| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cystitis, Interstitial | D018856 | 2 associated lipids |
| Asthma, Aspirin-Induced | D055963 | 2 associated lipids |
| Optic Neuropathy, Ischemic | D018917 | 2 associated lipids |
| Idiopathic Pulmonary Fibrosis | D054990 | 4 associated lipids |
| Graves Ophthalmopathy | D049970 | 3 associated lipids |
| Leukemia, B-Cell | D015448 | 3 associated lipids |
| Airway Remodeling | D056151 | 3 associated lipids |
| Pulmonary Aspergillosis | D055732 | 1 associated lipids |
| Decapitation | D049248 | 2 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Aldrovandi M et al. | Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation. | 2013 | J. Lipid Res. | pmid:23883581 |
| Fujishima H et al. | Chemotactic responses of peripheral blood eosinophils to prostaglandin D2 in atopic keratoconjunctivitis. | 2013 | Ann. Allergy Asthma Immunol. | pmid:23886231 |
| Kaikkonen S et al. | Prostaglandin 15d-PGJ(2) inhibits androgen receptor signaling in prostate cancer cells. | 2013 | Mol. Endocrinol. | pmid:23192983 |
| Schmidt JA et al. | Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma. | 2013 | Br. J. Pharmacol. | pmid:23146091 |
| Bogacka I et al. | The involvement of peroxisome proliferator activated receptors (PPARs) in prostaglandin F2α production by porcine endometrium. | 2013 | Reprod Biol | pmid:24287039 |
| Mruwat R et al. | Phospholipase A2 in experimental allergic bronchitis: a lesson from mouse and rat models. | 2013 | PLoS ONE | pmid:24204651 |
| Brose SA and Golovko MY | Eicosanoid post-mortem induction in kidney tissue is prevented by microwave irradiation. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24113545 |
| Wang Y et al. | Optimization of phenylacetic acid derivatives for CRTH2 and DP selective antagonism. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22119474 |
| Alba G et al. | Transcription of liver X receptor is down-regulated by 15-deoxy-Δ(12,14)-prostaglandin J(2) through oxidative stress in human neutrophils. | 2012 | PLoS ONE | pmid:23115616 |
| Hossain MS et al. | Stable expression of lipocalin-type prostaglandin D synthase in cultured preadipocytes impairs adipogenesis program independently of endogenous prostanoids. | 2012 | Exp. Cell Res. | pmid:22100987 |
| Pettipher R et al. | Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22106101 |
| Paulitschke V et al. | Proteome analysis identified the PPARγ ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction. | 2012 | PLoS ONE | pmid:23049949 |
| Bain G et al. | Pharmacodynamics, pharmacokinetics, and safety of AM211: a novel and potent antagonist of the prostaglandin D2 receptor type 2. | 2012 | J Clin Pharmacol | pmid:22110163 |
| Syeda PK et al. | A monoclonal antibody specific for Δ12-prostaglandin J2 and its utilization in the immunological assay in cell culture system of adipocytes. | 2012 | Hybridoma (Larchmt) | pmid:23098304 |
| Gates D et al. | Apo J/clusterin expression and secretion: evidence for 15-deoxy-Δ(12,14)-PGJ(2)-dependent mechanism. | 2012 | Biochim. Biophys. Acta | pmid:22138303 |
| Weng Y et al. | Prostaglandin metabolite induces inhibition of TRPA1 and channel-dependent nociception. | 2012 | Mol Pain | pmid:23013719 |
| Ravindra KC et al. | Targeting of histone acetyltransferase p300 by cyclopentenone prostaglandin Δ(12)-PGJ(2) through covalent binding to Cys(1438). | 2012 | Chem. Res. Toxicol. | pmid:22141352 |
| Sedej M et al. | D-type prostanoid receptor enhances the signaling of chemoattractant receptor-homologous molecule expressed on T(H)2 cells. | 2012 | J. Allergy Clin. Immunol. | pmid:21930295 |
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| Kristensen DM et al. | Paracetamol (acetaminophen), aspirin (acetylsalicylic acid) and indomethacin are anti-androgenic in the rat foetal testis. | 2012 | Int. J. Androl. | pmid:22612476 |
| Hogrefe C et al. | Single impact cartilage trauma and TNF-α: interactive effects do not increase early cell death and indicate the need for bi-/multidirectional therapeutic approaches. | 2012 | Int. J. Mol. Med. | pmid:22922824 |
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| Lee S et al. | Lipocalin-type prostaglandin D2 synthase protein regulates glial cell migration and morphology through myristoylated alanine-rich C-kinase substrate: prostaglandin D2-independent effects. | 2012 | J. Biol. Chem. | pmid:22275363 |
| Mantel A et al. | Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis. | 2012 | J. Invest. Dermatol. | pmid:22170488 |
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