| MeSH term | MeSH ID | Detail |
|---|---|---|
| Encephalomyelitis, Autoimmune, Experimental | D004681 | 26 associated lipids |
| Translocation, Genetic | D014178 | 20 associated lipids |
| Catalepsy | D002375 | 30 associated lipids |
| Dermatitis, Atopic | D003876 | 19 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
| Leukemia, T-Cell | D015458 | 23 associated lipids |
| Rhinitis, Allergic, Perennial | D012221 | 6 associated lipids |
| Blood Platelet Disorders | D001791 | 12 associated lipids |
| Urticaria | D014581 | 13 associated lipids |
| Gastrointestinal Hemorrhage | D006471 | 27 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fox CC et al. | Enhancement of human intestinal mast cell mediator release in active ulcerative colitis. | 1990 | Gastroenterology | pmid:1693122 |
| Ikai K and Fukushima M | Effects of cytotoxic prostaglandin, delta 12-PGJ2 on protein synthesis and cytoskeleton in transformed epidermal cells in culture. | 1990 | Arch. Dermatol. Res. | pmid:1693839 |
| Ashby B | Novel mechanism of heterologous desensitization of adenylate cyclase: prostaglandins bind with different affinities to both stimulatory and inhibitory receptors on platelets. | 1990 | Mol. Pharmacol. | pmid:1695318 |
| Knapp HR | Reduced allergen-induced nasal congestion and leukotriene synthesis with an orally active 5-lipoxygenase inhibitor. | 1990 | N. Engl. J. Med. | pmid:1701029 |
| Liu MC et al. | Evidence for elevated levels of histamine, prostaglandin D2, and other bronchoconstricting prostaglandins in the airways of subjects with mild asthma. | 1990 | Am. Rev. Respir. Dis. | pmid:2368958 |
| GarcÃa-Sáinz JA et al. | Melittin stimulates liver glycogenolysis and the release of prostaglandin D2 and thromboxane B2. | 1990 | Biochem. J. | pmid:2375756 |
| Zavoico GB et al. | Enhancement of thrombin- and ionomycin-stimulated prostacyclin and platelet-activating factor production in cultured endothelial cells by a tumor-promoting phorbol ester. | 1990 | J. Cell. Physiol. | pmid:2113537 |
| Woodward DF et al. | Studies on the ocular pharmacology of prostaglandin D2. | 1990 | Invest. Ophthalmol. Vis. Sci. | pmid:2298534 |
| Goh Y and Nakajima M | Stimulatory effects of prostaglandin D2 analogues on adenylate cyclase in rabbit iris-ciliary body membrane fractions. | 1990 | Exp. Eye Res. | pmid:2249731 |
| Khan SH and Sorof S | Preferential binding of growth inhibitory prostaglandins by the target protein of a carcinogen. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2251282 |
| Nishimura G | [Antitumor activity and cell cycle effects of delta 12-PGJ2 in vivo]. | 1990 | Nihon Gan Chiryo Gakkai Shi | pmid:2351856 |
| Ford WD et al. | Pulmonary hypertension in lambs with congenital diaphragmatic hernia: vasodilator prostaglandins, isoprenaline, and tolazoline. | 1990 | J. Pediatr. Surg. | pmid:2352080 |
| Okumura T and Saito K | Effect of prostaglandins on glycogenesis and glycogenolysis in primary cultures of rat hepatocytes--a role of prostaglandin D2 in the liver. | 1990 | Prostaglandins | pmid:2353117 |
| Perreault T et al. | Pulmonary vascular effects of prostaglandin D2 in newborn pig. | 1990 | Am. J. Physiol. | pmid:2337164 |
| Ingenito EP et al. | Bronchoalveolar lavage cell and mediator responses to hyperpnea-induced bronchoconstriction in the guinea pig. | 1990 | Am. Rev. Respir. Dis. | pmid:2339838 |
| Williams WR et al. | In vitro tests for the diagnosis of aspirin-sensitive asthma. | 1990 | J. Allergy Clin. Immunol. | pmid:2146311 |
| Atsmon J et al. | Formation of thiol conjugates of 9-deoxy-delta 9,delta 12(E)-prostaglandin D2 and delta 12(E)-prostaglandin D2. | 1990 | Biochemistry | pmid:2340271 |
| vom Dahl S et al. | Stimulation of release of prostaglandin D2 and thromboxane B2 from perfused rat liver by extracellular adenosine. | 1990 | Biochem. J. | pmid:2396991 |
| Atsmon J et al. | Conjugation of 9-deoxy-delta 9,delta 12(E)-prostaglandin D2 with intracellular glutathione and enhancement of its antiproliferative activity by glutathione depletion. | 1990 | Cancer Res. | pmid:2306739 |
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| Nambu F et al. | Inhibitory effects of OKY-046 on spasmogen-induced bronchoconstrictions in sensitized and non-sensitized guinea pigs. | 1990 | Jpn. J. Pharmacol. | pmid:2313938 |
| Simpkins CO et al. | Prostaglandin D2 modulates human neutrophil intracellular calcium flux and inhibits superoxide release via its ring carbonyl. | 1990 | Life Sci. | pmid:2319907 |
| Gadsby JE et al. | Prostaglandin F2 alpha receptors on enzyme-dissociated pig luteal cells throughout the estrous cycle. | 1990 | Endocrinology | pmid:2153525 |
| Friedmann PS et al. | Ultraviolet stimulated melanogenesis by human melanocytes is augmented by di-acyl glycerol but not TPA. | 1990 | J. Cell. Physiol. | pmid:2303529 |
| Deffebach ME et al. | Prostaglandins alter methacholine-induced secretion in ferret in vitro trachea. | 1990 | Am. J. Physiol. | pmid:2407140 |
| Urade Y et al. | Mast cells contain spleen-type prostaglandin D synthetase. | 1990 | J. Biol. Chem. | pmid:2403560 |
| Mori H et al. | Augmentation of antiproliferative activity of recombinant human tumor necrosis factor by delta 12-prostaglandin J2. | 1990 | J Biol Response Mod | pmid:2341865 |
| Bochner BS et al. | Interleukin-1 is released at sites of human cutaneous allergic reactions. | 1990 | J. Allergy Clin. Immunol. | pmid:2262641 |
| Doyle WJ et al. | Physiologic responses to intranasal dose-response challenges with histamine, methacholine, bradykinin, and prostaglandin in adult volunteers with and without nasal allergy. | 1990 | J. Allergy Clin. Immunol. | pmid:2262647 |
| Kudo M et al. | [Prostaglandin D2-endogenous regulator of physiological sleep-inhibited CRF-induced ACTH secretion from rat anterior pituitary cells]. | 1990 | Nihon Naibunpi Gakkai Zasshi | pmid:1962750 |
| Kawano S et al. | Protective effect of PGD2 against ethanol-induced gastric mucosal injury in rats. | 1990 | J. Clin. Gastroenterol. | pmid:2212542 |
| Woodward DF et al. | Thromboxane A2-mimetics are potent microvascular permeability factors in the conjunctiva. | 1990 | J. Pharmacol. Exp. Ther. | pmid:2213558 |
| Katsuura G et al. | Involvement of organum vasculosum of lamina terminalis and preoptic area in interleukin 1 beta-induced ACTH release. | 1990 | Am. J. Physiol. | pmid:1967907 |
| Vigano' T et al. | Binding sites for histamine and sulfidopeptide leukotrienes in normal and hypersensitized human lung fragments. | 1990 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2144691 |
| Eggleston PA et al. | Disassociation of the release of histamine and arachidonic acid metabolites from osmotically activated basophils and human lung mast cells. | 1990 | Am. Rev. Respir. Dis. | pmid:1691604 |
| Fukushima M | Prostaglandin J2--anti-tumour and anti-viral activities and the mechanisms involved. | 1990 | Eicosanoids | pmid:2073399 |
| Inoue M et al. | Interactions between the brain renin-angiotensin system and brain prostanoids in the control of vasopressin secretion. | 1990 | Exp Brain Res | pmid:2073934 |
| Bennegård B et al. | Luteotropic effects of prostaglandins I2 and D2 on isolated human corpora luteum. | 1990 | Fertil. Steril. | pmid:2168845 |
| Bettazzoli L et al. | Incorporation of arachidonic acid into glycerophospholipids of a murine bone marrow derived mast cell. | 1990 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2169185 |
| Seiler S et al. | SQ-27986 inhibition of platelet aggregation is mediated through activation of platelet prostaglandin D2 receptors. | 1990 | Prostaglandins | pmid:2171039 |
| Eriksson LO et al. | Prostaglandin E2 binding sites in human renal tissue: characterization and localization by radioligand binding and autoradiography. | 1990 | Acta Physiol. Scand. | pmid:2173350 |
| Brass EP and Garrity MJ | Structural specificity for prostaglandin effects on hepatocyte glycogenolysis. | 1990 | Biochem. J. | pmid:2158311 |
| Lysz TW et al. | Kupffer cell-hepatocyte interactions and the changes in 1-14C-arachidonate incorporation in response to endotoxin in vitro. | 1990 | Prostaglandins | pmid:2112770 |
| Jongejan RC et al. | Effects of inflammatory mediators on the responsiveness of isolated human airways to methacholine. | 1990 | Am. Rev. Respir. Dis. | pmid:2240835 |
| Okuda-Ashitaka E et al. | Cyclic AMP-mediated inhibition of cell growth by prostaglandin D2 in a fibroblastic cell line (EBTr). | 1990 | Eicosanoids | pmid:1705811 |
| Nakahata N et al. | PGJ2 and delta 12PGJ2 inhibit cell growth accompanied with inhibition of phosphoinositide turnover in human astrocytoma cells. | 1990 | Prostaglandins | pmid:2177901 |
| Massey WA and Lichtenstein LM | The effects of antihistamines beyond H1 antagonism in allergic inflammation. | 1990 | J. Allergy Clin. Immunol. | pmid:1979797 |
| White RP et al. | Eicosanoid levels in CSF of premature infants with posthemorrhagic hydrocephalus. | 1990 | Am. J. Med. Sci. | pmid:2321665 |
| Broide DH et al. | Airway levels of mast cell-derived mediators in exercise-induced asthma. | 1990 | Am. Rev. Respir. Dis. | pmid:1689974 |
| Undem BJ et al. | Inhibition by adenosine 3':5'-monophosphate of eicosanoid and platelet-activating factor biosynthesis in the mouse PT-18 mast cell. | 1990 | J. Biol. Chem. | pmid:1691175 |
| Proud D et al. | Inflammatory mediator release on conjunctival provocation of allergic subjects with allergen. | 1990 | J. Allergy Clin. Immunol. | pmid:1692049 |
| Miadonna A et al. | Mediator release after endobronchial antigen challenge in patients with respiratory allergy. | 1990 | J. Allergy Clin. Immunol. | pmid:1692050 |
| Schulman ES et al. | Histochemical heterogeneity of dispersed human lung mast cells. | 1990 | J. Immunol. | pmid:1692857 |
| D'Onofrio C et al. | The antiproliferative effect of prostaglandin A and J on HTLV-I transformed cells is associated with induction of a heat-shock protein. | 1990 Sep-Oct | Pharmacol. Res. | pmid:2284244 |
| Giles H et al. | A comparative study of the prostanoid receptor profile of 9 alpha 11 beta-prostaglandin F2 and prostaglandin D2. | 1991 | Br. J. Pharmacol. | pmid:1665742 |
| Georgitis JW et al. | Nasal inflammatory mediator release in ragweed allergic rhinitis: correlation with cellular influx into nasal secretions. | 1991 | Int. Arch. Allergy Appl. Immunol. | pmid:1666629 |
| Takayanagi I et al. | Effects of aging on alpha 2-adrenoceptor mechanisms in isolated guinea-pig tracheal preparations. | 1991 | Eur. J. Pharmacol. | pmid:1674919 |
| Goerg KJ et al. | Antisecretory effect of prostaglandin D2 in rat colon in vitro: action sites. | 1991 | Am. J. Physiol. | pmid:1676243 |
| Fox CC et al. | Modulation of mediator release from human intestinal mast cells by sulfasalazine and 5-aminosalicylic acid. | 1991 | Dig. Dis. Sci. | pmid:1703070 |
| Keenan CM and Rangachari PK | Contrasting effects of PGE2 and PGD2: ion transport in the canine proximal colon. | 1991 | Am. J. Physiol. | pmid:2003610 |
| Roberts LJ and Oates JA | Biochemical diagnosis of systemic mast cell disorders. | 1991 | J. Invest. Dermatol. | pmid:16799604 |
| Sinzinger H et al. | Platelet lipoxygenase defect (Wien-Penzing defect) in two patients with myocardial infarction. | 1991 | Am. J. Hematol. | pmid:1899965 |
| Morii H and Watanabe Y | Solubilization of prostaglandin D2 binding protein from porcine temporal cortex. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1989614 |
| Dore-Duffy P et al. | Cerebrospinal fluid eicosanoid levels: endogenous PGD2 and LTC4 synthesis by antigen-presenting cells that migrate to the central nervous system. | 1991 | Neurology | pmid:1992386 |
| Wenzel SE et al. | Bronchoalveolar lavage fluid mediator levels 5 minutes after allergen challenge in atopic subjects with asthma: relationship to the development of late asthmatic responses. | 1991 | J. Allergy Clin. Immunol. | pmid:1993813 |
| Norman P et al. | BAY u3405 is a potent and competitive antagonist of U46619, PGD2 and 9 alpha, 11 beta PGF2 alpha-induced contractions of airway smooth muscle. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1952564 |
| Nowak D et al. | Comparison of airway responsiveness to prostaglandin D2 and histamine, methacholine or exercise in healthy and asthmatic subjects. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1952573 |
| Alving K et al. | The possible role of prostaglandin D2 in the long-lasting airways vasodilatation induced by allergen in the sensitized pig. | 1991 | Acta Physiol. Scand. | pmid:1957709 |
| Gebicke-Haerter PJ et al. | Pertussis and cholera toxins inhibit prostaglandin synthesis in rat astrocyte cultures at distinct metabolic steps. | 1991 | Biochem. Pharmacol. | pmid:1909527 |
| Sasaki H et al. | Human ovarian cancer cell lines resistant to cisplatin, doxorubicin, and L-phenylalanine mustard are sensitive to delta 7-prostaglandin A1 and delta 12-prostaglandin J2. | 1991 | Gynecol. Oncol. | pmid:2026357 |
| Marui N et al. | Delta 12-prostaglandin J2 mimics heat shock in inducing cell cycle arrest at G1 phase. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1930204 |
| Nakajima M et al. | Effects of prostaglandin D2 and its analogue, BW245C, on intraocular pressure in humans. | 1991 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:1937072 |
| Perreault T and De Marte J | Endothelin-1 has a dilator effect on neonatal pig pulmonary vasculature. | 1991 | J. Cardiovasc. Pharmacol. | pmid:1719291 |
| van der Donk EM et al. | Leukotriene C4 formation by enriched human basophil preparations from normal and asthmatic subjects. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1719566 |
| Murakami M et al. | Group II phospholipase A2 inhibitors suppressed lysophosphatidylserine-dependent degranulation of rat peritoneal mast cells. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1721808 |
| Myers AC et al. | Influence of antigen on membrane properties of guinea pig bronchial ganglion neurons. | 1991 | J. Appl. Physiol. | pmid:1721906 |
| Misawa M and Kanai Y | Effect of the new antiallergic drug epinastine on chemical mediator induced bronchoconstrictions in guinea pigs. | 1991 | Arzneimittelforschung | pmid:1725697 |
| Abman SH and Accurso FJ | Sustained fetal pulmonary vasodilation with prolonged atrial natriuretic factor and GMP infusions. | 1991 | Am. J. Physiol. | pmid:1847014 |
| Sladek K et al. | Formation of PGD2 after allergen inhalation in atopic asthmatics. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1847781 |
| King LS et al. | Pulmonary vascular effects of prostaglandin D2, but not its systemic vascular or airway effects, are mediated through thromboxane receptor activation. | 1991 | Circ. Res. | pmid:1825033 |
| Arzubiaga C et al. | Neuropeptide Y, a putative cotransmitter in noradrenergic neurons, induces mast cell degranulation but not prostaglandin D2 release. | 1991 | J. Allergy Clin. Immunol. | pmid:1825102 |
| Koshihara Y et al. | Prostaglandin D2 stimulates calcification by human osteoblastic cells. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825424 |
| Rubin DB et al. | The influence of exogenous eicosanoids on the radiation response of cultured bovine aortic endothelial cells. | 1991 | Radiat. Res. | pmid:1898781 |
| Atsmon J et al. | Modulation of the antiproliferative activity of 9-deoxy-delta 9,delta 12(E)-PGD2 by conjugation with intracellular glutathione. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825432 |
| Akerboom T et al. | Cholestasis and changes of portal pressure caused by chlorpromazine in the perfused rat liver. | 1991 | Hepatology | pmid:1899850 |
| Koizumi K et al. | Induction of 31,000 protein by PGD2-treated vascular endothelial cells. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825433 |
| Morrow JD et al. | A stable isotope dilution mass spectrometric assay for the major urinary metabolite of PGD2. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825560 |
| Howarth P et al. | The comparative nasal effects of prostaglandin D2 in normal and rhinitic subjects. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825579 |
| Gundel RH et al. | The effects of a 5-lipoxygenase inhibitor on antigen-induced mediator release, late-phase bronchoconstriction and cellular infiltrates in primates. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825582 |
| Watanabe K et al. | The structure and function of prostaglandin F synthase. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825592 |
| Woodward DF et al. | Studies on leukotriene D4 as an eosinophil chemoattractant. | 1991 | Drugs Exp Clin Res | pmid:1841046 |
| Gebicke-Haerter PJ et al. | Regulation and glucocorticoid-independent induction of lipocortin I in cultured astrocytes. | 1991 | J. Neurochem. | pmid:1828830 |
| Walls AF et al. | Inflammatory mediators and cellular infiltration of the lungs in a guinea pig model of the late asthmatic reaction. | 1991 | Lung | pmid:1921474 |
| Crivellari MT et al. | Eicosanoid release and mepyramine, LTC4 and LTD4 binding in passively sensitized human lung parenchyma in vitro. | 1991 | Biochem. Pharmacol. | pmid:1859453 |
| Francis HP et al. | The thromboxane receptor antagonist BAY u3405 reverses prostaglandin D2 (PGD2)-induced bronchoconstriction in the anaesthetised guinea pig. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1835329 |
| Kobayashi Y et al. | Syntheses of 2,6-dideoxy-6-fluoro-2-[(3R and 3S)-3- hydroxytetradecanamido]-3-O-[(3R)-3-(tetradecanoyloxy)tetra decanoyl]-D- glucopyranose 4-(dihydrogen phosphate) and 2-deoxy-2-[(3R and 3S)-3- hydroxytetradecanamido]-3-O-[(3R)-3-(tetradecanoyloxy)tetra decanoyl]- alpha-D-glucopyranosyl fluoride 4-(dihydrogen phosphate): fluorosugar analogues of GLA-60. | 1991 | Carbohydr. Res. | pmid:1813114 |
| Ney P and Schrör K | PGD2 and its mimetic ZK 110.841 are potent inhibitors of receptor-mediated activation of human neutrophils. | 1991 | Eicosanoids | pmid:1647806 |
| Gundel RH et al. | Antigen-induced mediator release in primates. | 1991 | Am. Rev. Respir. Dis. | pmid:1648317 |
| Marriott DR et al. | Substance P-induced release of prostaglandins from astrocytes: regional specialisation and correlation with phosphoinositol metabolism. | 1991 | J. Neurochem. | pmid:1702831 |
| Smith GS et al. | Adaptive cytoprotection against alcohol injury in the rat stomach is not due to increased prostanoid synthesis. | 1991 | Prostaglandins | pmid:1906621 |