Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kawano S et al. | Protective effect of PGD2 against ethanol-induced gastric mucosal injury in rats. | 1990 | J. Clin. Gastroenterol. | pmid:2212542 |
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El-Shazly AE et al. | IFN-γ and TNF-α potentiate prostaglandin D2-induced human eosinophil chemotaxis through up-regulation of CRTH2 surface receptor. | 2011 | Int. Immunopharmacol. | pmid:21835268 |
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Nakahata N et al. | PGJ2 and delta 12PGJ2 inhibit cell growth accompanied with inhibition of phosphoinositide turnover in human astrocytoma cells. | 1990 | Prostaglandins | pmid:2177901 |
Hernandez JM and Janssen LJ | Thromboxane prostanoid receptor activation amplifies airway stretch-activated contractions assessed in perfused intact bovine bronchial segments. | 2011 | J. Pharmacol. Exp. Ther. | pmid:21768224 |
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Higuchi S et al. | Involvement of Th2 cytokines in the mouse model of flutamide-induced acute liver injury. | 2012 | J Appl Toxicol | pmid:21735453 |
Eriksson LO et al. | Prostaglandin E2 binding sites in human renal tissue: characterization and localization by radioligand binding and autoradiography. | 1990 | Acta Physiol. Scand. | pmid:2173350 |
Song NY et al. | Multidrug resistance-associated protein 1 mediates 15-deoxy-Δ(12,14)-prostaglandin J2-induced expression of glutamate cysteine ligase expression via Nrf2 signaling in human breast cancer cells. | 2011 | Chem. Res. Toxicol. | pmid:21728338 |
Chowdhury AA et al. | Sustained expression of lipocalin-type prostaglandin D synthase in the antisense direction positively regulates adipogenesis in cloned cultured preadipocytes. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21726533 |
Koyama J et al. | Simultaneous determination of histamine and prostaglandin D2 using an LC-ESI-MS/MS method with positive/negative ion-switching ionization modes: application to the study of anti-allergic flavonoids on the degranulation of KU812 cells. | 2011 | Anal Bioanal Chem | pmid:21725829 |
Cichocka-Jarosz E et al. | Serum tryptase level is a better predictor of systemic side effects than prostaglandin D2 metabolites during venom immunotherapy in children. | 2011 | J Investig Allergol Clin Immunol | pmid:21721371 |
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Farhat A et al. | Hematopoietic-Prostaglandin D2 synthase through PGD2 production is involved in the adult ovarian physiology. | 2011 | J Ovarian Res | pmid:21352547 |