| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pleurisy | D010998 | 20 associated lipids |
| Parkinsonian Disorders | D020734 | 20 associated lipids |
| Translocation, Genetic | D014178 | 20 associated lipids |
| Sarcoma 180 | D012510 | 21 associated lipids |
| Myocardial Infarction | D009203 | 21 associated lipids |
| Helicobacter Infections | D016481 | 21 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Erythema | D004890 | 22 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fox CC et al. | Enhancement of human intestinal mast cell mediator release in active ulcerative colitis. | 1990 | Gastroenterology | pmid:1693122 |
| Ikai K and Fukushima M | Effects of cytotoxic prostaglandin, delta 12-PGJ2 on protein synthesis and cytoskeleton in transformed epidermal cells in culture. | 1990 | Arch. Dermatol. Res. | pmid:1693839 |
| Ashby B | Novel mechanism of heterologous desensitization of adenylate cyclase: prostaglandins bind with different affinities to both stimulatory and inhibitory receptors on platelets. | 1990 | Mol. Pharmacol. | pmid:1695318 |
| Atkins PC et al. | In vivo antigen-induced cutaneous mediator release: simultaneous comparisons of histamine, tryptase, and prostaglandin D2 release and the effect of oral corticosteroid administration. | 1990 | J. Allergy Clin. Immunol. | pmid:1698845 |
| Zavoico GB et al. | Enhancement of thrombin- and ionomycin-stimulated prostacyclin and platelet-activating factor production in cultured endothelial cells by a tumor-promoting phorbol ester. | 1990 | J. Cell. Physiol. | pmid:2113537 |
| Nishimura G | [Antitumor activity and cell cycle effects of delta 12-PGJ2 in vivo]. | 1990 | Nihon Gan Chiryo Gakkai Shi | pmid:2351856 |
| Ford WD et al. | Pulmonary hypertension in lambs with congenital diaphragmatic hernia: vasodilator prostaglandins, isoprenaline, and tolazoline. | 1990 | J. Pediatr. Surg. | pmid:2352080 |
| Okumura T and Saito K | Effect of prostaglandins on glycogenesis and glycogenolysis in primary cultures of rat hepatocytes--a role of prostaglandin D2 in the liver. | 1990 | Prostaglandins | pmid:2353117 |
| Perreault T et al. | Pulmonary vascular effects of prostaglandin D2 in newborn pig. | 1990 | Am. J. Physiol. | pmid:2337164 |
| Ingenito EP et al. | Bronchoalveolar lavage cell and mediator responses to hyperpnea-induced bronchoconstriction in the guinea pig. | 1990 | Am. Rev. Respir. Dis. | pmid:2339838 |
| Williams WR et al. | In vitro tests for the diagnosis of aspirin-sensitive asthma. | 1990 | J. Allergy Clin. Immunol. | pmid:2146311 |
| Atsmon J et al. | Formation of thiol conjugates of 9-deoxy-delta 9,delta 12(E)-prostaglandin D2 and delta 12(E)-prostaglandin D2. | 1990 | Biochemistry | pmid:2340271 |
| vom Dahl S et al. | Stimulation of release of prostaglandin D2 and thromboxane B2 from perfused rat liver by extracellular adenosine. | 1990 | Biochem. J. | pmid:2396991 |
| Winter JS et al. | A stimulatory effect of interleukin-1 on adrenocortical cortisol secretion mediated by prostaglandins. | 1990 | Endocrinology | pmid:2169407 |
| Atsmon J et al. | Conjugation of 9-deoxy-delta 9,delta 12(E)-prostaglandin D2 with intracellular glutathione and enhancement of its antiproliferative activity by glutathione depletion. | 1990 | Cancer Res. | pmid:2306739 |
| Kikuchi Y et al. | [Therapeutic values of prostaglandin D2 in nude mice bearing human ovarian carcinoma]. | 1990 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:2313142 |
| Nambu F et al. | Inhibitory effects of OKY-046 on spasmogen-induced bronchoconstrictions in sensitized and non-sensitized guinea pigs. | 1990 | Jpn. J. Pharmacol. | pmid:2313938 |
| Simpkins CO et al. | Prostaglandin D2 modulates human neutrophil intracellular calcium flux and inhibits superoxide release via its ring carbonyl. | 1990 | Life Sci. | pmid:2319907 |
| Gadsby JE et al. | Prostaglandin F2 alpha receptors on enzyme-dissociated pig luteal cells throughout the estrous cycle. | 1990 | Endocrinology | pmid:2153525 |
| Friedmann PS et al. | Ultraviolet stimulated melanogenesis by human melanocytes is augmented by di-acyl glycerol but not TPA. | 1990 | J. Cell. Physiol. | pmid:2303529 |
| Deffebach ME et al. | Prostaglandins alter methacholine-induced secretion in ferret in vitro trachea. | 1990 | Am. J. Physiol. | pmid:2407140 |
| Urade Y et al. | Mast cells contain spleen-type prostaglandin D synthetase. | 1990 | J. Biol. Chem. | pmid:2403560 |
| Mori H et al. | Augmentation of antiproliferative activity of recombinant human tumor necrosis factor by delta 12-prostaglandin J2. | 1990 | J Biol Response Mod | pmid:2341865 |
| Bochner BS et al. | Interleukin-1 is released at sites of human cutaneous allergic reactions. | 1990 | J. Allergy Clin. Immunol. | pmid:2262641 |
| Doyle WJ et al. | Physiologic responses to intranasal dose-response challenges with histamine, methacholine, bradykinin, and prostaglandin in adult volunteers with and without nasal allergy. | 1990 | J. Allergy Clin. Immunol. | pmid:2262647 |
| Nishino S et al. | Prostaglandin E2 levels in cerebrospinal fluid of normal and narcoleptic dogs. | 1990 | Biol. Psychiatry | pmid:2268692 |
| Katsuura G et al. | Involvement of organum vasculosum of lamina terminalis and preoptic area in interleukin 1 beta-induced ACTH release. | 1990 | Am. J. Physiol. | pmid:1967907 |
| Eggleston PA et al. | Disassociation of the release of histamine and arachidonic acid metabolites from osmotically activated basophils and human lung mast cells. | 1990 | Am. Rev. Respir. Dis. | pmid:1691604 |
| Fukushima M | Prostaglandin J2--anti-tumour and anti-viral activities and the mechanisms involved. | 1990 | Eicosanoids | pmid:2073399 |
| Inoue M et al. | Interactions between the brain renin-angiotensin system and brain prostanoids in the control of vasopressin secretion. | 1990 | Exp Brain Res | pmid:2073934 |
| Bennegård B et al. | Luteotropic effects of prostaglandins I2 and D2 on isolated human corpora luteum. | 1990 | Fertil. Steril. | pmid:2168845 |
| Bettazzoli L et al. | Incorporation of arachidonic acid into glycerophospholipids of a murine bone marrow derived mast cell. | 1990 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2169185 |
| Seiler S et al. | SQ-27986 inhibition of platelet aggregation is mediated through activation of platelet prostaglandin D2 receptors. | 1990 | Prostaglandins | pmid:2171039 |
| Eriksson LO et al. | Prostaglandin E2 binding sites in human renal tissue: characterization and localization by radioligand binding and autoradiography. | 1990 | Acta Physiol. Scand. | pmid:2173350 |
| Lysz TW et al. | Kupffer cell-hepatocyte interactions and the changes in 1-14C-arachidonate incorporation in response to endotoxin in vitro. | 1990 | Prostaglandins | pmid:2112770 |
| Koyama Y et al. | Prostaglandin production by isolated Kupffer cells. | 1990 | Gastroenterol. Jpn. | pmid:2227259 |
| Okuda-Ashitaka E et al. | Cyclic AMP-mediated inhibition of cell growth by prostaglandin D2 in a fibroblastic cell line (EBTr). | 1990 | Eicosanoids | pmid:1705811 |
| Hamid-Bloomfield S et al. | The role of prostanoid TP- and DP-receptors in the bronchoconstrictor effect of inhaled PGD2 in anaesthetized guinea-pigs: effect of the DP-antagonist BW A868C. | 1990 | Br. J. Pharmacol. | pmid:2119842 |
| Ito S et al. | Evaluation of ZK110841 and AH6809, an agonist and an antagonist of prostaglandin DP-receptors on human platelets, with a PGD2-responsive cell line from bovine embryonic trachea. | 1990 | Br. J. Pharmacol. | pmid:2158830 |
| Imura Y et al. | Antagonistic action of AA-2414 on thromboxane A2/prostaglandin endoperoxide receptor in platelets and blood vessels. | 1990 | Jpn. J. Pharmacol. | pmid:2137886 |
| Featherstone RL et al. | Evidence for thromboxane receptor mediated contraction of guinea-pig and human airways in vitro by prostaglandin (PG) D2, 9 alpha,11 beta-PGF2 and PGF2 alpha. | 1990 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:2142256 |
| Tzung SP et al. | Suppression of hepatic lymphokine-activated killer cell induction by murine Kupffer cells and hepatocytes. | 1990 | Hepatology | pmid:2210667 |
| Virgolini I et al. | Effects of bopindolol on platelet function in hypertension at rest and during exercise. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2143586 |
| Nakahata N et al. | PGJ2 and delta 12PGJ2 inhibit cell growth accompanied with inhibition of phosphoinositide turnover in human astrocytoma cells. | 1990 | Prostaglandins | pmid:2177901 |
| Massey WA and Lichtenstein LM | The effects of antihistamines beyond H1 antagonism in allergic inflammation. | 1990 | J. Allergy Clin. Immunol. | pmid:1979797 |
| White RP et al. | Eicosanoid levels in CSF of premature infants with posthemorrhagic hydrocephalus. | 1990 | Am. J. Med. Sci. | pmid:2321665 |
| Broide DH et al. | Airway levels of mast cell-derived mediators in exercise-induced asthma. | 1990 | Am. Rev. Respir. Dis. | pmid:1689974 |
| Undem BJ et al. | Inhibition by adenosine 3':5'-monophosphate of eicosanoid and platelet-activating factor biosynthesis in the mouse PT-18 mast cell. | 1990 | J. Biol. Chem. | pmid:1691175 |
| Proud D et al. | Inflammatory mediator release on conjunctival provocation of allergic subjects with allergen. | 1990 | J. Allergy Clin. Immunol. | pmid:1692049 |
| Miadonna A et al. | Mediator release after endobronchial antigen challenge in patients with respiratory allergy. | 1990 | J. Allergy Clin. Immunol. | pmid:1692050 |
| Schulman ES et al. | Histochemical heterogeneity of dispersed human lung mast cells. | 1990 | J. Immunol. | pmid:1692857 |
| Saitoh O et al. | Effect of amogastrin on the release of various prostaglandins into gastric lumen in man. | 1989 Mar-Apr | Jpn. J. Med. | pmid:2733241 |
| Tejedor M et al. | Potentiation of radiation toxicity in C-6 glioma cells by prostaglandin D2. | 1989 Jul-Aug | Anticancer Res. | pmid:2817802 |
| Black PN et al. | Effect of inhaled leukotriene B4 alone and in combination with prostaglandin D2 on bronchial responsiveness to histamine in normal subjects. | 1989 | Thorax | pmid:2548300 |
| Kuiper J et al. | Induction of ornithine decarboxylase in rat liver by phorbol ester is mediated by prostanoids from Kupffer cells. | 1989 | J. Biol. Chem. | pmid:2708347 |
| Kawabe Y et al. | Genesis and recovery of ethanol-induced gastric lesions in rats: possible involvement of prostaglandin D2. | 1989 | Am. J. Gastroenterol. | pmid:2916522 |
| Sakai T et al. | Protection by cycloheximide against cytotoxicity induced by vincristine, colchicine, or delta 12-prostaglandin J2 on human osteosarcoma cells. | 1989 | Cancer Res. | pmid:2917351 |
| Phillips GD and Holgate ST | Interaction of inhaled LTC4 with histamine and PGD2 on airway caliber in asthma. | 1989 | J. Appl. Physiol. | pmid:2917934 |
| Ban M et al. | A flavonoid inhibitor of 5-lipoxygenase inhibits leukotriene production following ischemia in gerbil brain. | 1989 | Stroke | pmid:2919414 |
| Naclerio RM et al. | The effect of cetirizine on early allergic response. | 1989 | Laryngoscope | pmid:2566879 |
| Ikai K et al. | Inhibitory effect of tranilast on prostaglandin D synthetase. | 1989 | Biochem. Pharmacol. | pmid:2475113 |
| Goto H et al. | The role of prostaglandin D2 in the genesis of indomethacin-induced gastric lesions in rats. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2595317 |
| Woodward DF et al. | Marked differential effects of prostanoid metabolites on rabbit intraocular pressure. | 1989 | Ophthalmic Res. | pmid:2626239 |
| Busshardt E et al. | Regulation of hepatic parenchymal and non-parenchymal cell function by the diadenine nucleotides Ap3A and Ap4A. | 1989 | Biochim. Biophys. Acta | pmid:2563228 |
| Nishino S et al. | Salivary prostaglandin concentrations: possible state indicators for major depression. | 1989 | Am J Psychiatry | pmid:2627202 |
| Charlesworth EN et al. | Cells and secretagogues involved in the human late-phase response. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468620 |
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| Benyon RC et al. | Differential release of histamine and eicosanoids from human skin mast cells activated by IgE-dependent and non-immunological stimuli. | 1989 | Br. J. Pharmacol. | pmid:2474353 |
| Emery DL et al. | Prostaglandin D2 causes accumulation of eosinophils in the lumen of the dog trachea. | 1989 | J. Appl. Physiol. | pmid:2793725 |
| Dubertret L et al. | Biological and cellular responses to grass pollen in sensitive patients. | 1989 | Dermatologica | pmid:2476344 |
| Wachs M et al. | Observations on the pathogenesis of nasal priming. | 1989 | J. Allergy Clin. Immunol. | pmid:2477429 |
| Yoshimura S et al. | Prostaglandin D2 receptor of mastocytoma P-815 cells--possible regulation by phosphorylation and dephosphorylation. | 1989 | Biochim. Biophys. Acta | pmid:2497784 |
| Ikai K et al. | Prostaglandin D2, a mediator in both immediate and delayed-type immune reactions in the skin. | 1989 | Dermatologica | pmid:2506083 |
| Hatanaka M et al. | Late-phase accumulation of inositol phosphates stimulated by prostaglandins D2 and F2 alpha in neuroblastoma x glioma hybrid NG108-15 cells. | 1989 | J. Neurochem. | pmid:2507741 |
| Urade Y et al. | The major source of endogenous prostaglandin D2 production is likely antigen-presenting cells. Localization of glutathione-requiring prostaglandin D synthetase in histiocytes, dendritic, and Kupffer cells in various rat tissues. | 1989 | J. Immunol. | pmid:2509561 |
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| Giles H et al. | The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist. | 1989 | Br. J. Pharmacol. | pmid:2924081 |
| Sugama K et al. | Stimulation of cAMP formation by prostaglandin D2 in primary cultures of bovine adrenal medullary cells: identification of the responsive population as fibroblasts. | 1989 | Biochim. Biophys. Acta | pmid:2538150 |
| Beasley RC et al. | Effect of a thromboxane receptor antagonist on PGD2- and allergen-induced bronchoconstriction. | 1989 | J. Appl. Physiol. | pmid:2525122 |
| Hayaishi O | Prostaglandin D2 and sleep. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526481 |
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| Thierauch KH et al. | Stable 9 beta- or 11 alpha-halogen-15-cyclohexyl-prostaglandins with high affinity to the PGD2-receptor. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526554 |
| Froissart P et al. | Modulation by phorbol 12-myristate 13-acetate of arachidonic acid release from rat basophilic leukemia cells stimulated with A23187. | 1989 | Biochim. Biophys. Acta | pmid:2496761 |
| Dieter P et al. | 4-Bromophenacyl bromide inhibits prostaglandin D2 synthesis from arachidonic acid rather than phospholipase A2 activity in liver macrophages. | 1989 | Biol. Chem. Hoppe-Seyler | pmid:2775481 |
| Coe JY et al. | A fetal-instrumented model to study age-specific responses to leukotriene D4 and prostaglandin D2 in unsedated newborn lambs. | 1989 | Can. J. Physiol. Pharmacol. | pmid:2776077 |
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| Thierauch KH et al. | ZK 110 841--a selective and potent prostaglandin D2 analogue. | 1989 | Prog. Clin. Biol. Res. | pmid:2798462 |
| Keenan CM and Rangachari PK | Eicosanoid interactions in the canine proximal colon. | 1989 | Am. J. Physiol. | pmid:2539737 |
| Ashida Y et al. | A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. | 1989 | Prostaglandins | pmid:2748922 |
| Raisz LG and Woodiel FN | Effect of alterations in the cyclopentane ring on bone resorptive activity of prostaglandin. | 1989 | Prostaglandins | pmid:2727307 |
| Wolfe LS et al. | Metabolism of prostaglandin D2 by human cerebral cortex into 9 alpha, 11 beta-prostaglandin F2 by an active NADPH-dependent 11-ketoreductase. | 1989 | J. Neurochem. | pmid:2723663 |
| Hayaishi O | Prostaglandin D2 and sleep. | 1989 | Ann. N. Y. Acad. Sci. | pmid:2774407 |
| Deckers IA et al. | Evidence for the involvement of prostaglandins in modulation of acetylcholine release from canine bronchial tissue. | 1989 | Eur. J. Pharmacol. | pmid:2806380 |
| Kuiper J et al. | Cellular communication inside the liver. Binding, conversion and metabolic effect of prostaglandin D2 on parenchymal liver cells. | 1989 | Biochem. J. | pmid:2818563 |