PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang Y et al. | Optimization of phenylacetic acid derivatives for CRTH2 and DP selective antagonism. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22119474 |
| Alba G et al. | Transcription of liver X receptor is down-regulated by 15-deoxy-Δ(12,14)-prostaglandin J(2) through oxidative stress in human neutrophils. | 2012 | PLoS ONE | pmid:23115616 |
| Hossain MS et al. | Stable expression of lipocalin-type prostaglandin D synthase in cultured preadipocytes impairs adipogenesis program independently of endogenous prostanoids. | 2012 | Exp. Cell Res. | pmid:22100987 |
| Pettipher R et al. | Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22106101 |
| Paulitschke V et al. | Proteome analysis identified the PPARγ ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction. | 2012 | PLoS ONE | pmid:23049949 |
| Syeda PK et al. | A monoclonal antibody specific for Δ12-prostaglandin J2 and its utilization in the immunological assay in cell culture system of adipocytes. | 2012 | Hybridoma (Larchmt) | pmid:23098304 |
| Weng Y et al. | Prostaglandin metabolite induces inhibition of TRPA1 and channel-dependent nociception. | 2012 | Mol Pain | pmid:23013719 |
| Sedej M et al. | D-type prostanoid receptor enhances the signaling of chemoattractant receptor-homologous molecule expressed on T(H)2 cells. | 2012 | J. Allergy Clin. Immunol. | pmid:21930295 |
| Higuchi S et al. | Involvement of Th2 cytokines in the mouse model of flutamide-induced acute liver injury. | 2012 | J Appl Toxicol | pmid:21735453 |
| Clemente-Napimoga JT et al. | 15d-PGJ2-loaded in nanocapsules enhance the antinociceptive properties into rat temporomandibular hypernociception. | 2012 | Life Sci. | pmid:22564409 |
| Inceoglu AB et al. | Inhibition of soluble epoxide hydrolase limits niacin-induced vasodilation in mice. | 2012 | J. Cardiovasc. Pharmacol. | pmid:22526297 |
| Higashi N et al. | Aspirin-intolerant asthma (AIA) assessment using the urinary biomarkers, leukotriene E4 (LTE4) and prostaglandin D2 (PGD2) metabolites. | 2012 | Allergol Int | pmid:22627848 |
| Kristensen DM et al. | Paracetamol (acetaminophen), aspirin (acetylsalicylic acid) and indomethacin are anti-androgenic in the rat foetal testis. | 2012 | Int. J. Androl. | pmid:22612476 |
| Hogrefe C et al. | Single impact cartilage trauma and TNF-α: interactive effects do not increase early cell death and indicate the need for bi-/multidirectional therapeutic approaches. | 2012 | Int. J. Mol. Med. | pmid:22922824 |
| Mantel A et al. | Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis. | 2012 | J. Invest. Dermatol. | pmid:22170488 |
| Farnesi-de-Assunção TS et al. | PPAR-γ agonists, mainly 15d-PGJ(2), reduce eosinophil recruitment following allergen challenge. | 2012 | Cell. Immunol. | pmid:22192475 |
| Kuriyan AE et al. | Electrophilic PPARγ ligands inhibit corneal fibroblast to myofibroblast differentiation in vitro: a potentially novel therapy for corneal scarring. | 2012 | Exp. Eye Res. | pmid:22178289 |
| Yang K et al. | [Changes of prostaglandin D2,carboxypeptidase A3 and platelet activating factor in guinea pig in anaphylactic shock]. | 2012 | Fa Yi Xue Za Zhi | pmid:22812216 |
| Komoda T and Nishikawa M | 6'-Hydroxyoxosorbicillinol, a new lipoxygenase inhibitor and PGD2/LTB4 release suppressor from Penicillium sp. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22785490 |
| Joo M and Sadikot RT | PGD synthase and PGD2 in immune resposne. | 2012 | Mediators Inflamm. | pmid:22791937 |
| Fujimori K et al. | Activation of adipogenesis by lipocalin-type prostaglandin D synthase-generated Δ¹²-PGJ₂ acting through PPARγ-dependent and independent pathways. | 2012 | Gene | pmid:22664386 |
| Cebola I and Peinado MA | Epigenetic deregulation of the COX pathway in cancer. | 2012 | Prog. Lipid Res. | pmid:22580191 |
| Liu X et al. | 15-Deoxy-Δ(12,14)-prostaglandin J(2) attenuates the biological activities of monocyte/macrophage cell lines. | 2012 | Eur. J. Cell Biol. | pmid:22560326 |
| Gross-Sondej I et al. | [Measurement of bronchoconstrictive eicosanoids in chronic obstructive pulmonary disease]. | 2012 | Pneumonol Alergol Pol | pmid:22370980 |
| Han Z et al. | 15-deoxy-Δ12,14 -prostaglandin J2 reduces recruitment of bone marrow-derived monocyte/macrophages in chronic liver injury in mice. | 2012 | Hepatology | pmid:22371273 |
| Syeda PK et al. | Generation of monoclonal antibody for 15-deoxy-Δ¹²,¹â´-prostaglandin Jâ‚‚ and development of enzyme-linked immunosorbent assay for its quantification in culture medium of adipocytes. | 2012 | Appl. Biochem. Biotechnol. | pmid:22391692 |
| Quinteiro MS et al. | The indirect antinociceptive mechanism of 15d-PGJ2 on rheumatoid arthritis-induced TMJ inflammatory pain in rats. | 2012 | Eur J Pain | pmid:22354681 |
| Prage EB et al. | Observation of two modes of inhibition of human microsomal prostaglandin E synthase 1 by the cyclopentenone 15-deoxy-Δ(12,14)-prostaglandin J(2). | 2012 | Biochemistry | pmid:22356188 |
| Numazawa S et al. | Possible involvement of transient receptor potential channels in electrophile-induced insulin secretion from RINm5F cells. | 2012 | Biol. Pharm. Bull. | pmid:22382320 |
| Lin YC et al. | The glutathionylation of p65 modulates NF-κB activity in 15-deoxy-Δ¹²,¹â´-prostaglandin Jâ‚‚-treated endothelial cells. | 2012 | Free Radic. Biol. Med. | pmid:22387200 |
| Carsin A et al. | [Physiopathology of aspirin intolerant asthma]. | 2012 | Rev Mal Respir | pmid:22405107 |
| Lefils-Lacourtablaise J et al. | The eicosapentaenoic acid metabolite 15-deoxy-δ(12,14)-prostaglandin J3 increases adiponectin secretion by adipocytes partly via a PPARγ-dependent mechanism. | 2013 | PLoS ONE | pmid:23734181 |
| Starkl P et al. | PLA2G3 promotes mast cell maturation and function. | 2013 | Nat. Immunol. | pmid:23685814 |
| Sánchez-Gómez FJ et al. | Modulation of GSTP1-1 oligomerization by electrophilic inflammatory mediators and reactive drugs. | 2013 | Inflamm Allergy Drug Targets | pmid:23596995 |
| Wappler EA et al. | Mitochondrial dynamics associated with oxygen-glucose deprivation in rat primary neuronal cultures. | 2013 | PLoS ONE | pmid:23658809 |
| Krohn IK et al. | Mast cell FcϵRI density and function dissociate from dependence on soluble IgE concentration at very low and very high IgE concentrations. | 2013 | J Asthma | pmid:23294195 |
| Rank MA et al. | Systemic reactions to allergen immunotherapy: a role for measuring a PGD2 metabolite? | 2013 | Ann. Allergy Asthma Immunol. | pmid:23244662 |
| Philibert P et al. | Unilateral cryptorchidism in mice mutant for Ptgds. | 2013 | Hum. Mutat. | pmid:23076868 |
| Kataoka N et al. | Indomethacin inhibits eosinophil migration to prostaglandin D2 : therapeutic potential of CRTH2 desensitization for eosinophilic pustular folliculitis. | 2013 | Immunology | pmid:23582181 |
| Lu Y et al. | Anti-inflammatory activity of hexane extracts from bones and internal organs of Anguilla japonica suppresses cyclooxygenase-2-dependent prostaglandin Dâ‚‚ generation in mast cells and anaphylaxis in mice. | 2013 | Food Chem. Toxicol. | pmid:23562928 |
| Sato A et al. | Synthesis and evaluation of 2,3-dinorprostaglandins: Dinor-PGD1 and 13-epi-dinor-PGD1 are peroxisome proliferator-activated receptor α/γ dual agonists. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23566516 |
| Yazid S et al. | Anti-allergic cromones inhibit histamine and eicosanoid release from activated human and murine mast cells by releasing Annexin A1. | 2013 | PLoS ONE | pmid:23527056 |
| Ayabe S et al. | Prostaglandin D2 inhibits collagen secretion from lung fibroblasts by activating the DP receptor. | 2013 | J. Pharmacol. Sci. | pmid:23538675 |
| Alhouayek M et al. | Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24101490 |
| Kuriyan AE et al. | Orbital fibroblasts from thyroid eye disease patients differ in proliferative and adipogenic responses depending on disease subtype. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:24135759 |
| Touitou V et al. | Sustained neuroprotection from a single intravitreal injection of PGJ2 in a rodent model of anterior ischemic optic neuropathy. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:24106118 |
| Tofield A | Niacin and statin intolerable for some people. | 2013 | Eur. Heart J. | pmid:24137778 |
| Napimoga MH et al. | Low doses of 15d-PGJ2 induce osteoblast activity in a PPAR-gamma independent manner. | 2013 | Int. Immunopharmacol. | pmid:23597428 |
| Juman S et al. | Effects of long-term oral administration of arachidonic acid and docosahexaenoic acid on the immune functions of young rats. | 2013 | Nutrients | pmid:23760060 |
| Wu D et al. | Novel biphasic role of resolvin D1 on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts is partly through PI3K/AKT and ERK2 pathways. | 2013 | Mediators Inflamm. | pmid:24174713 |