PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Fetal Alcohol Spectrum Disorders D063647 6 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Airway Remodeling D056151 3 associated lipids
Asthma, Aspirin-Induced D055963 2 associated lipids
Pulmonary Aspergillosis D055732 1 associated lipids
Acute Lung Injury D055371 33 associated lipids
Idiopathic Pulmonary Fibrosis D054990 4 associated lipids
Angioedemas, Hereditary D054179 2 associated lipids
Atherosclerosis D050197 85 associated lipids
Graves Ophthalmopathy D049970 3 associated lipids
Decapitation D049248 2 associated lipids
Mastocytosis, Systemic D034721 1 associated lipids
Tauopathies D024801 6 associated lipids
Coronary Restenosis D023903 10 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Fetal Weight D020567 12 associated lipids
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Stroke D020521 32 associated lipids
Muscular Dystrophy, Duchenne D020388 11 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Sleep Disorders, Circadian Rhythm D020178 3 associated lipids
Thrombophilia D019851 6 associated lipids
Endotoxemia D019446 27 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Optic Neuropathy, Ischemic D018917 2 associated lipids
Cystitis, Interstitial D018856 2 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Vasculitis, Leukocytoclastic, Cutaneous D018366 5 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Coronavirus Infections D018352 4 associated lipids
Cholangiocarcinoma D018281 7 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Liver Failure, Acute D017114 11 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Helicobacter Infections D016481 21 associated lipids
Lymphoma, T-Cell D016399 11 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Choroid Diseases D015862 2 associated lipids
Nasal Obstruction D015508 4 associated lipids
HTLV-I Infections D015490 3 associated lipids
Leukemia, Basophilic, Acute D015471 9 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Leukemia, B-Cell D015448 3 associated lipids
Weight Loss D015431 56 associated lipids
Reperfusion Injury D015427 65 associated lipids
Zollinger-Ellison Syndrome D015043 1 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Moulin D et al. Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1beta-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor beta/delta-dependent mechanism. 2005 Arthritis Rheum. pmid:15751073
Farrajota K et al. Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism. 2005 Arthritis Rheum. pmid:15641079
de Paulis A et al. Human synovial mast cells. I. Ultrastructural in situ and in vitro immunologic characterization. 1996 Arthritis Rheum. pmid:8670335
Maicas N et al. Prostaglandin D2 regulates joint inflammation and destruction in murine collagen-induced arthritis. 2012 Arthritis Rheum. pmid:21898357
Zayed N et al. Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2. 2008 Arthritis Rheum. pmid:18975308
Murakami Y et al. Inhibition of monosodium urate monohydrate crystal-induced acute inflammation by retrovirally transfected prostaglandin D synthase. 2003 Arthritis Rheum. pmid:14558100
Inoue K et al. Effects of 15-deoxy-delta(12,14)-prostaglandin J2 on nuclear localization of GATA-3 in the murine lung in the presence of lipopolysaccharide. 2005 Arzneimittelforschung pmid:15819389
Inoue K et al. Effects of 15-deoxy-delta12,14-prostaglandin J2 on the cyclooxygenase-2 expression in the murine lung in the presence of lipopolysaccharide. 2004 Arzneimittelforschung pmid:15612612
Misawa M and Kanai Y Effect of the new antiallergic drug epinastine on chemical mediator induced bronchoconstrictions in guinea pigs. 1991 Arzneimittelforschung pmid:1725697
Arisawa M et al. Suppressive effect of prostaglandin D2 on prolactin secretion from rat anterior pituitary. 1985 Asia Oceania J Obstet Gynaecol pmid:3860198
Arisawa M et al. Direct suppressive effect of prostaglandin D2 on growth hormone secretion from rat anterior pituitary. 1984 Asia Oceania J Obstet Gynaecol pmid:6598030
Muhammad SN et al. 15d-PGJ2 Induces Apoptosis of MCF-7 and MDA-MB-231 Cells via Increased Intracellular Calcium and Activation of Caspases, Independent of ERα and ERβ. 2016 Asian Pac. J. Cancer Prev. pmid:27509924
Yaacob NS et al. Influence of 17β-estradiol on 15-deoxy-δ12,14 prostaglandin J2 -induced apoptosis in MCF-7 and MDA-MB-231 cells. 2013 Asian Pac. J. Cancer Prev. pmid:24377602
Jin YR et al. Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity. 2007 Atherosclerosis pmid:17092506
Fu Y et al. Upregulation of interleukin-8 expression by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2) in human THP-1 macrophages. 2002 Atherosclerosis pmid:11755918
Beatty CH et al. Metabolism of arachidonic acid by macaque platelets. Implications for studies on atherosclerosis. 1985 Atherosclerosis pmid:3924062
Abbate R et al. Decreased number of PGD2 binding sites on platelets from patients with type IIa hyperlipoproteinemia. 1985 Atherosclerosis pmid:3857047
Nilsson J and Olsson AG Prostaglandin E1 inhibits DNA synthesis in arterial smooth muscle cells stimulated with platelet-derived growth factor. 1984 Atherosclerosis pmid:6093830
Chang MC et al. Antiplatelet effect by p-cresol, a uremic and environmental toxicant, is related to inhibition of reactive oxygen species, ERK/p38 signaling and thromboxane A2 production. 2011 Atherosclerosis pmid:21993412
Ledwidge MT et al. In vivo impact of prodrug isosorbide-5-nicotinate-2-aspirinate on lipids and prostaglandin D2: is this a new immediate-release therapeutic option for niacin? 2012 Atherosclerosis pmid:22326030
Inoue T et al. Lipocalin-type prostaglandin D synthase is a powerful biomarker for severity of stable coronary artery disease. 2008 Atherosclerosis pmid:18436228
Meyers CD et al. Nicotinic acid induces secretion of prostaglandin D2 in human macrophages: an in vitro model of the niacin flush. 2007 Atherosclerosis pmid:16945375
Tachi M et al. Mass spectrometric determination of prostanoids in rat hypothalamic paraventricular nucleus microdialysates. 2014 Auton Neurosci pmid:24447364
Jin YR et al. An antithrombotic agent, NQ301, inhibits thromboxane A2 receptor and synthase activity in rabbit platelets. 2005 Basic Clin. Pharmacol. Toxicol. pmid:16128910
Li P et al. [Effect of peroxisome proliferator-activated receptor-γ on endothelial cells oxidative stress induced by Porphyromonas gingivalis]. 2015 Beijing Da Xue Xue Bao pmid:26679661
Li CF et al. [Effect of peroxisome proliferators-activated receptor-gamma in the mechanisms of sulindac against large intestine carcinoma]. 2007 Beijing Da Xue Xue Bao pmid:17304332
Varma D et al. Comparison of UHPLC and HPLC methods for the assay of prostanoids: "are the methods equivalent in terms of accuracy and precision?". 2011 Bioanalysis pmid:21510759
Ueno R et al. Prostaglandin D2 induces sleep when microinjected into the preoptic area of conscious rats. 1982 Biochem. Biophys. Res. Commun. pmid:6960896
Fukushima M et al. 9-deoxy-delta 9-prostaglandin D2, a prostaglandin D2 derivative with potent antineoplastic and weak smooth muscle-contracting activities. 1982 Biochem. Biophys. Res. Commun. pmid:6961920
Kawabe H et al. Differential calcium effects on prostaglandin D2 generation and histamine release from isolated rat peritoneal mast cells. 1987 Biochem. Biophys. Res. Commun. pmid:2436614
Wächtershäuser A et al. PPAR-gamma is selectively upregulated in Caco-2 cells by butyrate. 2000 Biochem. Biophys. Res. Commun. pmid:10833422
Ohno K et al. Metabolic dehydration of prostaglandin E2 and cellular uptake of the dehydration product: correlation with prostaglandin E2-induced growth inhibition. 1986 Biochem. Biophys. Res. Commun. pmid:3464277
Dieter P et al. Functional coupling of cyclooxygenase 1 and 2 to discrete prostanoid synthases in liver macrophages. 2000 Biochem. Biophys. Res. Commun. pmid:11027502
Tanaka K et al. Effects of prostaglandin D2 on helper T cell functions. 2004 Biochem. Biophys. Res. Commun. pmid:15044085
Onozaki A et al. Rapid change of glucose concentration promotes mesangial cell proliferation via VEGF: inhibitory effects of thiazolidinedione. 2004 Biochem. Biophys. Res. Commun. pmid:15047143
Kuiper J et al. The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells. 1988 Biochem. Biophys. Res. Commun. pmid:3144970
Chock SP and Schmauder-Chock EA Synthesis of prostaglandins and eicosanoids by the mast cell secretory granule. 1988 Biochem. Biophys. Res. Commun. pmid:3190706
Niwa Y et al. Opposite effects of PU.1 on mast cell stimulation. 2008 Biochem. Biophys. Res. Commun. pmid:18680724
Engdahl R et al. 15-Deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) mediates repression of TNF-alpha by decreasing levels of acetylated histone H3 and H4 at its promoter. 2007 Biochem. Biophys. Res. Commun. pmid:17532302
Azuma Y et al. 15-Deoxy-delta(12,14)-prostaglandin J(2) inhibits IL-10 and IL-12 production by macrophages. 2001 Biochem. Biophys. Res. Commun. pmid:11327705
Satoh T et al. Prostaglandin J2 and its metabolites promote neurite outgrowth induced by nerve growth factor in PC12 cells. 1999 Biochem. Biophys. Res. Commun. pmid:10222233
Satarug S et al. Prostaglandin D2 induces heme oxygenase-1 mRNA expression through the DP2 receptor. 2008 Biochem. Biophys. Res. Commun. pmid:18957281
Sakuma S et al. Existence of an enzymatic pathway furnishing arachidonic acid for prostaglandin synthesis from arachidonoyl CoA in rabbit kidney medulla. 1994 Biochem. Biophys. Res. Commun. pmid:8048918
Keelan JA et al. 15-Deoxy-Delta(12,14)-prostaglandin J(2), a ligand for peroxisome proliferator-activated receptor-gamma, induces apoptosis in JEG3 choriocarcinoma cells. 1999 Biochem. Biophys. Res. Commun. pmid:10471366
Ehara N et al. Activators of PPARgamma antagonize protection of cardiac myocytes by endothelin-1. 2004 Biochem. Biophys. Res. Commun. pmid:15358182
Gayarre J et al. Addition of electrophilic lipids to actin alters filament structure. 2006 Biochem. Biophys. Res. Commun. pmid:16979589
Erman A and Nasjletti A Enhancement of renal medulla prostaglandin synthetase activity by dexamethasone treatment in the rat. 1984 Biochem. Biophys. Res. Commun. pmid:6428405
Farrow B and Evers BM Activation of PPARgamma increases PTEN expression in pancreatic cancer cells. 2003 Biochem. Biophys. Res. Commun. pmid:12535639
Yamamoto N et al. Mechanism of inhibition of herpes simplex virus replication by delta 7-prostaglandin A1 and delta 12-prostaglandin J2. 1987 Biochem. Biophys. Res. Commun. pmid:3040001
Hirai H et al. Gene structure and functional properties of mouse CRTH2, a prostaglandin D2 receptor. 2003 Biochem. Biophys. Res. Commun. pmid:12878180