| MeSH term | MeSH ID | Detail |
|---|---|---|
| Precancerous Conditions | D011230 | 48 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Respiratory Sounds | D012135 | 3 associated lipids |
| Retinopathy of Prematurity | D012178 | 9 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Rhinitis, Allergic, Perennial | D012221 | 6 associated lipids |
| Sarcoidosis | D012507 | 13 associated lipids |
| Sarcoma 180 | D012510 | 21 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Akabane H et al. | Effects of salmeterol xinafoate and fluticasone propionate on immunological activation of human cultured mast cells. | 2006 | Allergol Int | pmid:17130681 |
| Ishimura M et al. | Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea. | 2006 | Allergol Int | pmid:17130683 |
| Mazid MA et al. | Endogenous 15-deoxy-Delta(12,14)-prostaglandin J(2) synthesized by adipocytes during maturation phase contributes to upregulation of fat storage. | 2006 | FEBS Lett. | pmid:17150216 |
| Rousseaux C and Desreumaux P | [The peroxisome-proliferator-activated gamma receptor and chronic inflammatory bowel disease (PPARgamma and IBD)]. | 2006 | J. Soc. Biol. | pmid:17151549 |
| Kang DS et al. | 15-deoxy-Delta12,14-prostaglandin J2 induces renal epithelial cell death through NF-kappaB-dependent and MAPK-independent mechanism. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16890972 |
| Nakata S et al. | 15-Deoxy-Delta12,14-prostaglandin J(2) induces death receptor 5 expression through mRNA stabilization independently of PPARgamma and potentiates TRAIL-induced apoptosis. | 2006 | Mol. Cancer Ther. | pmid:16891469 |
| Wang XS and Lau HY | Beta-adrenoceptor-mediated inhibition of mediator release from human peripheral blood-derived mast cells. | 2006 | Clin. Exp. Pharmacol. Physiol. | pmid:16895550 |
| Zhang A et al. | Prostaglandin D2 inhibits TGF-beta1-induced epithelial-to-mesenchymal transition in MDCK cells. | 2006 | Am. J. Physiol. Renal Physiol. | pmid:16896186 |
| Chaffer CL et al. | PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma. | 2006 | BMC Cancer | pmid:16519808 |
| Pérez S et al. | The 2-series prostaglandins suppress VLDL secretion in an inflammatory condition-dependent manner in primary rat hepatocytes. | 2006 | Biochim. Biophys. Acta | pmid:16545597 |
| Wise H | Lack of interaction between prostaglandin E2 receptor subtypes in regulating adenylyl cyclase activity in cultured rat dorsal root ganglion cells. | 2006 | Eur. J. Pharmacol. | pmid:16545798 |
| Chiang PC et al. | Induction of Fas clustering and apoptosis by coral prostanoid in human hormone-resistant prostate cancer cells. | 2006 | Eur. J. Pharmacol. | pmid:16806159 |
| Xie Y et al. | Differentiation-dependent regulation of the cyclooxygenase cascade during adipogenesis suggests a complex role for prostaglandins. | 2006 | Diabetes Obes Metab | pmid:16367886 |
| Ogburn KD et al. | Prostaglandin J2 reduces catechol-O-methyltransferase activity and enhances dopamine toxicity in neuronal cells. | 2006 | Neurobiol. Dis. | pmid:16406650 |
| Honma Y et al. | Effects of indomethacin and dexamethasone on mechanical scratching-induced cutaneous barrier disruption in mice. | 2006 | Exp. Dermatol. | pmid:16761958 |
| El Mezayen R et al. | Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation. | 2006 | Immunol. Lett. | pmid:16762422 |
| Lin TN et al. | 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:16385084 |
| Kobayashi M et al. | ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin. | 2006 | Genes Cells | pmid:16824197 |
| Ding J et al. | Cyclooxygenase isozymes are expressed in human myeloma cells but not involved in anti-proliferative effect of cyclooxygenase inhibitors. | 2006 | Mol. Carcinog. | pmid:16385588 |
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| Zhang M et al. | Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats by activation of peroxisome proliferator-activated receptor gamma. | 2006 | Int. Immunopharmacol. | pmid:16782535 |
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| Yucel-Lindberg T et al. | Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts. | 2006 | Cell. Signal. | pmid:16766159 |
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| Sugimoto M et al. | Role of COX-1 and COX-2 on skin PGs biosynthesis by mechanical scratching in mice. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16815697 |
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| BrazÃs P et al. | Dermal microdialysis in the dog: in vivo assessment of the effect of cyclosporin A on cutaneous histamine and prostaglandin D2 release. | 2006 | Vet. Dermatol. | pmid:16674731 |
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| Helliwell RJ et al. | Gestational age-dependent up-regulation of prostaglandin D synthase (PGDS) and production of PGDS-derived antiinflammatory prostaglandins in human placenta. | 2006 | J. Clin. Endocrinol. Metab. | pmid:16291703 |
| Grill M et al. | Systemic inflammation induces COX-2 mediated prostaglandin D2 biosynthesis in mice spinal cord. | 2006 | Neuropharmacology | pmid:16182321 |
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| Zhao X et al. | 15d-Prostaglandin J2 activates peroxisome proliferator-activated receptor-gamma, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats. | 2006 | J. Cereb. Blood Flow Metab. | pmid:16208315 |
| Landar A et al. | Induction of the permeability transition and cytochrome c release by 15-deoxy-Delta12,14-prostaglandin J2 in mitochondria. | 2006 | Biochem. J. | pmid:16268779 |
| Cesario RM et al. | Differentiation and growth inhibition mediated via the RXR:PPARgamma heterodimer in colon cancer. | 2006 | Cancer Lett. | pmid:16271436 |
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| Garg TK and Chang JY | Methylmercury causes oxidative stress and cytotoxicity in microglia: attenuation by 15-deoxy-delta 12, 14-prostaglandin J2. | 2006 | J. Neuroimmunol. | pmid:16225932 |
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| Maciejewski-Lenoir D et al. | Langerhans cells release prostaglandin D2 in response to nicotinic acid. | 2006 | J. Invest. Dermatol. | pmid:17008871 |
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| Millán O et al. | Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis. | 2006 | Carcinogenesis | pmid:16113051 |
| Tanaka H et al. | Polymer-assisted solution-phase synthesis and neurite-outgrowth-promoting activity of 15-deoxy-delta(12,14)-PGJ2 derivatives. | 2006 | Chem Asian J | pmid:17441107 |
| Kim EH et al. | Upregulation of VEGF by 15-deoxy-Delta12,14-prostaglandin J2 via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cells. | 2006 | Ann. N. Y. Acad. Sci. | pmid:17384282 |
| Sugimoto M et al. | Time course changes of scratching counts, dermatitis symptoms, and levels of cutaneous prostaglandins in NC/Nga mice. | 2006 | Exp. Dermatol. | pmid:17002684 |
| Feldon SE et al. | Activated human T lymphocytes express cyclooxygenase-2 and produce proadipogenic prostaglandins that drive human orbital fibroblast differentiation to adipocytes. | 2006 | Am. J. Pathol. | pmid:17003477 |
| Peeraully MR et al. | Prostaglandin D2 and J2-series (PGJ2, Delta12-PGJ2) prostaglandins stimulate IL-6 and MCP-1, but inhibit leptin, expression and secretion by 3T3-L1 adipocytes. | 2006 | Pflugers Arch. | pmid:16924534 |
| Eucker J et al. | Peroxisome proliferator-activated receptor-gamma ligands inhibit proliferation and induce apoptosis in mantle cell lymphoma. | 2006 | Anticancer Drugs | pmid:16926626 |
| Satoh T et al. | Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor. | 2006 | J. Immunol. | pmid:16888024 |
| Sugimoto M et al. | COX-1 inhibition enhances scratching behaviour in NC/Nga mice with atopic dermatitis. | 2006 | Exp. Dermatol. | pmid:16842596 |
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| Lim HJ et al. | PPARgamma activation induces CD36 expression and stimulates foam cell like changes in rVSMCs. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16939881 |
| Chiba T et al. | Prostaglandin D2 induces IL-8 and GM-CSF by bronchial epithelial cells in a CRTH2-independent pathway. | 2006 | Int. Arch. Allergy Immunol. | pmid:16940740 |
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| Moulin D et al. | Effect of peroxisome proliferator activated receptor (PPAR)gamma agonists on prostaglandins cascade in joint cells. | 2006 | Biorheology | pmid:16912428 |
| Yeh CH et al. | Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators. | 2006 | Shock | pmid:16912651 |
| Ye F et al. | Quantitative characterization of 15-deoxy-delta(12,14)-prostaglandin J2 in regulating EGFPSmad2 translocation in CHO cells through PPARgamma/TGFbeta/Smad2 pathway. | 2006 | Cell. Physiol. Biochem. | pmid:16914899 |
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| Ulven T and Kostenis E | Targeting the prostaglandin D2 receptors DP and CRTH2 for treatment of inflammation. | 2006 | Curr Top Med Chem | pmid:16918458 |
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| Chou YH et al. | The possible role of heat shock factor-1 in the negative regulation of heme oxygenase-1. | 2005 | Int. J. Biochem. Cell Biol. | pmid:15618017 |
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| Na HK et al. | ET-18-O-CH3-induced apoptosis is causally linked to COX-2 upregulation in H-ras transformed human breast epithelial cells. | 2005 | FEBS Lett. | pmid:16253239 |
| Sugimoto H et al. | CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses. | 2005 | Eur. J. Pharmacol. | pmid:16256979 |
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| Kim KA et al. | 15d-Deoxy-Delta12,14-prostaglandin J2 modulates collagen type I synthesis in human hepatic stellate cells by inducing oxidative stress. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16098720 |
| Chen C and Bazan NG | Lipid signaling: sleep, synaptic plasticity, and neuroprotection. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099392 |
| Mouihate A et al. | Fever suppression in near-term pregnant rats is dissociated from LPS-activated signaling pathways. | 2005 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:16037126 |
| Nakae K et al. | Functional role of prostacyclin receptor in rat dorsal root ganglion neurons. | 2005 | Neurosci. Lett. | pmid:16039053 |
| Gelir E et al. | Effect of rapid-eye-movement sleep deprivation on rat hypothalamic prostaglandins. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16039105 |
| Masini E et al. | Reduction of antigen-induced respiratory abnormalities and airway inflammation in sensitized guinea pigs by a superoxide dismutase mimetic. | 2005 | Free Radic. Biol. Med. | pmid:16043023 |
| Artwohl M et al. | Thiazolidinediones inhibit apoptosis and heat shock protein 60 expression in human vascular endothelial cells. | 2005 | Thromb. Haemost. | pmid:15886792 |
| Malki S et al. | Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation. | 2005 | EMBO J. | pmid:15889150 |
| Wang Z and Figueiredo-Pereira ME | Inhibition of sequestosome 1/p62 up-regulation prevents aggregation of ubiquitinated proteins induced by prostaglandin J2 without reducing its neurotoxicity. | 2005 | Mol. Cell. Neurosci. | pmid:15911346 |
| Ishida A et al. | Characterization of cAMP-dependent proteolysis of GATA-6. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15913546 |
| Honma Y et al. | Prostaglandin D2 and prostaglandin E2 accelerate the recovery of cutaneous barrier disruption induced by mechanical scratching in mice. | 2005 | Eur. J. Pharmacol. | pmid:16000196 |
| Kim HJ et al. | 15-Deoxy-delta12,14-PGJ2 inhibits IL-6-induced Stat3 phosphorylation in lymphocytes. | 2005 | Exp. Mol. Med. | pmid:16000871 |
| Ibabe A et al. | Modulation of peroxisome proliferator-activated receptors (PPARs) by PPAR(alpha)- and PPAR(gamma)-specific ligands and by 17beta-estradiol in isolated zebrafish hepatocytes. | 2005 | Toxicol In Vitro | pmid:15964169 |
| Pande V and Ramos MJ | Molecular recognition of 15-deoxy-delta(12,14)-prostaglandin J2 by nuclear factor-kappa B and other cellular proteins. | 2005 | Bioorg. Med. Chem. Lett. | pmid:16006125 |
| Inoue K et al. | Effects of 15-deoxy-Delta12,14-prostaglandin J2 on the expression of Toll-like receptor 4 and 2 in the murine lung in the presence of lipopolysaccharide. | 2005 | Clin. Exp. Pharmacol. Physiol. | pmid:15743408 |
| Berry EB et al. | Nanomolar and micromolar effects of 15-deoxy-delta 12,14-prostaglandin J2 on amnion-derived WISH epithelial cells: differential roles of peroxisome proliferator-activated receptors gamma and delta and nuclear factor kappa B. | 2005 | Mol. Pharmacol. | pmid:15821150 |
| Lindström TM and Bennett PR | 15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implications. | 2005 | J. Clin. Endocrinol. Metab. | pmid:15755849 |
| Takashima T et al. | Relationship between peroxisome proliferator-activated receptor-gamma expression and differentiation of human esophageal squamous cell carcinoma. | 2005 | Oncol. Rep. | pmid:15756430 |