Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Bettazzoli L et al. | Incorporation of arachidonic acid into glycerophospholipids of a murine bone marrow derived mast cell. | 1990 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2169185 |
Sladek K et al. | Formation of PGD2 after allergen inhalation in atopic asthmatics. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1847781 |
Koshihara Y et al. | Prostaglandin D2 stimulates calcification by human osteoblastic cells. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825424 |
Wolfe LS et al. | Synthesis and functions of cyclooxygenase and lipoxygenase products in brain: new findings and an appraisal. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2568735 |
Thierauch KH et al. | Stable 9 beta- or 11 alpha-halogen-15-cyclohexyl-prostaglandins with high affinity to the PGD2-receptor. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526554 |
Frölich JC et al. | Advances in the analysis of eicosanoids by ELISA and GC/MS/MS. | 1986 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2949561 |
Seibert K et al. | 9 alpha, 11 beta-prostaglandin F2: formation and metabolism by human lung and contractile effects on human bronchial smooth muscle. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959045 |
Roberts LJ et al. | PGD2 is transformed by human coronary arteries to 9 alpha, 11 beta-PGF2, which contracts human coronary artery rings. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959090 |
Watanabe K et al. | Stereospecific conversion of prostaglandin D2 to 9 alpha, 11 beta-prostaglandin F2 and prostaglandin H2 to prostaglandin F2 alpha by PGF synthetase. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959094 |
Wendelborn DF et al. | Isomeric prostaglandin F2 compounds: a new family of eicosanoids produced in vivo in humans. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959099 |
Pugliese G et al. | 9 alpha, 11 beta-prostaglandin F2: a new prostanoid with selective biosynthesis and unique biological activity. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959104 |
Robinson C et al. | Effects of inhaled 9 alpha, 11 beta-prostaglandin F2 on airway function in man. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960146 |
Roberts LJ | Recent metabolic findings bring into question the reliability of existing methods for quantification of PGF2 alpha and its metabolites in human biological fluids. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960165 |
Watanabe K et al. | Biosynthesis of prostaglandin F2 alpha from prostaglandins H2 and D2 by an apparently homogeneous enzyme. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936081 |
Liston TE et al. | Prostaglandin D2 is metabolized in humans to 9 alpha,11 beta-prostaglandin F2, a novel biologically active prostaglandin. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936123 |
Toda N et al. | Neuroeffector actions of prostaglandins on isolated arteries. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936153 |
Ueno R et al. | Prostaglandin D2: a cerebral sleep-regulating substance in rats. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936173 |
Ichikawa A et al. | Up-regulation of prostaglandin D2 receptors by agonist binding to beta-adrenoceptors in rabbit platelets. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3004152 |
Omini C et al. | Prostaglandin D2 and the cholinergic system in guinea pig airways. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2823557 |
Viganò T et al. | Adenosine and eicosanoid release from immunologically challenged human lung fragments. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2823581 |