PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Blancou P and Anegon I | Editorial: Heme oxygenase-1 and dendritic cells: what else? | 2010 | J. Leukoc. Biol. | pmid:20123679 |
| Nørregaard R et al. | Urinary tract obstruction induces transient accumulation of COX-2-derived prostanoids in kidney tissue. | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20147610 |
| Dionne S et al. | PPARgamma ligand 15-deoxy-delta 12,14-prostaglandin J2 sensitizes human colon carcinoma cells to TWEAK-induced apoptosis. | 2010 | Anticancer Res. | pmid:20150631 |
| Zhu F et al. | Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases. | 2010 | Cell Death Differ. | pmid:20150912 |
| Orlichenko LS et al. | Transcriptional regulation of CXC-ELR chemokines KC and MIP-2 in mouse pancreatic acini. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20671197 |
| Fujitani Y et al. | Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo. | 2010 | FEBS J. | pmid:20136655 |
| Syed MA et al. | Expression of TREM-1 is inhibited by PGD2 and PGJ2 in macrophages. | 2010 | Exp. Cell Res. | pmid:20797396 |
| Lou HQ et al. | [CRTH2 antagonist ameliorates airway inflammation in rats with asthma]. | 2010 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:20175238 |
| He R et al. | The prostaglandin Dâ‚‚ receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge. | 2010 | J. Allergy Clin. Immunol. | pmid:20713302 |
| Schell C et al. | 15-Deoxy-delta 12-14-prostaglandin-J2 induces hypertrophy and loss of contractility in human testicular peritubular cells: implications for human male fertility. | 2010 | Endocrinology | pmid:20133451 |
| Poncin S et al. | Oxidative stress: a required condition for thyroid cell proliferation. | 2010 | Am. J. Pathol. | pmid:20093493 |
| Wang Y et al. | Role of cyclooxygenase-2 signaling pathway dysfunction in unexplained recurrent spontaneous abortion. | 2010 | Chin. Med. J. | pmid:20819509 |
| Xiao Y et al. | 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-gamma-dependent and mediated by the caspase-3-dependent apoptotic pathway. | 2010 | FEBS J. | pmid:20050918 |
| Li H et al. | Serum amyloid A activates peroxisome proliferator-activated receptor γ through extracellularly regulated kinase 1/2 and COX-2 expression in hepatocytes. | 2010 | Biochemistry | pmid:20853849 |
| Bancos S et al. | Induction of heme oxygenase-1 in normal and malignant B lymphocytes by 15-deoxy-Delta(12,14)-prostaglandin J(2) requires Nrf2. | 2010 | Cell. Immunol. | pmid:20064636 |
| Pacienza N et al. | 15-deoxy-Delta(12,14)-PGJ(2) induces cell cycle arrest and apoptosis of haematopoietic progenitors. | 2010 | Br. J. Haematol. | pmid:19764987 |
| Lee CM et al. | Prostaglandin expression profile in hypoxic osteoblastic cells. | 2010 | J. Bone Miner. Metab. | pmid:19471853 |
| Kim SH et al. | Toluene diisocyanate (TDI) regulates haem oxygenase-1/ferritin expression: implications for toluene diisocyanate-induced asthma. | 2010 | Clin. Exp. Immunol. | pmid:20345975 |
| Zimmer M et al. | The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. | 2010 | Cancer Res. | pmid:20354189 |
| Yamaguchi S et al. | Delta12-prostaglandin J2 as a product and ligand of human serum albumin: formation of an unusual covalent adduct at His146. | 2010 | J. Am. Chem. Soc. | pmid:20014793 |
| Lin TH et al. | Upregulation of heme oxygenase-1 inhibits the maturation and mineralization of osteoblasts. | 2010 | J. Cell. Physiol. | pmid:20020468 |
| Hovsepian E et al. | 15-deoxy-Delta12,14 prostaglandin GJ2 but not rosiglitazone regulates metalloproteinase 9, NOS-2, and cyclooxygenase 2 expression and functions by peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms in cardiac cells. | 2010 | Shock | pmid:19997048 |
| Théoleyre S et al. | HtrA3 is regulated by 15-deoxy-Delta12,14-prostaglandin J2 independently of PPARgamma in clear cell renal cell carcinomas. | 2010 | Biochem. Biophys. Res. Commun. | pmid:19951697 |
| Shim J et al. | The peroxisome proliferator-activated receptor gamma ligands, pioglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2), have antineoplastic effects against hepatitis B virus-associated hepatocellular carcinoma cells. | 2010 | Int. J. Oncol. | pmid:19956851 |
| Bach-Ngohou K et al. | Enteric glia modulate epithelial cell proliferation and differentiation through 15-deoxy-12,14-prostaglandin J2. | 2010 | J. Physiol. (Lond.) | pmid:20478974 |
| Masoodi M et al. | Prostaglandin D production in FM55 melanoma cells is regulated by alpha-melanocyte-stimulating hormone and is not related to melanin production. | 2010 | Exp. Dermatol. | pmid:20482620 |
| Galvão Nascimento N et al. | Contribution of mast cells to the oedema induced by Bothrops moojeni snake venom and a pharmacological assessment of the inflammatory mediators involved. | 2010 Feb-Mar | Toxicon | pmid:19703484 |
| Mathurin K et al. | An interaction between L-prostaglandin D synthase and arrestin increases PGD2 production. | 2011 | J. Biol. Chem. | pmid:21112970 |
| Wingard CJ et al. | Mast cells contribute to altered vascular reactivity and ischemia-reperfusion injury following cerium oxide nanoparticle instillation. | 2011 | Nanotoxicology | pmid:21043986 |
| MartÃnez-Gras I et al. | The anti-inflammatory prostaglandin 15d-PGJ2 and its nuclear receptor PPARgamma are decreased in schizophrenia. | 2011 | Schizophr. Res. | pmid:21334179 |
| Chbicheb S et al. | EGR1 expression: a calcium and ERK1/2 mediated PPARγ-independent event involved in the antiproliferative effect of 15-deoxy-Δ12,14-prostaglandin J2 and thiazolidinediones in breast cancer cells. | 2011 | Biochem. Pharmacol. | pmid:21338579 |
| Qiu Z et al. | Cough reflex sensitivity and airway inflammation in patients with chronic cough due to non-acid gastro-oesophageal reflux. | 2011 | Respirology | pmid:21342332 |
| Wang JJ and Mak OT | Induction of apoptosis by 15d-PGJ2 via ROS formation: an alternative pathway without PPARγ activation in non-small cell lung carcinoma A549 cells. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21396480 |
| Murata T et al. | Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22106279 |
| Yamamoto Y et al. | Proteomic identification of protein targets for 15-deoxy-Δ(12,14)-prostaglandin J2 in neuronal plasma membrane. | 2011 | PLoS ONE | pmid:21445266 |
| Mackay GA and Stewart AG | R2D(2) for C(4)Eo: an 'alliance' of PGD(2) receptors is required for LTC(4) production by human eosinophils. | 2011 | Br. J. Pharmacol. | pmid:21426314 |
| Huang ZL et al. | The role of adenosine in the regulation of sleep. | 2011 | Curr Top Med Chem | pmid:21401496 |
| Kamauchi S and Urade Y | [Hematopoietic prostaglandin D synthase inhibitors for the treatment of duchenne muscular dystrophy]. | 2011 | Brain Nerve | pmid:22068479 |
| Flachs P et al. | Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids. | 2011 | Diabetologia | pmid:21779874 |
| Aung G et al. | Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines. | 2011 | Immunology | pmid:21214543 |
| Hovsepian E et al. | Modulation of inflammatory response and parasitism by 15-Deoxy-Δ(12,14) prostaglandin J(2) in Trypanosoma cruzi-infected cardiomyocytes. | 2011 | Int. J. Parasitol. | pmid:21215746 |
| Lotz C et al. | Activation of peroxisome-proliferator-activated receptors α and γ mediates remote ischemic preconditioning against myocardial infarction in vivo. | 2011 | Exp. Biol. Med. (Maywood) | pmid:21163821 |
| Charles RL et al. | Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation. | 2011 | Circ. Res. | pmid:21164107 |
| Eguchi M et al. | Lipopolysaccharide induces proinflammatory cytokines and chemokines in experimental otitis media through the prostaglandin D2 receptor (DP)-dependent pathway. | 2011 | Clin. Exp. Immunol. | pmid:21166666 |
| Oh YC et al. | Anti-allergic effects of sinomenine by inhibition of prostaglandin Dâ‚‚ and leukotriene Câ‚„ in mouse bone marrow-derived mast cells. | 2011 | Immunopharmacol Immunotoxicol | pmid:21080779 |
| Cichocka-Jarosz E et al. | Serum tryptase level is a better predictor of systemic side effects than prostaglandin D2 metabolites during venom immunotherapy in children. | 2011 | J Investig Allergol Clin Immunol | pmid:21721371 |
| Nabe T et al. | Inhibition of hematopoietic prostaglandin D synthase improves allergic nasal blockage in guinea pigs. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21601002 |
| Jin M et al. | Anti-inflammatory activity of 6-hydroxy-2,7-dimethoxy-1,4-henanthraquinone from tuberous roots of yam (Dioscorea batatas) through inhibition of prostaglandin Dâ‚‚ and leukotriene Câ‚„ production in mouse bone marrow-derived mast cells. | 2011 | Arch. Pharm. Res. | pmid:21975811 |
| Urade Y and Hayaishi O | Prostaglandin D2 and sleep/wake regulation. | 2011 | Sleep Med Rev | pmid:22024172 |
| Wan CJ et al. | [PPARgamma agonists against respiratory syncytial virus infection in vitro study]. | 2011 | Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi | pmid:22734242 |