PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Actinobacillus Infections D000189 4 associated lipids
Adenocarcinoma D000230 166 associated lipids
Alzheimer Disease D000544 76 associated lipids
Anal Gland Neoplasms D000694 1 associated lipids
Anaphylaxis D000707 35 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Ascariasis D001196 3 associated lipids
Asthma D001249 52 associated lipids
Astrocytoma D001254 15 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Blister D001768 16 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
Body Weight D001835 333 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Bronchial Spasm D001986 18 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Carcinoma, Renal Cell D002292 12 associated lipids
Carotid Artery Thrombosis D002341 7 associated lipids
Catalepsy D002375 30 associated lipids
Cataract D002386 34 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Brain Ischemia D002545 89 associated lipids
Cholangitis D002761 3 associated lipids
Chondrosarcoma D002813 9 associated lipids
Colitis D003092 69 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Coronary Disease D003327 70 associated lipids
Cough D003371 19 associated lipids
Cryptococcosis D003453 3 associated lipids
Cryptorchidism D003456 2 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Dehydration D003681 11 associated lipids
Drug Eruptions D003875 30 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Dirofilariasis D004184 3 associated lipids
Down Syndrome D004314 18 associated lipids
Dyskinesia, Drug-Induced D004409 15 associated lipids
Edema D004487 152 associated lipids
Encephalitis D004660 15 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Epilepsy, Tonic-Clonic D004830 2 associated lipids
Erythema D004890 22 associated lipids
Fever D005334 35 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Vigano' T et al. Binding sites for histamine and sulfidopeptide leukotrienes in normal and hypersensitized human lung fragments. 1990 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2144691
Bettazzoli L et al. Incorporation of arachidonic acid into glycerophospholipids of a murine bone marrow derived mast cell. 1990 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2169185
Morrow JD et al. A stable isotope dilution mass spectrometric assay for the major urinary metabolite of PGD2. 1991 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:1825560
Howarth P et al. The comparative nasal effects of prostaglandin D2 in normal and rhinitic subjects. 1991 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:1825579
Gundel RH et al. The effects of a 5-lipoxygenase inhibitor on antigen-induced mediator release, late-phase bronchoconstriction and cellular infiltrates in primates. 1991 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:1825582
Watanabe K et al. The structure and function of prostaglandin F synthase. 1991 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:1825592
Hayaishi O Prostaglandin D2 and sleep. 1989 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2526481
Watanabe Y et al. Positron emission tomography studies using [11C]ester of prostaglandin D2. 1989 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2526503
Fukushima M et al. Prostaglandin A and J: antitumor and antiviral prostaglandins. 1989 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2526507
Thierauch KH et al. Stable 9 beta- or 11 alpha-halogen-15-cyclohexyl-prostaglandins with high affinity to the PGD2-receptor. 1989 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2526554
Wendelborn DF et al. Isomeric prostaglandin F2 compounds: a new family of eicosanoids produced in vivo in humans. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2959099
Pugliese G et al. 9 alpha, 11 beta-prostaglandin F2: a new prostanoid with selective biosynthesis and unique biological activity. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2959104
Robinson C et al. Effects of inhaled 9 alpha, 11 beta-prostaglandin F2 on airway function in man. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960146
Roberts LJ Recent metabolic findings bring into question the reliability of existing methods for quantification of PGF2 alpha and its metabolites in human biological fluids. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960165
Prakash C et al. Synthesis of putative prostaglandin D2 metabolites. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960191
Watanabe Y et al. Synthesis of 11C-labeled prostaglandins and positron emission tomography studies using the rhesus monkey. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960207
Hayaishi O et al. Prostaglandin D2 induces sleep when infused into the cerebral ventricle of conscious monkeys. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960208
Narumiya S and Fukushima M Active transport and cellular accumulation of cyclopentenone prostaglandins: a mechanism of prostaglandin-induced growth inhibition. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960214
Ono K et al. Suppressive effects of various antitumor prostaglandin derivatives on the activity levels of DNA polymerases in human cultured tumor cells. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960215
Ichikawa A et al. Up-regulation of prostaglandin D2 receptors by agonist binding to beta-adrenoceptors in rabbit platelets. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:3004152