Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Imashuku S et al. | Tumor differentiation--application of prostaglandins in the treatment of neuroblastoma. | 1985 | Prog. Clin. Biol. Res. | pmid:2986176 |
Makino S | [Physiological and pharmacological actions of prostaglandins and related substances: inflammation and allergy]. | 1985 | Nippon Rinsho | pmid:2989584 |
Siegl AM and Daly JW | Receptor (norepinephrine), P-site (2',5'-dideoxyadenosine), and calcium-mediated inhibition of prostaglandin and forskolin-activated cyclic AMP-generating systems in human platelets. | 1985 | J Cyclic Nucleotide Protein Phosphor Res | pmid:2991349 |
Hall TJ et al. | Decreased natural killer cell activity in atopic eczema. | 1985 | Immunology | pmid:3876984 |
Förstermann U et al. | Studies on the mechanism of central cardiovascular and temperature responses to prostaglandin D2. | 1985 | Prostaglandins Leukot Med | pmid:2991946 |
Hamid S and Whittle BJ | Interaction of prostaglandin D2 with prostacyclin, carbacyclin and the hydantoin prostaglandin, BW245C, in guinea-pig platelets. | 1985 | Br. J. Pharmacol. | pmid:2992652 |
Narumiya S and Toda N | Different responsiveness of prostaglandin D2-sensitive systems to prostaglandin D2 and its analogues. | 1985 | Br. J. Pharmacol. | pmid:2992661 |
Thompson NT and Scrutton MC | Intracellular calcium fluxes in human platelets. | 1985 | Eur. J. Biochem. | pmid:3918866 |
Kimura H et al. | Modulatory effects of prostaglandin D2, E2 and F2 alpha on the postsynaptic actions of inhibitory and excitatory amino acids in cerebellar Purkinje cell dendrites in vitro. | 1985 | Brain Res. | pmid:2859088 |
Urade Y et al. | Purification and characterization of rat brain prostaglandin D synthetase. | 1985 | J. Biol. Chem. | pmid:3930495 |
Kiyomiya K and Oh-ishi S | Involvement of arachidonic acid metabolites in acute inflammation: detection of 6-keto-PGF1 alpha, thromboxane B2 and PGD2 in rat pleurisy induced by phorbol myristate acetate. | 1985 | Jpn. J. Pharmacol. | pmid:3936958 |
Campbell WB and Gomez-Sanchez CE | Absence of prostacyclin involvement in angiotensin-induced aldosterone secretion in rat adrenal cells. | 1985 | Endocrinology | pmid:3924581 |
Lewis RA et al. | Pharmacologic regulation of mediator generation and release from the murine bone marrow derived mast cell. | 1985 | Int. Arch. Allergy Appl. Immunol. | pmid:2409010 |
Norman PS et al. | Mediator release after allergic and physical nasal challenges. | 1985 | Int. Arch. Allergy Appl. Immunol. | pmid:2409027 |
Majewska MD and Chuang DM | Benzodiazepines enhance the muscimol-dependent activation of phospholipase A2 in glioma C6 cells. | 1985 | J. Pharmacol. Exp. Ther. | pmid:2857784 |
Robin JL et al. | Regulation of mediator release from mouse bone marrow-derived mast cells by glucocorticoids. | 1985 | J. Immunol. | pmid:3161947 |
Holgate ST et al. | The release and role of inflammatory mediators in asthma. | 1985 | Clin Immunol Rev | pmid:2417772 |
Beatty CH et al. | Metabolism of arachidonic acid by macaque platelets. Implications for studies on atherosclerosis. | 1985 | Atherosclerosis | pmid:3924062 |
Baud L et al. | Lipoxygenase products mediate the attachment of rat macrophages to glomeruli in vitro. | 1985 | Kidney Int. | pmid:3927056 |
Armstrong RA et al. | Competitive antagonism at thromboxane receptors in human platelets. | 1985 | Br. J. Pharmacol. | pmid:2580580 |
Hollingsworth EB and Patrick GA | The effects produced by prostaglandin D2 on serotonin turnover and release and tryptophan uptake. | 1985 | Pharmacol. Biochem. Behav. | pmid:2581275 |
Fox CC et al. | Isolation and characterization of human intestinal mucosal mast cells. | 1985 | J. Immunol. | pmid:2582045 |
Naclerio RM et al. | Inflammatory mediators in late antigen-induced rhinitis. | 1985 | N. Engl. J. Med. | pmid:2582257 |
Westcott JY and Murphy RC | Effect of alcohols on arachidonic acid metabolism in murine mastocytoma cells and human polymorphonuclear leukocytes. | 1985 | Biochim. Biophys. Acta | pmid:2982416 |
Bhattacharya SK et al. | Prostaglandin D2 mediated specific increase in rat brain serotonin. | 1985 | Proc. West. Pharmacol. Soc. | pmid:3865228 |
Walenga RW et al. | Re-examination of the assay for plasma prostanoids by solid-phase extraction, and radioimmunoassay. | 1985 | Prostaglandins Leukot Med | pmid:3865240 |
Okuyama S et al. | Redifferentiation of cancer cells: bestatin, estradiol, and prostaglandin D2. | 1985 | Ann. N. Y. Acad. Sci. | pmid:3868328 |
Okuyama S and Mishina H | Principia of cancer therapy. X. Prostaglandin D2 triggers redifferentiation of the bestatin-treated breast cancer cells in vitro. | 1985 | Sci Rep Res Inst Tohoku Univ Med | pmid:3870142 |
Okuyama S and Mishina H | Principia of cancer therapy. XI. Prostaglandin D2 induces redifferentiation of M1 leukemia cells in vitro irrespective of bestatin. | 1985 | Sci Rep Res Inst Tohoku Univ Med | pmid:3870143 |
Murray JJ et al. | Prostaglandin D2 is released during acute allergic bronchospasm in man. | 1985 | Trans. Assoc. Am. Physicians | pmid:3870298 |
Kasukabe T et al. | Specific inhibition by prostaglandin D2 and its metabolites of lysozyme synthesis in mouse macrophage-like cell line, Mm-1. | 1985 | Biochim. Biophys. Acta | pmid:3855662 |
Narumiya S and Fukushima M | delta 12-Prostaglandin J2, an ultimate metabolite of prostaglandin D2 exerting cell growth inhibition. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3857041 |
Abbate R et al. | Decreased number of PGD2 binding sites on platelets from patients with type IIa hyperlipoproteinemia. | 1985 | Atherosclerosis | pmid:3857047 |
Watanabe K et al. | Enzymatic formation of prostaglandin F2 alpha from prostaglandin H2 and D2. Purification and properties of prostaglandin F synthetase from bovine lung. | 1985 | J. Biol. Chem. | pmid:3858278 |
Gause GE et al. | Hemodynamic effects of postpulmonary administration of prostaglandin D2 in fetal animals. | 1985 | Proc. Soc. Exp. Biol. Med. | pmid:3858885 |
Seregi A et al. | The formation and regional distribution of prostaglandins D2 and F2 alpha in the brain of spontaneously convulsing gerbils. | 1985 | Brain Res. | pmid:3859353 |
Ikai K et al. | Effect of ultraviolet irradiation on mast cell-deficient W/Wv mice. | 1985 | J. Invest. Dermatol. | pmid:3859552 |
Knepel W et al. | Inhibition by prostaglandin E2 of the release of vasopressin and beta-endorphin from rat pituitary neurointermediate lobe or medial basal hypothalamus in vitro. | 1985 | J. Endocrinol. | pmid:3160802 |
Weinreb RN et al. | Prostanoids in rabbit aqueous humor: effect of laser photocoagulation of the iris. | 1985 | Invest. Ophthalmol. Vis. Sci. | pmid:3860488 |
Nielsen JA and Sparber SB | Central administration of prostaglandin E2 facilitates while F2 alpha attenuates acute dependence upon morphine rats. | 1985 | Pharmacol. Biochem. Behav. | pmid:3860881 |
Rajtar G et al. | Prostaglandins and human platelet aggregation. Implications for the anti-aggregating activity of thromboxane-synthase inhibitors. | 1985 | Biochem. Pharmacol. | pmid:3918536 |
Mendieta CF et al. | Biosynthesis of prostaglandins in gingiva of patients with chronic periodontitis. | 1985 | J. Periodontol. | pmid:3919173 |
Robinson C and Holgate ST | Mast cell-dependent inflammatory mediators and their putative role in bronchial asthma. | 1985 | Clin. Sci. | pmid:2981650 |
Fortini A et al. | Heparin does not interfere with prostacyclin and prostaglandin D2 binding to platelets. | 1985 | Thromb. Res. | pmid:3001968 |
Wasserman SI | The mast cell and theophylline in asthma. | 1985 | Am. J. Med. | pmid:3002176 |
Bushfield M et al. | Inhibition of platelet-activating-factor-induced human platelet activation by prostaglandin D2. Differential sensitivity of platelet transduction processes and functional responses to inhibition by cyclic AMP. | 1985 | Biochem. J. | pmid:3002327 |
Ichikawa A et al. | Up-regulation of prostaglandin D2 receptors by agonist binding to beta-adrenoceptors in rabbit platelets. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3004152 |
Pugliese G et al. | Hepatic transformation of prostaglandin D2 to a new prostanoid, 9 alpha,11 beta-prostaglandin F2, that inhibits platelet aggregation and constricts blood vessels. | 1985 | J. Biol. Chem. | pmid:3863819 |
Gay SW and Kosher RA | Prostaglandin synthesis during the course of limb cartilage differentiation in vitro. | 1985 | J Embryol Exp Morphol | pmid:3867724 |
Ueno R et al. | Changes of enzymes involved in prostaglandin metabolism and prostaglandin binding proteins in rat brain during development and aging. | 1985 | J. Neurochem. | pmid:3925085 |