PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Imashuku S et al. | Tumor differentiation--application of prostaglandins in the treatment of neuroblastoma. | 1985 | Prog. Clin. Biol. Res. | pmid:2986176 |
| Makino S | [Physiological and pharmacological actions of prostaglandins and related substances: inflammation and allergy]. | 1985 | Nippon Rinsho | pmid:2989584 |
| Siegl AM and Daly JW | Receptor (norepinephrine), P-site (2',5'-dideoxyadenosine), and calcium-mediated inhibition of prostaglandin and forskolin-activated cyclic AMP-generating systems in human platelets. | 1985 | J Cyclic Nucleotide Protein Phosphor Res | pmid:2991349 |
| Förstermann U et al. | Studies on the mechanism of central cardiovascular and temperature responses to prostaglandin D2. | 1985 | Prostaglandins Leukot Med | pmid:2991946 |
| Hamid S and Whittle BJ | Interaction of prostaglandin D2 with prostacyclin, carbacyclin and the hydantoin prostaglandin, BW245C, in guinea-pig platelets. | 1985 | Br. J. Pharmacol. | pmid:2992652 |
| Narumiya S and Toda N | Different responsiveness of prostaglandin D2-sensitive systems to prostaglandin D2 and its analogues. | 1985 | Br. J. Pharmacol. | pmid:2992661 |
| Bertelé V et al. | Refractoriness of platelets to prostaglandins after infusion in rabbits. | 1985 | J. Lab. Clin. Med. | pmid:2997353 |
| Thompson NT and Scrutton MC | Intracellular calcium fluxes in human platelets. | 1985 | Eur. J. Biochem. | pmid:3918866 |
| Kimura H et al. | Modulatory effects of prostaglandin D2, E2 and F2 alpha on the postsynaptic actions of inhibitory and excitatory amino acids in cerebellar Purkinje cell dendrites in vitro. | 1985 | Brain Res. | pmid:2859088 |
| Urade Y et al. | Purification and characterization of rat brain prostaglandin D synthetase. | 1985 | J. Biol. Chem. | pmid:3930495 |
| Schick B and Austen KF | Pharmacological modulation of activation-secretion of rat serosal mast cells by chymase, an endogenous secretory granule protease. | 1985 | Immunology | pmid:3935569 |
| Fitscha P et al. | Platelet sensitivity to antiaggregatory prostaglandins (PGE1,D2,I2) in patients with peripheral vascular disease. | 1985 | Am. J. Hematol. | pmid:3885723 |
| Campbell WB and Gomez-Sanchez CE | Absence of prostacyclin involvement in angiotensin-induced aldosterone secretion in rat adrenal cells. | 1985 | Endocrinology | pmid:3924581 |
| Lad PM et al. | Receptor-specific threshold effects of cyclic AMP are involved in the regulation of enzyme release and superoxide production from human neutrophils. | 1985 | Biochim. Biophys. Acta | pmid:2411298 |
| Finney MJ et al. | Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation. | 1985 | Br. J. Pharmacol. | pmid:2411319 |
| Fowler JC et al. | Prostaglandins block a Ca2+-dependent slow spike afterhyperpolarization independent of effects on Ca2+ influx in visceral afferent neurons. | 1985 | Brain Res. | pmid:2412652 |
| Levi-Schaffer F et al. | Fibroblasts maintain the phenotype and viability of the rat heparin-containing mast cell in vitro. | 1985 | J. Immunol. | pmid:2413121 |
| Forman MB et al. | Increased adventitial mast cells in a patient with coronary spasm. | 1985 | N. Engl. J. Med. | pmid:2413358 |
| Togias AG et al. | Nasal challenge with cold, dry air results in release of inflammatory mediators. Possible mast cell involvement. | 1985 | J. Clin. Invest. | pmid:2414318 |
| Robin JL et al. | Regulation of mediator release from mouse bone marrow-derived mast cells by glucocorticoids. | 1985 | J. Immunol. | pmid:3161947 |
| Schulman ES and Anderson CL | Lung hypersensitivity responses: dissociation of human lung mast cell leukotriene C4 (LTC4) from histamine release. | 1985 | Prog. Clin. Biol. Res. | pmid:2415994 |
| Creticos PS et al. | Nasal challenge with ragweed pollen in hay fever patients. Effect of immunotherapy. | 1985 | J. Clin. Invest. | pmid:2416777 |
| Holgate ST et al. | The release and role of inflammatory mediators in asthma. | 1985 | Clin Immunol Rev | pmid:2417772 |
| Beatty CH et al. | Metabolism of arachidonic acid by macaque platelets. Implications for studies on atherosclerosis. | 1985 | Atherosclerosis | pmid:3924062 |
| Lewis RA and Robin JL | Arachidonic acid derivatives as mediators of asthma. | 1985 | J. Allergy Clin. Immunol. | pmid:3926852 |
| Armstrong RA et al. | Competitive antagonism at thromboxane receptors in human platelets. | 1985 | Br. J. Pharmacol. | pmid:2580580 |
| Hollingsworth EB and Patrick GA | The effects produced by prostaglandin D2 on serotonin turnover and release and tryptophan uptake. | 1985 | Pharmacol. Biochem. Behav. | pmid:2581275 |
| Fox CC et al. | Isolation and characterization of human intestinal mucosal mast cells. | 1985 | J. Immunol. | pmid:2582045 |
| Naclerio RM et al. | Inflammatory mediators in late antigen-induced rhinitis. | 1985 | N. Engl. J. Med. | pmid:2582257 |
| Kasukabe T et al. | Specific inhibition by prostaglandin D2 and its metabolites of lysozyme synthesis in mouse macrophage-like cell line, Mm-1. | 1985 | Biochim. Biophys. Acta | pmid:3855662 |
| Narumiya S and Fukushima M | delta 12-Prostaglandin J2, an ultimate metabolite of prostaglandin D2 exerting cell growth inhibition. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3857041 |
| Abbate R et al. | Decreased number of PGD2 binding sites on platelets from patients with type IIa hyperlipoproteinemia. | 1985 | Atherosclerosis | pmid:3857047 |
| Watanabe K et al. | Enzymatic formation of prostaglandin F2 alpha from prostaglandin H2 and D2. Purification and properties of prostaglandin F synthetase from bovine lung. | 1985 | J. Biol. Chem. | pmid:3858278 |
| Gause GE et al. | Hemodynamic effects of postpulmonary administration of prostaglandin D2 in fetal animals. | 1985 | Proc. Soc. Exp. Biol. Med. | pmid:3858885 |
| Seregi A et al. | The formation and regional distribution of prostaglandins D2 and F2 alpha in the brain of spontaneously convulsing gerbils. | 1985 | Brain Res. | pmid:3859353 |
| Ikai K et al. | Effect of ultraviolet irradiation on mast cell-deficient W/Wv mice. | 1985 | J. Invest. Dermatol. | pmid:3859552 |
| Arisawa M et al. | Suppressive effect of prostaglandin D2 on prolactin secretion from rat anterior pituitary. | 1985 | Asia Oceania J Obstet Gynaecol | pmid:3860198 |
| Spannhake EW et al. | Influence of mediators of anaphylaxis on collateral ventilation and the lung periphery of the dog. | 1985 | J. Pharmacol. Exp. Ther. | pmid:3860642 |
| Rocklin RE et al. | Decreased sensitivity of atopic mononuclear cells to prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2). | 1985 | J. Immunol. | pmid:3160784 |
| Knepel W et al. | Inhibition by prostaglandin E2 of the release of vasopressin and beta-endorphin from rat pituitary neurointermediate lobe or medial basal hypothalamus in vitro. | 1985 | J. Endocrinol. | pmid:3160802 |
| Weinreb RN et al. | Prostanoids in rabbit aqueous humor: effect of laser photocoagulation of the iris. | 1985 | Invest. Ophthalmol. Vis. Sci. | pmid:3860488 |
| Nielsen JA and Sparber SB | Central administration of prostaglandin E2 facilitates while F2 alpha attenuates acute dependence upon morphine rats. | 1985 | Pharmacol. Biochem. Behav. | pmid:3860881 |
| Watanabe Y et al. | Specific bindings of prostaglandin D2, E2 and F2 alpha in postmortem human brain. | 1985 | Brain Res. | pmid:2994820 |
| Fortini A et al. | Heparin does not interfere with prostacyclin and prostaglandin D2 binding to platelets. | 1985 | Thromb. Res. | pmid:3001968 |
| Wasserman SI | The mast cell and theophylline in asthma. | 1985 | Am. J. Med. | pmid:3002176 |
| Bushfield M et al. | Inhibition of platelet-activating-factor-induced human platelet activation by prostaglandin D2. Differential sensitivity of platelet transduction processes and functional responses to inhibition by cyclic AMP. | 1985 | Biochem. J. | pmid:3002327 |
| Ichikawa A et al. | Up-regulation of prostaglandin D2 receptors by agonist binding to beta-adrenoceptors in rabbit platelets. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3004152 |
| Bhattacharya SK and Parmar SS | Prostaglandin D2-induced potentiation of hexobarbitone hypnosis in rats: role of 5-hydroxytryptamine. | 1985 | J. Pharm. Pharmacol. | pmid:2868104 |
| Whittle BJ et al. | Specificity between the anti-aggregatory actions of prostacyclin, prostaglandin E1 and D2 on platelets. | 1985 | Adv. Exp. Med. Biol. | pmid:2871707 |
| Ueno R et al. | Changes of enzymes involved in prostaglandin metabolism and prostaglandin binding proteins in rat brain during development and aging. | 1985 | J. Neurochem. | pmid:3925085 |