| MeSH term | MeSH ID | Detail |
|---|---|---|
| Erythema | D004890 | 22 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Brain Damage, Chronic | D001925 | 6 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Thrombocytopenia | D013921 | 15 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Cough | D003371 | 19 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim HJ et al. | ROSics: chemistry and proteomics of cysteine modifications in redox biology. | 2015 Mar-Apr | Mass Spectrom Rev | pmid:24916017 |
| Le Loupp AG et al. | [Dual role for prostaglandin D2 in intestinal epithelial homeostasis]. | 2015 Jun-Jul | Med Sci (Paris) | pmid:26152165 |
| Huang L et al. | 15d-PGJ2 Reduced Microglia Activation and Alleviated Neurological Deficit of Ischemic Reperfusion in Diabetic Rat Model. | 2015 | Biomed Res Int | pmid:26844229 |
| Li P et al. | [Effect of peroxisome proliferator-activated receptor-γ on endothelial cells oxidative stress induced by Porphyromonas gingivalis]. | 2015 | Beijing Da Xue Xue Bao | pmid:26679661 |
| Benedetti F and Dogue S | Different Placebos, Different Mechanisms, Different Outcomes: Lessons for Clinical Trials. | 2015 | PLoS ONE | pmid:26536471 |
| Li XY et al. | 15-Deoxy-prostaglandin J2 anti-inflammation in a rat model of chronic obstructive pulmonary disease and human bronchial epithelial cells via Nrf2 activation. | 2015 | Genet. Mol. Res. | pmid:26535717 |
| Le Loupp AG et al. | Activation of the prostaglandin D2 metabolic pathway in Crohn's disease: involvement of the enteric nervous system. | 2015 | BMC Gastroenterol | pmid:26338799 |
| Xu X et al. | Effect of Salusin-β on Peroxisome Proliferator-Activated Receptor Gamma Gene Expression in Vascular Smooth Muscle Cells and its Possible Mechanism. | 2015 | Cell. Physiol. Biochem. | pmid:26279448 |
| Busse WW et al. | Biomarker Profiles in Asthma With High vs Low Airway Reversibility and Poor Disease Control. | 2015 | Chest | pmid:26226215 |
| Tsutsumi S et al. | Cerebrospinal fluid drainage through the diploic and spinal epidural veins. | 2015 | J. Anat. | pmid:26184099 |
| Jeon KI et al. | Inhibitory effects of PPARγ ligands on TGF-β1-induced CTGF expression in cat corneal fibroblasts. | 2015 | Exp. Eye Res. | pmid:26142957 |
| Cossette C et al. | Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes. | 2015 | Biochem. Pharmacol. | pmid:26032638 |
| Guan PP et al. | The role of cyclooxygenase-2, interleukin-1β and fibroblast growth factor-2 in the activation of matrix metalloproteinase-1 in sheared-chondrocytes and articular cartilage. | 2015 | Sci Rep | pmid:25992485 |
| Tang F et al. | Inhibitory effect of methyleugenol on IgE-mediated allergic inflammation in RBL-2H3 cells. | 2015 | Mediators Inflamm. | pmid:25960618 |
| Guan NN et al. | Receptors involved in the modulation of guinea pig urinary bladder motility by prostaglandin D2. | 2015 | Br. J. Pharmacol. | pmid:25917171 |
| Mirza RE et al. | Macrophage PPARγ and impaired wound healing in type 2 diabetes. | 2015 | J. Pathol. | pmid:25875529 |
| Gao D et al. | Rosiglitzone suppresses angiotensin II-induced production of KLF5 and cell proliferation in rat vascular smooth muscle cells. | 2015 | PLoS ONE | pmid:25874449 |
| Wojno ED et al. | The prostaglandin Dâ‚‚ receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung. | 2015 | Mucosal Immunol | pmid:25850654 |
| Virtue S et al. | Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans. | 2015 | Int J Obes (Lond) | pmid:25801691 |
| Nittner-Marszalska M et al. | 9α,11β-PGF2, a Prostaglandin D2 Metabolite, as a Marker of Mast Cell Activation in Bee Venom-Allergic Patients. | 2015 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:25763689 |
| Maier NK et al. | The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes. | 2015 | J. Immunol. | pmid:25681332 |
| Wall SB et al. | Rac1 modification by an electrophilic 15-deoxy Δ(12,14)-prostaglandin J2 analog. | 2015 | Redox Biol | pmid:25677088 |
| Hosoi T et al. | Possible involvement of 15-deoxy-Δ(12,14) -prostaglandin J2 in the development of leptin resistance. | 2015 | J. Neurochem. | pmid:25662180 |
| Meng Y et al. | Angiotensin II-induced Egr-1 expression is suppressed by peroxisome proliferator-activated receptor-γ ligand 15d-PGJ₂ in macrophages. | 2015 | Cell. Physiol. Biochem. | pmid:25591955 |
| Penas F et al. | Treatment in vitro with PPARα and PPARγ ligands drives M1-to-M2 polarization of macrophages from T. cruzi-infected mice. | 2015 | Biochim. Biophys. Acta | pmid:25557389 |
| Oishi Y et al. | The roles of prostaglandin E2 and D2 in lipopolysaccharide-mediated changes in sleep. | 2015 | Brain Behav. Immun. | pmid:25532785 |
| Fukuoka T et al. | Prostaglandin D synthase is a potential novel therapeutic agent for the treatment of gastric carcinomas expressing PPARγ. | 2015 | Int. J. Cancer | pmid:25516376 |
| Xue L et al. | Prostaglandin D2 and leukotriene E4 synergize to stimulate diverse TH2 functions and TH2 cell/neutrophil crosstalk. | 2015 | J. Allergy Clin. Immunol. | pmid:25441644 |
| Roviezzo F et al. | S1P-induced airway smooth muscle hyperresponsiveness and lung inflammation in vivo: molecular and cellular mechanisms. | 2015 | Br. J. Pharmacol. | pmid:25439580 |
| Maher SA et al. | Prostaglandin D2 and the role of the DP1, DP2 and TP receptors in the control of airway reflex events. | 2015 | Eur. Respir. J. | pmid:25323233 |
| Rossitto M et al. | Multiple roles of the prostaglandin D2 signaling pathway in reproduction. | 2015 | Reproduction | pmid:25269616 |
| Hyun J et al. | Human intestinal epithelial cells express interleukin-10 through Toll-like receptor 4-mediated epithelial-macrophage crosstalk. | 2015 | J Innate Immun | pmid:25171731 |
| Kimura LF et al. | Mast cells and histamine play an important role in edema and leukocyte recruitment induced by Potamotrygon motoro stingray venom in mice. | 2015 | Toxicon | pmid:26100666 |
| Kim KR et al. | 15-deoxy-δ12,14-prostaglandin j2 inhibits osteolytic breast cancer bone metastasis and estrogen deficiency-induced bone loss. | 2015 | PLoS ONE | pmid:25859665 |
| Ishii T | Close teamwork between Nrf2 and peroxiredoxins 1 and 6 for the regulation of prostaglandin D2 and E2 production in macrophages in acute inflammation. | 2015 | Free Radic. Biol. Med. | pmid:25968070 |
| Säfholm J et al. | Prostaglandin E2 inhibits mast cell-dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor. | 2015 | J. Allergy Clin. Immunol. | pmid:25962903 |
| Wallert M et al. | α-Tocopherol long-chain metabolite α-13'-COOH affects the inflammatory response of lipopolysaccharide-activated murine RAW264.7 macrophages. | 2015 | Mol Nutr Food Res | pmid:25943249 |
| Ott D et al. | Prostaglandin D2 modulates calcium signals induced by prostaglandin E2 in neurons of rat dorsal root ganglia. | 2015 | Neurosci. Lett. | pmid:25912777 |
| Willenberg I et al. | Determining cyclooxygenase-2 activity in three different test systems utilizing online-solid phase extraction-liquid chromatography-mass spectrometry for parallel quantification of prostaglandin E(2), D(2) and thromboxane B(2). | 2015 | J Chromatogr A | pmid:25777050 |
| Savinainen JR et al. | Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A). | 2014 | PLoS ONE | pmid:25290914 |
| Kuroyanagi G et al. | Suppression by resveratrol of prostaglandin D2-stimulated osteoprotegerin synthesis in osteoblasts. | 2014 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24813642 |
| Moon TC et al. | Expression of DP2 (CRTh2), a prostaglandin Dâ‚‚ receptor, in human mast cells. | 2014 | PLoS ONE | pmid:25268140 |
| Afrin LB | Mast cell activation syndrome as a significant comorbidity in sickle cell disease. | 2014 | Am. J. Med. Sci. | pmid:25171546 |
| Liu C et al. | 15d-PGJâ‚‚ decreases PGEâ‚‚ synthesis in HBx-positive liver cells by interfering EGR1 binding to mPGES-1 promoter. | 2014 | Biochem. Pharmacol. | pmid:25108236 |
| GarcÃa-Bueno B et al. | Pro-/anti-inflammatory dysregulation in patients with first episode of psychosis: toward an integrative inflammatory hypothesis of schizophrenia. | 2014 | Schizophr Bull | pmid:23486748 |
| Iwanaga K et al. | Mast cell-derived prostaglandin D2 inhibits colitis and colitis-associated colon cancer in mice. | 2014 | Cancer Res. | pmid:24879565 |
| Song Y et al. | [PPAR-γ agonist inhibits the expressions of chemokines induced by IFN-γ and TNF-α in renal tubular epithelial cells]. | 2014 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:25001926 |
| Shivers KY et al. | PACAP27 prevents Parkinson-like neuronal loss and motor deficits but not microglia activation induced by prostaglandin J2. | 2014 | Biochim. Biophys. Acta | pmid:24970746 |
| Kumar S et al. | Phaseolin: a 47.5kDa protein of red kidney bean (Phaseolus vulgaris L.) plays a pivotal role in hypersensitivity induction. | 2014 | Int. Immunopharmacol. | pmid:24468678 |
| Moniot B et al. | Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis. | 2014 | Development | pmid:25142465 |