PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Norman P | DP(2) receptor antagonists in development. | 2010 | Expert Opin Investig Drugs | pmid:20615077 |
| Pedersen PJ et al. | Prostaglandin phospholipid conjugates with unusual biophysical and cytotoxic properties. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20591667 |
| Bai YJ et al. | A LC-MS-based method for quantification of biomarkers from serum of allergic rats. | 2010 | Molecules | pmid:20657485 |
| Reddy RC and Standiford TJ | Nrf2 and PPAR{gamma}: PPARtnering against oxidant-induced lung injury. | 2010 | Am. J. Respir. Crit. Care Med. | pmid:20634499 |
| Ahmad AS et al. | Prostaglandin D2 DP1 receptor is beneficial in ischemic stroke and in acute exicitotoxicity in young and old mice. | 2010 | Age (Dordr) | pmid:20640551 |
| Shah S et al. | Efficacy and safety of extended-release niacin/laropiprant plus statin vs. doubling the dose of statin in patients with primary hypercholesterolaemia or mixed dyslipidaemia. | 2010 | Int. J. Clin. Pract. | pmid:20518948 |
| Genovese A et al. | Human cardiac mast cells in anaphylaxis. | 2010 | Chem Immunol Allergy | pmid:20519884 |
| Diers AR et al. | Modulation of mammary cancer cell migration by 15-deoxy-delta(12,14)-prostaglandin J(2): implications for anti-metastatic therapy. | 2010 | Biochem. J. | pmid:20536428 |
| Vong L et al. | A pro-resolution mediator, prostaglandin D(2), is specifically up-regulated in individuals in long-term remission from ulcerative colitis. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20547854 |
| Lehmann GM et al. | Novel anti-adipogenic activity produced by human fibroblasts. | 2010 | Am. J. Physiol., Cell Physiol. | pmid:20554910 |
| Schuligoi R et al. | CRTH2 and D-type prostanoid receptor antagonists as novel therapeutic agents for inflammatory diseases. | 2010 | Pharmacology | pmid:20559016 |
| Kaur S et al. | Induction of prostaglandin D2 through the p38 MAPK pathway is responsible for the antipruritic activity of sertaconazole nitrate. | 2010 | J. Invest. Dermatol. | pmid:20505747 |
| Rodrigues WF et al. | 15d-PGJ(2) modulates acute immune responses to Trypanosoma cruzi infection. | 2010 | Mem. Inst. Oswaldo Cruz | pmid:20428671 |
| Blancou P and Anegon I | Editorial: Heme oxygenase-1 and dendritic cells: what else? | 2010 | J. Leukoc. Biol. | pmid:20123679 |
| Nørregaard R et al. | Urinary tract obstruction induces transient accumulation of COX-2-derived prostanoids in kidney tissue. | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20147610 |
| Dionne S et al. | PPARgamma ligand 15-deoxy-delta 12,14-prostaglandin J2 sensitizes human colon carcinoma cells to TWEAK-induced apoptosis. | 2010 | Anticancer Res. | pmid:20150631 |
| Zhu F et al. | Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases. | 2010 | Cell Death Differ. | pmid:20150912 |
| Orlichenko LS et al. | Transcriptional regulation of CXC-ELR chemokines KC and MIP-2 in mouse pancreatic acini. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20671197 |
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| Syed MA et al. | Expression of TREM-1 is inhibited by PGD2 and PGJ2 in macrophages. | 2010 | Exp. Cell Res. | pmid:20797396 |
| Byrns MC et al. | Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:20036328 |
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| Subra C et al. | Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins. | 2010 | J. Lipid Res. | pmid:20424270 |
| Hatanaka M et al. | 15d-prostaglandin J2 enhancement of nerve growth factor-induced neurite outgrowth is blocked by the chemoattractant receptor- homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist CAY10471 in PC12 cells. | 2010 | J. Pharmacol. Sci. | pmid:20424389 |
| Zhang F et al. | Peroxisome proliferator-activated receptor-gamma agonists suppress iNOS expression induced by LPS in rat primary Schwann cells. | 2010 | J. Neuroimmunol. | pmid:19942298 |
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| Hanks BC et al. | Evaluation of anti-inflammatory and chondroprotective effects of peroxisome proliferator-activated receptor gamma agonists in cartilage and synovial explants from dogs. | 2010 | Am. J. Vet. Res. | pmid:20919899 |
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| Li H et al. | Serum amyloid A activates peroxisome proliferator-activated receptor γ through extracellularly regulated kinase 1/2 and COX-2 expression in hepatocytes. | 2010 | Biochemistry | pmid:20853849 |
| Pacienza N et al. | 15-deoxy-Delta(12,14)-PGJ(2) induces cell cycle arrest and apoptosis of haematopoietic progenitors. | 2010 | Br. J. Haematol. | pmid:19764987 |
| Lee CM et al. | Prostaglandin expression profile in hypoxic osteoblastic cells. | 2010 | J. Bone Miner. Metab. | pmid:19471853 |
| Cerrato S et al. | Effects of palmitoylethanolamide on immunologically induced histamine, PGD2 and TNFalpha release from canine skin mast cells. | 2010 | Vet. Immunol. Immunopathol. | pmid:19625089 |
| Pérez-Novo CA et al. | CRTH2 mediates the activation of human Th2 cells in response to PGD(2) released from IgE/anti-IgE treated nasal polyp tissue. | 2010 | Allergy | pmid:19839971 |
| Mo C et al. | PPARgamma regulates LIF-induced growth and self-renewal of mouse ES cells through Tyk2-Stat3 pathway. | 2010 | Cell. Signal. | pmid:19922793 |
| Kanda N et al. | Prostaglandin D2 induces the production of human beta-defensin-3 in human keratinocytes. | 2010 | Biochem. Pharmacol. | pmid:19925780 |
| Biburger M et al. | Pivotal Advance: Heme oxygenase 1 expression by human CD4+ T cells is not sufficient for their development of immunoregulatory capacity. | 2010 | J. Leukoc. Biol. | pmid:19797297 |
| Toaldo C et al. | PPARgamma ligands inhibit telomerase activity and hTERT expression through modulation of the Myc/Mad/Max network in colon cancer cells. | 2010 | J. Cell. Mol. Med. | pmid:19912441 |
| Diers AR et al. | Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanisms. | 2010 | Biochem. J. | pmid:19916962 |
| Morgenweck J et al. | Activation of peroxisome proliferator-activated receptor gamma in brain inhibits inflammatory pain, dorsal horn expression of Fos, and local edema. | 2010 | Neuropharmacology | pmid:19891980 |
| Liu JY et al. | Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model. | 2010 | Biochem. Pharmacol. | pmid:19896470 |
| Shimura C et al. | Dendritic cells express hematopoietic prostaglandin D synthase and function as a source of prostaglandin D2 in the skin. | 2010 | Am. J. Pathol. | pmid:20008150 |
| Yamaguchi S et al. | Delta12-prostaglandin J2 as a product and ligand of human serum albumin: formation of an unusual covalent adduct at His146. | 2010 | J. Am. Chem. Soc. | pmid:20014793 |
| Lin TH et al. | Upregulation of heme oxygenase-1 inhibits the maturation and mineralization of osteoblasts. | 2010 | J. Cell. Physiol. | pmid:20020468 |
| Hovsepian E et al. | 15-deoxy-Delta12,14 prostaglandin GJ2 but not rosiglitazone regulates metalloproteinase 9, NOS-2, and cyclooxygenase 2 expression and functions by peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms in cardiac cells. | 2010 | Shock | pmid:19997048 |
| Théoleyre S et al. | HtrA3 is regulated by 15-deoxy-Delta12,14-prostaglandin J2 independently of PPARgamma in clear cell renal cell carcinomas. | 2010 | Biochem. Biophys. Res. Commun. | pmid:19951697 |
| Shim J et al. | The peroxisome proliferator-activated receptor gamma ligands, pioglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2), have antineoplastic effects against hepatitis B virus-associated hepatocellular carcinoma cells. | 2010 | Int. J. Oncol. | pmid:19956851 |
| Kolaczkowska E et al. | Resident peritoneal macrophages and mast cells are important cellular sites of COX-1 and COX-2 activity during acute peritoneal inflammation. | 2009 Nov-Dec | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:19885646 |
| Moreira V et al. | Effects of Bothrops asper snake venom on the expression of cyclooxygenases and production of prostaglandins by peritoneal leukocytes in vivo, and by isolated neutrophils and macrophages in vitro. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19155166 |
| Hayden RE et al. | Treatment of primary CLL cells with bezafibrate and medroxyprogesterone acetate induces apoptosis and represses the pro-proliferative signal of CD40-ligand, in part through increased 15dDelta12,14,PGJ2. | 2009 | Leukemia | pmid:18923439 |
| Kase K et al. | Inhibitory action of roxithromycin on histamine release and prostaglandin D2 production from beta-defensin 2-stimulated mast cells. | 2009 | Int. J. Mol. Med. | pmid:19212651 |
| Ricart KC et al. | The permissive role of mitochondria in the induction of haem oxygenase-1 in endothelial cells. | 2009 | Biochem. J. | pmid:19161347 |
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| O'Brien JJ et al. | 15-deoxy-Delta12,14 prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis. | 2009 | J. Thromb. Haemost. | pmid:18983509 |
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| Mohri I et al. | Inhibition of prostaglandin D synthase suppresses muscular necrosis. | 2009 | Am. J. Pathol. | pmid:19359520 |
| Moriai M et al. | Down-regulation of hTERT expression plays an important role in 15-deoxy-Delta12,14-prostaglandin J2-induced apoptosis in cancer cells. | 2009 | Int. J. Oncol. | pmid:19360348 |
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| Boehme SA et al. | A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation. | 2009 | Int. Immunol. | pmid:19066314 |
| Boehme SA et al. | Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanisms. | 2009 | Int. Immunol. | pmid:19066315 |
| Ding Q et al. | Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes. | 2009 | Endocrinology | pmid:19074584 |
| Schröder R et al. | The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation. | 2009 | J. Biol. Chem. | pmid:19010788 |
| Eichele K et al. | R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway. | 2009 | Pharm. Res. | pmid:19015962 |
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| Johansson S et al. | CC16 inhibits the migration of eosinophils towards the formyl peptide fMLF but not towards PGD2. | 2009 | Inflammation | pmid:19132521 |
| Kim DH et al. | 15-Deoxy-Delta12,14-prostaglandin J2 upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: possible roles of iron and ROS. | 2009 | Carcinogenesis | pmid:19136476 |
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| Shichijo M et al. | A prostaglandin D2 receptor antagonist modifies experimental asthma in sheep. | 2009 | Clin. Exp. Allergy | pmid:19486034 |
| Wang X et al. | Potential effects of peroxisome proliferator-activated receptor activator on LPS-induced lung injury in rats. | 2009 | Pulm Pharmacol Ther | pmid:19489131 |
| Tokudome S et al. | Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis. | 2009 | J. Clin. Invest. | pmid:19451694 |
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| Brechbuhl HM et al. | Select cyclopentenone prostaglandins trigger glutathione efflux and the role of ABCG2 transport. | 2009 | Free Radic. Biol. Med. | pmid:19520157 |
| Ramji DP | Growth hormone-releasing peptides, CD36, and stimulation of cholesterol efflux: cyclooxygenase-2 is the link. | 2009 | Cardiovasc. Res. | pmid:19520704 |
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| Yamamura K et al. | Intracellular protein phosphorylation in eosinophils and the functional relevance in cytokine production. | 2009 | Int. Arch. Allergy Immunol. | pmid:19494504 |
| Chiba T et al. | 15-Deoxy-Delta(12,14)-prostaglandin J2 induces IL-8 and GM-CSF in a human airway epithelial cell line (NCI-H292). | 2009 | Int. Arch. Allergy Immunol. | pmid:19494510 |
| Niki E | Lipid peroxidation: physiological levels and dual biological effects. | 2009 | Free Radic. Biol. Med. | pmid:19500666 |
| Suk FM et al. | 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibits fibrogenic response in human hepatoma cells. | 2009 | Toxicol. Lett. | pmid:19429239 |
| Kansanen E et al. | Regulation of Nrf2-dependent gene expression by 15-deoxy-Delta12,14-prostaglandin J2. | 2009 | Free Radic. Biol. Med. | pmid:19573595 |
| Cocca C et al. | 15-Deoxi-Delta(12,14)-prostaglandin J2 is a tubulin-binding agent that destabilizes microtubules and induces mitotic arrest. | 2009 | Biochem. Pharmacol. | pmid:19576185 |
| Thura M et al. | GIF-0173 protects against cerebral infarction through DP1 receptor activation. | 2009 | Exp. Neurol. | pmid:19576888 |
| Bernardo A et al. | Peroxisome proliferator-activated receptor-gamma agonists promote differentiation and antioxidant defenses of oligodendrocyte progenitor cells. | 2009 | J. Neuropathol. Exp. Neurol. | pmid:19535992 |
| Bujold K et al. | CD36-mediated cholesterol efflux is associated with PPARgamma activation via a MAPK-dependent COX-2 pathway in macrophages. | 2009 | Cardiovasc. Res. | pmid:19377069 |
| Mrabet-Dahbi S et al. | Murine mast cells secrete a unique profile of cytokines and prostaglandins in response to distinct TLR2 ligands. | 2009 | Exp. Dermatol. | pmid:19382314 |
| Li H and Pauza CD | Effects of 15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) and rosiglitazone on human gammadelta2 T cells. | 2009 | PLoS ONE | pmid:19888466 |
| Landrier JF et al. | Adiponectin expression is induced by vitamin E via a peroxisome proliferator-activated receptor gamma-dependent mechanism. | 2009 | Endocrinology | pmid:19833717 |
| Lauring B et al. | Laropiprant in combination with extended-release niacin does not alter urine 11-dehydrothromboxane B2, a marker of in vivo platelet function, in healthy, hypercholesterolemic, and diabetic subjects. | 2009 | J Clin Pharmacol | pmid:19833861 |
| Hironaka A et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) impairs the functions of histone acetyltransferases through their insolubilization in cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19799872 |
| Pustovrh MC et al. | MMP/ TIMP balance is modulated in vitro by 15dPGJ(2) in fetuses and placentas from diabetic rats. | 2009 | Eur. J. Clin. Invest. | pmid:19811527 |
| Piprek RP | Genetic mechanisms underlying male sex determination in mammals. | 2009 | J. Appl. Genet. | pmid:19875885 |