PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Khan E and Abu-Amer Y | Activation of peroxisome proliferator-activated receptor-gamma inhibits differentiation of preosteoblasts. | 2003 | J. Lab. Clin. Med. | pmid:12878983 |
| Yuan ZY et al. | [Peroxisome proliferation-activated receptor-gamma ligands ameliorate autoimmune myocarditis associated with inhibition of T cell immunity]. | 2003 | Zhonghua Yi Xue Za Zhi | pmid:14703419 |
| Ceaser EK et al. | Oxidized low-density lipoprotein and 15-deoxy-delta 12,14-PGJ2 increase mitochondrial complex I activity in endothelial cells. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12881207 |
| Zanoni G et al. | First enantioselective total synthesis of (8S,12R,15S)-prostaglandin J(2). | 2003 | J. Org. Chem. | pmid:12895084 |
| Genovese A et al. | Protein Fv produced during viral hepatitis is an endogenous immunoglobulin superantigen activating human heart mast cells. | 2003 | Int. Arch. Allergy Immunol. | pmid:14707465 |
| Bishop-Bailey D and Warner TD | PPARgamma ligands induce prostaglandin production in vascular smooth muscle cells: indomethacin acts as a peroxisome proliferator-activated receptor-gamma antagonist. | 2003 | FASEB J. | pmid:12897060 |
| Souza SC et al. | TNF-alpha induction of lipolysis is mediated through activation of the extracellular signal related kinase pathway in 3T3-L1 adipocytes. | 2003 | J. Cell. Biochem. | pmid:12898507 |
| Zhuang H et al. | Prostaglandins of J series control heme oxygenase expression: potential significance in modulating neuroinflammation. | 2003 | Ann. N. Y. Acad. Sci. | pmid:12853315 |
| Pestel S et al. | Inhibition of prostaglandin D2 clearance in rat hepatocytes by the thromboxane receptor antagonists daltroban and ifetroban and the thromboxane synthase inhibitor furegrelate. | 2003 | Biochem. Pharmacol. | pmid:12906929 |
| Pritts EA et al. | Peroxisome proliferator-activated receptor-gamma ligand inhibition of RANTES production by human endometriotic stromal cells is mediated through an upstream promoter element. | 2003 | Fertil. Steril. | pmid:12909507 |
| Zanoni G et al. | A --> J prostaglandin swap: a new tactic for cyclopentenone prostaglandin synthesis. | 2003 | J. Org. Chem. | pmid:12919053 |
| Nencioni A et al. | Cyclopentenone prostaglandins induce lymphocyte apoptosis by activating the mitochondrial apoptosis pathway independent of external death receptor signaling. | 2003 | J. Immunol. | pmid:14607914 |
| Zhang M et al. | [Apoptosis of human lung cancer cells induced by activated peroxisome proliferator-activated receptor-gamma and its mechanism]. | 2003 | Zhonghua Yi Xue Za Zhi | pmid:12921638 |
| Honda K et al. | Prostaglandin D2 reinforces Th2 type inflammatory responses of airways to low-dose antigen through bronchial expression of macrophage-derived chemokine. | 2003 | J. Exp. Med. | pmid:12925672 |
| Adachi H et al. | Molecular characterization of human and rat organic anion transporter OATP-D. | 2003 | Am. J. Physiol. Renal Physiol. | pmid:14631946 |
| Mueller C et al. | Peroxisome proliferator-activated receptor gamma ligands attenuate immunological symptoms of experimental allergic asthma. | 2003 | Arch. Biochem. Biophys. | pmid:14522590 |
| Hu VY et al. | COX-2 and prostanoid expression in micturition pathways after cyclophosphamide-induced cystitis in the rat. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12388444 |
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| Hashimoto K et al. | The PPARgamma ligand, 15d-PGJ2, attenuates the severity of cerulein-induced acute pancreatitis. | 2003 | Pancreas | pmid:12826907 |
| Montuschi P et al. | Exhaled leukotrienes and prostaglandins in COPD. | 2003 | Thorax | pmid:12832671 |
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| Taba Y et al. | 15-deoxy-delta 12,14-prostaglandin J2 and laminar fluid shear stress stabilize c-IAP1 in vascular endothelial cells. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12623786 |
| Fukuchi K et al. | Apoptosis in human oral squamous cell carcinomas is induced by 15-deoxy-delta 12,14-prostaglandin J2 but not by troglitazone. | 2003 | J. Dent. Res. | pmid:14514760 |
| Józkowicz A et al. | Prostaglandin-J(2) upregulates expression of matrix metalloproteinase-1 independently of activation of peroxisome proliferator-activated receptor-gamma. | 2003 | Acta Biochim. Pol. | pmid:14515149 |
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| Lee CH and Edwards AM | Differential expression of c-fos and c-myc protooncogenes by estrogens, xenobiotics and other growth-stimulatory agents in primary rat hepatocytes. | 2003 | Arch. Toxicol. | pmid:12632255 |
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| Jelson GS et al. | Modulation of guinea pig intrinsic cardiac neurons by prostaglandins. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12791585 |
| Okano H et al. | The PPARgamma ligand, 15-Deoxy-Delta12,14-PGJ2, regulates apoptosis-related protein expression in cholangio cell carcinoma cells. | 2003 | Int. J. Mol. Med. | pmid:14612959 |
| Rehan V and Torday J | Hyperoxia augments pulmonary lipofibroblast-to-myofibroblast transdifferentiation. | 2003 | Cell Biochem. Biophys. | pmid:12794266 |
| Aoun P et al. | Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells. | 2003 | Invest. Ophthalmol. Vis. Sci. | pmid:12824244 |
| Ajmone-Cat MA et al. | Prolonged exposure of microglia to lipopolysaccharide modifies the intracellular signaling pathways and selectively promotes prostaglandin E2 synthesis. | 2003 | J. Neurochem. | pmid:14622099 |
| Sugimoto H et al. | An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12649388 |
| Chung SW et al. | Inhibition of interleukin-4 production in CD4+ T cells by peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands: involvement of physical association between PPAR-gamma and the nuclear factor of activated T cells transcription factor. | 2003 | Mol. Pharmacol. | pmid:14573767 |
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| Saito S et al. | 15-Deoxy-Delta(12,14)-prostaglandin J2 induces apoptosis through activation of the CHOP gene in HeLa cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14575689 |
| Smith SA et al. | Effects of peroxisome proliferator-activated receptor gamma ligands ciglitazone and 15-deoxy-delta 12,14-prostaglandin J2 on rat cultured cerebellar granule neuronal viability. | 2003 | J. Neurosci. Res. | pmid:12774315 |
| Zamuner SR et al. | Cyclooxygenase 2 mediates post-inflammatory colonic secretory and barrier dysfunction. | 2003 | Gut | pmid:14633948 |
| Armoni M et al. | Peroxisome proliferator-activated receptor-gamma represses GLUT4 promoter activity in primary adipocytes, and rosiglitazone alleviates this effect. | 2003 | J. Biol. Chem. | pmid:12777391 |
| Shibata T et al. | An endogenous electrophile that modulates the regulatory mechanism of protein turnover: inhibitory effects of 15-deoxy-Delta 12,14-prostaglandin J2 on proteasome. | 2003 | Biochemistry | pmid:14636064 |
| Liu H et al. | PPARgamma ligands and ATRA inhibit the invasion of human breast cancer cells in vitro. | 2003 | Breast Cancer Res. Treat. | pmid:12779083 |
| Villegas I et al. | A new flavonoid derivative, dosmalfate, attenuates the development of dextran sulphate sodium-induced colitis in mice. | 2003 | Int. Immunopharmacol. | pmid:14636824 |
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| Kim EJ et al. | Peroxisome proliferator-activated receptor-gamma activator 15-deoxy-Delta12,14-prostaglandin J2 inhibits neuroblastoma cell growth through induction of apoptosis: association with extracellular signal-regulated kinase signal pathway. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12966153 |
| Yagami T et al. | Novel binding sites of 15-deoxy-Delta12,14-prostaglandin J2 in plasma membranes from primary rat cortical neurons. | 2003 | Exp. Cell Res. | pmid:14597421 |
| Collin M and Thiemermann C | The PPAR-gamma ligand 15-deoxy(delta12,14) prostaglandin J2 reduces the liver injury in endotoxic shock. | 2003 | Eur. J. Pharmacol. | pmid:12969773 |
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| Caivano M et al. | 15-Deoxy-Delta12,14-prostaglandin J2 regulates endogenous Cot MAPK kinase kinase 1 activity induced by lipopolysaccharide. | 2003 | J. Biol. Chem. | pmid:14557273 |
| Murakami Y et al. | Inhibition of monosodium urate monohydrate crystal-induced acute inflammation by retrovirally transfected prostaglandin D synthase. | 2003 | Arthritis Rheum. | pmid:14558100 |
| Niyonsaba F et al. | Epithelial cell-derived antibacterial peptides human beta-defensins and cathelicidin: multifunctional activities on mast cells. | 2003 | Curr Drug Targets Inflamm Allergy | pmid:14561157 |
| Chen YX et al. | 15d-PGJ2 inhibits cell growth and induces apoptosis of MCG-803 human gastric cancer cell line. | 2003 | World J. Gastroenterol. | pmid:14562367 |
| Komar CM and Curry TE | Inverse relationship between the expression of messenger ribonucleic acid for peroxisome proliferator-activated receptor gamma and P450 side chain cleavage in the rat ovary. | 2003 | Biol. Reprod. | pmid:12700202 |
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| Bernardo A et al. | 15-deoxy-delta12,14-prostaglandin J2 regulates the functional state and the survival of microglial cells through multiple molecular mechanisms. | 2003 | J. Neurochem. | pmid:14535956 |
| Castaño E and Gil J | 15-deoxy-delta12,14 prostaglandin J2 synergizes with phorbol ester to induce proliferation in Swiss 3T3 cells independently of peroxisome proliferator-activated receptor gamma and PGD2 receptors. | 2003 | J. Cell. Physiol. | pmid:12704651 |
| Ianaro A et al. | 2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-kappaB. | 2003 | FEBS Lett. | pmid:14550540 |
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| Cippitelli M et al. | The cyclopentenone-type prostaglandin 15-deoxy-delta 12,14-prostaglandin J2 inhibits CD95 ligand gene expression in T lymphocytes: interference with promoter activation via peroxisome proliferator-activated receptor-gamma-independent mechanisms. | 2003 | J. Immunol. | pmid:12707336 |
| Heinemann A et al. | Delta 12-prostaglandin J2, a plasma metabolite of prostaglandin D2, causes eosinophil mobilization from the bone marrow and primes eosinophils for chemotaxis. | 2003 | J. Immunol. | pmid:12707356 |
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| Oliva JL et al. | The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12684535 |
| Paumi CM et al. | Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. | 2003 | Biochemistry | pmid:12731885 |
| Gosset P et al. | Prostaglandin D2 affects the maturation of human monocyte-derived dendritic cells: consequence on the polarization of naive Th cells. | 2003 | J. Immunol. | pmid:12734337 |
| Lu S et al. | Specific gene expression of isoforms in cyclooxygenase pathway to generate PGJ2 derivatives during the differentiation of 3T3-L1 adipocytes. | 2003 | Adv. Exp. Med. Biol. | pmid:12751756 |
| Imaizumi T et al. | 15-deoxy-delta(12,14)-prostaglandin J2 inhibits IFN-gamma-induced galectin-9 expression in cultured human umbilical vein endothelial cells. | 2003 | Int. Arch. Allergy Immunol. | pmid:12759491 |
| Patel HJ et al. | Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy. | 2003 | J. Immunol. | pmid:12594295 |
| Ruan XZ et al. | PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway. | 2003 | J. Am. Soc. Nephrol. | pmid:12595494 |
| Cuzzocrea S et al. | The cyclopentenone prostaglandin 15-deoxy-delta(12,14)- PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat. | 2003 | Br. J. Pharmacol. | pmid:12598422 |
| Castrillo A et al. | Potentiation of protein kinase C zeta activity by 15-deoxy-delta(12,14)-prostaglandin J(2) induces an imbalance between mitogen-activated protein kinases and NF-kappa B that promotes apoptosis in macrophages. | 2003 | Mol. Cell. Biol. | pmid:12556480 |
| Farrow B and Evers BM | Activation of PPARgamma increases PTEN expression in pancreatic cancer cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12535639 |
| Park EJ et al. | 15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia. | 2003 | J. Biol. Chem. | pmid:12584205 |
| Hinz B et al. | 15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12604364 |
| Jung KM et al. | Activation of p38 mitogen-activated protein kinase and activator protein-1 during the promotion of neurite extension of PC-12 cells by 15-deoxy-delta12,14-prostaglandin J2. | 2003 | Mol. Pharmacol. | pmid:12606768 |
| Abe M et al. | GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12615657 |
| Qin C et al. | Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells. | 2003 | Cancer Res. | pmid:12615709 |
| Kajekar R et al. | Role of cyclooxygenase activation and prostaglandins in antigen-induced excitability changes of bronchial parasympathetic ganglia neurons. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12618420 |
| Wanichkul T et al. | Cytokine regulation by peroxisome proliferator-activated receptor gamma in human endometrial cells. | 2003 | Fertil. Steril. | pmid:12620489 |
| Monneret G et al. | 15R-methyl-prostaglandin D2 is a potent and selective CRTH2/DP2 receptor agonist in human eosinophils. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12490611 |
| Li L et al. | RasGRP4 regulates the expression of prostaglandin D2 in human and rat mast cell lines. | 2003 | J. Biol. Chem. | pmid:12493770 |
| Winnett G et al. | Prostaglandin J2 metabolites inhibit aromatase activity by redox-sensitive mechanisms: potential implications for breast cancer therapy. | 2003 | Int. J. Cancer | pmid:12494466 |
| Weber SM et al. | Inhibition of IFN-gamma -induced STAT1 activation by 15- deoxy-Delta 12,14-prostaglandin J2. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12517740 |
| Pang L et al. | Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors. | 2003 | J. Immunol. | pmid:12517972 |
| Neuschäfer-Rube F et al. | Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor. | 2003 | Biochem. J. | pmid:12519077 |
| Calnek DS et al. | Peroxisome proliferator-activated receptor gamma ligands increase release of nitric oxide from endothelial cells. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12524224 |
| Hashimoto T et al. | Effects of nonsteroidal anti-inflammatory drugs on experimental allergic conjunctivitis in Guinea pigs. | 2003 | J Ocul Pharmacol Ther | pmid:14733714 |
| Hirai H et al. | Gene structure and functional properties of mouse CRTH2, a prostaglandin D2 receptor. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12878180 |
| Zhang X et al. | Unexpected sensitivity of synthetic Renilla luciferase control vectors to treatment with a cyclopentenone prostaglandin. | 2003 | BioTechniques | pmid:14682047 |