Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kerr JS et al. | Effects of recombinant interleukin-1 beta on phospholipase A2 activity, phospholipase A2 mRNA levels, and eicosanoid formation in rabbit chondrocytes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2558648 |
Kawabe Y et al. | Genesis and recovery of ethanol-induced gastric lesions in rats: possible involvement of prostaglandin D2. | 1989 | Am. J. Gastroenterol. | pmid:2916522 |
Sakai T et al. | Protection by cycloheximide against cytotoxicity induced by vincristine, colchicine, or delta 12-prostaglandin J2 on human osteosarcoma cells. | 1989 | Cancer Res. | pmid:2917351 |
Phillips GD and Holgate ST | Interaction of inhaled LTC4 with histamine and PGD2 on airway caliber in asthma. | 1989 | J. Appl. Physiol. | pmid:2917934 |
Ban M et al. | A flavonoid inhibitor of 5-lipoxygenase inhibits leukotriene production following ischemia in gerbil brain. | 1989 | Stroke | pmid:2919414 |
Zehr BB et al. | Use of segmental airway lavage to obtain relevant mediators from the lungs of asthmatic and control subjects. | 1989 | Chest | pmid:2539958 |
Benyon RC | The human skin mast cell. | 1989 | Clin. Exp. Allergy | pmid:2667702 |
Leynadier F | [Mast cells and basophils in asthma]. | 1989 | Ann. Biol. Clin. (Paris) | pmid:2675683 |
Hamid-Bloomfield S and Whittle BJ | Antagonism of PGD2 vasodepressor responses in the rat in vivo by the novel, selective antagonist, BW A868C. | 1989 | Br. J. Pharmacol. | pmid:2647205 |
Kuiper J et al. | The role of prostaglandins in endotoxin stimulated glycogenolysis in the liver. | 1989 | Agents Actions | pmid:2653002 |
Amano N et al. | The effect of pentobarbital and ether anesthesia on rat brain PGD2 content. | 1989 | Agressologie | pmid:2610292 |
Shram SI et al. | [Preparation and properties of prostaglandin D2 labelled with tritium with high molar radioactivity]. | 1989 | Bioorg. Khim. | pmid:2590255 |
Yamada K | [The effect of prostaglandin D2 on rat testicular testosterone levels]. | 1989 | Nihon Naibunpi Gakkai Zasshi | pmid:2591605 |
Goto H et al. | The role of prostaglandin D2 in the genesis of indomethacin-induced gastric lesions in rats. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2595317 |
Busshardt E et al. | Regulation of hepatic parenchymal and non-parenchymal cell function by the diadenine nucleotides Ap3A and Ap4A. | 1989 | Biochim. Biophys. Acta | pmid:2563228 |
Trist DG et al. | The antagonism by BW A868C of PGD2 and BW245C activation of human platelet adenylate cyclase. | 1989 | Br. J. Pharmacol. | pmid:2466517 |
Triggiani M et al. | Inhibition of histamine and prostaglandin D2 release from human lung mast cells by ciclosporin A. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468619 |
Charlesworth EN et al. | Cells and secretagogues involved in the human late-phase response. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468620 |
Church MK et al. | Interaction of neuropeptides with human mast cells. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468622 |
Charlesworth EN et al. | Cutaneous late-phase response to allergen. Mediator release and inflammatory cell infiltration. | 1989 | J. Clin. Invest. | pmid:2468688 |
Charlesworth EN et al. | Effect of cetirizine on mast cell-mediator release and cellular traffic during the cutaneous late-phase reaction. | 1989 | J. Allergy Clin. Immunol. | pmid:2469708 |
Church MK et al. | Mast cells, neuropeptides and inflammation. | 1989 | Agents Actions | pmid:2473641 |
van Overveld FJ | Mediator release from human lung mast cell subtypes in chronic bronchitis and emphysema. | 1989 | Agents Actions | pmid:2473645 |
Stürzebecher S et al. | Effects of PGD2, PGE1, and PGI2-analogues on PGDF-release and aggregation of human gelfiltered platelets. | 1989 | Prog. Clin. Biol. Res. | pmid:2477855 |
Cohan VL et al. | Dexamethasone does not inhibit the release of mediators from human mast cells residing in airway, intestine, or skin. | 1989 | Am. Rev. Respir. Dis. | pmid:2478059 |
Reshef A et al. | The pattern and kinetics in human skin of erythema and mediators during the acute and late-phase response (LPR). | 1989 | J. Allergy Clin. Immunol. | pmid:2478604 |
Marone G et al. | Human basophil/mast cell releasability. VII. Heterogeneity of the effect of adenosine on mediator secretion. | 1989 | Life Sci. | pmid:2480501 |
Giles H et al. | The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist. | 1989 | Br. J. Pharmacol. | pmid:2924081 |
Reiss TF et al. | Local mediator release after antigen challenge of a bronchial segment in allergic dogs. | 1989 | Am. J. Physiol. | pmid:2481982 |
Levi-Schaffer F and Shalit M | Differential release of histamine and prostaglandin D2 in rat peritoneal mast cells activated with peptides. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2482257 |
Beasley RC et al. | Effect of a thromboxane receptor antagonist on PGD2- and allergen-induced bronchoconstriction. | 1989 | J. Appl. Physiol. | pmid:2525122 |
Thierauch KH et al. | ZK 110 841--a selective and potent prostaglandin D2 analogue. | 1989 | Prog. Clin. Biol. Res. | pmid:2798462 |
Ashida Y et al. | A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. | 1989 | Prostaglandins | pmid:2748922 |
Raisz LG and Woodiel FN | Effect of alterations in the cyclopentane ring on bone resorptive activity of prostaglandin. | 1989 | Prostaglandins | pmid:2727307 |
Wolfe LS et al. | Metabolism of prostaglandin D2 by human cerebral cortex into 9 alpha, 11 beta-prostaglandin F2 by an active NADPH-dependent 11-ketoreductase. | 1989 | J. Neurochem. | pmid:2723663 |
Rodriguez y Baena R et al. | Effects of nicardipine on the ex vivo release of eicosanoids after experimental subarachnoid hemorrhage. | 1989 | J. Neurosurg. | pmid:2585083 |
Marone G | Control mechanisms of mediator release in human basophils and mast cells. | 1988 Nov-Dec | Immunol. Invest. | pmid:2465995 |
Fukui A et al. | Effects of prostaglandin D2 and omeprazole on indomethacin-induced gastric ulcers in rats. | 1988 | Clin. Exp. Pharmacol. Physiol. | pmid:3149561 |
Vigano T et al. | Prostaglandin synthetase inhibition and formation of lipoxygenase products in immunologically challenged normal human lung parenchyma. | 1988 | Eicosanoids | pmid:3152489 |
Casteleijn E et al. | Prostaglandin D2 mediates the stimulation of glycogenolysis in the liver by phorbol ester. | 1988 | Biochem. J. | pmid:3162673 |
Ishioka C et al. | Inhibitory effects of prostaglandin A2 on c-myc expression and cell cycle progression in human leukemia cell line HL-60. | 1988 | Cancer Res. | pmid:3162825 |
Soifer SJ et al. | Effects of prostaglandin D2 on pulmonary arterial pressure and oxygenation in newborn infants with persistent pulmonary hypertension. | 1988 | J. Pediatr. | pmid:3162978 |
Wasserman SI | Basic mechanisms in asthma. | 1988 | Ann Allergy | pmid:3163472 |
Sonoki H et al. | [Effects of 3,4-diaminopyridine on the contractions of guinea-pig tracheal smooth muscle induced by histamine and prostaglandin D2]. | 1988 | Nippon Yakurigaku Zasshi | pmid:3163668 |
Ujihara M et al. | Biochemical and immunological demonstration of prostaglandin D2, E2, and F2 alpha formation from prostaglandin H2 by various rat glutathione S-transferase isozymes. | 1988 | Arch. Biochem. Biophys. | pmid:3041912 |
Foreman D et al. | Anhydrolevuglandin D2 inhibits the uterotonic activity of prostaglandins F2 alpha and D2. | 1988 | Prostaglandins | pmid:3163807 |
Schulman ES et al. | Differential effects of the complement peptides, C5a and C5a des Arg on human basophil and lung mast cell histamine release. | 1988 | J. Clin. Invest. | pmid:2449462 |
Robinson C et al. | The immunoglobulin E- and calcium-dependent release of histamine and eicosanoids from human dispersed mastocytosis spleen cells. | 1988 | J. Invest. Dermatol. | pmid:2450144 |
Holgate ST et al. | The contribution of mast cell mediators to acute allergic reactions in human skin and airways. | 1988 | Allergy | pmid:2451448 |
Schulman ES et al. | Density heterogeneity of human lung mast cells. | 1988 | J. Allergy Clin. Immunol. | pmid:2455745 |