Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Menon R et al. | Amniotic fluid eicosanoids in preterm and term births: effects of risk factors for spontaneous preterm labor. | 2011 | Obstet Gynecol | pmid:21691170 |
Chowdhury AA et al. | 15-Deoxy-Δ(12,14)-prostaglandin J(2) interferes inducible synthesis of prostaglandins E(2) and F(2α) that suppress subsequent adipogenesis program in cultured preadipocytes. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21699992 |
Farhat A et al. | Hematopoietic-Prostaglandin D2 synthase through PGD2 production is involved in the adult ovarian physiology. | 2011 | J Ovarian Res | pmid:21352547 |
Luker T et al. | Zwitterionic CRTh2 antagonists. | 2011 | J. Med. Chem. | pmid:21355602 |
Bräutigam K et al. | Combined treatment with TRAIL and PPARγ ligands overcomes chemoresistance of ovarian cancer cell lines. | 2011 | J. Cancer Res. Clin. Oncol. | pmid:20878528 |
Alves C et al. | Effects of 15d-PGJâ‚‚-loaded poly(D,L-lactide-co-glycolide) nanocapsules on inflammation. | 2011 | Br. J. Pharmacol. | pmid:20883476 |
Crosignani S et al. | Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases. | 2011 | J. Med. Chem. | pmid:21916510 |
Moniot B et al. | Hematopoietic prostaglandin D synthase (H-Pgds) is expressed in the early embryonic gonad and participates to the initial nuclear translocation of the SOX9 protein. | 2011 | Dev. Dyn. | pmid:21887724 |
Kanai Y et al. | Identification of novel oxidized levuglandin D2 in marine red alga and mouse tissue. | 2011 | J. Lipid Res. | pmid:21893678 |
Wang P et al. | Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1. | 2011 | FASEB J. | pmid:21715681 |
Ahmed SR et al. | Prostaglandin D2 regulates CD4+ memory T cell trafficking across blood vascular endothelium and primes these cells for clearance across lymphatic endothelium. | 2011 | J. Immunol. | pmid:21715691 |
Galvão Nascimento N et al. | Contribution of mast cells to the oedema induced by Bothrops moojeni snake venom and a pharmacological assessment of the inflammatory mediators involved. | 2010 Feb-Mar | Toxicon | pmid:19703484 |
Dionne S et al. | PPARgamma ligand 15-deoxy-delta 12,14-prostaglandin J2 sensitizes human colon carcinoma cells to TWEAK-induced apoptosis. | 2010 | Anticancer Res. | pmid:20150631 |
Zhu F et al. | Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases. | 2010 | Cell Death Differ. | pmid:20150912 |
Orlichenko LS et al. | Transcriptional regulation of CXC-ELR chemokines KC and MIP-2 in mouse pancreatic acini. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20671197 |
Fujitani Y et al. | Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo. | 2010 | FEBS J. | pmid:20136655 |
Syed MA et al. | Expression of TREM-1 is inhibited by PGD2 and PGJ2 in macrophages. | 2010 | Exp. Cell Res. | pmid:20797396 |
Lou HQ et al. | [CRTH2 antagonist ameliorates airway inflammation in rats with asthma]. | 2010 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:20175238 |
He R et al. | The prostaglandin Dâ‚‚ receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge. | 2010 | J. Allergy Clin. Immunol. | pmid:20713302 |
Schell C et al. | 15-Deoxy-delta 12-14-prostaglandin-J2 induces hypertrophy and loss of contractility in human testicular peritubular cells: implications for human male fertility. | 2010 | Endocrinology | pmid:20133451 |
Poncin S et al. | Oxidative stress: a required condition for thyroid cell proliferation. | 2010 | Am. J. Pathol. | pmid:20093493 |
Wang Y et al. | Role of cyclooxygenase-2 signaling pathway dysfunction in unexplained recurrent spontaneous abortion. | 2010 | Chin. Med. J. | pmid:20819509 |
Xiao Y et al. | 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-gamma-dependent and mediated by the caspase-3-dependent apoptotic pathway. | 2010 | FEBS J. | pmid:20050918 |
van den Brule S et al. | The D prostanoid receptor agonist BW245C [(4S)-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidineheptanoic acid] inhibits fibroblast proliferation and bleomycin-induced lung fibrosis in mice. | 2010 | J. Pharmacol. Exp. Ther. | pmid:20719937 |
Watanabe K et al. | 15-deoxy-delta 12,14-prostaglandin J2 prevents inflammatory response and endothelial cell damage in rats with acute obstructive cholangitis. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20056897 |
Kar R et al. | Mitochondrial remodeling following fission inhibition by 15d-PGJ2 involves molecular changes in mitochondrial fusion protein OPA1. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20678484 |
Satoh T et al. | Indomethacin-induced reduction in CRTH2 in eosinophilic pustular folliculitis (Ofuji's disease): a proposed mechanism of action. | 2010 | Acta Derm. Venereol. | pmid:20107720 |
Akin C et al. | Mast cell activation syndrome: Proposed diagnostic criteria. | 2010 | J. Allergy Clin. Immunol. | pmid:21035176 |
Veliça P et al. | Prostaglandin D2 inhibits C2C12 myogenesis. | 2010 | Mol. Cell. Endocrinol. | pmid:20109525 |
Gallant MA et al. | Increased concentrations of prostaglandin D2 during post-fracture bone remodeling. | 2010 | J. Rheumatol. | pmid:20080921 |
Zhang HX et al. | Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-Delta(12,14)-prostaglandin J(2). | 2010 | Exp. Neurol. | pmid:20083106 |
Li H et al. | Serum amyloid A activates peroxisome proliferator-activated receptor γ through extracellularly regulated kinase 1/2 and COX-2 expression in hepatocytes. | 2010 | Biochemistry | pmid:20853849 |
Pacienza N et al. | 15-deoxy-Delta(12,14)-PGJ(2) induces cell cycle arrest and apoptosis of haematopoietic progenitors. | 2010 | Br. J. Haematol. | pmid:19764987 |
Oh YC et al. | Anti-allergic activity of a platycodon root ethanol extract. | 2010 | Int J Mol Sci | pmid:20717534 |
Lee CM et al. | Prostaglandin expression profile in hypoxic osteoblastic cells. | 2010 | J. Bone Miner. Metab. | pmid:19471853 |
Kim SH et al. | Toluene diisocyanate (TDI) regulates haem oxygenase-1/ferritin expression: implications for toluene diisocyanate-induced asthma. | 2010 | Clin. Exp. Immunol. | pmid:20345975 |
Zimmer M et al. | The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. | 2010 | Cancer Res. | pmid:20354189 |
Koyama M et al. | Histone deacetylase inhibitors and 15-deoxy-Delta12,14-prostaglandin J2 synergistically induce apoptosis. | 2010 | Clin. Cancer Res. | pmid:20371690 |
Kim DH et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) stabilizes, but functionally inactivates p53 by binding to the cysteine 277 residue. | 2010 | Oncogene | pmid:20208557 |
Cho HY et al. | Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice. | 2010 | Am. J. Respir. Crit. Care Med. | pmid:20224069 |
Krall CM et al. | Food deprivation alters thermoregulatory responses to lipopolysaccharide by enhancing cryogenic inflammatory signaling via prostaglandin D2. | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20393159 |
Hovsepian E et al. | 15-deoxy-Delta12,14 prostaglandin GJ2 but not rosiglitazone regulates metalloproteinase 9, NOS-2, and cyclooxygenase 2 expression and functions by peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms in cardiac cells. | 2010 | Shock | pmid:19997048 |
Théoleyre S et al. | HtrA3 is regulated by 15-deoxy-Delta12,14-prostaglandin J2 independently of PPARgamma in clear cell renal cell carcinomas. | 2010 | Biochem. Biophys. Res. Commun. | pmid:19951697 |
Shim J et al. | The peroxisome proliferator-activated receptor gamma ligands, pioglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2), have antineoplastic effects against hepatitis B virus-associated hepatocellular carcinoma cells. | 2010 | Int. J. Oncol. | pmid:19956851 |
Bach-Ngohou K et al. | Enteric glia modulate epithelial cell proliferation and differentiation through 15-deoxy-12,14-prostaglandin J2. | 2010 | J. Physiol. (Lond.) | pmid:20478974 |
Masoodi M et al. | Prostaglandin D production in FM55 melanoma cells is regulated by alpha-melanocyte-stimulating hormone and is not related to melanin production. | 2010 | Exp. Dermatol. | pmid:20482620 |
Hilliard M et al. | The anti-inflammatory prostaglandin 15-deoxy-delta(12,14)-PGJ2 inhibits CRM1-dependent nuclear protein export. | 2010 | J. Biol. Chem. | pmid:20457605 |
Yokoyama Y et al. | 15-Deoxy-Delta12,14-prostaglandin J2 inhibits angiotensin II-induced fibronectin expression via hepatocyte growth factor induction in human peritoneal mesothelial cells. | 2010 | Ther Apher Dial | pmid:20438519 |
Romanovsky AA and Garami A | Prostaglandin riddles in energy metabolism: E is for excess, D is for depletion. Focus on "Food deprivation alters thermoregulatory responses to lipopolysaccharide by enhancing cryogenic inflammatory signaling via prostaglandin D2". | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20410482 |
Shiraya K et al. | A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules. | 2010 | J. Biol. Chem. | pmid:20448048 |