| MeSH term | MeSH ID | Detail |
|---|---|---|
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Pancreatitis, Acute Necrotizing | D019283 | 18 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Down Syndrome | D004314 | 18 associated lipids |
| Cough | D003371 | 19 associated lipids |
| Hypothermia | D007035 | 19 associated lipids |
| Peptic Ulcer | D010437 | 19 associated lipids |
| Dermatitis, Atopic | D003876 | 19 associated lipids |
| Parkinsonian Disorders | D020734 | 20 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Barrow SE et al. | Measurement of prostaglandin D2 and identification of metabolites in human plasma during intravenous infusion. | 1984 | Prostaglandins | pmid:6441188 |
| Bertelé V et al. | Pharmacologic inhibition of thromboxane synthetase and platelet aggregation: modulatory role of cyclooxygenase products. | 1984 | Blood | pmid:6426554 |
| Gresele P et al. | Serum albumin enhances the impairment of platelet aggregation with thromboxane synthase inhibition by increasing the formation of prostaglandin D2. | 1984 | Biochem. Pharmacol. | pmid:6430299 |
| Vicenzi E et al. | Human mononuclear phagocytes from different anatomical sites differ in their capacity to metabolize arachidonic acid. | 1984 | Clin. Exp. Immunol. | pmid:6432383 |
| Nishi S et al. | Different effects of prostaglandin E1, E2 and D2 on pancreatic somatostatin release. | 1984 | Horm. Metab. Res. | pmid:6152434 |
| Neely SM et al. | Mechanism and characteristics of platelet activation by haematin. | 1984 | Br. J. Haematol. | pmid:6383458 |
| Uchizono K | [Studies of sleep inducing substance]. | 1984 | Nippon Rinsho | pmid:6384575 |
| Philips JB and Lyrene RK | Prostaglandins, related compounds, and the perinatal pulmonary circulation. | 1984 | Clin Perinatol | pmid:6386270 |
| Goetzl EJ | Asthma: new mediators and old problems. | 1984 | N. Engl. J. Med. | pmid:6330554 |
| Vincent JE et al. | The effect of 5-(2-chlorobenzyl)-5,6,7,7a-tetrahydro 4H-thieno (3.2-C)-pyridine-2-one hydrochloride (PCR 3787), a metabolite of ticlopidine, on the aggregation of human platelets in vitro and on the aggregation inhibiting action of PGI2 and PGD2. | 1984 | Prostaglandins Leukot Med | pmid:6396655 |
| Weichman BM et al. | SK&F 88046: a unique pharmacologic antagonist of bronchoconstriction induced by leukotriene D4, thromboxane and prostaglandins F2 alpha and D2 in vitro. | 1984 | J. Pharmacol. Exp. Ther. | pmid:6582266 |
| Higashida H et al. | Facilitation of synaptic transmission by prostaglandin D2 at synapses between NG108-15 hybrid and muscle cells. | 1984 | Brain Res. | pmid:6324947 |
| Bertelé V et al. | SQ 22536, an adenylate-cyclase inhibitor, prevents the antiplatelet effect of dazoxiben, a thromboxane-synthetase inhibitor. | 1984 | Thromb. Haemost. | pmid:6326343 |
| Chapnick BM | Divergent influences of leukotrienes C4, D4, and E4 on mesenteric and renal blood flow. | 1984 | Am. J. Physiol. | pmid:6326595 |
| Gardiner PJ and Browne JL | Tussive activity of inhaled PGD2 in the cat and characterisation of the receptor(s) involved. | 1984 | Prostaglandins Leukot Med | pmid:6328541 |
| Zavoico GB and Feinstein MB | Cytoplasmic Ca2+ in platelets is controlled by cyclic AMP: antagonism between stimulators and inhibitors of adenylate cyclase. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6329175 |
| Pan IQ et al. | Alteration of platelet responses to metabolites of arachidonic acid by oral contraceptives. | 1984 | Br. J. Haematol. | pmid:6089860 |
| Nilsson J and Olsson AG | Prostaglandin E1 inhibits DNA synthesis in arterial smooth muscle cells stimulated with platelet-derived growth factor. | 1984 | Atherosclerosis | pmid:6093830 |
| Seregi A et al. | Decreased levels of brain cyclo-oxygenase products as a possible cause of increased seizure susceptibility in convulsion-prone gerbils. | 1984 | Brain Res. | pmid:6430471 |
| Ikai K et al. | Prostaglandin D2 and prostaglandin D synthetase in mast cell deficient mice. | 1984 | Prostaglandins | pmid:6435183 |
| Holgate ST and Robinson C | 6,9-deepoxy-6,9-(phenylimino)-delta 6,8-Prostaglandin I1, (U-60,257) stimulates prostaglandin D2 and inhibits thromboxane B2 release from ionophore challenged human dispersed lung cells. | 1984 | Br. J. Pharmacol. | pmid:6439267 |
| Erman A and Nasjletti A | Enhancement of renal medulla prostaglandin synthetase activity by dexamethasone treatment in the rat. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6428405 |
| Holgate ST et al. | Anaphylactic- and calcium-dependent generation of prostaglandin D2 (PGD2), thromboxane B2, and other cyclooxygenase products of arachidonic acid by dispersed human lung cells and relationship to histamine release. | 1984 | J. Immunol. | pmid:6206153 |
| Schleimer RP et al. | Inflammatory mediators and mechanisms of release from purified human basophils and mast cells. | 1984 | J. Allergy Clin. Immunol. | pmid:6208229 |
| Mahmud I et al. | On the identification and biological properties of prostaglandin J2. | 1984 | Prostaglandins Leukot Med | pmid:6597446 |
| Arisawa M et al. | Direct suppressive effect of prostaglandin D2 on growth hormone secretion from rat anterior pituitary. | 1984 | Asia Oceania J Obstet Gynaecol | pmid:6598030 |
| Newman JH and Sheller JR | Arachidonic acid metabolites in the healthy and diseased lung. | 1984 | Am. J. Med. Sci. | pmid:6091454 |
| Ogorochi T et al. | Regional distribution of prostaglandins D2, E2, and F2 alpha and related enzymes in postmortem human brain. | 1984 | J. Neurochem. | pmid:6427411 |
| Gal D et al. | Effect of radiation on prostaglandin production by human bowel in vitro. | 1984 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:6588048 |
| Brus R et al. | Effect of prostaglandins on morphine-induced catalepsy in mice. | 1983 Sep-Dec | Acta Physiol Pol | pmid:6679984 |
| Gaetani P et al. | [Prostaglandin D2 in subarachnoid hemorrhage. Biological and diagnostic implications]. | 1983 Jul-Aug | Riv Patol Nerv Ment | pmid:6598516 |
| Ogino N et al. | Phagocytic activity of cultured retinal pigment epithelial cells from chick embryo: inhibition by melatonin and cyclic AMP, and its reversal by taurine and cyclic GMP. | 1983 | Ophthalmic Res. | pmid:6136017 |
| Ruzicka T et al. | Inhibition of rat mast cell arachidonic acid cyclooxygenase by dapsone. | 1983 | J. Allergy Clin. Immunol. | pmid:6413566 |
| Westcott JY and Murphy RC | The interaction of ethanol and exogenous arachidonic acid in the formation of leukotrienes and prostaglandin D2 in mastocytoma cells. | 1983 | Prostaglandins | pmid:6316419 |
| Meuten DJ et al. | Hypercalcemia in dogs with adenocarcinoma derived from apocrine glands of the anal sac. Biochemical and histomorphometric investigations. | 1983 | Lab. Invest. | pmid:6300551 |
| Town MH et al. | Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors. | 1983 | Prostaglandins | pmid:6302737 |
| Hawk JL et al. | Increased concentrations of arachidonic acid, prostaglandins E2, D2, and 6-oxo-F1 alpha, and histamine in human skin following UVA irradiation. | 1983 | J. Invest. Dermatol. | pmid:6343514 |
| Ahlquist DA et al. | Factors influencing metabolism of arachidonic acid in guinea pig gastric mucosa. | 1983 | Am. J. Physiol. | pmid:6401937 |
| Whittle BJ et al. | Platelet and cardiovascular activity of the hydantoin BW245C, a potent prostaglandin analogue. | 1983 | Prostaglandins | pmid:6344147 |
| Homma T and Malik KU | Effect of secretin and caerulein in canine pancreas: relation to prostaglandins. | 1983 | Am. J. Physiol. | pmid:6344655 |
| Naclerio RM et al. | Mediator release after nasal airway challenge with allergen. | 1983 | Am. Rev. Respir. Dis. | pmid:6354022 |
| Inoué S | [Sleep substances: their roles and evolution]. | 1983 | Seikagaku | pmid:6355327 |
| Tasaka K et al. | Prostaglandin D2 induces release of luteinizing hormone from the rat pituitary gland without the modulation of hypothalamic luteinizing hormone releasing hormone. | 1983 | J. Endocrinol. | pmid:6361197 |
| Horie H et al. | Modulation by prostaglandin D2 of glucagon and insulin secretion in the perfused rat pancreas. | 1983 | Prostaglandins Leukot Med | pmid:6361782 |
| Lifschitz MD | Renal effects of nonsteroidal anti-inflammatory agents. | 1983 | J. Lab. Clin. Med. | pmid:6411840 |
| Drummond WH | Persistent pulmonary hypertension of the neonate (persistent fetal circulation syndrome). | 1983 | Adv Pediatr | pmid:6424420 |
| Yamashita A et al. | Autoradiographic localization of a binding protein(s) specific for prostaglandin D2 in rat brain. | 1983 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6310617 |
| Hall TJ and Brostoff J | Inhibition of human natural killer cell activity by prostaglandin D2. | 1983 | Immunol. Lett. | pmid:6321333 |
| Bedwani JR et al. | Effects of prostaglandins E2, I2 and D2 on pig nasal vasculature. | 1983 | Clin Otolaryngol Allied Sci | pmid:6357570 |
| Schleimer RP et al. | Effects of dexamethasone on mediator release from human lung fragments and purified human lung mast cells. | 1983 | J. Clin. Invest. | pmid:6134755 |
| Gimeno AL et al. | Prostacyclin induces a surprising long-lasting motility in quiescent uterine strips (indomethacin-treated) isolated from ovariectomized rats. | 1983 | Prostaglandins | pmid:6361911 |
| Norman PS | The John Sheldon memorial lecture. Review of nasal therapy: update. | 1983 | J. Allergy Clin. Immunol. | pmid:6195204 |
| Ennis M et al. | Action of 3-isobutyl-1-methylxanthine and prostaglandins D2 and E1 on histamine release from rat and guinea pig mast cells. | 1983 | Int. Arch. Allergy Appl. Immunol. | pmid:6196300 |
| Gensini GF et al. | Ticlopidine activity on platelet function in patients with enhanced platelet aggregation. A short-term crossover study. | 1983 | Haemostasis | pmid:6228500 |
| Osama H et al. | Inhibition of brain prostaglandin D synthetase and prostaglandin D2 dehydrogenase by some saturated and unsaturated fatty acids. | 1983 | Biochim. Biophys. Acta | pmid:6407532 |
| Scott HW et al. | Hazards in operative management of patients with systemic mastocytosis. | 1983 | Ann. Surg. | pmid:6189461 |
| Schulman ES et al. | Heterogeneity of human mast cells. | 1983 | J. Immunol. | pmid:6194221 |
| Stringfellow DA | Prostaglandins and metastasis. | 1983 | Symp Fundam Cancer Res | pmid:6206537 |
| Feinstein MB et al. | The cytoplasmic concentration of free calcium in platelets is controlled by stimulators of cyclic AMP production (PGD2, PGE1, forskolin). | 1983 | Biochem. Biophys. Res. Commun. | pmid:6307295 |
| Watanabe Y et al. | Localization of prostaglandin D2 binding protein and NADP-linked 15-hydroxyprostaglandin D2 dehydrogenase in the Purkinje cells of miniature pig cerebellum. | 1983 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6308629 |
| Feinstein MB et al. | Reversal of thrombin-induced myosin phosphorylation and the assembly of cytoskeletal structures in platelets by the adenylate cyclase stimulants prostaglandin D2 and forskolin. | 1983 | J. Biol. Chem. | pmid:6571835 |
| Sakai T et al. | Prostaglandin D2 inhibits the proliferation of human neuroblastoma cells. | 1983 | Cancer Lett. | pmid:6572553 |
| Kootte AM et al. | The flush syndrome: an expression of systemic mastocytosis with increased prostaglandin D2 production. | 1983 | Neth J Med | pmid:6572798 |
| Abelson MB et al. | Aspirin therapy in vernal conjunctivitis. | 1983 | Am. J. Ophthalmol. | pmid:6573138 |
| Gerritsen ME | PGD2 formation in the vasculature: characteristics of rat tail vein prostaglandin endoperoxide-D isomerase. | 1983 | Prostaglandins | pmid:6573722 |
| Simmet T and Jaffe BM | Inhibition of B-16 melanoma growth in vitro by prostaglandin D2. | 1983 | Prostaglandins | pmid:6573723 |
| Kondo K et al. | Effects of intracerebroventricular administration of prostaglandin D2 and angiotensin II on blood pressure in conscious rats. | 1983 | Jpn Heart J | pmid:6574266 |
| Hensby CN et al. | Prostaglandins in human skin disease. | 1983 | Br. J. Dermatol. | pmid:6574787 |
| Higashida H et al. | Cytotoxic action of prostaglandin D2 on mouse neuroblastoma cells. | 1983 | Int. J. Cancer | pmid:6574994 |
| Ohkubo T et al. | Effect of prostaglandin D2 on pain and inflammation. | 1983 | Jpn. J. Pharmacol. | pmid:6576182 |
| Philips JB and Lyrene RK | Persistent pulmonary hypertension and prostaglandin D2. | 1983 | Prog. Clin. Biol. Res. | pmid:6577475 |
| Fukushima M | [Development of antineoplastic prostaglandins]. | 1983 | Gan To Kagaku Ryoho | pmid:6577812 |
| Schulman ES et al. | Purified human basophils and mast cells: current concepts of mediator release. | 1983 | Eur J Respir Dis Suppl | pmid:6578086 |
| Fitzpatrick FA and Wynalda MA | Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro. | 1983 | J. Biol. Chem. | pmid:6578214 |
| Juhlin L et al. | Effect of infrared irradiation on the recoverable levels of free arachidonic acid and prostaglandins in human forearm skin. | 1983 | J. Invest. Dermatol. | pmid:6578272 |
| Ruzicka T et al. | Changes in arachidonic acid metabolism in UV-irradiated hairless mouse skin. | 1983 | J. Invest. Dermatol. | pmid:6578273 |
| Soifer SJ et al. | The developmental effects of prostaglandin D2 on the pulmonary and systemic circulations in the newborn lamb. | 1983 | J. Dev. Physiol. | pmid:6579103 |
| Miyake A et al. | Prostaglandin D2 stimulates secretion of luteinizing hormone from pituitary gland in vitro. | 1983 | Acta Endocrinol. | pmid:6579807 |
| Belegu M et al. | beta-Adrenergic blockade of prostaglandin E2- and D2-induced erythroid colony formation. | 1983 | Am. J. Physiol. | pmid:6579847 |
| Lysz TW et al. | Measurement of prostaglandin biosynthetic capacity in discrete areas of the rabbit hippocampal formation. | 1983 | J. Neurosci. Res. | pmid:6580469 |
| Ishizawa M | Contractile effects of PGD2 and PGF2 alpha on mechanical and electrical activities in longitudinal and circular muscles of the guinea-pig colon. | 1983 | Prostaglandins | pmid:6580679 |
| Bregman MD and Meyskens FL | In vitro modulation of human and murine melanoma growth by prostanoid analogues. | 1983 | Prostaglandins | pmid:6581509 |
| Chiabrando C et al. | Quantitative profiling of prostaglandins and thromboxane by high-resolution gas chromatography-selected--ion monitoring. | 1983 | J. Chromatogr. | pmid:6584432 |
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| Carr BR et al. | Prostaglandin secretion by the neocortex and fetal zones of the human fetal adrenal gland. | 1983 | J. Clin. Endocrinol. Metab. | pmid:6313732 |
| Poynard T et al. | Secretory diarrhea and prostaglandin D2 overproduction in systemic mastocytosis. | 1982 | N. Engl. J. Med. | pmid:6953312 |
| Fukushima M et al. | Prostaglandin D2, a potential antineoplastic agent. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6953969 |
| Watanabe T et al. | NADP-linked 15-hydroxyprostaglandin dehydrogenase for prostaglandin D in human blood platelets. | 1982 | Arch. Biochem. Biophys. | pmid:6954879 |
| Sirén AL | Central cardiovascular and thermal effects of prostaglandin D2 in rats. | 1982 | Prostaglandins Leukot Med | pmid:6955803 |
| Mitchell MD et al. | The human placenta: a major source of prostaglandin D2. | 1982 | Prostaglandins Leukot Med | pmid:6955806 |
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| Toda N | Different responsiveness of a variety of isolated dog arteries to prostaglandin D2. | 1982 | Prostaglandins | pmid:6950464 |
| Kennedy I et al. | Studies on the characterisation of prostanoid receptors: a proposed classification. | 1982 | Prostaglandins | pmid:6131499 |
| Qureshi Z and Cagen LM | Prostaglandins F2 alpha produced by rabbit renal slices is not a metabolite of prostaglandins E2. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6803799 |
| Lewis RA et al. | Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE. | 1982 | J. Immunol. | pmid:6809826 |
| Karniguian A et al. | Prostaglandins: specific inhibition of platelet adhesion to collagen and relationship with cAMP level. | 1982 | Prostaglandins | pmid:6287536 |
| Shimizu T et al. | Specific binding of prostaglandin D2 to rat brain synaptic membrane. Occurrence, properties, and distribution. | 1982 | J. Biol. Chem. | pmid:6292197 |
| Ruzicka T and Printz MP | Arachidonic acid metabolism in guinea pig skin. | 1982 | Biochim. Biophys. Acta | pmid:6809055 |
| Kinoshita F et al. | Suppressive effect of prostaglandin (PG)D2 on pulsatile luteinizing hormone release in conscious castrated rats. | 1982 | Endocrinology | pmid:6951712 |
| Okamatsu S and Lefer AM | Cardiac effects of prostaglandins during global ischemia in isolated perfused cat hearts. | 1982 | Prostaglandins Leukot Med | pmid:6952273 |