| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pancreatitis, Acute Necrotizing | D019283 | 18 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Down Syndrome | D004314 | 18 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Cough | D003371 | 19 associated lipids |
| Hypothermia | D007035 | 19 associated lipids |
| Peptic Ulcer | D010437 | 19 associated lipids |
| Dermatitis, Atopic | D003876 | 19 associated lipids |
| Parkinsonian Disorders | D020734 | 20 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Black PN et al. | Effect of inhaled leukotriene B4 alone and in combination with prostaglandin D2 on bronchial responsiveness to histamine in normal subjects. | 1989 | Thorax | pmid:2548300 |
| Kuiper J et al. | Induction of ornithine decarboxylase in rat liver by phorbol ester is mediated by prostanoids from Kupffer cells. | 1989 | J. Biol. Chem. | pmid:2708347 |
| Kawabe Y et al. | Genesis and recovery of ethanol-induced gastric lesions in rats: possible involvement of prostaglandin D2. | 1989 | Am. J. Gastroenterol. | pmid:2916522 |
| Sakai T et al. | Protection by cycloheximide against cytotoxicity induced by vincristine, colchicine, or delta 12-prostaglandin J2 on human osteosarcoma cells. | 1989 | Cancer Res. | pmid:2917351 |
| Phillips GD and Holgate ST | Interaction of inhaled LTC4 with histamine and PGD2 on airway caliber in asthma. | 1989 | J. Appl. Physiol. | pmid:2917934 |
| Ban M et al. | A flavonoid inhibitor of 5-lipoxygenase inhibits leukotriene production following ischemia in gerbil brain. | 1989 | Stroke | pmid:2919414 |
| Ikai K et al. | Inhibitory effect of tranilast on prostaglandin D synthetase. | 1989 | Biochem. Pharmacol. | pmid:2475113 |
| Woodward DF et al. | Marked differential effects of prostanoid metabolites on rabbit intraocular pressure. | 1989 | Ophthalmic Res. | pmid:2626239 |
| Busshardt E et al. | Regulation of hepatic parenchymal and non-parenchymal cell function by the diadenine nucleotides Ap3A and Ap4A. | 1989 | Biochim. Biophys. Acta | pmid:2563228 |
| Nishino S et al. | Salivary prostaglandin concentrations: possible state indicators for major depression. | 1989 | Am J Psychiatry | pmid:2627202 |
| Church MK et al. | Interaction of neuropeptides with human mast cells. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468622 |
| Charlesworth EN et al. | Cutaneous late-phase response to allergen. Mediator release and inflammatory cell infiltration. | 1989 | J. Clin. Invest. | pmid:2468688 |
| Charlesworth EN et al. | Effect of cetirizine on mast cell-mediator release and cellular traffic during the cutaneous late-phase reaction. | 1989 | J. Allergy Clin. Immunol. | pmid:2469708 |
| Church MK et al. | Mast cells, neuropeptides and inflammation. | 1989 | Agents Actions | pmid:2473641 |
| van Overveld FJ | Mediator release from human lung mast cell subtypes in chronic bronchitis and emphysema. | 1989 | Agents Actions | pmid:2473645 |
| Benyon RC et al. | Differential release of histamine and eicosanoids from human skin mast cells activated by IgE-dependent and non-immunological stimuli. | 1989 | Br. J. Pharmacol. | pmid:2474353 |
| Emery DL et al. | Prostaglandin D2 causes accumulation of eosinophils in the lumen of the dog trachea. | 1989 | J. Appl. Physiol. | pmid:2793725 |
| Dubertret L et al. | Biological and cellular responses to grass pollen in sensitive patients. | 1989 | Dermatologica | pmid:2476344 |
| Wachs M et al. | Observations on the pathogenesis of nasal priming. | 1989 | J. Allergy Clin. Immunol. | pmid:2477429 |
| Asbóth G et al. | The relation between thromboxane and prostaglandin synthesis in human decidua tissue: a comparison of eicosanoid synthesis in minced tissue with that in a cell-free preparation. | 1989 | Biochim. Biophys. Acta | pmid:2493805 |
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| Thierauch KH et al. | Stable 9 beta- or 11 alpha-halogen-15-cyclohexyl-prostaglandins with high affinity to the PGD2-receptor. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526554 |
| Coe JY et al. | A fetal-instrumented model to study age-specific responses to leukotriene D4 and prostaglandin D2 in unsedated newborn lambs. | 1989 | Can. J. Physiol. Pharmacol. | pmid:2776077 |
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| Thierauch KH et al. | ZK 110 841--a selective and potent prostaglandin D2 analogue. | 1989 | Prog. Clin. Biol. Res. | pmid:2798462 |
| Ashida Y et al. | A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. | 1989 | Prostaglandins | pmid:2748922 |
| Raisz LG and Woodiel FN | Effect of alterations in the cyclopentane ring on bone resorptive activity of prostaglandin. | 1989 | Prostaglandins | pmid:2727307 |
| Wolfe LS et al. | Metabolism of prostaglandin D2 by human cerebral cortex into 9 alpha, 11 beta-prostaglandin F2 by an active NADPH-dependent 11-ketoreductase. | 1989 | J. Neurochem. | pmid:2723663 |
| Hayaishi O | Prostaglandin D2 and sleep. | 1989 | Ann. N. Y. Acad. Sci. | pmid:2774407 |
| Deckers IA et al. | Evidence for the involvement of prostaglandins in modulation of acetylcholine release from canine bronchial tissue. | 1989 | Eur. J. Pharmacol. | pmid:2806380 |
| Kuiper J et al. | Cellular communication inside the liver. Binding, conversion and metabolic effect of prostaglandin D2 on parenchymal liver cells. | 1989 | Biochem. J. | pmid:2818563 |
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| Casteleijn E et al. | Endotoxin stimulates glycogenolysis in the liver by means of intercellular communication. | 1988 | J. Biol. Chem. | pmid:3284878 |
| Barr RM et al. | The in vitro 5-lipoxygenase and cyclo-oxygenase inhibitor L-652,343 does not inhibit 5-lipoxygenase in vivo in human skin. | 1988 | Br J Clin Pharmacol | pmid:2835975 |
| Giles H and Leff P | The biology and pharmacology of PGD2. | 1988 | Prostaglandins | pmid:3283848 |
| Featherstone RL et al. | Active sensitization of guinea-pig airways in vivo enhances in vivo and in vitro responsiveness. | 1988 | Eur. Respir. J. | pmid:3229483 |
| Petrini B et al. | Modulation of lymphocyte and monocyte responses in vitro by 9-deoxy-delta 9-prostaglandin D2 and 9-deoxy-delta 9-delta 12-prostaglandin D2. | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:3229858 |
| Hayaishi O | Sleep-wake regulation by prostaglandins D2 and E2. | 1988 | J. Biol. Chem. | pmid:3049580 |
| Beasley R et al. | Comparative vascular effects of histamine, prostaglandin (PG) D2 and its metabolite 9 alpha,11 beta-PGF2 in human skin. | 1988 | Clin. Allergy | pmid:3242978 |
| Ohishi K et al. | Increased level of salivary prostaglandins in patients with major depression. | 1988 | Biol. Psychiatry | pmid:3422573 |
| Casteleijn E et al. | Hormonal control of glycogenolysis in parenchymal liver cells by Kupffer and endothelial liver cells. | 1988 | J. Biol. Chem. | pmid:3422638 |
| Kuiper J et al. | Identification of prostaglandin D2 as the major eicosanoid from liver endothelial and Kupffer cells. | 1988 | Biochim. Biophys. Acta | pmid:3126817 |
| Hahn HL | [Inflammatory mediators in the pathogenesis of obstructive bronchial diseases: consequences for therapy]. | 1988 | Verh Dtsch Ges Inn Med | pmid:2905102 |
| Altin JG and Bygrave FL | Prostaglandin F2 alpha and the thromboxane A2 analogue ONO-11113 stimulate Ca2+ fluxes and other physiological responses in rat liver. Further evidence that prostanoids may be involved in the action of arachidonic acid and platelet-activating factor. | 1988 | Biochem. J. | pmid:3128268 |
| Kawata R et al. | Prostaglandin synthesis by the cochlea. | 1988 | Prostaglandins | pmid:3129756 |
| Heavey DJ et al. | Generation of leukotriene C4, leukotriene B4, and prostaglandin D2 by immunologically activated rat intestinal mucosa mast cells. | 1988 | J. Immunol. | pmid:2450136 |
| Parsons WG and Roberts LJ | Transformation of prostaglandin D2 to isomeric prostaglandin F2 compounds by human eosinophils. A potential mast cell-eosinophil interaction. | 1988 | J. Immunol. | pmid:3139758 |
| Kuiper J et al. | The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3144970 |
| Nakagomi T et al. | Effect of removal of the endothelium on vasocontraction in canine and rabbit basilar arteries. | 1988 | J. Neurosurg. | pmid:2895803 |
| Fukui A et al. | Effects of prostaglandin D2 and omeprazole on indomethacin-induced gastric ulcers in rats. | 1988 | Clin. Exp. Pharmacol. Physiol. | pmid:3149561 |
| Vigano T et al. | Prostaglandin synthetase inhibition and formation of lipoxygenase products in immunologically challenged normal human lung parenchyma. | 1988 | Eicosanoids | pmid:3152489 |
| Casteleijn E et al. | Prostaglandin D2 mediates the stimulation of glycogenolysis in the liver by phorbol ester. | 1988 | Biochem. J. | pmid:3162673 |
| Ishioka C et al. | Inhibitory effects of prostaglandin A2 on c-myc expression and cell cycle progression in human leukemia cell line HL-60. | 1988 | Cancer Res. | pmid:3162825 |
| Miadonna A et al. | Mediators and allergic inflammation of human airways. | 1988 | Respiration | pmid:2466314 |
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| Wasserman SI | Basic mechanisms in asthma. | 1988 | Ann Allergy | pmid:3163472 |
| Lebel B et al. | Spontaneous and non-specific release of histamine and PGD2 by bronchoalveolar lavage cells from asthmatic and normal subjects: effect of nedocromil sodium. | 1988 | Clin. Allergy | pmid:2468432 |
| Sonoki H et al. | [Effects of 3,4-diaminopyridine on the contractions of guinea-pig tracheal smooth muscle induced by histamine and prostaglandin D2]. | 1988 | Nippon Yakurigaku Zasshi | pmid:3163668 |
| Ujihara M et al. | Biochemical and immunological demonstration of prostaglandin D2, E2, and F2 alpha formation from prostaglandin H2 by various rat glutathione S-transferase isozymes. | 1988 | Arch. Biochem. Biophys. | pmid:3041912 |
| Foreman D et al. | Anhydrolevuglandin D2 inhibits the uterotonic activity of prostaglandins F2 alpha and D2. | 1988 | Prostaglandins | pmid:3163807 |
| Moore PK et al. | Effect of fibrinopeptides A and B on human and rat platelet aggregation in vitro. | 1988 | Eur. J. Pharmacol. | pmid:3053211 |
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| Casteleijn E et al. | Conditioned media of Kupffer and endothelial liver cells influence protein phosphorylation in parenchymal liver cells. Involvement of prostaglandins. | 1988 | Biochem. J. | pmid:3166374 |
| Hoult JR et al. | Organ selective conversion of prostaglandin D2 to 9 alpha, 11 beta-prostaglandin F2 and its subsequent metabolism in rat, rabbit and guinea pig. | 1988 | Biochem. Pharmacol. | pmid:3178873 |
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| Schulman ES et al. | Differential effects of the complement peptides, C5a and C5a des Arg on human basophil and lung mast cell histamine release. | 1988 | J. Clin. Invest. | pmid:2449462 |
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| Robinson C et al. | The immunoglobulin E- and calcium-dependent release of histamine and eicosanoids from human dispersed mastocytosis spleen cells. | 1988 | J. Invest. Dermatol. | pmid:2450144 |
| Holgate ST et al. | The contribution of mast cell mediators to acute allergic reactions in human skin and airways. | 1988 | Allergy | pmid:2451448 |
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| Rao PS et al. | The effect of prostaglandin D2 on angiotensin converting enzyme. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2845437 |
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| Lebel B et al. | Correlation between symptoms and the threshold for release of mediators in nasal secretions during nasal challenge with grass-pollen grains. | 1988 | J. Allergy Clin. Immunol. | pmid:2461405 |
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| Takei M et al. | Role of cyclic AMP during histamine release. Histamine release is not directly related to increase in cyclic AMP levels in rat mast cells activated by concanavalin A, anti-IgE, antigen, prostaglandin D2 and isoproterenol. | 1988 | Biol. Chem. Hoppe-Seyler | pmid:2463844 |
| Wang D et al. | Aminophylline reduces air-flow-induced constriction in the canine lung periphery. | 1988 | Am. Rev. Respir. Dis. | pmid:3422143 |
| Wendelborn DF et al. | Isomeric prostaglandin F2 compounds arising from prostaglandin D2: a family of icosanoids produced in vivo in humans. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3422430 |
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| Shohami E et al. | Experimental closed head injury in rats: prostaglandin production in a noninjured zone. | 1988 | Neurosurgery | pmid:3164097 |
| Dieter P et al. | Ca2+ requirement of prostanoid but not of superoxide production by rat Kupffer cells. | 1988 | Eur. J. Biochem. | pmid:2846298 |
| Thierauch KH et al. | Stable 9 beta- or 11 alpha-halogen-15-cyclohexyl-prostaglandins with high affinity to the PGD2-receptor. | 1988 | Prostaglandins | pmid:2847246 |
| Kashimura M et al. | Prostaglandin D2 diminishes transmucosal potential difference in rat colonic mucosa in vitro in contrast to the increasing effect of prostaglandin E1. | 1988 | Prostaglandins | pmid:2854645 |
| Lahoua Z et al. | Serum-induced arachidonic acid release and prostaglandin biosynthesis are potentiated by oxygenated sterols in NRK 49F cells. | 1988 | Biochim. Biophys. Acta | pmid:3124881 |
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| Morimoto A et al. | Multiple control of fever production in the central nervous system of rabbits. | 1988 | J. Physiol. (Lond.) | pmid:3261794 |
| Kleeberger SR et al. | The role of mediators in the response of the canine peripheral lung to 1 ppm ozone. | 1988 | Am. Rev. Respir. Dis. | pmid:2829670 |
| Yokotani K et al. | Sympathoadrenomedullary system mediation of the prostaglandin E2-induced central inhibition of gastric acid output in rats. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3422095 |
| Robinson C et al. | The metabolism of prostaglandin D2 after inhalation or intravenous infusion in normal men. | 1988 | Biochim. Biophys. Acta | pmid:3196723 |
| Miwa N et al. | Prostaglandin induces Ca2+ influx and cyclic GMP formation in mouse neuroblastoma X rat glioma hybrid NG108-15 cells in culture. | 1988 | J. Neurochem. | pmid:2834513 |
| Armour CL et al. | Prostaglandin F2 alpha augments the response to parasympathetic fibre stimulation in an isolated innervated preparation of rabbit trachea. | 1988 | J Auton Pharmacol | pmid:3198665 |