PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Sarcoidosis D012507 13 associated lipids
Pleurisy D010998 20 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cataract D002386 34 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Sarcoma 180 D012510 21 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Precancerous Conditions D011230 48 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Hypotension D007022 41 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Coronary Disease D003327 70 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Rhinitis D012220 10 associated lipids
Melanoma D008545 69 associated lipids
Asthma D001249 52 associated lipids
Hyperemia D006940 25 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Leukemia P388 D007941 43 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Myocardial Infarction D009203 21 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

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Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Mutalithas K et al. CRTH2 expression on T cells in asthma. 2010 Clin. Exp. Immunol. pmid:20491797
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Norman P DP(2) receptor antagonists in development. 2010 Expert Opin Investig Drugs pmid:20615077
Pedersen PJ et al. Prostaglandin phospholipid conjugates with unusual biophysical and cytotoxic properties. 2010 Bioorg. Med. Chem. Lett. pmid:20591667
Bai YJ et al. A LC-MS-based method for quantification of biomarkers from serum of allergic rats. 2010 Molecules pmid:20657485
Syed MA et al. Expression of TREM-1 is inhibited by PGD2 and PGJ2 in macrophages. 2010 Exp. Cell Res. pmid:20797396
Lou HQ et al. [CRTH2 antagonist ameliorates airway inflammation in rats with asthma]. 2010 Zhejiang Da Xue Xue Bao Yi Xue Ban pmid:20175238
He R et al. The prostaglandin Dâ‚‚ receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge. 2010 J. Allergy Clin. Immunol. pmid:20713302
Schell C et al. 15-Deoxy-delta 12-14-prostaglandin-J2 induces hypertrophy and loss of contractility in human testicular peritubular cells: implications for human male fertility. 2010 Endocrinology pmid:20133451
Poncin S et al. Oxidative stress: a required condition for thyroid cell proliferation. 2010 Am. J. Pathol. pmid:20093493
Wang Y et al. Role of cyclooxygenase-2 signaling pathway dysfunction in unexplained recurrent spontaneous abortion. 2010 Chin. Med. J. pmid:20819509
Xiao Y et al. 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-gamma-dependent and mediated by the caspase-3-dependent apoptotic pathway. 2010 FEBS J. pmid:20050918
van den Brule S et al. The D prostanoid receptor agonist BW245C [(4S)-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidineheptanoic acid] inhibits fibroblast proliferation and bleomycin-induced lung fibrosis in mice. 2010 J. Pharmacol. Exp. Ther. pmid:20719937
Watanabe K et al. 15-deoxy-delta 12,14-prostaglandin J2 prevents inflammatory response and endothelial cell damage in rats with acute obstructive cholangitis. 2010 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:20056897
Kar R et al. Mitochondrial remodeling following fission inhibition by 15d-PGJ2 involves molecular changes in mitochondrial fusion protein OPA1. 2010 Biochem. Biophys. Res. Commun. pmid:20678484
Satoh T et al. Indomethacin-induced reduction in CRTH2 in eosinophilic pustular folliculitis (Ofuji's disease): a proposed mechanism of action. 2010 Acta Derm. Venereol. pmid:20107720
Akin C et al. Mast cell activation syndrome: Proposed diagnostic criteria. 2010 J. Allergy Clin. Immunol. pmid:21035176
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Buga GM et al. L-4F alters hyperlipidemic (but not healthy) mouse plasma to reduce platelet aggregation. 2010 Arterioscler. Thromb. Vasc. Biol. pmid:19965777
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Byrns MC et al. Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer. 2010 J. Steroid Biochem. Mol. Biol. pmid:20036328
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Subra C et al. Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins. 2010 J. Lipid Res. pmid:20424270
Bancos S et al. Induction of heme oxygenase-1 in normal and malignant B lymphocytes by 15-deoxy-Delta(12,14)-prostaglandin J(2) requires Nrf2. 2010 Cell. Immunol. pmid:20064636
Oh YC et al. Anti-allergic activity of a platycodon root ethanol extract. 2010 Int J Mol Sci pmid:20717534
Lee CM et al. Prostaglandin expression profile in hypoxic osteoblastic cells. 2010 J. Bone Miner. Metab. pmid:19471853
Kim SH et al. Toluene diisocyanate (TDI) regulates haem oxygenase-1/ferritin expression: implications for toluene diisocyanate-induced asthma. 2010 Clin. Exp. Immunol. pmid:20345975
Zimmer M et al. The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. 2010 Cancer Res. pmid:20354189
Koyama M et al. Histone deacetylase inhibitors and 15-deoxy-Delta12,14-prostaglandin J2 synergistically induce apoptosis. 2010 Clin. Cancer Res. pmid:20371690
Kim DH et al. 15-Deoxy-Delta(12,14)-prostaglandin J(2) stabilizes, but functionally inactivates p53 by binding to the cysteine 277 residue. 2010 Oncogene pmid:20208557
Cho HY et al. Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice. 2010 Am. J. Respir. Crit. Care Med. pmid:20224069
Krall CM et al. Food deprivation alters thermoregulatory responses to lipopolysaccharide by enhancing cryogenic inflammatory signaling via prostaglandin D2. 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20393159
Lee JJ et al. The protective effects of paclitaxel on platelet aggregation through the inhibition of thromboxane A2 synthase. 2010 Arch. Pharm. Res. pmid:20361303
Pérez-Novo CA et al. CRTH2 mediates the activation of human Th2 cells in response to PGD(2) released from IgE/anti-IgE treated nasal polyp tissue. 2010 Allergy pmid:19839971
Mo C et al. PPARgamma regulates LIF-induced growth and self-renewal of mouse ES cells through Tyk2-Stat3 pathway. 2010 Cell. Signal. pmid:19922793
Kanda N et al. Prostaglandin D2 induces the production of human beta-defensin-3 in human keratinocytes. 2010 Biochem. Pharmacol. pmid:19925780
Shim J et al. The peroxisome proliferator-activated receptor gamma ligands, pioglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2), have antineoplastic effects against hepatitis B virus-associated hepatocellular carcinoma cells. 2010 Int. J. Oncol. pmid:19956851
Bach-Ngohou K et al. Enteric glia modulate epithelial cell proliferation and differentiation through 15-deoxy-12,14-prostaglandin J2. 2010 J. Physiol. (Lond.) pmid:20478974
Masoodi M et al. Prostaglandin D production in FM55 melanoma cells is regulated by alpha-melanocyte-stimulating hormone and is not related to melanin production. 2010 Exp. Dermatol. pmid:20482620
Hilliard M et al. The anti-inflammatory prostaglandin 15-deoxy-delta(12,14)-PGJ2 inhibits CRM1-dependent nuclear protein export. 2010 J. Biol. Chem. pmid:20457605
Yokoyama Y et al. 15-Deoxy-Delta12,14-prostaglandin J2 inhibits angiotensin II-induced fibronectin expression via hepatocyte growth factor induction in human peritoneal mesothelial cells. 2010 Ther Apher Dial pmid:20438519
Romanovsky AA and Garami A Prostaglandin riddles in energy metabolism: E is for excess, D is for depletion. Focus on "Food deprivation alters thermoregulatory responses to lipopolysaccharide by enhancing cryogenic inflammatory signaling via prostaglandin D2". 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20410482
Shiraya K et al. A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules. 2010 J. Biol. Chem. pmid:20448048
Mishra N et al. Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-Delta(12,14)-prostaglandin J2. 2010 Biochem. Biophys. Res. Commun. pmid:20307494
Guo N et al. Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease. 2010 J. Biol. Chem. pmid:20308056
Poncin S et al. N-acetylcysteine and 15 deoxy-{delta}12,14-prostaglandin J2 exert a protective effect against autoimmune thyroid destruction in vivo but not against interleukin-1{alpha}/interferon {gamma}-induced inhibitory effects in thyrocytes in vitro. 2010 Am. J. Pathol. pmid:20489149
Kolaczkowska E et al. Resident peritoneal macrophages and mast cells are important cellular sites of COX-1 and COX-2 activity during acute peritoneal inflammation. 2009 Nov-Dec Arch. Immunol. Ther. Exp. (Warsz.) pmid:19885646
Moreira V et al. Effects of Bothrops asper snake venom on the expression of cyclooxygenases and production of prostaglandins by peritoneal leukocytes in vivo, and by isolated neutrophils and macrophages in vitro. 2009 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:19155166
Csanky E et al. Lipid metabolite levels of prostaglandin D2 and eicosapentaenoic acid recovered from bronchoalveolar lavage fluid correlate with lung function of chronic obstructive pulmonary disease patients and controls. 2009 Electrophoresis pmid:19294692
Kase K et al. Inhibitory action of roxithromycin on histamine release and prostaglandin D2 production from beta-defensin 2-stimulated mast cells. 2009 Int. J. Mol. Med. pmid:19212651
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Passeron T et al. Upregulation of SOX9 inhibits the growth of human and mouse melanomas and restores their sensitivity to retinoic acid. 2009 J. Clin. Invest. pmid:19273910
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Whelan CJ Evidence that 13-14 di-hydro, 15-keto prostaglandin D(2)-induced airway eosinophilia in guinea-pigs is independent of interleukin-5. 2009 Inflamm. Res. pmid:19184361
Liu J et al. Peroxisome proliferator-activated receptor-gamma ligands 15-deoxy-delta(12,14)-prostaglandin J2 and pioglitazone inhibit hydroxyl peroxide-induced TNF-alpha and lipopolysaccharide-induced CXC chemokine expression in neonatal rat cardiac myocytes. 2009 Shock pmid:19174742
Kolaczkowska E et al. Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9. 2009 Immunology pmid:19175797
Joo M et al. Lipopolysaccharide-dependent interaction between PU.1 and c-Jun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages. 2009 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:19181746
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Moriai M et al. Down-regulation of hTERT expression plays an important role in 15-deoxy-Delta12,14-prostaglandin J2-induced apoptosis in cancer cells. 2009 Int. J. Oncol. pmid:19360348
Boehme SA et al. Murine bone marrow-derived mast cells express chemoattractant receptor-homologous molecule expressed on T-helper class 2 cells (CRTh2). 2009 Int. Immunol. pmid:19346259
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Ono E et al. Increased production of cysteinyl leukotrienes and prostaglandin D2 during human anaphylaxis. 2009 Clin. Exp. Allergy pmid:19128354
Shin SW et al. 15d-PGJ2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity. 2009 Clin. Cancer Res. pmid:19690198
Wendeburg L et al. Resveratrol inhibits prostaglandin formation in IL-1beta-stimulated SK-N-SH neuronal cells. 2009 J Neuroinflammation pmid:19751497
Ferguson HE et al. Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism. 2009 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:19734319
Kim DH et al. Effects of 15-deoxy-delta 12, 14-prostaglandin J2 on the expression of p53 in MCF-7 cells. 2009 Ann. N. Y. Acad. Sci. pmid:19723057
Song NY et al. 15-Deoxy-delta 12, 14-prostaglandin J2 induces upregulation of multidrug resistance-associated protein 1 via Nrf2 activation in human breast cancer cells. 2009 Ann. N. Y. Acad. Sci. pmid:19723058
Di Francesco L et al. Induction of prostacyclin by steady laminar shear stress suppresses tumor necrosis factor-alpha biosynthesis via heme oxygenase-1 in human endothelial cells. 2009 Circ. Res. pmid:19122175
Wang WM et al. PPAR-gamma agonists inhibit TGF-beta1-induced chemokine expression in human tubular epithelial cells. 2009 Acta Pharmacol. Sin. pmid:19098936
Waku T et al. Atomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligands. 2009 FEBS Lett. pmid:19101554
Selg E et al. Two different mechanisms for modulation of bronchoconstriction in guinea-pigs by cyclooxygenase metabolites. 2009 Prostaglandins Other Lipid Mediat. pmid:19103301
Dong YW et al. Suppression of pancreatic carcinoma growth by activating peroxisome proliferator-activated receptor gamma involves angiogenesis inhibition. 2009 World J. Gastroenterol. pmid:19152448
Koinuma S et al. The resetting of the circadian rhythm by Prostaglandin J2 is distinctly phase-dependent. 2009 FEBS Lett. pmid:19111547
Baregamian N et al. PPAR-gamma agonist protects against intestinal injury during necrotizing enterocolitis. 2009 Biochem. Biophys. Res. Commun. pmid:19114032
Byrns MC and Penning TM Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. 2009 Chem. Biol. Interact. pmid:19010312
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Bernardo A et al. Peroxisome proliferator-activated receptor-gamma agonists promote differentiation and antioxidant defenses of oligodendrocyte progenitor cells. 2009 J. Neuropathol. Exp. Neurol. pmid:19535992
Comabella M et al. Plasma levels of 15d-PGJ are not altered in multiple sclerosis. 2009 Eur. J. Neurol. pmid:19538219
Qin HD et al. Upregulation of peroxisome proliferator-activated receptor-gamma and NADPH oxidases are involved in restenosis after balloon injury. 2009 J. Cell. Physiol. pmid:19562688
Leduc M et al. Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands. 2009 J. Pharmacol. Exp. Ther. pmid:19584306
Bai G et al. Regulation of ANP secretion from isolated atria by prostaglandins and cyclooxygenase-2. 2009 Peptides pmid:19539681
Pierre SR et al. Subchronic infusion of the product of inflammation prostaglandin J2 models sporadic Parkinson's disease in mice. 2009 J Neuroinflammation pmid:19630993
Pena-dos-Santos DR et al. Activation of peripheral kappa/delta opioid receptors mediates 15-deoxy-(Delta12,14)-prostaglandin J2 induced-antinociception in rat temporomandibular joint. 2009 Neuroscience pmid:19647045
Asano S et al. Effects of prostaglandin D2 on Na-dependent phosphate transport activity and its intracellular signaling mechanism in osteoblast-like cells. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19616422
Gao W et al. Prostaglandin D2 produced by hematopoietic prostaglandin D synthase contributes to LPS-induced fever. 2009 J. Physiol. Pharmacol. pmid:19617658
Hironaka A et al. 15-Deoxy-Delta(12,14)-prostaglandin J(2) impairs the functions of histone acetyltransferases through their insolubilization in cells. 2009 Biochem. Biophys. Res. Commun. pmid:19799872
Ohinata K et al. Complement C5a stimulates food intake via a prostaglandin D(2)- and neuropeptide Y-dependent mechanism in mice. 2009 Prostaglandins Other Lipid Mediat. pmid:19800413
Tagen M et al. Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content. 2009 J. Immunol. pmid:19846869
Prakash J et al. Albumin-binding and tumor vasculature determine the antitumor effect of 15-deoxy-Delta-(12,14)-prostaglandin-J(2) in vivo. 2009 Neoplasia pmid:20019843