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Treatment of primary CLL cells with bezafibrate and medroxyprogesterone acetate induces apoptosis and represses the pro-proliferative signal of CD40-ligand, in part through increased 15dDelta12,14,PGJ2. |
2009 |
Leukemia |
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Lipid metabolite levels of prostaglandin D2 and eicosapentaenoic acid recovered from bronchoalveolar lavage fluid correlate with lung function of chronic obstructive pulmonary disease patients and controls. |
2009 |
Electrophoresis |
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Kase K et al. |
Inhibitory action of roxithromycin on histamine release and prostaglandin D2 production from beta-defensin 2-stimulated mast cells. |
2009 |
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The permissive role of mitochondria in the induction of haem oxygenase-1 in endothelial cells. |
2009 |
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15-Deoxy-Delta(12,14)-prostaglandin J(2) induces mitochondrial-dependent apoptosis through inhibition of PKA/NF-kappaB in renal proximal epithelial cells. |
2009 |
Toxicology |
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Quarello E and Trabbia A |
High-definition flow combined with spatiotemporal image correlation in the diagnosis of fetal coarctation of the aorta. |
2009 |
Ultrasound Obstet Gynecol |
pmid:19194864
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Kolaczkowska E et al. |
Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9. |
2009 |
Immunology |
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Lipopolysaccharide-dependent interaction between PU.1 and c-Jun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages. |
2009 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
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Prostaglandin D(2) sustains the pyrogenic effect of prostaglandin E(2). |
2009 |
Eur. J. Pharmacol. |
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Peroxisome proliferator-activated receptor gamma agonists enhance lung maturation in a neonatal rat model. |
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Expression and characterization of PGD2 receptors in chronic rhinosinusitis: modulation of DP and CRTH2 by PGD2. |
2009 |
Int. Arch. Allergy Immunol. |
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The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J(2) delays lipopolysaccharide-induced preterm delivery and reduces mortality in the newborn mouse. |
2009 |
Endocrinology |
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Tsuji T et al. |
Reduction of nuclear peroxisome proliferator-activated receptor gamma expression in methamphetamine-induced neurotoxicity and neuroprotective effects of ibuprofen. |
2009 |
Neurochem. Res. |
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Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids. |
2009 |
J. Mol. Biol. |
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Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor. |
2009 |
Dig. Dis. Sci. |
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15-deoxy-Delta12,14 prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis. |
2009 |
J. Thromb. Haemost. |
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15-Deoxy-Delta12,14-prostaglandin J2 inhibits HIV-1 transactivating protein, Tat, through covalent modification. |
2009 |
FASEB J. |
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Inhibition of prostaglandin D synthase suppresses muscular necrosis. |
2009 |
Am. J. Pathol. |
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Down-regulation of hTERT expression plays an important role in 15-deoxy-Delta12,14-prostaglandin J2-induced apoptosis in cancer cells. |
2009 |
Int. J. Oncol. |
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Boehme SA et al. |
Murine bone marrow-derived mast cells express chemoattractant receptor-homologous molecule expressed on T-helper class 2 cells (CRTh2). |
2009 |
Int. Immunol. |
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Involvement of Propionibacterium acnes in the augmentation of lipogenesis in hamster sebaceous glands in vivo and in vitro. |
2009 |
J. Invest. Dermatol. |
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Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts. |
2009 |
Am. J. Respir. Cell Mol. Biol. |
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Effects of 15-deoxy-delta 12, 14-prostaglandin J2 on the expression of p53 in MCF-7 cells. |
2009 |
Ann. N. Y. Acad. Sci. |
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15-Deoxy-delta 12, 14-prostaglandin J2 induces upregulation of multidrug resistance-associated protein 1 via Nrf2 activation in human breast cancer cells. |
2009 |
Ann. N. Y. Acad. Sci. |
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15-Deoxy-delta 12, 14,-prostaglandin J2 suppresses nuclear factor-kappaB-mediated apoptosis of Helicobacter pylori-infected gastric epithelial cells. |
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Ann. N. Y. Acad. Sci. |
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Increased expression and cellular localization of lipocalin-type prostaglandin D synthase in Helicobacter pylori-induced gastritis. |
2009 |
J. Pathol. |
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[Molecular mechanisms of insomnia]. |
2009 |
Nippon Rinsho |
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Peroxisome proliferator-activated receptor-gamma is essential in the pathogenesis of gastric carcinoma. |
2009 |
World J. Gastroenterol. |
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Biomarkers in the diagnosis of anaphylaxis: making nature disclose her mysteries. |
2009 |
Clin. Exp. Allergy |
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A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation. |
2009 |
Int. Immunol. |
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Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanisms. |
2009 |
Int. Immunol. |
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Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes. |
2009 |
Endocrinology |
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The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation. |
2009 |
J. Biol. Chem. |
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R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway. |
2009 |
Pharm. Res. |
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Elevated concentrations of 15-deoxy-Delta12,14-prostaglandin J2 in chronic liver disease propose therapeutic trials with peroxisome proliferator activated receptor gamma-inducing drugs. |
2009 |
Liver Int. |
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The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds. |
2009 |
Mol. Cell. Biol. |
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Biochemical, functional, and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase. |
2009 |
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CC16 inhibits the migration of eosinophils towards the formyl peptide fMLF but not towards PGD2. |
2009 |
Inflammation |
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15-Deoxy-Delta12,14-prostaglandin J2 upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: possible roles of iron and ROS. |
2009 |
Carcinogenesis |
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Induction of prostacyclin by steady laminar shear stress suppresses tumor necrosis factor-alpha biosynthesis via heme oxygenase-1 in human endothelial cells. |
2009 |
Circ. Res. |
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PPAR-gamma agonists inhibit TGF-beta1-induced chemokine expression in human tubular epithelial cells. |
2009 |
Acta Pharmacol. Sin. |
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Atomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligands. |
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FEBS Lett. |
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Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. |
2009 |
Chem. Biol. Interact. |
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Methods for imaging and detecting modification of proteins by reactive lipid species. |
2009 |
Free Radic. Biol. Med. |
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A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells. |
2009 |
Oncogene |
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Activation of peroxisome proliferator-activated receptor-gamma inhibits transforming growth factor-beta1 induction of connective tissue growth factor and extracellular matrix in hypertrophic scar fibroblasts in vitro. |
2009 |
Arch. Dermatol. Res. |
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Quantitative characterization of prostaglandins in the uterus of early pregnant cattle. |
2009 |
Reproduction |
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A prostaglandin D2 receptor antagonist modifies experimental asthma in sheep. |
2009 |
Clin. Exp. Allergy |
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Potential effects of peroxisome proliferator-activated receptor activator on LPS-induced lung injury in rats. |
2009 |
Pulm Pharmacol Ther |
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Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis. |
2009 |
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Eicosapentaenoic acid is more effective than docosahexaenoic acid in inhibiting proinflammatory mediator production and transcription from LPS-induced human asthmatic alveolar macrophage cells. |
2009 |
Clin Nutr |
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Proteasome-caspase-cathepsin sequence leading to tau pathology induced by prostaglandin J2 in neuronal cells. |
2009 |
J. Neurochem. |
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15-Deoxy-Delta(12,14)-prostaglandin-J(2) reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1alpha degradation. |
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Cell. Mol. Life Sci. |
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Select cyclopentenone prostaglandins trigger glutathione efflux and the role of ABCG2 transport. |
2009 |
Free Radic. Biol. Med. |
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Cardiovasc. Res. |
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Novel function of CRTH2 in preventing apoptosis of human Th2 cells through activation of the phosphatidylinositol 3-kinase pathway. |
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J. Immunol. |
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Intracellular protein phosphorylation in eosinophils and the functional relevance in cytokine production. |
2009 |
Int. Arch. Allergy Immunol. |
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15-Deoxy-Delta(12,14)-prostaglandin J2 induces IL-8 and GM-CSF in a human airway epithelial cell line (NCI-H292). |
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Int. Arch. Allergy Immunol. |
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Lipid peroxidation: physiological levels and dual biological effects. |
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Free Radic. Biol. Med. |
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15-deoxy-Delta(12,14)-prostaglandin J(2) inhibits fibrogenic response in human hepatoma cells. |
2009 |
Toxicol. Lett. |
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Regulation of Nrf2-dependent gene expression by 15-deoxy-Delta12,14-prostaglandin J2. |
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Free Radic. Biol. Med. |
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15-Deoxi-Delta(12,14)-prostaglandin J2 is a tubulin-binding agent that destabilizes microtubules and induces mitotic arrest. |
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Biochem. Pharmacol. |
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GIF-0173 protects against cerebral infarction through DP1 receptor activation. |
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Exp. Neurol. |
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Peroxisome proliferator-activated receptor-gamma agonists promote differentiation and antioxidant defenses of oligodendrocyte progenitor cells. |
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J. Neuropathol. Exp. Neurol. |
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Plasma levels of 15d-PGJ are not altered in multiple sclerosis. |
2009 |
Eur. J. Neurol. |
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Upregulation of peroxisome proliferator-activated receptor-gamma and NADPH oxidases are involved in restenosis after balloon injury. |
2009 |
J. Cell. Physiol. |
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Effects of prostaglandin D2 on Na-dependent phosphate transport activity and its intracellular signaling mechanism in osteoblast-like cells. |
2009 |
Prostaglandins Leukot. Essent. Fatty Acids |
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Prostaglandin D2 produced by hematopoietic prostaglandin D synthase contributes to LPS-induced fever. |
2009 |
J. Physiol. Pharmacol. |
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Butterfield JH |
Survey of aspirin administration in systemic mastocytosis. |
2009 |
Prostaglandins Other Lipid Mediat. |
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The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation. |
2009 |
Development |
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Genistein induces adipogenesis but inhibits leptin induction in human synovial fibroblasts. |
2009 |
Lab. Invest. |
pmid:19434061
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The 15-deoxy-Delta12,14-prostaglandin J2 inhibits LPS-stimulated AKT and NF-kappaB activation and suppresses interleukin-6 in osteoblast-like cells MC3T3E-1. |
2009 |
Life Sci. |
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In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties. |
2009 |
Br. J. Pharmacol. |
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CD36-mediated cholesterol efflux is associated with PPARgamma activation via a MAPK-dependent COX-2 pathway in macrophages. |
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Cardiovasc. Res. |
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Murine mast cells secrete a unique profile of cytokines and prostaglandins in response to distinct TLR2 ligands. |
2009 |
Exp. Dermatol. |
pmid:19382314
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Li H and Pauza CD |
Effects of 15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) and rosiglitazone on human gammadelta2 T cells. |
2009 |
PLoS ONE |
pmid:19888466
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Landrier JF et al. |
Adiponectin expression is induced by vitamin E via a peroxisome proliferator-activated receptor gamma-dependent mechanism. |
2009 |
Endocrinology |
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Lauring B et al. |
Laropiprant in combination with extended-release niacin does not alter urine 11-dehydrothromboxane B2, a marker of in vivo platelet function, in healthy, hypercholesterolemic, and diabetic subjects. |
2009 |
J Clin Pharmacol |
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Hironaka A et al. |
15-Deoxy-Delta(12,14)-prostaglandin J(2) impairs the functions of histone acetyltransferases through their insolubilization in cells. |
2009 |
Biochem. Biophys. Res. Commun. |
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Ohinata K et al. |
Complement C5a stimulates food intake via a prostaglandin D(2)- and neuropeptide Y-dependent mechanism in mice. |
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Prostaglandins Other Lipid Mediat. |
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Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content. |
2009 |
J. Immunol. |
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AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects. |
2009 |
Cancer Res. |
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Prakash J et al. |
Albumin-binding and tumor vasculature determine the antitumor effect of 15-deoxy-Delta-(12,14)-prostaglandin-J(2) in vivo. |
2009 |
Neoplasia |
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Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia. |
2009 |
PLoS ONE |
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Pustovrh MC et al. |
MMP/ TIMP balance is modulated in vitro by 15dPGJ(2) in fetuses and placentas from diabetic rats. |
2009 |
Eur. J. Clin. Invest. |
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Genetic mechanisms underlying male sex determination in mammals. |
2009 |
J. Appl. Genet. |
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Effects of Bothrops asper snake venom on the expression of cyclooxygenases and production of prostaglandins by peritoneal leukocytes in vivo, and by isolated neutrophils and macrophages in vitro. |
2009 Feb-Mar |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:19155166
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Kolaczkowska E et al. |
Resident peritoneal macrophages and mast cells are important cellular sites of COX-1 and COX-2 activity during acute peritoneal inflammation. |
2009 Nov-Dec |
Arch. Immunol. Ther. Exp. (Warsz.) |
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Modulation of mammary cancer cell migration by 15-deoxy-delta(12,14)-prostaglandin J(2): implications for anti-metastatic therapy. |
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Biochem. J. |
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A pro-resolution mediator, prostaglandin D(2), is specifically up-regulated in individuals in long-term remission from ulcerative colitis. |
2010 |
Proc. Natl. Acad. Sci. U.S.A. |
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Novel anti-adipogenic activity produced by human fibroblasts. |
2010 |
Am. J. Physiol., Cell Physiol. |
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CRTH2 and D-type prostanoid receptor antagonists as novel therapeutic agents for inflammatory diseases. |
2010 |
Pharmacology |
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Peroxisome proliferator-activated receptor-gamma agonists suppress iNOS expression induced by LPS in rat primary Schwann cells. |
2010 |
J. Neuroimmunol. |
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Evaluation of anti-inflammatory and chondroprotective effects of peroxisome proliferator-activated receptor gamma agonists in cartilage and synovial explants from dogs. |
2010 |
Am. J. Vet. Res. |
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Concise and enantioselective total synthesis of 15-deoxy-Δ-(12,14)-prostaglandin J(2). |
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J. Org. Chem. |
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Chronic immobilisation stress ameliorates clinical score and neuroinflammation in a MOG-induced EAE in Dark Agouti rats: mechanisms implicated. |
2010 |
J Neuroinflammation |
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Anti-allergic activity of a platycodon root ethanol extract. |
2010 |
Int J Mol Sci |
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PPARgamma ligands inhibit telomerase activity and hTERT expression through modulation of the Myc/Mad/Max network in colon cancer cells. |
2010 |
J. Cell. Mol. Med. |
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Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanisms. |
2010 |
Biochem. J. |
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Activation of peroxisome proliferator-activated receptor gamma in brain inhibits inflammatory pain, dorsal horn expression of Fos, and local edema. |
2010 |
Neuropharmacology |
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