PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schleimer RP et al. | Selective inhibition of arachidonic acid metabolite release from human lung tissue by antiinflammatory steroids. | 1986 | J. Immunol. | pmid:3082976 |
| Viganò T et al. | Stimulus-related difference in the formation of leukotrienes and PGD2 after immunological and non-immunological challenge of human lung parenchyma "in vitro". | 1986 | Prostaglandins Leukot Med | pmid:3020580 |
| Koshihara Y and Kawamura M | Inhibitory effect of prostaglandin D2 on DNA synthesis in nuclei. | 1986 | Prostaglandins Leukot Med | pmid:3020589 |
| Jaschonek K et al. | The binding of 6-oxo-prostaglandin E1 to platelet prostanoid receptors. | 1986 | Prostaglandins Leukot Med | pmid:3020591 |
| Saito H et al. | Bio-synthesis of PGD2 and TXB2 by rabbit blood monocytes. | 1986 | Prostaglandins | pmid:3086936 |
| Hickok NJ et al. | Characterization of prostaglandin endoperoxide synthase from a human cell line. | 1986 | Biochim. Biophys. Acta | pmid:3087430 |
| MacIntyre DE et al. | Receptors and receptor mechanisms of endogenous platelet stimulatory and inhibitory mediators. | 1986 | Agents Actions Suppl. | pmid:3028106 |
| Tanaka A et al. | Antiherpetic action of prostaglandin D2. | 1986 | Prostaglandins Leukot Med | pmid:3029784 |
| Suzuki H et al. | [Inhibition of growth of human endometrial adenocarcinoma cells in vitro treated with prostaglandin F2 alpha, E2, D2 and J2]. | 1986 | Nihon Naibunpi Gakkai Zasshi | pmid:3465609 |
| Ashby B | Kinetic evidence indicating separate stimulatory and inhibitory prostaglandin receptors on platelet membranes. | 1986 | J Cyclic Nucleotide Protein Phosphor Res | pmid:2432105 |
| Koro O et al. | Release of prostaglandin D2 and histamine in a case of localized heat urticaria, and effect of treatments. | 1986 | Br. J. Dermatol. | pmid:2432916 |
| Watanabe K | [PGF synthetase]. | 1986 | Seikagaku | pmid:3084680 |
| Blomgren H et al. | Prostaglandin sensitivity of the PHA-response of blood lymphocytes following radiation therapy for breast cancer. | 1986 | Radiother Oncol | pmid:3466235 |
| Kriseman T et al. | Analysis of airway responses to A23187 in the cat. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3095538 |
| Shimizu Y et al. | Cycloheximide reduces PGD2 or delta 12-PGJ2 cytotoxicity on NCG cells. | 1986 | Prostaglandins | pmid:3099333 |
| Narumiya S et al. | Site and mechanism of growth inhibition by prostaglandins. II. Temperature-dependent transfer of a cyclopentenone prostaglandin to nuclei. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3772805 |
| Bregman MD et al. | Inhibition of human melanoma growth by prostaglandin A, D, and J analogues. | 1986 | Cancer Res. | pmid:3698005 |
| Kato T et al. | Antitumor activity of delta 7-prostaglandin A1 and delta 12-prostaglandin J2 in vitro and in vivo. | 1986 | Cancer Res. | pmid:3708585 |
| Keeting PE et al. | Rat lens prostaglandin biosynthesis during galactose-induced cataractogenesis. | 1986 | Exp. Eye Res. | pmid:3028846 |
| Horiguchi S et al. | Alterations in nociception after intracisternal administration of prostaglandin D2, E2 or F2 alpha to conscious mice. | 1986 | Eur. J. Pharmacol. | pmid:3458588 |
| Maclouf J et al. | Development of a radioimmunoassay for prostaglandin D2 using an antiserum against 11-methoxime prostaglandin D2. | 1986 | Prostaglandins | pmid:3456623 |
| Barnes VF and Heavey DJ | Effect of prostaglandin D2 on histamine-induced weals in human skin. | 1986 | Br. J. Pharmacol. | pmid:3456816 |
| Gaetani P et al. | Prostaglandin D2 monitoring in human CSF after subarachnoid hemorrhage: the possible role of prostaglandin D2 in the genesis of cerebral vasospasm. | 1986 | Ital J Neurol Sci | pmid:3456998 |
| Sugiyama T et al. | Platelet prostaglandin D2 dehydrogenase in patients with myeloproliferative disorders. | 1986 | Prostaglandins Leukot Med | pmid:3457389 |
| Omini C et al. | Prostaglandin D2 (PGD2) potentiates cholinergic responsiveness in guinea-pig trachea. | 1986 | J Auton Pharmacol | pmid:3464602 |
| Kikuchi Y et al. | Inhibition of human ovarian cancer cell growth in vitro and in nude mice by prostaglandin D2. | 1986 | Cancer Res. | pmid:3458525 |
| Hamilton RG et al. | Dirofilaria immitis: diethylcarbamazine-induced anaphylactoid reactions in infected dogs. | 1986 | Exp. Parasitol. | pmid:3458592 |
| Nakagawa Y et al. | [Effect of prostaglandin D2 on the growth of mouse glioma]. | 1986 | Gan To Kagaku Ryoho | pmid:3459395 |
| Naclerio R et al. | The role of inflammatory mediators in allergic rhinitis. | 1986 | Ear Nose Throat J | pmid:3459645 |
| Wogensen L and Warberg J | Effect of prostaglandin D2 on the release of luteinizing hormone and prolactin in castrated and intact male rats. | 1986 | Acta Endocrinol. | pmid:3461657 |
| Murray JJ et al. | Release of prostaglandin D2 into human airways during acute antigen challenge. | 1986 | N. Engl. J. Med. | pmid:3462506 |
| Honda C and Tabuchi K | [Effects of prostaglandin D2 on cultured glioma cells]. | 1986 | Gan To Kagaku Ryoho | pmid:3463248 |
| Makhoul RG and Gewertz BL | Renal prostaglandins. | 1986 | J. Surg. Res. | pmid:3511324 |
| Dutta-Roy AK et al. | Prostacyclin stimulation of the activation of blood coagulation factor X by platelets. | 1986 | Science | pmid:3001935 |
| Haxhiu MA et al. | [Bronchial response to prostaglandins (F2 alpha and D2) and leukotrienes in patients with bronchial asthma]. | 1986 Jan-Mar | Plucne Bolesti | pmid:3466189 |
| Zijlstra FJ et al. | Formation of prostaglandins and leukotrienes by human lung tissue in vitro after activation by the calcium ionophore A23187. | 1987 | Eur. J. Clin. Invest. | pmid:2822430 |
| Seibert K et al. | 9 alpha, 11 beta-prostaglandin F2: formation and metabolism by human lung and contractile effects on human bronchial smooth muscle. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959045 |
| Roberts LJ et al. | PGD2 is transformed by human coronary arteries to 9 alpha, 11 beta-PGF2, which contracts human coronary artery rings. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959090 |
| Watanabe K et al. | Stereospecific conversion of prostaglandin D2 to 9 alpha, 11 beta-prostaglandin F2 and prostaglandin H2 to prostaglandin F2 alpha by PGF synthetase. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959094 |
| Wendelborn DF et al. | Isomeric prostaglandin F2 compounds: a new family of eicosanoids produced in vivo in humans. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959099 |
| Pugliese G et al. | 9 alpha, 11 beta-prostaglandin F2: a new prostanoid with selective biosynthesis and unique biological activity. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959104 |
| Narumiya S et al. | Site and mechanism of growth inhibition by prostaglandins. III. Distribution and binding of prostaglandin A2 and delta 12-prostaglandin J2 in nuclei. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3302206 |
| Robinson C et al. | Effects of inhaled 9 alpha, 11 beta-prostaglandin F2 on airway function in man. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960146 |
| Roberts LJ | Recent metabolic findings bring into question the reliability of existing methods for quantification of PGF2 alpha and its metabolites in human biological fluids. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960165 |
| Jacobsen S et al. | Synergism between thapsigargin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate on the release of [14C]arachidonic acid and histamine from rat peritoneal mast cells. | 1987 | Biochem. Pharmacol. | pmid:2435291 |
| Prakash C et al. | Synthesis of putative prostaglandin D2 metabolites. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960191 |
| Kawabe H et al. | Differential calcium effects on prostaglandin D2 generation and histamine release from isolated rat peritoneal mast cells. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2436614 |
| Ruzicka T and Auböck J | Arachidonic acid metabolism in guinea pig Langerhans cells: studies on cyclooxygenase and lipoxygenase pathways. | 1987 | J. Immunol. | pmid:3098849 |
| Westcott JY et al. | Eicosanoids in human ventricular cerebrospinal fluid following severe brain injury. | 1987 | Prostaglandins | pmid:2835791 |
| Goh Y et al. | Content and formation of prostaglandins and distribution of prostaglandin-related enzyme activities in the rat ocular system. | 1987 | Biochim. Biophys. Acta | pmid:3477292 |
| Brown MS et al. | Arachidonic acid metabolites during nasal challenge. | 1987 | Arch. Otolaryngol. Head Neck Surg. | pmid:3099812 |
| Bhattacharya SK and Parmar SS | Prostaglandin D2 inhibits pentylenetetrazole-induced convulsions in rats by a serotonin-mediated mechanism. | 1987 | Pharm. Res. | pmid:2977646 |
| Anton RF and Randall CL | Central nervous system prostaglandins and ethanol. | 1987 | Alcohol. Clin. Exp. Res. | pmid:3105343 |
| Levi-Schaffer F et al. | Mouse bone marrow-derived mast cells cocultured with fibroblasts. Morphology and stimulation-induced release of histamine, leukotriene B4, leukotriene C4, and prostaglandin D2. | 1987 | J. Immunol. | pmid:2445814 |
| Church MK and Hiroi J | Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by anti-allergic drugs and salbutamol. | 1987 | Br. J. Pharmacol. | pmid:2435353 |
| Pearce FL et al. | Some studies on human pulmonary mast cells obtained by bronchoalveolar lavage and by enzymic dissociation of whole lung tissue. | 1987 | Int. Arch. Allergy Appl. Immunol. | pmid:2437052 |
| Weinreich D and Undem BJ | Immunological regulation of synaptic transmission in isolated guinea pig autonomic ganglia. | 1987 | J. Clin. Invest. | pmid:2437156 |
| Bushfield M et al. | Effects of protein kinase C activation on human platelet cyclic AMP metabolism. | 1987 | FEBS Lett. | pmid:2820806 |
| Williams KA et al. | Effects of activation of protein kinase C on the agonist-induced stimulation and inhibition of cyclic AMP formation in intact human platelets. | 1987 | Biochem. J. | pmid:2444206 |
| Lawrence ID et al. | Purification and characterization of human skin mast cells. Evidence for human mast cell heterogeneity. | 1987 | J. Immunol. | pmid:2444649 |
| Benyon RC et al. | Prostaglandin D2 release from human skin mast cells in response to ionophore A23187. | 1987 | Br. J. Pharmacol. | pmid:2447989 |
| Underwood DC et al. | Blockade of thromboxane responses in the airway of the cat by SQ 29,548. | 1987 | J. Appl. Physiol. | pmid:2440845 |
| Levi-Schaffer F et al. | Co-culture of human lung-derived mast cells with mouse 3T3 fibroblasts: morphology and IgE-mediated release of histamine, prostaglandin D2, and leukotrienes. | 1987 | J. Immunol. | pmid:2439587 |
| Leung KB et al. | Some further properties of human pulmonary mast cells recovered by bronchoalveolar lavage and enzymic dispersion of lung tissue. | 1987 | Agents Actions | pmid:2440274 |
| Church MK et al. | Non-IgE-dependent bacteria-induced histamine release from human lung and tonsillar mast cells. | 1987 | Clin. Allergy | pmid:2441900 |
| Kosaka Y et al. | Oxatomide inhibits the release of bronchoconstrictor arachidonic acid metabolites (iLTC4 and PGD2) from rat mast cells and guinea-pig lung. | 1987 | Agents Actions | pmid:2442981 |
| Pipkorn U et al. | Effect of short-term systemic glucocorticoid treatment on human nasal mediator release after antigen challenge. | 1987 | J. Clin. Invest. | pmid:2443539 |
| Rodriguez R et al. | Effect of nimodipine on arachidonic acid metabolites after subarachnoid hemorrhage. | 1987 | Acta Neurol. Scand. | pmid:3120489 |
| Namima M and Okamoto K | Modulatory action of prostaglandin D2 on the release of 3H-norepinephrine from rat cerebellar slices. | 1987 | Jpn. J. Pharmacol. | pmid:2883337 |
| Omini C et al. | Prostaglandin D2 and the cholinergic system in guinea pig airways. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2823557 |
| Viganò T et al. | Adenosine and eicosanoid release from immunologically challenged human lung fragments. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2823581 |
| Tilden SJ et al. | Effects of OKY 1581 on bronchoconstrictor responses to arachidonic acid and PGH2. | 1987 | J. Appl. Physiol. | pmid:2954941 |
| Foreman D et al. | Effects of E2 levuglandins on the contractile activity of the rat uterus. | 1987 | Prostaglandins | pmid:3317517 |
| Shimizu Y et al. | Selective synthesis and retention of 66k protein in a human neuroblastoma cell line (NCG) treated with a cytotoxic dosage of delta 12-prostaglandin J2. | 1987 | Prostaglandins | pmid:3449899 |
| Suzuki F et al. | Methyl ester of prostaglandin D2 as a delivery system of prostaglandin D2 into brain. | 1987 | Biochim. Biophys. Acta | pmid:3467795 |
| Richelsen B | Relationship between binding and action of different prostaglandins in rat adipocytes with special reference to PGE2 and PGI2. | 1987 | Biochem. Pharmacol. | pmid:2825710 |
| Hayashi H et al. | Metabolism of prostaglandin D2 in isolated rat lung: the stereospecific formation of 9 alpha,11 beta-prostaglandin F2 from prostaglandin D2. | 1987 | Biochim. Biophys. Acta | pmid:3467796 |
| Drummond WH and Carter RL | Cardiac depressant and circulatory effects of prostaglandin D2 in developing lambs. | 1987 | Am. J. Physiol. | pmid:3468806 |
| Burgess JR et al. | Enzymatic transformation of PGH2 to PGF2 alpha catalyzed by glutathione S-transferases. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3468949 |
| Beasley CR et al. | 9 alpha,11 beta-prostaglandin F2, a novel metabolite of prostaglandin D2 is a potent contractile agonist of human and guinea pig airways. | 1987 | J. Clin. Invest. | pmid:3469218 |
| Greaves MW et al. | [New pharmacologic developments in physical urticaria--therapeutic consequences]. | 1987 | Z. Hautkr. | pmid:3472418 |
| Goto H | [Quantitative determination of prostaglandin D2 in the rat gastric mucosa by high performance liquid chromatography]. | 1987 | Nihon Shokakibyo Gakkai Zasshi | pmid:3473244 |
| Kariya T et al. | Platelet abnormality with no response to PGD2 in a patient with metastatic pancreas carcinoma and myeloproliferative disorder. | 1987 | Nippon Ketsueki Gakkai Zasshi | pmid:3473883 |
| Holgate ST | Contribution of inflammatory mediators to the immediate asthmatic reaction. | 1987 | Am. Rev. Respir. Dis. | pmid:3473955 |
| Hayashi H et al. | Determination of 9 alpha, 11 beta-prostaglandin F2 by stereospecific antibody in various rat tissues. | 1987 | Prostaglandins | pmid:3474704 |
| Maurice PD et al. | The effect of prostaglandin D2 on the response of human skin to histamine. | 1987 | J. Invest. Dermatol. | pmid:3476674 |
| Berryman GK et al. | Amniotic fluid prostaglandin D2 in spontaneous and augmented labor. | 1987 | Life Sci. | pmid:3476816 |
| Kikuchi Y et al. | Inhibitory effects of neuroendocrine hormones on human ovarian cancer cell proliferation in vitro. | 1987 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:3479504 |
| Tran-Thi TA et al. | Studies on synthesis and degradation of eicosanoids by rat hepatocytes in primary culture. | 1987 | J. Hepatol. | pmid:2828463 |
| Stier CT et al. | Renal response to 9 alpha, 11 beta-prostaglandin F2 in the rat. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3479549 |
| Yatomi A et al. | Prostaglandins affect the central nervous system to produce hyperglycemia in rats. | 1987 | Endocrinology | pmid:3474143 |
| Hanasaki K et al. | Beta 2-adrenergic regulation of prostaglandin D2 receptor in rabbit platelets. | 1987 | Biochim. Biophys. Acta | pmid:2880608 |
| Holgate ST et al. | Primary and secondary effector cells in the pathogenesis of bronchial asthma. | 1987 | Int. Arch. Allergy Appl. Immunol. | pmid:3553030 |
| Rao PS et al. | Dose-dependent effects of prostaglandin D2 on hemodynamics, renal function, and blood gas analyses. | 1987 | Am. J. Obstet. Gynecol. | pmid:3555078 |
| Kinoshita T et al. | Predominance of prostaglandin D2 and I2 in the rat gastric mucosa--analysis by high-performance liquid chromatography. | 1987 | Biochem. Int. | pmid:3555501 |
| Matsuura H and Imaya H | [Effect of prostaglandin (delta 12-PGJ2) on host immunity--an experimental study]. | 1987 | Gan To Kagaku Ryoho | pmid:3592721 |
| Yamamoto N et al. | Mechanism of inhibition of herpes simplex virus replication by delta 7-prostaglandin A1 and delta 12-prostaglandin J2. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3040001 |
| Bhattacharya SK and Rao PJ | Prostaglandin D2-induced catalepsy in rats: role of 5-hydroxytryptamine. | 1987 | J. Pharm. Pharmacol. | pmid:2890744 |
| Tamaoki J et al. | Cholinergic neuromodulation by prostaglandin D2 in canine airway smooth muscle. | 1987 | J. Appl. Physiol. | pmid:2891674 |
| Shimojima T et al. | [Effects of prostaglandins on superoxide production by human polymorphonuclear leukocytes]. | 1987 | Nihon Shishubyo Gakkai Kaishi | pmid:2851629 |