PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Campbell A et al. | Overview of allergic mechanisms. Ebastine has more than an antihistamine effect. | 1996 | Drugs | pmid:8983912 |
| Ogasawara T et al. | Mouse bone marrow-derived mast cells undergo exocytosis, prostanoid generation, and cytokine expression in response to G protein-activating polybasic compounds after coculture with fibroblasts in the presence of c-kit ligand. | 1997 | J. Immunol. | pmid:8977215 |
| Ashraf MM et al. | Type II phospholipase A2 is linked to cyclooxygenase-2-mediated delayed prostaglandin D2 generation by cultured mouse mast cells following FcepsilonRI- and cytokine-dependent activation. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8954964 |
| Santos J et al. | Regulation of intestinal mast cells and luminal protein release by cerebral thyrotropin-releasing hormone in rats. | 1996 | Gastroenterology | pmid:8942724 |
| Vedin I et al. | Stimulation of tumor necrosis factor-alpha release from lipopolysaccharide-activated human blood monocytes by prostaglandin J2 and metabolites of prostaglandin J2. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8931117 |
| Higashiyama K et al. | Induction of c-fos protooncogene transcription and apoptosis by delta 12-prostaglandin J2 in human Pl-21 myeloid leukemia and RC-K8 pre-B lymphoma cells. | 1996 | Prostaglandins | pmid:8908616 |
| Urade Y et al. | Molecular mechanism of sleep regulation by prostaglandin D2. | 1996 | J Lipid Mediat Cell Signal | pmid:8906548 |
| Hayaishi O | Tryptophan, oxygenase, and sleep. | 1996 | Adv. Exp. Med. Biol. | pmid:8906236 |
| Ishimoto T et al. | Importance of the phospholipase D-initiated sequential pathway for arachidonic acid release and prostaglandin D2 generation by rat peritoneal mast cells. | 1996 | J. Biochem. | pmid:8902628 |
| Lydford SJ et al. | Interaction of BW A868C, a prostanoid DP-receptor antagonist, with two receptor subtypes in the rabbit isolated saphenous vein. | 1996 | Prostaglandins | pmid:8880898 |
| de Graaf-in t Veld C et al. | Relationship between nasal hyperreactivity, mediators and eosinophils in patients with perennial allergic rhinitis and controls. | 1996 | Clin. Exp. Allergy | pmid:8877155 |
| Naclerio RM et al. | Origin of late phase histamine release. | 1996 | J. Allergy Clin. Immunol. | pmid:8876545 |
| Kim HS et al. | Intracellular glutathione level modulates the induction of apoptosis by delta 12-prostaglandin J2. | 1996 | Prostaglandins | pmid:8873236 |
| Knol EF et al. | The role of basophils in allergic disease. | 1996 | Eur Respir J Suppl | pmid:8871057 |
| Woodiel FN et al. | Anabolic effects of prostaglandins in cultured fetal rat calvariae: structure-activity relations and signal transduction pathway. | 1996 | J. Bone Miner. Res. | pmid:8864899 |
| Conti C et al. | Inhibition of poliovirus replication by prostaglandins A and J in human cells. | 1996 | Antimicrob. Agents Chemother. | pmid:8834882 |
| Chung HS et al. | Heat contact urticaria--a case report. | 1996 | Yonsei Med. J. | pmid:8826790 |
| Bingham CO et al. | A heparin-sensitive phospholipase A2 and prostaglandin endoperoxide synthase-2 are functionally linked in the delayed phase of prostaglandin D2 generation in mouse bone marrow-derived mast cells. | 1996 | J. Biol. Chem. | pmid:8824228 |
| Wang DY et al. | Prostaglandin D2 measurement in nasal secretions is not a reliable marker for mast cell activation in atopic patients. | 1995 | Clin. Exp. Allergy | pmid:8821304 |
| Sharif NA et al. | Characterization of the ocular antiallergic and antihistaminic effects of olopatadine (AL-4943A), a novel drug for treating ocular allergic diseases. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8819509 |