PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kase K et al. | Inhibitory action of roxithromycin on histamine release and prostaglandin D2 production from beta-defensin 2-stimulated mast cells. | 2009 | Int. J. Mol. Med. | pmid:19212651 |
| Ricart KC et al. | The permissive role of mitochondria in the induction of haem oxygenase-1 in endothelial cells. | 2009 | Biochem. J. | pmid:19161347 |
| Lee DR et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) induces mitochondrial-dependent apoptosis through inhibition of PKA/NF-kappaB in renal proximal epithelial cells. | 2009 | Toxicology | pmid:19167456 |
| Quarello E and Trabbia A | High-definition flow combined with spatiotemporal image correlation in the diagnosis of fetal coarctation of the aorta. | 2009 | Ultrasound Obstet Gynecol | pmid:19194864 |
| Ishii T et al. | Pivotal role of mast cells in pruritogenesis in patients with myeloproliferative disorders. | 2009 | Blood | pmid:19196660 |
| Passeron T et al. | Upregulation of SOX9 inhibits the growth of human and mouse melanomas and restores their sensitivity to retinoic acid. | 2009 | J. Clin. Invest. | pmid:19273910 |
| Yuan ZB et al. | Temporal expression of cyclooxygenase-2 in peritoneal macrophages of rats and effects of panax notoginseng saponins. | 2009 | Inflamm. Res. | pmid:19184357 |
| Whelan CJ | Evidence that 13-14 di-hydro, 15-keto prostaglandin D(2)-induced airway eosinophilia in guinea-pigs is independent of interleukin-5. | 2009 | Inflamm. Res. | pmid:19184361 |
| Liu J et al. | Peroxisome proliferator-activated receptor-gamma ligands 15-deoxy-delta(12,14)-prostaglandin J2 and pioglitazone inhibit hydroxyl peroxide-induced TNF-alpha and lipopolysaccharide-induced CXC chemokine expression in neonatal rat cardiac myocytes. | 2009 | Shock | pmid:19174742 |
| Kolaczkowska E et al. | Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9. | 2009 | Immunology | pmid:19175797 |
| Kalantari P et al. | 15-Deoxy-Delta12,14-prostaglandin J2 inhibits HIV-1 transactivating protein, Tat, through covalent modification. | 2009 | FASEB J. | pmid:19299483 |
| Mohri I et al. | Inhibition of prostaglandin D synthase suppresses muscular necrosis. | 2009 | Am. J. Pathol. | pmid:19359520 |
| Moriai M et al. | Down-regulation of hTERT expression plays an important role in 15-deoxy-Delta12,14-prostaglandin J2-induced apoptosis in cancer cells. | 2009 | Int. J. Oncol. | pmid:19360348 |
| Boehme SA et al. | Murine bone marrow-derived mast cells express chemoattractant receptor-homologous molecule expressed on T-helper class 2 cells (CRTh2). | 2009 | Int. Immunol. | pmid:19346259 |
| Iinuma K et al. | Involvement of Propionibacterium acnes in the augmentation of lipogenesis in hamster sebaceous glands in vivo and in vitro. | 2009 | J. Invest. Dermatol. | pmid:19282842 |
| Ferguson HE et al. | Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts. | 2009 | Am. J. Respir. Cell Mol. Biol. | pmid:19286977 |
| Xue L et al. | Interaction between prostaglandin D and chemoattractant receptor-homologous molecule expressed on Th2 cells mediates cytokine production by Th2 lymphocytes in response to activated mast cells. | 2009 | Clin. Exp. Immunol. | pmid:19220324 |
| Ono E et al. | Increased production of cysteinyl leukotrienes and prostaglandin D2 during human anaphylaxis. | 2009 | Clin. Exp. Allergy | pmid:19128354 |
| Shin SW et al. | 15d-PGJ2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity. | 2009 | Clin. Cancer Res. | pmid:19690198 |
| Wendeburg L et al. | Resveratrol inhibits prostaglandin formation in IL-1beta-stimulated SK-N-SH neuronal cells. | 2009 | J Neuroinflammation | pmid:19751497 |
| Ferguson HE et al. | Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism. | 2009 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:19734319 |
| Kim DH et al. | Effects of 15-deoxy-delta 12, 14-prostaglandin J2 on the expression of p53 in MCF-7 cells. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723057 |
| Song NY et al. | 15-Deoxy-delta 12, 14-prostaglandin J2 induces upregulation of multidrug resistance-associated protein 1 via Nrf2 activation in human breast cancer cells. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723058 |
| Johansson S et al. | CC16 inhibits the migration of eosinophils towards the formyl peptide fMLF but not towards PGD2. | 2009 | Inflammation | pmid:19132521 |
| Kim DH et al. | 15-Deoxy-Delta12,14-prostaglandin J2 upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: possible roles of iron and ROS. | 2009 | Carcinogenesis | pmid:19136476 |
| Di Francesco L et al. | Induction of prostacyclin by steady laminar shear stress suppresses tumor necrosis factor-alpha biosynthesis via heme oxygenase-1 in human endothelial cells. | 2009 | Circ. Res. | pmid:19122175 |
| Wang WM et al. | PPAR-gamma agonists inhibit TGF-beta1-induced chemokine expression in human tubular epithelial cells. | 2009 | Acta Pharmacol. Sin. | pmid:19098936 |
| Waku T et al. | Atomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligands. | 2009 | FEBS Lett. | pmid:19101554 |
| Selg E et al. | Two different mechanisms for modulation of bronchoconstriction in guinea-pigs by cyclooxygenase metabolites. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19103301 |
| Dong YW et al. | Suppression of pancreatic carcinoma growth by activating peroxisome proliferator-activated receptor gamma involves angiogenesis inhibition. | 2009 | World J. Gastroenterol. | pmid:19152448 |
| Koinuma S et al. | The resetting of the circadian rhythm by Prostaglandin J2 is distinctly phase-dependent. | 2009 | FEBS Lett. | pmid:19111547 |
| Baregamian N et al. | PPAR-gamma agonist protects against intestinal injury during necrotizing enterocolitis. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19114032 |
| Byrns MC and Penning TM | Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. | 2009 | Chem. Biol. Interact. | pmid:19010312 |
| Suk FM et al. | 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibits fibrogenic response in human hepatoma cells. | 2009 | Toxicol. Lett. | pmid:19429239 |
| Kansanen E et al. | Regulation of Nrf2-dependent gene expression by 15-deoxy-Delta12,14-prostaglandin J2. | 2009 | Free Radic. Biol. Med. | pmid:19573595 |
| Cocca C et al. | 15-Deoxi-Delta(12,14)-prostaglandin J2 is a tubulin-binding agent that destabilizes microtubules and induces mitotic arrest. | 2009 | Biochem. Pharmacol. | pmid:19576185 |
| Thura M et al. | GIF-0173 protects against cerebral infarction through DP1 receptor activation. | 2009 | Exp. Neurol. | pmid:19576888 |
| Bernardo A et al. | Peroxisome proliferator-activated receptor-gamma agonists promote differentiation and antioxidant defenses of oligodendrocyte progenitor cells. | 2009 | J. Neuropathol. Exp. Neurol. | pmid:19535992 |
| Comabella M et al. | Plasma levels of 15d-PGJ are not altered in multiple sclerosis. | 2009 | Eur. J. Neurol. | pmid:19538219 |
| Qin HD et al. | Upregulation of peroxisome proliferator-activated receptor-gamma and NADPH oxidases are involved in restenosis after balloon injury. | 2009 | J. Cell. Physiol. | pmid:19562688 |
| Leduc M et al. | Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands. | 2009 | J. Pharmacol. Exp. Ther. | pmid:19584306 |
| Bai G et al. | Regulation of ANP secretion from isolated atria by prostaglandins and cyclooxygenase-2. | 2009 | Peptides | pmid:19539681 |
| Pierre SR et al. | Subchronic infusion of the product of inflammation prostaglandin J2 models sporadic Parkinson's disease in mice. | 2009 | J Neuroinflammation | pmid:19630993 |
| Pena-dos-Santos DR et al. | Activation of peripheral kappa/delta opioid receptors mediates 15-deoxy-(Delta12,14)-prostaglandin J2 induced-antinociception in rat temporomandibular joint. | 2009 | Neuroscience | pmid:19647045 |
| Asano S et al. | Effects of prostaglandin D2 on Na-dependent phosphate transport activity and its intracellular signaling mechanism in osteoblast-like cells. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19616422 |
| Hironaka A et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) impairs the functions of histone acetyltransferases through their insolubilization in cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19799872 |
| Ohinata K et al. | Complement C5a stimulates food intake via a prostaglandin D(2)- and neuropeptide Y-dependent mechanism in mice. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19800413 |
| Tagen M et al. | Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content. | 2009 | J. Immunol. | pmid:19846869 |
| Davies NJ et al. | AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects. | 2009 | Cancer Res. | pmid:19487289 |
| Prakash J et al. | Albumin-binding and tumor vasculature determine the antitumor effect of 15-deoxy-Delta-(12,14)-prostaglandin-J(2) in vivo. | 2009 | Neoplasia | pmid:20019843 |