PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nojima H et al. | Arachidonic acid and prostaglandin D2 cooperatively accelerate desensitization of nicotinic acetylcholine receptor channel in mouse skeletal muscles. | 2000 | Brain Res. | pmid:10661520 |
| Galli A et al. | Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells. | 2000 | Hepatology | pmid:10613734 |
| Kuwamoto K et al. | Possible involvement of enhanced prostaglandin E2 production in the photosensitivity in xeroderma pigmentosum group A model mice. | 2000 | J. Invest. Dermatol. | pmid:10651981 |
| Faveeuw C et al. | Peroxisome proliferator-activated receptor gamma activators inhibit interleukin-12 production in murine dendritic cells. | 2000 | FEBS Lett. | pmid:11119715 |
| Padilla J et al. | Peroxisome proliferator activator receptor-gamma agonists and 15-deoxy-Delta(12,14)(12,14)-PGJ(2) induce apoptosis in normal and malignant B-lineage cells. | 2000 | J. Immunol. | pmid:11120820 |
| Sharif NA et al. | Pharmacology and autoradiography of human DP prostanoid receptors using [(3)H]-BWA868C, a DP receptor-selective antagonist radioligand. | 2000 | Br. J. Pharmacol. | pmid:11082108 |
| Hortelano S et al. | Contribution of cyclopentenone prostaglandins to the resolution of inflammation through the potentiation of apoptosis in activated macrophages. | 2000 | J. Immunol. | pmid:11086094 |
| Fukushima S et al. | Preparation and evaluation of o/w type emulsions containing antitumor prostaglandin. | 2000 | Adv. Drug Deliv. Rev. | pmid:11104898 |
| Honma S et al. | Effects of naturally-occurring acid fog on inflammatory mediators in airway and pulmonary functions in asthmatic patients. | 2000 | Respir Med | pmid:11059945 |
| Kershenovich A et al. | Angiotensin II does not mediate the pressor response to PGD2 (icv). | 2000 | J Renin Angiotensin Aldosterone Syst | pmid:11967813 |
| Maggi LB et al. | Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression. | 2000 | Diabetes | pmid:10868955 |
| Abdelaziz MM et al. | The potential of active metabolites of antihistamines in the management of allergic disease. | 2000 | Allergy | pmid:10843422 |
| Norwitz ER and Wilson T | Secretory component: a potential regulator of endometrial-decidual prostaglandin production in early human pregnancy. | 2000 | Am. J. Obstet. Gynecol. | pmid:10920317 |
| Yoshida Y et al. | Prostaglandin E (EP) receptor subtypes and sleep: promotion by EP4 and inhibition by EP1/EP2. | 2000 | Neuroreport | pmid:10923657 |
| Marra F et al. | Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells. | 2000 | Gastroenterology | pmid:10930382 |
| Ikeda Y et al. | Suppression of rat thromboxane synthase gene transcription by peroxisome proliferator-activated receptor gamma in macrophages via an interaction with NRF2. | 2000 | J. Biol. Chem. | pmid:10930400 |
| Kitatani K et al. | Role of phospholipase D-derived phosphatidic acid as a substrate for phospholipase A2 in RBL-2H3 cells. | 2000 | Biol. Pharm. Bull. | pmid:11145171 |
| Furutani K et al. | Substance P- and antigen-induced release of leukotriene B4, prostaglandin D2 and histamine from guinea pig skin by different mechanisms in vitro. | 1999 Jul-Aug | Arch. Dermatol. Res. | pmid:10482019 |
| Thornhill J and Asselin J | Temperature and hemodynamic changes associated with increased neural damage to global hemispheric hypoxic ischemia by prior prostaglandin E2, D2 and F2alpha administration. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10574644 |
| Tokuda H et al. | Prostaglandin D2 induces interleukin-6 synthesis via Ca2+ mobilization in osteoblasts: regulation by protein kinase C. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10582659 |
| Uehara Y | [Prostaglandin D2]. | 1999 | Nippon Rinsho | pmid:10635955 |
| Graf BA et al. | Biphenotypic B/macrophage cells express COX-1 and up-regulate COX-2 expression and prostaglandin E(2) production in response to pro-inflammatory signals. | 1999 | Eur. J. Immunol. | pmid:10556836 |
| Petersen LJ and Skov PS | The effect of salmeterol and salbutamol on mediator release and skin responses in immediate and late phase allergic cutaneous reactions. | 1999 | Inflamm. Res. | pmid:10563469 |
| Wise H | Characterization of chimeric prostacyclin/prostaglandin D(2) receptors. | 1999 | Eur. J. Pharmacol. | pmid:10611468 |
| Lin Q et al. | Ligand selectivity of the peroxisome proliferator-activated receptor alpha. | 1999 | Biochemistry | pmid:9890897 |
| Vaidya S et al. | 15-Deoxy-Delta12,1412,14-prostaglandin J2 inhibits the beta2 integrin-dependent oxidative burst: involvement of a mechanism distinct from peroxisome proliferator-activated receptor gamma ligation. | 1999 | J. Immunol. | pmid:10570310 |
| Chou TC and Li CY | Inhibitory mechanisms of dantrolene on platelet aggregation. | 1999 | Thromb. Res. | pmid:10593433 |
| Sarraf P et al. | Loss-of-function mutations in PPAR gamma associated with human colon cancer. | 1999 | Mol. Cell | pmid:10394368 |
| Jang MK et al. | Regulation of ferritin light chain gene expression by oxidized low-density lipoproteins in human monocytic THP-1 cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10558912 |
| Heneka MT et al. | Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric oxide synthase. | 1999 | J. Neuroimmunol. | pmid:10695726 |
| Herschman HR | Function and regulation of prostaglandin synthase 2. | 1999 | Adv. Exp. Med. Biol. | pmid:10667302 |
| Murakami M et al. | Regulation of prostaglandin, leukotriene, and platelet-activating factor metabolism in mast cells. | 1999 | Adv. Exp. Med. Biol. | pmid:10667307 |
| Charpigny G et al. | Correlation of increased concentration of ovine endometrial cyclooxygenase 2 with the increase in PGE2 and PGD2 in the late luteal phase. | 1999 | J. Reprod. Fertil. | pmid:10690199 |
| Satoh H et al. | Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARgamma on vascular endothelial function. | 1999 | Biochem. Biophys. Res. Commun. | pmid:9920814 |
| Conti C et al. | Antiviral effect of hyperthermic treatment in rhinovirus infection. | 1999 | Antimicrob. Agents Chemother. | pmid:10103186 |
| Shichijo M et al. | Role of cyclic 3',5'-adenosine monophosphate in the regulation of chemical mediator release and cytokine production from cultured human mast cells. | 1999 | J. Allergy Clin. Immunol. | pmid:10329844 |
| Eguchi N et al. | Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9892701 |
| Cordoba-Rodriguez R et al. | Calcium regulation of a slow post-spike hyperpolarization in vagal afferent neurons. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393875 |
| Bishop-Bailey D and Hla T | Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-Delta12, 14-prostaglandin J2. | 1999 | J. Biol. Chem. | pmid:10358055 |
| Mita H et al. | Generation of thromboxane A2 from highly purified human sinus mast cells after immunological stimulation. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10359019 |
| Gilroy DW et al. | Inducible cyclooxygenase may have anti-inflammatory properties. | 1999 | Nat. Med. | pmid:10371510 |
| Kwon G et al. | Tumor necrosis factor alpha-induced pancreatic beta-cell insulin resistance is mediated by nitric oxide and prevented by 15-deoxy-Delta12,14-prostaglandin J2 and aminoguanidine. A role for peroxisome proliferator-activated receptor gamma activation and inos expression. | 1999 | J. Biol. Chem. | pmid:10373483 |
| Herbertsson H et al. | The 650-kDa 12(S)-hydroxyeicosatetraenoic acid binding complex: occurrence in human platelets, identification of hsp90 as a constituent, and binding properties of its 50-kDa subunit. | 1999 | Arch. Biochem. Biophys. | pmid:10375396 |
| Sinha D et al. | 15-Deoxy-delta(12,14) prostaglandin J2: a putative endogenous promoter of adipogenesis suppresses the ob gene. | 1999 | Metab. Clin. Exp. | pmid:10381155 |
| O'Sullivan S et al. | Analyses of prostaglandin D2 metabolites in urine: comparison between enzyme immunoassay and negative ion chemical ionisation gas chromatography-mass spectrometry. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10410385 |
| Satoh T et al. | Prostaglandin J2 and its metabolites promote neurite outgrowth induced by nerve growth factor in PC12 cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10222233 |
| Goetze S et al. | PPAR gamma-ligands inhibit migration mediated by multiple chemoattractants in vascular smooth muscle cells. | 1999 | J. Cardiovasc. Pharmacol. | pmid:10226869 |
| Kitamura Y et al. | Activators of peroxisome proliferator-activated receptor-gamma (PPARgamma) inhibit inducible nitric oxide synthase expression but increase heme oxygenase-1 expression in rat glial cells. | 1999 | Neurosci. Lett. | pmid:10203248 |
| Rouaud C et al. | The cyclo-oxygenase-dependent regulation of rabbit vein contraction: evidence for a prostaglandin E2-mediated relaxation. | 1999 | Br. J. Pharmacol. | pmid:10051118 |
| Makker HK et al. | Airway endothelin levels in asthma: influence of endobronchial hypertonic saline challenge. | 1999 | Clin. Exp. Allergy | pmid:10051729 |
| Marx N et al. | PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10073956 |
| Walch L et al. | Prostanoid receptors involved in the relaxation of human pulmonary vessels. | 1999 | Br. J. Pharmacol. | pmid:10193765 |
| Norel X et al. | Prostanoid receptors involved in the relaxation of human bronchial preparations. | 1999 | Br. J. Pharmacol. | pmid:10193766 |
| Chen Y et al. | Formation of reactive cyclopentenone compounds in vivo as products of the isoprostane pathway. | 1999 | J. Biol. Chem. | pmid:10196163 |
| Koro O et al. | Chemical mediators in atopic dermatitis: involvement of leukotriene B4 released by a type I allergic reaction in the pathogenesis of atopic dermatitis. | 1999 | J. Allergy Clin. Immunol. | pmid:10200017 |
| Petrova TV et al. | Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10200320 |
| Brambilla R et al. | Cyclo-oxygenase-2 mediates P2Y receptor-induced reactive astrogliosis. | 1999 | Br. J. Pharmacol. | pmid:10188963 |
| Xin X et al. | Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo. | 1999 | J. Biol. Chem. | pmid:10085162 |
| Asano M et al. | Troglitazone and pioglitazone attenuate agonist-dependent Ca2+ mobilization and cell proliferation in vascular smooth muscle cells. | 1999 | Br. J. Pharmacol. | pmid:10516648 |
| Alvarez-Dolado M et al. | Retinoic acid and 1,25-dihydroxyvitamin D3 inhibit tenascin-C expression in rat glioma C6 cells. | 1999 | J. Neurosci. Res. | pmid:10502285 |
| Jackson SM et al. | Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10479650 |
| Sawada H et al. | Regulation of type V phospholipase A2 expression and function by proinflammatory stimuli. | 1999 | Eur. J. Biochem. | pmid:10469147 |
| Keelan JA et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2), a ligand for peroxisome proliferator-activated receptor-gamma, induces apoptosis in JEG3 choriocarcinoma cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10471366 |
| Pucci ML et al. | Cloning of mouse prostaglandin transporter PGT cDNA: species-specific substrate affinities. | 1999 | Am. J. Physiol. | pmid:10484490 |
| Santos J et al. | Characterisation of immune mediator release during the immediate response to segmental mucosal challenge in the jejunum of patients with food allergy. | 1999 | Gut | pmid:10486364 |
| Anderson LE et al. | Prostaglandin moieties that determine receptor binding specificity in the bovine corpus luteum. | 1999 | J. Reprod. Fertil. | pmid:10505064 |
| Clay CE et al. | Influence of J series prostaglandins on apoptosis and tumorigenesis of breast cancer cells. | 1999 | Carcinogenesis | pmid:10506103 |
| Valmaseda A et al. | Opposite regulation of PPAR-alpha and -gamma gene expression by both their ligands and retinoic acid in brown adipocytes. | 1999 | Mol. Cell. Endocrinol. | pmid:10509805 |
| Reddy ST et al. | Genetic evidence for distinct roles of COX-1 and COX-2 in the immediate and delayed phases of prostaglandin synthesis in mast cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10548515 |
| Stillman BA et al. | Importance of the extracellular domain for prostaglandin EP(2) receptor function. | 1999 | Mol. Pharmacol. | pmid:10462542 |
| Wright DH et al. | A novel biological role for prostaglandin D2 is suggested by distribution studies of the rat DP prostanoid receptor. | 1999 | Eur. J. Pharmacol. | pmid:10448933 |
| Su CG et al. | A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response. | 1999 | J. Clin. Invest. | pmid:10449430 |
| Miadonna A et al. | Nasal response to a single antigen challenge in patients with allergic rhinitis - inflammatory cell recruitment persists up to 48 hours. | 1999 | Clin. Exp. Allergy | pmid:10383595 |
| Hayaishi O | Prostaglandin D2 and sleep--a molecular genetic approach. | 1999 | J Sleep Res | pmid:10389108 |
| Salińska E et al. | Role of Ca2+ release from ryanodine stores in generation of NMDA-induced Ca2+ signal in rabbit hippocampus. | 1999 | Ross Fiziol Zh Im I M Sechenova | pmid:10389178 |
| Pelton PD et al. | PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10425206 |
| Chinery R et al. | Prostaglandin J2 and 15-deoxy-delta12,14-prostaglandin J2 induce proliferation of cyclooxygenase-depleted colorectal cancer cells. | 1999 | Cancer Res. | pmid:10364000 |
| Crider JY et al. | Prostaglandin DP receptors positively coupled to adenylyl cyclase in embryonic bovine tracheal (EBTr) cells: pharmacological characterization using agonists and antagonists. | 1999 | Br. J. Pharmacol. | pmid:10369474 |
| Chan CL and Lau HY | Prostanoid DP receptor activation inhibits anti-IgE induced histamine release from rat peritoneal mast cells. | 1999 | Inflamm. Res. | pmid:10350148 |
| Urade Y and Hayaishi O | Prostaglandin D2 and sleep regulation. | 1999 | Biochim. Biophys. Acta | pmid:9989291 |
| Sakamoto H et al. | Effect of intracellular glutathione on the production of prostaglandin D2 in RBL-2H3 cells oxidized by tert-butyl hydroperoxide. | 1999 | J. Biochem. | pmid:9880802 |
| Obata T et al. | Eicosapentaenoic acid inhibits prostaglandin D2 generation by inhibiting cyclo-oxygenase-2 in cultured human mast cells. | 1999 | Clin. Exp. Allergy | pmid:10457118 |
| Ricote M et al. | The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. | 1998 | Nature | pmid:9422508 |
| Jiang C et al. | PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. | 1998 | Nature | pmid:9422509 |
| Tan W et al. | Modulation of nicotinic AChR channels by prostaglandin E2 in chick sympathetic ganglion neurons. | 1998 | J. Neurophysiol. | pmid:9463448 |
| Nagoshi H et al. | Prostaglandin D2 inhibits inducible nitric oxide synthase expression in rat vascular smooth muscle cells. | 1998 | Circ. Res. | pmid:9468191 |
| Gambero A and Gomes JC | Pharmacological antagonism of Anchietia salutaris extracts on the contraction induced by prostaglandin D2 and U46619 in guinea-pig lung parenchymal strips. | 1998 | J. Pharm. Pharmacol. | pmid:9877316 |
| Gao T et al. | Arachidonic acid metabolism to prostaglandin E2, D2, F2alpha, and I2 in the plerocercoid of Spirometra erinaceieuropaei. | 1998 | J. Parasitol. | pmid:9920298 |
| Ohtani-Fujita N et al. | p53-Independent activation of the gadd45 promoter by Delta12-prostaglandin J2. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9792828 |
| Tada K et al. | Induction of cyclooxygenase-2 by secretory phospholipases A2 in nerve growth factor-stimulated rat serosal mast cells is facilitated by interaction with fibroblasts and mediated by a mechanism independent of their enzymatic functions. | 1998 | J. Immunol. | pmid:9794438 |
| Arakida Y et al. | In vitro pharmacologic profile of YM158, a new dual antagonist for LTD4 and TXA2 receptors. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9808690 |
| Madhu C et al. | Penetration of natural prostaglandins and their ester prodrugs and analogs across human ocular tissues in vitro. | 1998 | J Ocul Pharmacol Ther | pmid:9811228 |
| Szczeklik A et al. | Salmeterol prevents aspirin-induced attacks of asthma and interferes with eicosanoid metabolism. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9769277 |
| Ikai K et al. | Induction of apoptosis, p53 and heme oxygenase-1 by cytotoxic prostaglandin delta12-PGJ2 in transformed endothelial cells. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654403 |
| Rosenbaum SE and Greenberg AS | The short- and long-term effects of tumor necrosis factor-alpha and BRL 49653 on peroxisome proliferator-activated receptor (PPAR)gamma2 gene expression and other adipocyte genes. | 1998 | Mol. Endocrinol. | pmid:9717841 |
| Yoshida T et al. | Inhibitory effects of prostaglandin D2 against the proliferation of human colon cancer cell lines and hepatic metastasis from colorectal cancer. | 1998 | Surg. Today | pmid:9697269 |
| Terao A et al. | Interleukin-1 induces slow-wave sleep at the prostaglandin D2-sensitive sleep-promoting zone in the rat brain. | 1998 | J. Neurosci. | pmid:9698346 |
| Scammell T et al. | Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9636223 |
| Moon TC et al. | Regulation of cyclooxygenase-2 and endogenous cytokine expression by bacterial lipopolysaccharide that acts in synergy with c-kit ligand and Fc epsilon receptor I crosslinking in cultured mast cells. | 1998 | Cell. Immunol. | pmid:9636692 |
| Iijima K et al. | Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in rat aortic smooth muscle cells. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9642130 |