PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Cystitis, Interstitial D018856 2 associated lipids
Asthma, Aspirin-Induced D055963 2 associated lipids
Optic Neuropathy, Ischemic D018917 2 associated lipids
Idiopathic Pulmonary Fibrosis D054990 4 associated lipids
Graves Ophthalmopathy D049970 3 associated lipids
Leukemia, B-Cell D015448 3 associated lipids
Airway Remodeling D056151 3 associated lipids
Pulmonary Aspergillosis D055732 1 associated lipids
Decapitation D049248 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

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Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Xie S et al. 15 deoxy delta12,14 PGJ2 induces procoagulant activity in cultured human endothelial cells. 2002 Thromb. Haemost. pmid:11916086
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Mondoro TH and Vostal JG Cold temperatures reduce the sensitivity of stored platelets to disaggregating agents. 2002 Platelets pmid:11918832
Noverr MC et al. Production of prostaglandins and leukotrienes by pathogenic fungi. 2002 Infect. Immun. pmid:11748207
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Fernández-Tomé Mdel C et al. Phospholipase C inhibitors and prostaglandins differentially regulate phosphatidylcholine synthesis in rat renal papilla. Evidence of compartmental regulation of CTP:phosphocholine cytidylyltransferase and CDP-choline:1,2-diacylglycerol cholinephosphotransferase. 2002 Biochim. Biophys. Acta pmid:12117562
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Hu VY et al. COX-2 and prostanoid expression in micturition pathways after cyclophosphamide-induced cystitis in the rat. 2003 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:12388444
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Ianaro A et al. Anti-inflammatory activity of 15-deoxy-delta12,14-PGJ2 and 2-cyclopenten-1-one: role of the heat shock response. 2003 Mol. Pharmacol. pmid:12815164
Hashimoto K et al. The PPARgamma ligand, 15d-PGJ2, attenuates the severity of cerulein-induced acute pancreatitis. 2003 Pancreas pmid:12826907
Urade Y et al. Sleep regulation in adenosine A2A receptor-deficient mice. 2003 Neurology pmid:14663019
Montuschi P et al. Exhaled leukotrienes and prostaglandins in COPD. 2003 Thorax pmid:12832671
Placha W et al. The effect of PPARgamma ligands on the proliferation and apoptosis of human melanoma cells. 2003 Melanoma Res. pmid:14512786
Taba Y et al. 15-deoxy-delta 12,14-prostaglandin J2 and laminar fluid shear stress stabilize c-IAP1 in vascular endothelial cells. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12623786
Fukuchi K et al. Apoptosis in human oral squamous cell carcinomas is induced by 15-deoxy-delta 12,14-prostaglandin J2 but not by troglitazone. 2003 J. Dent. Res. pmid:14514760
Józkowicz A et al. Prostaglandin-J(2) upregulates expression of matrix metalloproteinase-1 independently of activation of peroxisome proliferator-activated receptor-gamma. 2003 Acta Biochim. Pol. pmid:14515149
Imaizumi T et al. 15-Deoxy-delta 12,14-prostaglandin J2 inhibits the expression of granulocyte-macrophage colony-stimulating factor in endothelial cells stimulated with lipopolysaccharide. 2003 Prostaglandins Other Lipid Mediat. pmid:14518569
Lee CH and Edwards AM Differential expression of c-fos and c-myc protooncogenes by estrogens, xenobiotics and other growth-stimulatory agents in primary rat hepatocytes. 2003 Arch. Toxicol. pmid:12632255
Yoshimura R et al. The effect of peroxisome proliferator-activated receptor-gamma ligand on urological cancer cells. 2003 Int. J. Mol. Med. pmid:14612958
Jelson GS et al. Modulation of guinea pig intrinsic cardiac neurons by prostaglandins. 2003 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:12791585
Okano H et al. The PPARgamma ligand, 15-Deoxy-Delta12,14-PGJ2, regulates apoptosis-related protein expression in cholangio cell carcinoma cells. 2003 Int. J. Mol. Med. pmid:14612959
Rehan V and Torday J Hyperoxia augments pulmonary lipofibroblast-to-myofibroblast transdifferentiation. 2003 Cell Biochem. Biophys. pmid:12794266
Aoun P et al. Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells. 2003 Invest. Ophthalmol. Vis. Sci. pmid:12824244
Ajmone-Cat MA et al. Prolonged exposure of microglia to lipopolysaccharide modifies the intracellular signaling pathways and selectively promotes prostaglandin E2 synthesis. 2003 J. Neurochem. pmid:14622099
Sugimoto H et al. An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro. 2003 J. Pharmacol. Exp. Ther. pmid:12649388
Chung SW et al. Inhibition of interleukin-4 production in CD4+ T cells by peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands: involvement of physical association between PPAR-gamma and the nuclear factor of activated T cells transcription factor. 2003 Mol. Pharmacol. pmid:14573767
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Saito S et al. 15-Deoxy-Delta(12,14)-prostaglandin J2 induces apoptosis through activation of the CHOP gene in HeLa cells. 2003 Biochem. Biophys. Res. Commun. pmid:14575689
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Zamuner SR et al. Cyclooxygenase 2 mediates post-inflammatory colonic secretory and barrier dysfunction. 2003 Gut pmid:14633948
Shibata T et al. An endogenous electrophile that modulates the regulatory mechanism of protein turnover: inhibitory effects of 15-deoxy-Delta 12,14-prostaglandin J2 on proteasome. 2003 Biochemistry pmid:14636064
Villegas I et al. A new flavonoid derivative, dosmalfate, attenuates the development of dextran sulphate sodium-induced colitis in mice. 2003 Int. Immunopharmacol. pmid:14636824
Inoue K et al. Effect of 15-deoxy-delta 12,14-prostaglandin J2 on acute lung injury induced by lipopolysaccharide in mice. 2003 Eur. J. Pharmacol. pmid:14642794
Garg TK and Chang JY Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. 2003 BMC Ophthalmol pmid:12659653
Komar CM and Curry TE Inverse relationship between the expression of messenger ribonucleic acid for peroxisome proliferator-activated receptor gamma and P450 side chain cleavage in the rat ovary. 2003 Biol. Reprod. pmid:12700202
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Castaño E and Gil J 15-deoxy-delta12,14 prostaglandin J2 synergizes with phorbol ester to induce proliferation in Swiss 3T3 cells independently of peroxisome proliferator-activated receptor gamma and PGD2 receptors. 2003 J. Cell. Physiol. pmid:12704651
Ianaro A et al. 2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-kappaB. 2003 FEBS Lett. pmid:14550540
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Cippitelli M et al. The cyclopentenone-type prostaglandin 15-deoxy-delta 12,14-prostaglandin J2 inhibits CD95 ligand gene expression in T lymphocytes: interference with promoter activation via peroxisome proliferator-activated receptor-gamma-independent mechanisms. 2003 J. Immunol. pmid:12707336
Heinemann A et al. Delta 12-prostaglandin J2, a plasma metabolite of prostaglandin D2, causes eosinophil mobilization from the bone marrow and primes eosinophils for chemotaxis. 2003 J. Immunol. pmid:12707356
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Söderström M et al. Novel prostaglandin D(2)-derived activators of peroxisome proliferator-activated receptor-gamma are formed in macrophage cell cultures. 2003 Biochim. Biophys. Acta pmid:12573447
Gibbons H et al. Hypothermia suppresses inducible nitric oxide synthase and stimulates cyclooxygenase-2 in lipopolysaccharide stimulated BV-2 cells. 2003 Brain Res. Mol. Brain Res. pmid:12573534
Patel HJ et al. Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy. 2003 J. Immunol. pmid:12594295
Ruan XZ et al. PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway. 2003 J. Am. Soc. Nephrol. pmid:12595494
Cuzzocrea S et al. The cyclopentenone prostaglandin 15-deoxy-delta(12,14)- PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat. 2003 Br. J. Pharmacol. pmid:12598422
Castrillo A et al. Potentiation of protein kinase C zeta activity by 15-deoxy-delta(12,14)-prostaglandin J(2) induces an imbalance between mitogen-activated protein kinases and NF-kappa B that promotes apoptosis in macrophages. 2003 Mol. Cell. Biol. pmid:12556480
Farrow B and Evers BM Activation of PPARgamma increases PTEN expression in pancreatic cancer cells. 2003 Biochem. Biophys. Res. Commun. pmid:12535639
Park EJ et al. 15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia. 2003 J. Biol. Chem. pmid:12584205
Hinz B et al. 15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism. 2003 Biochem. Biophys. Res. Commun. pmid:12604364
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Abe M et al. GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells. 2003 Arterioscler. Thromb. Vasc. Biol. pmid:12615657
Qin C et al. Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells. 2003 Cancer Res. pmid:12615709
Kajekar R et al. Role of cyclooxygenase activation and prostaglandins in antigen-induced excitability changes of bronchial parasympathetic ganglia neurons. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12618420
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Hashimoto T et al. Effects of nonsteroidal anti-inflammatory drugs on experimental allergic conjunctivitis in Guinea pigs. 2003 J Ocul Pharmacol Ther pmid:14733714
Hirai H et al. Gene structure and functional properties of mouse CRTH2, a prostaglandin D2 receptor. 2003 Biochem. Biophys. Res. Commun. pmid:12878180
Zhang X et al. Unexpected sensitivity of synthetic Renilla luciferase control vectors to treatment with a cyclopentenone prostaglandin. 2003 BioTechniques pmid:14682047