Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Xu X et al. | Effect of Salusin-β on Peroxisome Proliferator-Activated Receptor Gamma Gene Expression in Vascular Smooth Muscle Cells and its Possible Mechanism. | 2015 | Cell. Physiol. Biochem. | pmid:26279448 |
Busse WW et al. | Biomarker Profiles in Asthma With High vs Low Airway Reversibility and Poor Disease Control. | 2015 | Chest | pmid:26226215 |
Tsutsumi S et al. | Cerebrospinal fluid drainage through the diploic and spinal epidural veins. | 2015 | J. Anat. | pmid:26184099 |
Jeon KI et al. | Inhibitory effects of PPARγ ligands on TGF-β1-induced CTGF expression in cat corneal fibroblasts. | 2015 | Exp. Eye Res. | pmid:26142957 |
Rossitto M et al. | Multiple roles of the prostaglandin D2 signaling pathway in reproduction. | 2015 | Reproduction | pmid:25269616 |
Hyun J et al. | Human intestinal epithelial cells express interleukin-10 through Toll-like receptor 4-mediated epithelial-macrophage crosstalk. | 2015 | J Innate Immun | pmid:25171731 |
Le Loupp AG et al. | [Dual role for prostaglandin D2 in intestinal epithelial homeostasis]. | 2015 Jun-Jul | Med Sci (Paris) | pmid:26152165 |
Kim HJ et al. | ROSics: chemistry and proteomics of cysteine modifications in redox biology. | 2015 Mar-Apr | Mass Spectrom Rev | pmid:24916017 |
Kanai K et al. | Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts. | 2016 | Allergol Int | pmid:27091669 |
Ma J et al. | Effect of the PGD2-DP signaling pathway on primary cultured rat hippocampal neuron injury caused by aluminum overload. | 2016 | Sci Rep | pmid:27089935 |
Zhou J et al. | Bone-marrow-derived mesenchymal stem cells inhibit gastric aspiration lung injury and inflammation in rats. | 2016 | J. Cell. Mol. Med. | pmid:27061967 |
Wang M et al. | The Responses of Pulmonary and Systemic Circulation and Airway to Allergic Mediators in Anesthetized Rats. | 2016 | Biol. Pharm. Bull. | pmid:27040628 |
Nagira Y et al. | Prostaglandin D2 Modulates Neuronal Excitation of the Trigeminal Ganglion to Augment Allergic Rhinitis in Guinea Pigs. | 2016 | J. Pharmacol. Exp. Ther. | pmid:26945085 |
Bambouskova M et al. | New Regulatory Roles of Galectin-3 in High-Affinity IgE Receptor Signaling. | 2016 | Mol. Cell. Biol. | pmid:26929198 |
Sykes DA et al. | Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy. | 2016 | Mol. Pharmacol. | pmid:26916831 |
Shin JS et al. | Direct analysis of prostaglandin-E2 and -D2 produced in an inflammatory cell reaction and its application for activity screening and potency evaluation using turbulent flow chromatography liquid chromatography-high resolution mass spectrometry. | 2016 | J Chromatogr A | pmid:27524299 |
Shibata T et al. | Identification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel. | 2016 | Sci Rep | pmid:26879669 |
Martinez-Cengotitabengoa M et al. | BDNF and NGF Signalling in Early Phases of Psychosis: Relationship With Inflammation and Response to Antipsychotics After 1 Year. | 2016 | Schizophr Bull | pmid:26130821 |
Hölscher C et al. | Defects in Peroxisomal 6-Phosphogluconate Dehydrogenase Isoform PGD2 Prevent Gametophytic Interaction in Arabidopsis thaliana. | 2016 | Plant Physiol. | pmid:26941195 |
Kugathas S et al. | Effects of Common Pesticides on Prostaglandin D2 (PGD2) Inhibition in SC5 Mouse Sertoli Cells, Evidence of Binding at the COX-2 Active Site, and Implications for Endocrine Disruption. | 2016 | Environ. Health Perspect. | pmid:26359731 |