PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| el-Lati SG et al. | Complement peptides C3a- and C5a-induced mediator release from dissociated human skin mast cells. | 1994 | J. Invest. Dermatol. | pmid:7513741 |
| Warren JB et al. | PGD2 is an intermediate in agonist-stimulated nitric oxide release in rabbit skin microcirculation. | 1994 | Am. J. Physiol. | pmid:7515584 |
| D'Onofrio C et al. | Antiproliferative activity of cyclopentenone prostaglandins in early HTLV-1 infection is independent of IL-2 and is associated with HSP70 induction. | 1994 | Leukemia | pmid:7516027 |
| Okayama Y et al. | In vitro effects of H1-antihistamines on histamine and PGD2 release from mast cells of human lung, tonsil, and skin. | 1994 | Allergy | pmid:7518654 |
| Darius H et al. | Inhibition of human platelets and polymorphonuclear neutrophils by the potent and metabolically stable prostaglandin D2 analog ZK 118.182. | 1994 | Eur. J. Pharmacol. | pmid:7522176 |
| Polosa R et al. | [Mast cell mediator release after endobronchial challenge with adenosine 5'-monophosphate in asthmatic subjects]. | 1994 Apr-Jun | Ann. Ital. Med. Int. | pmid:7522500 |
| Takei M and Endo K | Histamine release and calcium concentrations in rat mast cells are dependent on intracellular ATP: effects of prostaglandin D2. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7524104 |
| Ko FN et al. | YC-1, a novel activator of platelet guanylate cyclase. | 1994 | Blood | pmid:7527671 |
| Kaye AD et al. | Analysis of thromboxane receptor-mediated responses in the feline pulmonary vascular bed. | 1995 | Crit. Care Med. | pmid:7528116 |
| Patella V et al. | Human heart mast cells. Isolation, purification, ultrastructure, and immunologic characterization. | 1995 | J. Immunol. | pmid:7533185 |
| Crankshaw DJ and Gaspar V | Pharmacological characterization in vitro of prostanoid receptors in the myometrium of nonpregnant ewes. | 1995 | J. Reprod. Fertil. | pmid:7535849 |
| Leal-Berumen I et al. | Prostanoid enhancement of interleukin-6 production by rat peritoneal mast cells. | 1995 | J. Immunol. | pmid:7536779 |
| Parker J et al. | Antiviral effect of cyclopentenone prostaglandins on vesicular stomatitis virus replication. | 1995 | Antiviral Res. | pmid:7537950 |
| Murakami M et al. | The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase. | 1995 | J. Exp. Med. | pmid:7540649 |
| Murakami M et al. | Interleukin 4 suppresses c-kit ligand-induced expression of cytosolic phospholipase A2 and prostaglandin endoperoxide synthase 2 and their roles in separate pathways of eicosanoid synthesis in mouse bone marrow-derived mast cells. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7541141 |
| Marone G et al. | Human heart mast cells in anaphylaxis and cardiovascular disease. | 1995 May-Jun | Int. Arch. Allergy Immunol. | pmid:7542106 |
| Horn EH et al. | Longitudinal studies of platelet cyclic AMP during healthy pregnancy and pregnancies at risk of pre-eclampsia. | 1995 | Clin. Sci. | pmid:7545563 |
| Charlesworth EN | Role of basophils and mast cells in acute and late reactions in the skin. | 1995 | Chem. Immunol. | pmid:7546286 |
| Ko FN et al. | Inhibition on platelet activation by shikonin derivatives isolated from Arnebia euchroma. | 1995 | Biochim. Biophys. Acta | pmid:7548232 |
| Reanmongkol W et al. | Inhibitory effect of alkaloids extracted from the stem bark of Hunteria zeylanica on 5-lipoxygenase activity in vitro. | 1995 | Biol. Pharm. Bull. | pmid:7550132 |
| Negishi M et al. | Involvement of protein kinase in delta 12-prostaglandin J2-induced expression of rat heme oxygenase-1 gene. | 1995 | FEBS Lett. | pmid:7556684 |
| Murakami M et al. | Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells. | 1995 | J. Biol. Chem. | pmid:7559381 |
| Rabe KF et al. | Hydrogen peroxide contracts human airways in vitro: role of epithelium. | 1995 | Am. J. Physiol. | pmid:7573466 |
| Hartmann K et al. | Effect of CC chemokines on mediator release from human skin mast cells and basophils. | 1995 | Int. Arch. Allergy Immunol. | pmid:7580286 |
| De Vries GW et al. | An EP receptor with a novel pharmacological profile in the T-cell line Jurkat. | 1995 | Br. J. Pharmacol. | pmid:7582550 |
| Hespeling U et al. | Feedback-inhibition of glucagon-stimulated glycogenolysis in hepatocyte/Kupffer cell cocultures by glucagon-elicited prostaglandin production in Kupffer cells. | 1995 | Hepatology | pmid:7590678 |
| Murakami M et al. | IgE-dependent activation of cytokine-primed mouse cultured mast cells induces a delayed phase of prostaglandin D2 generation via prostaglandin endoperoxide synthase-2. | 1995 | J. Immunol. | pmid:7594606 |
| Terao A et al. | Roles of prostaglandins D2 and E2 in interleukin-1-induced activation of norepinephrine turnover in the brain and peripheral organs of rats. | 1995 | J. Neurochem. | pmid:7595573 |
| Matsumoto K et al. | Novel function of prostaglandins as inducers of gene expression of HGF and putative mediators of tissue regeneration. | 1995 | J. Biochem. | pmid:7608139 |
| Kawata R et al. | Prostaglandin synthase 1 and prostaglandin synthase 2 both participate in activation-induced prostaglandin D2 production in mast cells. | 1995 | J. Immunol. | pmid:7608559 |
| Peden DB and Dailey L | Modulation of mast cell functions by in vitro ozone exposure. | 1995 | Am. J. Physiol. | pmid:7611432 |
| Serrero G and Lepak NM | Prostaglandin F2 alpha inhibits epidermal growth factor binding to cellular receptors on adipocyte precursors in primary culture. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7626101 |
| Lee JH et al. | Induction of p53 and apoptosis by delta 12-PGJ2 in human hepatocarcinoma SK-HEP-1 cells. | 1995 | FEBS Lett. | pmid:7628635 |
| Ikai K et al. | Effect of cytotoxic prostaglandin, delta 12-prostaglandin J2 on E-cadherin expression in transformed epidermal cells in culture. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7630918 |
| Hu ZQ et al. | An essential role of prostaglandin E on mouse mast cell induction. | 1995 | J. Immunol. | pmid:7636261 |
| Araki M et al. | Isoflurane modulates phorbol myristate acetate-, prostaglandin D2-, and prostaglandin E2-induced alterations in hepatic flow and metabolism in the perfused liver in fasted rats. | 1994 | Anesth. Analg. | pmid:7639362 |
| Boie Y et al. | Molecular cloning and characterization of the human prostanoid DP receptor. | 1995 | J. Biol. Chem. | pmid:7642548 |
| Pandey HP et al. | Circadian variations of prostaglandins D2, E2, and F2 alpha in the cerebrospinal fluid of anesthetized rats. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7646520 |
| Refsnes M et al. | On the mechanisms of the growth-promoting effect of prostaglandins in hepatocytes: the relationship between stimulation of DNA synthesis and signaling mediated by adenylyl cyclase and phosphoinositide-specific phospholipase C. | 1995 | J. Cell. Physiol. | pmid:7650056 |
| Koizumi T et al. | Identification of a cis-regulatory element for delta 12-prostaglandin J2-induced expression of the rat heme oxygenase gene. | 1995 | J. Biol. Chem. | pmid:7665598 |
| Bull HA et al. | Basophil mediator release in atopic dermatitis. | 1993 | J. Invest. Dermatol. | pmid:7680056 |
| Campbell AM et al. | Modulation of eicosanoid and histamine release from human dispersed lung cells by terfenadine. | 1993 | Allergy | pmid:7681268 |
| Campbell AM et al. | Conjunctival provocation tests with codeine phosphate. Effect of disodium cromoglycate. | 1993 | Ann Allergy | pmid:7687104 |
| Charlesworth EN et al. | Cutaneous late-phase response in food-allergic children and adolescents with atopic dermatitis. | 1993 | Clin. Exp. Allergy | pmid:7687509 |
| al-Laith M and Pearce FL | On the mechanism of action of sodium orthovanadate in inducing histamine release from rat peritoneal mast cells. | 1993 | Int. Arch. Allergy Immunol. | pmid:7689004 |
| Marone G et al. | Mechanisms of activation of human mast cells and basophils by general anesthetic drugs. | 1993 | Ann Fr Anesth Reanim | pmid:7690200 |
| Naclerio RM | Effects of antihistamines on inflammatory mediators. | 1993 | Ann Allergy | pmid:7690526 |
| Maxwell DL et al. | Inhaled nedocromil sodium reduces histamine release from isolated large airway segments of asthmatic subjects in vivo. | 1993 | Eur. Respir. J. | pmid:7693506 |
| Satoh S et al. | Promotion of sleep by prostaglandin D2 in rats made insomniac by pretreatment with para-chlorophenylalanine. | 1994 | Neurosci. Res. | pmid:7708292 |
| Leifke E et al. | In vivo comparative study of the seizure- and ischemia-induced synthesis of eicosanoids in the brain of gerbils. | 1994 Sep-Oct | Arch Int Pharmacodyn Ther | pmid:7710301 |
| Downard CD et al. | Topical benzoic acid induces the increased biosynthesis of prostaglandin D2 in human skin in vivo. | 1995 | Clin. Pharmacol. Ther. | pmid:7712673 |
| Georgitis JW et al. | Chronic sinusitis: characterization of cellular influx and inflammatory mediators in sinus lavage fluid. | 1995 | Int. Arch. Allergy Immunol. | pmid:7719157 |
| Parker CW et al. | Modulation of IL-4 production in murine spleen cells by prostaglandins. | 1995 | Cell. Immunol. | pmid:7720090 |
| Brouwer A et al. | Production of eicosanoids and cytokines by Kupffer cells from young and old rats stimulated by endotoxin. | 1995 | Clin. Sci. | pmid:7720347 |
| Rodrigues M et al. | Synergistic antiplatelet action of nitric oxide (NO) with PGD2 and its metabolite PGJ2--relevance for cerebral circulation? | 1994 | J. Physiol. Pharmacol. | pmid:7727795 |
| Butterfield JH et al. | Aspirin idiosyncrasy in systemic mast cell disease: a new look at mediator release during aspirin desensitization. | 1995 | Mayo Clin. Proc. | pmid:7731260 |
| Wang D et al. | Concentrations of chemical mediators in nasal secretions after nasal allergen challenges in atopic patients. | 1995 | Eur Arch Otorhinolaryngol | pmid:7734974 |
| Wood-Baker R et al. | The reproducibility and effect on non-specific airway responsiveness of inhaled prostaglandin D2 and leukotriene D4 in asthmatic subjects. | 1995 | Br J Clin Pharmacol | pmid:7742148 |
| Imamura Y et al. | Mechanism of phospholipase D activation induced by prostaglandin D2 in osteoblast-like cells: function of Ca2+/calmodulin. | 1995 | Cell. Signal. | pmid:7756110 |
| Hashimoto N et al. | Prostanoid secretion by rat hepatic sinusoidal endothelial cells and its regulation by exogenous adenosine triphosphate. | 1995 | Hepatology | pmid:7768516 |
| Pilbeam CC et al. | Autoregulation of inducible prostaglandin G/H synthase in osteoblastic cells by prostaglandins. | 1995 | J. Bone Miner. Res. | pmid:7785462 |
| Johnston SL et al. | Prostaglandin D2-induced bronchoconstriction is mediated only in part by the thromboxane prostanoid receptor. | 1995 | Eur. Respir. J. | pmid:7789486 |
| Guh JH et al. | Antiplatelet effect of gingerol isolated from Zingiber officinale. | 1995 | J. Pharm. Pharmacol. | pmid:7791032 |
| Lanas AI et al. | Non-steroidal anti-inflammatory drugs and prostaglandin effects on pepsinogen secretion by dispersed human peptic cells. | 1995 | Gut | pmid:7797113 |
| Grewe M et al. | Interleukin-10 production by cultured human keratinocytes: regulation by ultraviolet B and ultraviolet A1 radiation. | 1995 | J. Invest. Dermatol. | pmid:7798637 |
| Pons F et al. | Pro-inflammatory and anti-inflammatory effects of the stable prostaglandin D2 analogue, ZK 118.182. | 1994 | Eur. J. Pharmacol. | pmid:7813544 |
| Hoffmann R et al. | Regulation of interleukin-6 receptor expression in rat Kupffer cells: modulation by cytokines, dexamethasone and prostaglandin E2. | 1994 | J. Hepatol. | pmid:7814800 |
| Fukushima M et al. | Prostaglandin J2 and related compounds. Mode of action in G1 arrest and preclinical results. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7825837 |
| Spatz M et al. | Vasoactive peptides and prostaglandin D2 in human cerebromicrovascular endothelium. | 1994 | J. Auton. Nerv. Syst. | pmid:7836668 |
| Moussard C et al. | Effect of chronic REM sleep deprivation on pituitary, hypothalamus and hippocampus PGE2 and PGD2 biosynthesis in the mouse. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846109 |
| van Haaster CM et al. | Differential release of histamine and prostaglandin D2 in rat peritoneal mast cells: roles of cytosolic calcium and protein tyrosine kinases. | 1995 | Biochim. Biophys. Acta | pmid:7857988 |
| Armstrong RA and Talpain E | Comparison of the prostaglandin E (EP) receptor of human neutrophils and HL-60 cells differentiated with DMSO. | 1994 | Prostaglandins | pmid:7878190 |
| Polosa R et al. | Release of mast-cell-derived mediators after endobronchial adenosine challenge in asthma. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7881647 |
| Scadding GK et al. | Effect of short-term treatment with fluticasone propionate nasal spray on the response to nasal allergen challenge. | 1994 | Br J Clin Pharmacol | pmid:7893587 |
| Minami T et al. | Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious mice. | 1994 | Pain | pmid:7916452 |
| Wu CC et al. | Antiplatelet effects of clausine-D isolated from Clausena excavata. | 1994 | Biochim. Biophys. Acta | pmid:7918571 |
| Kantha SS | Histamine-interleukin-prostaglandin pathway: a hypothesis for a biochemical cycle regulating sleep and wakefulness. | 1994 | Med. Hypotheses | pmid:7935077 |
| Ohara H et al. | Reduction of prostaglandin D2 to 9 alpha,11 beta-prostaglandin F2 by a human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isozyme. | 1994 | Biochim. Biophys. Acta | pmid:7948008 |
| Lacal PM et al. | Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. I. Cell differentiation determines sensitivity to prostaglandins and virus infection. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7965770 |
| Lacal PM et al. | Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. II. Regulation of synthesis of inducible p72 heat shock protein. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7965771 |
| Hirata M et al. | Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7972033 |
| Morrow JD et al. | Release of markedly increased quantities of prostaglandin D2 from the skin in vivo in humans following the application of sorbic acid. | 1994 | Arch Dermatol | pmid:7979442 |
| Lahaye DH et al. | Effect of bradykinin on loss of density-dependent growth inhibition of normal rat kidney cells. | 1994 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:7981625 |
| Toth P et al. | Administration of human chorionic gonadotropin affects sleep-wake phases and other associated behaviors in cycling female rats. | 1994 | Brain Res. | pmid:7987667 |
| Matsumura H et al. | Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7991572 |
| Athari A et al. | Prostaglandin F2 alpha and D2 release from primary Ito cell cultures after stimulation with noradrenaline and ATP but not adenosine. | 1994 | Hepatology | pmid:8020883 |
| Touqui L et al. | Excretion of platelet activating factor-acetylhydrolase and phospholipase A2 into nasal fluids after allergenic challenge: possible role in the regulation of platelet activating factor release. | 1994 | J. Allergy Clin. Immunol. | pmid:8027488 |
| Murphy PJ et al. | Nonsteroidal anti-inflammatory drugs affect normal sleep patterns in humans. | 1994 | Physiol. Behav. | pmid:8047572 |
| Peden DB et al. | Hydrogen peroxide effects on rat mast cell function. | 1994 | Am. J. Physiol. | pmid:8048546 |
| Sakuma S et al. | Existence of an enzymatic pathway furnishing arachidonic acid for prostaglandin synthesis from arachidonoyl CoA in rabbit kidney medulla. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8048918 |
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| Gotoh M et al. | Desensitization of prostaglandin F2 alpha receptor-mediated phosphoinositide hydrolysis in cultured rat astrocytes. | 1994 | Neurochem. Res. | pmid:8065525 |
| Murakami M et al. | Prostaglandin endoperoxide synthase-1 and -2 couple to different transmembrane stimuli to generate prostaglandin D2 in mouse bone marrow-derived mast cells. | 1994 | J. Biol. Chem. | pmid:8071353 |
| Tran-Thi TA et al. | Effects of hypoxia on the oxygen-dependent metabolism of prostaglandins and adenosine in liver cells. | 1994 | J. Hepatol. | pmid:8071531 |
| Chen WY et al. | The effect of 3-[2-(cyclopropylamino)ethoxy]xanthone on platelet thromboxane formation. | 1994 | Thromb. Res. | pmid:8073410 |
| Small P et al. | Effects of intensity of early response to allergen on the late phase of both the nose and skin. | 1994 | Ann Allergy | pmid:8092561 |
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| Twentyman OP et al. | The effect of H1-receptor blockade on the development of early- and late-phase bronchoconstriction and increased bronchial responsiveness in allergen-induced asthma. | 1993 | J. Allergy Clin. Immunol. | pmid:8099592 |
| Tudorić N et al. | Phosphoramidon augments contraction of guinea pig tracheal smooth muscle induced by histamine and leukotriene-D4. | 1994 | Int. Arch. Allergy Immunol. | pmid:8111247 |
| Grunnet N et al. | Absence of glycogen cycling in cultured rat hepatocytes. | 1994 | Arch. Biochem. Biophys. | pmid:8117107 |