res. | pmid:12543809 |
| Castrillo A et al. | Potentiation of protein kinase C zeta activity by 15-deoxy-delta(12,14)-prostaglandin J(2) induces an imbalance between mitogen-activated protein kinases and NF-kappa B that promotes apoptosis in macrophages. | 2003 | Mol. Cell. Biol. | pmid:12556480 |
| Moore RM et al. | Physiological apoptotic agents have different effects upon human amnion epithelial and mesenchymal cells. | 2003 Feb-Mar | Placenta | pmid:12566244 |
| Tanaka H et al. | Possible involvement of prostaglandins F(2alpha) and D(2) in acetylcholine-induced positive inotropy in isolated mouse left atria. | 2003 | Pharmacology | pmid:12571412 |
| Söderström M et al. | Novel prostaglandin D(2)-derived activators of peroxisome proliferator-activated receptor-gamma are formed in macrophage cell cultures. | 2003 | Biochim. Biophys. Acta | pmid:12573447 |
| Gibbons H et al. | Hypothermia suppresses inducible nitric oxide synthase and stimulates cyclooxygenase-2 in lipopolysaccharide stimulated BV-2 cells. | 2003 | Brain Res. Mol. Brain Res. | pmid:12573534 |
| Park EJ et al. | 15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia. | 2003 | J. Biol. Chem. | pmid:12584205 |
| Patel HJ et al. | Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy. | 2003 | J. Immunol. | pmid:12594295 |
| Ruan XZ et al. | PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway. | 2003 | J. Am. Soc. Nephrol. | pmid:12595494 |
| Cuzzocrea S et al. | The cyclopentenone prostaglandin 15-deoxy-delta(12,14)- PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat. | 2003 | Br. J. Pharmacol. | pmid:12598422 |
| Hinz B et al. | 15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12604364 |
| Jung KM et al. | Activation of p38 mitogen-activated protein kinase and activator protein-1 during the promotion of neurite extension of PC-12 cells by 15-deoxy-delta12,14-prostaglandin J2. | 2003 | Mol. Pharmacol. | pmid:12606768 |
| Hirano A et al. | Arachidonic acid-induced channel- and carrier-type ion transport across planar bilayer lipid membranes. | 2003 | Anal Sci | pmid:12608744 |
| Abe M et al. | GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12615657 |
| Qin C et al. | Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells. | 2003 | Cancer Res. | pmid:12615709 |
| Kanehara H et al. | Thrombomodulin expression by THP-1 but not by vascular endothelial cells is upregulated by pioglitazone. | 2002 | Thromb. Res. | pmid:12617986 |
| Kajekar R et al. | Role of cyclooxygenase activation and prostaglandins in antigen-induced excitability changes of bronchial parasympathetic ganglia neurons. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12618420 |
| Wanichkul T et al. | Cytokine regulation by peroxisome proliferator-activated receptor gamma in human endometrial cells. | 2003 | Fertil. Steril. | pmid:12620489 |
| Taba Y et al. | 15-deoxy-delta 12,14-prostaglandin J2 and laminar fluid shear stress stabilize c-IAP1 in vascular endothelial cells. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12623786 |
| Hashimoto K et al. | Peroxisome proliferator-activated receptor gamma ligand inhibits cell growth and invasion of human pancreatic cancer cells. | 2002 | Int J Gastrointest Cancer | pmid:12630765 |
| Tzanakakis GN et al. | The preventive effect of ketoconazole on experimental metastasis from a human pancreatic carcinoma may be related to its effect on prostaglandin synthesis. | 2002 | Int J Gastrointest Cancer | pmid:12630766 |
| Lee CH and Edwards AM | Differential expression of c-fos and c-myc protooncogenes by estrogens, xenobiotics and other growth-stimulatory agents in primary rat hepatocytes. | 2003 | Arch. Toxicol. | pmid:12632255 |
| Lee TS et al. | Induction of heme oxygenase-1 expression in murine macrophages is essential for the anti-inflammatory effect of low dose 15-deoxy-Delta 12,14-prostaglandin J2. | 2003 | J. Biol. Chem. | pmid:12642589 |
| Houston KD et al. | Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma. | 2003 | Cancer Res. | pmid:12649180 |