| MeSH term | MeSH ID | Detail |
|---|---|---|
| Parkinsonian Disorders | D020734 | 20 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Pleurisy | D010998 | 20 associated lipids |
| Sarcoma 180 | D012510 | 21 associated lipids |
| Myocardial Infarction | D009203 | 21 associated lipids |
| Helicobacter Infections | D016481 | 21 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Erythema | D004890 | 22 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Black PN et al. | Effect of inhaled leukotriene B4 alone and in combination with prostaglandin D2 on bronchial responsiveness to histamine in normal subjects. | 1989 | Thorax | pmid:2548300 |
| Kuiper J et al. | Induction of ornithine decarboxylase in rat liver by phorbol ester is mediated by prostanoids from Kupffer cells. | 1989 | J. Biol. Chem. | pmid:2708347 |
| Ishikawa H et al. | [Changes of protein and RNA content in accumulated G1 cells by delta12-PGJ2]. | 1989 | Gan To Kagaku Ryoho | pmid:2930205 |
| Koshihara Y and Kawamura M | Prostaglandin D2 stimulates calcification of human osteoblastic cells. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2930558 |
| Ban M et al. | A flavonoid inhibitor of 5-lipoxygenase inhibits leukotriene production following ischemia in gerbil brain. | 1989 | Stroke | pmid:2919414 |
| Ikai K et al. | Inhibitory effect of tranilast on prostaglandin D synthetase. | 1989 | Biochem. Pharmacol. | pmid:2475113 |
| Yamada K | [The effect of prostaglandin D2 on rat testicular testosterone levels]. | 1989 | Nihon Naibunpi Gakkai Zasshi | pmid:2591605 |
| Goto H et al. | The role of prostaglandin D2 in the genesis of indomethacin-induced gastric lesions in rats. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2595317 |
| Woodward DF et al. | Marked differential effects of prostanoid metabolites on rabbit intraocular pressure. | 1989 | Ophthalmic Res. | pmid:2626239 |
| Busshardt E et al. | Regulation of hepatic parenchymal and non-parenchymal cell function by the diadenine nucleotides Ap3A and Ap4A. | 1989 | Biochim. Biophys. Acta | pmid:2563228 |
| Nishino S et al. | Salivary prostaglandin concentrations: possible state indicators for major depression. | 1989 | Am J Psychiatry | pmid:2627202 |
| Triggiani M et al. | Inhibition of histamine and prostaglandin D2 release from human lung mast cells by ciclosporin A. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468619 |
| Charlesworth EN et al. | Cells and secretagogues involved in the human late-phase response. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468620 |
| Church MK et al. | Interaction of neuropeptides with human mast cells. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468622 |
| Charlesworth EN et al. | Cutaneous late-phase response to allergen. Mediator release and inflammatory cell infiltration. | 1989 | J. Clin. Invest. | pmid:2468688 |
| Charlesworth EN et al. | Effect of cetirizine on mast cell-mediator release and cellular traffic during the cutaneous late-phase reaction. | 1989 | J. Allergy Clin. Immunol. | pmid:2469708 |
| Church MK et al. | Mast cells, neuropeptides and inflammation. | 1989 | Agents Actions | pmid:2473641 |
| van Overveld FJ | Mediator release from human lung mast cell subtypes in chronic bronchitis and emphysema. | 1989 | Agents Actions | pmid:2473645 |
| Benyon RC et al. | Differential release of histamine and eicosanoids from human skin mast cells activated by IgE-dependent and non-immunological stimuli. | 1989 | Br. J. Pharmacol. | pmid:2474353 |
| Emery DL et al. | Prostaglandin D2 causes accumulation of eosinophils in the lumen of the dog trachea. | 1989 | J. Appl. Physiol. | pmid:2793725 |
| Dubertret L et al. | Biological and cellular responses to grass pollen in sensitive patients. | 1989 | Dermatologica | pmid:2476344 |
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| Hatanaka M et al. | Late-phase accumulation of inositol phosphates stimulated by prostaglandins D2 and F2 alpha in neuroblastoma x glioma hybrid NG108-15 cells. | 1989 | J. Neurochem. | pmid:2507741 |
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| Lapointe DS and Olson MS | Platelet-activating factor-stimulated hepatic glycogenolysis is not mediated through cyclooxygenase-derived metabolites of arachidonic acid. | 1989 | J. Biol. Chem. | pmid:2501299 |
| Asbóth G et al. | The relation between thromboxane and prostaglandin synthesis in human decidua tissue: a comparison of eicosanoid synthesis in minced tissue with that in a cell-free preparation. | 1989 | Biochim. Biophys. Acta | pmid:2493805 |
| Beasley RC et al. | Effect of a thromboxane receptor antagonist on PGD2- and allergen-induced bronchoconstriction. | 1989 | J. Appl. Physiol. | pmid:2525122 |
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| Fukushima M et al. | Prostaglandin A and J: antitumor and antiviral prostaglandins. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526507 |
| Thierauch KH et al. | Stable 9 beta- or 11 alpha-halogen-15-cyclohexyl-prostaglandins with high affinity to the PGD2-receptor. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526554 |
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| Deckers IA et al. | Evidence for the involvement of prostaglandins in modulation of acetylcholine release from canine bronchial tissue. | 1989 | Eur. J. Pharmacol. | pmid:2806380 |
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| Ikai K and Imamura S | Prostaglandin D2 in the skin. | 1988 | Int. J. Dermatol. | pmid:3286543 |
| Hardy CC et al. | Bronchoconstrictor and antibronchoconstrictor properties of inhaled prostacyclin in asthma. | 1988 | J. Appl. Physiol. | pmid:3288608 |
| Pienkowski MM et al. | Prostaglandin D2 and histamine during the immediate and the late-phase components of allergic cutaneous responses. | 1988 | J. Allergy Clin. Immunol. | pmid:3292634 |
| Ito S et al. | Problems in production of prostaglandin D2-specific antibody. | 1988 | Eicosanoids | pmid:3273218 |
| Saito K et al. | Blood components contribute to rise in gerbil brain levels of leukotriene-like immunoreactivity after ischemia and reperfusion. | 1988 | Stroke | pmid:3274043 |
| Giles H and Leff P | The biology and pharmacology of PGD2. | 1988 | Prostaglandins | pmid:3283848 |
| Featherstone RL et al. | Active sensitization of guinea-pig airways in vivo enhances in vivo and in vitro responsiveness. | 1988 | Eur. Respir. J. | pmid:3229483 |
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| Hayaishi O | Sleep-wake regulation by prostaglandins D2 and E2. | 1988 | J. Biol. Chem. | pmid:3049580 |
| Beasley R et al. | Comparative vascular effects of histamine, prostaglandin (PG) D2 and its metabolite 9 alpha,11 beta-PGF2 in human skin. | 1988 | Clin. Allergy | pmid:3242978 |
| Casteleijn E et al. | Hormonal control of glycogenolysis in parenchymal liver cells by Kupffer and endothelial liver cells. | 1988 | J. Biol. Chem. | pmid:3422638 |
| Yamamoto K et al. | Muramyl dipeptide-elicited production of PGD2 from astrocytes in culture. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3056405 |
| Hahn HL | [Inflammatory mediators in the pathogenesis of obstructive bronchial diseases: consequences for therapy]. | 1988 | Verh Dtsch Ges Inn Med | pmid:2905102 |
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| Altin JG and Bygrave FL | Prostaglandin F2 alpha and the thromboxane A2 analogue ONO-11113 stimulate Ca2+ fluxes and other physiological responses in rat liver. Further evidence that prostanoids may be involved in the action of arachidonic acid and platelet-activating factor. | 1988 | Biochem. J. | pmid:3128268 |
| Koh T et al. | Serotonin involvement in the inhibition of luteinizing hormone (LH) release induced by prostaglandin D2 (PGD2) in castrated male rats. | 1988 | Eur. J. Pharmacol. | pmid:2969338 |
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| Kuiper J et al. | The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3144970 |
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| Casteleijn E et al. | Conditioned media of Kupffer and endothelial liver cells influence protein phosphorylation in parenchymal liver cells. Involvement of prostaglandins. | 1988 | Biochem. J. | pmid:3166374 |
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| Takei M et al. | Role of cyclic AMP during histamine release. Histamine release is not directly related to increase in cyclic AMP levels in rat mast cells activated by concanavalin A, anti-IgE, antigen, prostaglandin D2 and isoproterenol. | 1988 | Biol. Chem. Hoppe-Seyler | pmid:2463844 |
| Wang D et al. | Aminophylline reduces air-flow-induced constriction in the canine lung periphery. | 1988 | Am. Rev. Respir. Dis. | pmid:3422143 |
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| Thierauch KH et al. | Stable 9 beta- or 11 alpha-halogen-15-cyclohexyl-prostaglandins with high affinity to the PGD2-receptor. | 1988 | Prostaglandins | pmid:2847246 |
| Ujihara M et al. | Prostaglandin D2 formation and characterization of its synthetases in various tissues of adult rats. | 1988 | Arch. Biochem. Biophys. | pmid:3124755 |
| Kashimura M et al. | Prostaglandin D2 diminishes transmucosal potential difference in rat colonic mucosa in vitro in contrast to the increasing effect of prostaglandin E1. | 1988 | Prostaglandins | pmid:2854645 |
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| Morimoto A et al. | Multiple control of fever production in the central nervous system of rabbits. | 1988 | J. Physiol. (Lond.) | pmid:3261794 |
| Robinson C et al. | The metabolism of prostaglandin D2 after inhalation or intravenous infusion in normal men. | 1988 | Biochim. Biophys. Acta | pmid:3196723 |
| Armour CL et al. | Prostaglandin F2 alpha augments the response to parasympathetic fibre stimulation in an isolated innervated preparation of rabbit trachea. | 1988 | J Auton Pharmacol | pmid:3198665 |