Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Zijlstra FJ et al. | Formation of prostaglandins and leukotrienes by human lung tissue in vitro after activation by the calcium ionophore A23187. | 1987 | Eur. J. Clin. Invest. | pmid:2822430 |
Prakash C et al. | Synthesis of putative prostaglandin D2 metabolites. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960191 |
Kawabe H et al. | Differential calcium effects on prostaglandin D2 generation and histamine release from isolated rat peritoneal mast cells. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2436614 |
Watanabe Y et al. | Synthesis of 11C-labeled prostaglandins and positron emission tomography studies using the rhesus monkey. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960207 |
Hayaishi O et al. | Prostaglandin D2 induces sleep when infused into the cerebral ventricle of conscious monkeys. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960208 |
Narumiya S and Fukushima M | Active transport and cellular accumulation of cyclopentenone prostaglandins: a mechanism of prostaglandin-induced growth inhibition. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960214 |
Ruzicka T and Auböck J | Arachidonic acid metabolism in guinea pig Langerhans cells: studies on cyclooxygenase and lipoxygenase pathways. | 1987 | J. Immunol. | pmid:3098849 |
Ono K et al. | Suppressive effects of various antitumor prostaglandin derivatives on the activity levels of DNA polymerases in human cultured tumor cells. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960215 |
Beasley R et al. | Cholinergic-mediated bronchoconstriction induced by prostaglandin D2, its initial metabolite 9 alpha,11 beta-PGF2, and PGF2 alpha in asthma. | 1987 | Am. Rev. Respir. Dis. | pmid:2960256 |
Saito R et al. | The effect of neurotransmitters on cataleptic behavior induced by PG D2 in rats. | 1987 | Pharmacol. Biochem. Behav. | pmid:2883669 |
Westcott JY et al. | Eicosanoids in human ventricular cerebrospinal fluid following severe brain injury. | 1987 | Prostaglandins | pmid:2835791 |
Goh Y et al. | Content and formation of prostaglandins and distribution of prostaglandin-related enzyme activities in the rat ocular system. | 1987 | Biochim. Biophys. Acta | pmid:3477292 |
Brown MS et al. | Arachidonic acid metabolites during nasal challenge. | 1987 | Arch. Otolaryngol. Head Neck Surg. | pmid:3099812 |
Chiabrando C et al. | Prostaglandin and thromboxane synthesis by M5076 ovarian reticulosarcoma during growth: effects of a thromboxane synthetase inhibitor. | 1987 | Cancer Res. | pmid:3100032 |
Bhattacharya SK and Parmar SS | Prostaglandin D2 inhibits pentylenetetrazole-induced convulsions in rats by a serotonin-mediated mechanism. | 1987 | Pharm. Res. | pmid:2977646 |
Anton RF and Randall CL | Central nervous system prostaglandins and ethanol. | 1987 | Alcohol. Clin. Exp. Res. | pmid:3105343 |
Santoro MG et al. | PGJ2, a new antiviral prostaglandin: inhibition of Sendai virus replication and alteration of virus protein synthesis. | 1987 | J. Gen. Virol. | pmid:3033130 |
Levi-Schaffer F et al. | Mouse bone marrow-derived mast cells cocultured with fibroblasts. Morphology and stimulation-induced release of histamine, leukotriene B4, leukotriene C4, and prostaglandin D2. | 1987 | J. Immunol. | pmid:2445814 |
Kozuka T et al. | Prostaglandin D2 release by guinea pig skin during in vitro anaphylaxis induced by antigen and compound 48/80. | 1987 | J. Invest. Dermatol. | pmid:2433354 |
Weinreich D and Undem BJ | Immunological regulation of synaptic transmission in isolated guinea pig autonomic ganglia. | 1987 | J. Clin. Invest. | pmid:2437156 |
Abdel-Malek ZA et al. | In vitro modulation of proliferation and melanization of S91 melanoma cells by prostaglandins. | 1987 | Cancer Res. | pmid:2438034 |
Bushfield M et al. | Effects of protein kinase C activation on human platelet cyclic AMP metabolism. | 1987 | FEBS Lett. | pmid:2820806 |
Underwood DC et al. | Blockade of thromboxane responses in the airway of the cat by SQ 29,548. | 1987 | J. Appl. Physiol. | pmid:2440845 |
Levi-Schaffer F et al. | Co-culture of human lung-derived mast cells with mouse 3T3 fibroblasts: morphology and IgE-mediated release of histamine, prostaglandin D2, and leukotrienes. | 1987 | J. Immunol. | pmid:2439587 |
Leung KB et al. | Some further properties of human pulmonary mast cells recovered by bronchoalveolar lavage and enzymic dispersion of lung tissue. | 1987 | Agents Actions | pmid:2440274 |
Church MK et al. | Non-IgE-dependent bacteria-induced histamine release from human lung and tonsillar mast cells. | 1987 | Clin. Allergy | pmid:2441900 |
Kosaka Y et al. | Oxatomide inhibits the release of bronchoconstrictor arachidonic acid metabolites (iLTC4 and PGD2) from rat mast cells and guinea-pig lung. | 1987 | Agents Actions | pmid:2442981 |
Pipkorn U et al. | Effect of short-term systemic glucocorticoid treatment on human nasal mediator release after antigen challenge. | 1987 | J. Clin. Invest. | pmid:2443539 |
Rodriguez R et al. | Effect of nimodipine on arachidonic acid metabolites after subarachnoid hemorrhage. | 1987 | Acta Neurol. Scand. | pmid:3120489 |
Tilden SJ et al. | Effects of OKY 1581 on bronchoconstrictor responses to arachidonic acid and PGH2. | 1987 | J. Appl. Physiol. | pmid:2954941 |
Foreman D et al. | Effects of E2 levuglandins on the contractile activity of the rat uterus. | 1987 | Prostaglandins | pmid:3317517 |
Suzuki F et al. | Methyl ester of prostaglandin D2 as a delivery system of prostaglandin D2 into brain. | 1987 | Biochim. Biophys. Acta | pmid:3467795 |
Richelsen B | Relationship between binding and action of different prostaglandins in rat adipocytes with special reference to PGE2 and PGI2. | 1987 | Biochem. Pharmacol. | pmid:2825710 |
Hayashi H et al. | Metabolism of prostaglandin D2 in isolated rat lung: the stereospecific formation of 9 alpha,11 beta-prostaglandin F2 from prostaglandin D2. | 1987 | Biochim. Biophys. Acta | pmid:3467796 |
Drummond WH and Carter RL | Cardiac depressant and circulatory effects of prostaglandin D2 in developing lambs. | 1987 | Am. J. Physiol. | pmid:3468806 |
Burgess JR et al. | Enzymatic transformation of PGH2 to PGF2 alpha catalyzed by glutathione S-transferases. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3468949 |
Beasley CR et al. | 9 alpha,11 beta-prostaglandin F2, a novel metabolite of prostaglandin D2 is a potent contractile agonist of human and guinea pig airways. | 1987 | J. Clin. Invest. | pmid:3469218 |
Kikuchi Y et al. | Inhibitory effects of neuroendocrine hormones on human ovarian cancer cell proliferation in vitro. | 1987 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:3479504 |
Stier CT et al. | Renal response to 9 alpha, 11 beta-prostaglandin F2 in the rat. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3479549 |
Amano N | [Effects of anesthesia and various types of stress on prostaglandin D2 (PGD2) contents in brain and plasma levels of stress hormones in rats]. | 1987 | Masui | pmid:3480360 |
Brunelli G et al. | PGD2 induces pulmonary hyperresponsiveness to acetylcholine in vivo in the guinea-pig. | 1987 | J Auton Pharmacol | pmid:3480891 |
Weinreich D and Wonderlin WF | Inhibition of calcium-dependent spike after-hyperpolarization increases excitability of rabbit visceral sensory neurones. | 1987 | J. Physiol. (Lond.) | pmid:3481834 |
Nakamura M et al. | In vivo effects of prostaglandins on human retinoblastoma cells in nude mice. | 1987 | Jpn. J. Ophthalmol. | pmid:3482290 |
Yatomi A et al. | Prostaglandins affect the central nervous system to produce hyperglycemia in rats. | 1987 | Endocrinology | pmid:3474143 |
Hanasaki K et al. | Beta 2-adrenergic regulation of prostaglandin D2 receptor in rabbit platelets. | 1987 | Biochim. Biophys. Acta | pmid:2880608 |
Holgate ST et al. | Primary and secondary effector cells in the pathogenesis of bronchial asthma. | 1987 | Int. Arch. Allergy Appl. Immunol. | pmid:3553030 |
Rao PS et al. | Dose-dependent effects of prostaglandin D2 on hemodynamics, renal function, and blood gas analyses. | 1987 | Am. J. Obstet. Gynecol. | pmid:3555078 |
Kinoshita T et al. | Predominance of prostaglandin D2 and I2 in the rat gastric mucosa--analysis by high-performance liquid chromatography. | 1987 | Biochem. Int. | pmid:3555501 |
Matsuura H and Imaya H | [Effect of prostaglandin (delta 12-PGJ2) on host immunity--an experimental study]. | 1987 | Gan To Kagaku Ryoho | pmid:3592721 |
Shimojima T et al. | [Effects of prostaglandins on superoxide production by human polymorphonuclear leukocytes]. | 1987 | Nihon Shishubyo Gakkai Kaishi | pmid:2851629 |