Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Lefils-Lacourtablaise J et al. | The eicosapentaenoic acid metabolite 15-deoxy-δ(12,14)-prostaglandin J3 increases adiponectin secretion by adipocytes partly via a PPARγ-dependent mechanism. | 2013 | PLoS ONE | pmid:23734181 |
Rank MA et al. | Systemic reactions to allergen immunotherapy: a role for measuring a PGD2 metabolite? | 2013 | Ann. Allergy Asthma Immunol. | pmid:23244662 |
Ramer R et al. | COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells. | 2013 | Mol. Cancer Ther. | pmid:23220503 |
Sato A et al. | Synthesis and evaluation of 2,3-dinorprostaglandins: Dinor-PGD1 and 13-epi-dinor-PGD1 are peroxisome proliferator-activated receptor α/γ dual agonists. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23566516 |
Yazid S et al. | Anti-allergic cromones inhibit histamine and eicosanoid release from activated human and murine mast cells by releasing Annexin A1. | 2013 | PLoS ONE | pmid:23527056 |
Ayabe S et al. | Prostaglandin D2 inhibits collagen secretion from lung fibroblasts by activating the DP receptor. | 2013 | J. Pharmacol. Sci. | pmid:23538675 |
Xu X et al. | Identification of 15d-PGJ2 as an antagonist of farnesoid X receptor: molecular modeling with biological evaluation. | 2013 | Steroids | pmid:23707573 |
Kuriyan AE et al. | Orbital fibroblasts from thyroid eye disease patients differ in proliferative and adipogenic responses depending on disease subtype. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:24135759 |
Tofield A | Niacin and statin intolerable for some people. | 2013 | Eur. Heart J. | pmid:24137778 |
Juman S et al. | Effects of long-term oral administration of arachidonic acid and docosahexaenoic acid on the immune functions of young rats. | 2013 | Nutrients | pmid:23760060 |