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2004 |
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PPAR activators and gastroenterology. |
2004 |
Drug News Perspect. |
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Peroxisome proliferator-activated receptor gamma ligands regulate myeloperoxidase expression in macrophages by an estrogen-dependent mechanism involving the -463GA promoter polymorphism. |
2004 |
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11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils. |
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Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2). |
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Metabolic and endocrine effects of a polyunsaturated fatty acid-rich diet in polycystic ovary syndrome. |
2004 |
J. Clin. Endocrinol. Metab. |
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[Prostaglandin D2 in allergy: PGD2 has dual receptor systems]. |
2004 |
Nippon Yakurigaku Zasshi |
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Recent progress in work on PGD2 antagonists for drugs targeting allergic diseases. |
2004 |
Curr. Pharm. Des. |
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Prostanoid DP1 receptor agonist inhibits the pruritic activity in NC/Nga mice with atopic dermatitis. |
2004 |
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A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonist. |
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Involvement of Sox-4 in the cytochrome c-dependent AIF-independent apoptotic pathway in HeLa cells induced by Delta12-prostaglandin J2. |
2004 |
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15-deoxy-delta12,14-prostaglandin-J2 inhibits expression of eNOS in human endothelial cells. |
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A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes. |
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Activation and role of MAP kinases in 15d-PGJ2-induced apoptosis in the human pancreatic cancer cell line MIA PaCa-2. |
2004 |
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Prostaglandins are powerful inducers of NGF and BDNF production in mouse astrocyte cultures. |
2004 |
FEBS Lett. |
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2004 |
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Rapid change of glucose concentration promotes mesangial cell proliferation via VEGF: inhibitory effects of thiazolidinedione. |
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Synthesis of prostaglandin F ethanolamide by prostaglandin F synthase and identification of Bimatoprost as a potent inhibitor of the enzyme: new enzyme assay method using LC/ESI/MS. |
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Transactivator protein BICP0 of bovine herpesvirus 1 (BHV-1) is blocked by prostaglandin D2 (PGD2), which points to a mechanism for PGD2-mediated inhibition of BHV-1 replication. |
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2004 |
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15-deoxy-delta12,14-prostaglandin J2 inhibits Bay 11-7085-induced sustained extracellular signal-regulated kinase phosphorylation and apoptosis in human articular chondrocytes and synovial fibroblasts. |
2004 |
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Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses. |
2004 |
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Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARgamma2 in the modulation of insulin secretion. |
2004 |
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2004 |
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Peroxisome proliferator-activated receptor gamma and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias. |
2004 |
Mol. Cancer Ther. |
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Induction of reversible cysteine-targeted protein oxidation by an endogenous electrophile 15-deoxy-delta12,14-prostaglandin J2. |
2004 |
Chem. Res. Toxicol. |
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Neurotoxic prostaglandin J2 enhances cyclooxygenase-2 expression in neuronal cells through the p38MAPK pathway: a death wish? |
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Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-delta 12,14-prostaglandin J2-induced heme oxygenase-1 expression. |
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Peroxisome proliferator-activated receptor-gamma suppresses cyclooxygenase-2 expression in human prostate cells. |
2004 |
Cancer Epidemiol. Biomarkers Prev. |
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Differential peroxisome proliferator-activated receptor-gamma isoform expression and agonist effects in normal and malignant prostate cells. |
2004 |
Cancer Epidemiol. Biomarkers Prev. |
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Ligands of peroxisome proliferator-activated receptor gamma induce apoptosis in multiple myeloma. |
2004 |
Anticancer Drugs |
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Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1. |
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Activators of PPARgamma antagonize protection of cardiac myocytes by endothelin-1. |
2004 |
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PPAR-gamma ligands inhibit the expression of inflammatory cytokines and attenuate autoimmune myocarditis. |
2004 |
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15d-prostaglandin J2 reduces multiple organ failure caused by wall-fragment of Gram-positive and Gram-negative bacteria. |
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2004 |
J. Hepatol. |
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Anti-apoptotic and pro-apoptotic effect of NEPP11 on manganese-induced apoptosis and JNK pathway activation in PC12 cells. |
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Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receptor-gamma-independent mechanism. |
2004 |
Cancer Res. |
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Differential modulation of human basophil functions through prostaglandin D2 receptors DP and chemoattractant receptor-homologous molecule expressed on Th2 cells/DP2. |
2004 |
Clin. Exp. Allergy |
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S. aureus-dependent microglial activation is selectively attenuated by the cyclopentenone prostaglandin 15-deoxy-Delta12,14- prostaglandin J2 (15d-PGJ2). |
2004 |
J. Neurochem. |
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Proinflammatory cytokines regulate LOX-1 expression in vascular smooth muscle cells. |
2004 |
Arterioscler. Thromb. Vasc. Biol. |
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Exp. Cell Res. |
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A potential role of 15-deoxy-delta(12,14)-prostaglandin J2 for induction of human articular chondrocyte apoptosis in arthritis. |
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Enhanced release of prostaglandin D2 during re-incubation of RAW 264.7 macrophage-like cells after treatment of both lipopolysaccharide and non-steroidal anti-inflammatory drugs. |
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Influence of peroxisome proliferator-activated receptor gamma activation by its endogenous ligand 15-deoxy Delta12,14 prostaglandin J2 on nitric oxide production in term placental tissues from diabetic women. |
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Mol. Hum. Reprod. |
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15-deoxy-delta (12,14)-PGJ2 inhibits astrocyte IL-1 signaling: inhibition of NF-kappaB and MAP kinase pathways and suppression of cytokine and chemokine expression. |
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Peroxisome proliferator-activated receptor-gamma and its ligands attenuate biologic functions of human natural killer cells. |
2004 |
Blood |
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Induction of proliferation by 15-deoxy-delta12,14-prostaglandin J2 and the precursors in monocytic leukemia U937. |
2004 |
Pharmacology |
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The novel synthetic oleanane triterpenoid CDDO (2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid) induces apoptosis in Mycosis fungoides/Sézary syndrome cells. |
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J. Invest. Dermatol. |
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Targeting of epidermal growth factor receptor by cyclopentenone prostaglandin 15-Deoxy-Delta12,14-prostaglandin J2 in human oral squamous carcinoma cells. |
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Delta12-Prostaglandin J2 inhibits the ubiquitin hydrolase UCH-L1 and elicits ubiquitin-protein aggregation without proteasome inhibition. |
2004 |
Biochem. Biophys. Res. Commun. |
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15-deoxy-delta12,14-prostaglandin J2-mediated ERK signaling inhibits gram-negative bacteria-induced RelA phosphorylation and interleukin-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity. |
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Fenofibrate, troglitazone, and 15-deoxy-Delta12,14-prostaglandin J2 close KATP channels and induce insulin secretion. |
2004 |
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Effect of peroxisome proliferator activated receptor gamma ligands on growth and gene expression profiles of gastric cancer cells. |
2004 |
Gut |
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A novel antipyretic action of 15-deoxy-Delta12,14-prostaglandin J2 in the rat brain. |
2004 |
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The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J2 ameliorates ischemic acute renal failure. |
2004 |
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The first total synthesis of 15-deoxy-Delta12,14-prostaglandin J2 and the unambiguous assignment of the C14 stereochemistry. |
2004 |
Org. Lett. |
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Physiological apoptotic agents have different effects upon human amnion epithelial and mesenchymal cells. |
2003 Feb-Mar |
Placenta |
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Hematopoietic prostaglandin D synthase. |
2003 Aug-Sep |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:12895599
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The second PGD(2) receptor CRTH2: structure, properties, and functions in leukocytes. |
2003 Aug-Sep |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:12895600
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A novel PGD(2) receptor expressed in eosinophils. |
2003 Aug-Sep |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:12895601
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Kabashima K and Narumiya S |
The DP receptor, allergic inflammation and asthma. |
2003 Aug-Sep |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:12895602
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PPARgamma ligands induce prostaglandin production in vascular smooth muscle cells: indomethacin acts as a peroxisome proliferator-activated receptor-gamma antagonist. |
2003 |
FASEB J. |
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TNF-alpha induction of lipolysis is mediated through activation of the extracellular signal related kinase pathway in 3T3-L1 adipocytes. |
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Prostaglandins of J series control heme oxygenase expression: potential significance in modulating neuroinflammation. |
2003 |
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Inhibition of prostaglandin D2 clearance in rat hepatocytes by the thromboxane receptor antagonists daltroban and ifetroban and the thromboxane synthase inhibitor furegrelate. |
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Biochem. Pharmacol. |
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Peroxisome proliferator-activated receptor-gamma ligand inhibition of RANTES production by human endometriotic stromal cells is mediated through an upstream promoter element. |
2003 |
Fertil. Steril. |
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A --> J prostaglandin swap: a new tactic for cyclopentenone prostaglandin synthesis. |
2003 |
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Cyclopentenone prostaglandins induce lymphocyte apoptosis by activating the mitochondrial apoptosis pathway independent of external death receptor signaling. |
2003 |
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Peroxisome proliferator-activated receptor gamma and ligands inhibit surfactant protein B gene expression in the lung. |
2003 |
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Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma. |
2003 |
Cancer Res. |
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Cytochrome C-dependent Fas-independent apoptotic pathway in HeLa cells induced by delta12-prostaglandin J2. |
2003 |
Exp. Mol. Med. |
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Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells. |
2003 |
Invest. Ophthalmol. Vis. Sci. |
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An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro. |
2003 |
J. Pharmacol. Exp. Ther. |
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[Sleep substances]. |
2003 |
No To Shinkei |
pmid:12649899
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Effects of peroxisome proliferator-activated receptor gamma ligands ciglitazone and 15-deoxy-delta 12,14-prostaglandin J2 on rat cultured cerebellar granule neuronal viability. |
2003 |
J. Neurosci. Res. |
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Cyclooxygenase 2 mediates post-inflammatory colonic secretory and barrier dysfunction. |
2003 |
Gut |
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Peroxisome proliferator-activated receptor-gamma represses GLUT4 promoter activity in primary adipocytes, and rosiglitazone alleviates this effect. |
2003 |
J. Biol. Chem. |
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An endogenous electrophile that modulates the regulatory mechanism of protein turnover: inhibitory effects of 15-deoxy-Delta 12,14-prostaglandin J2 on proteasome. |
2003 |
Biochemistry |
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PPARgamma ligands and ATRA inhibit the invasion of human breast cancer cells in vitro. |
2003 |
Breast Cancer Res. Treat. |
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A new flavonoid derivative, dosmalfate, attenuates the development of dextran sulphate sodium-induced colitis in mice. |
2003 |
Int. Immunopharmacol. |
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Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists. 1. Bicyclo[2.2.1]heptane derivatives. |
2003 |
J. Med. Chem. |
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Effect of 15-deoxy-delta 12,14-prostaglandin J2 on acute lung injury induced by lipopolysaccharide in mice. |
2003 |
Eur. J. Pharmacol. |
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Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists. 2. 6,6-Dimethylbicyclo[3.1.1]heptane derivatives. |
2003 |
J. Med. Chem. |
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Activation of nuclear receptors by prostaglandins. |
2003 |
Thromb. Res. |
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Novel binding sites of 15-deoxy-Delta12,14-prostaglandin J2 in plasma membranes from primary rat cortical neurons. |
2003 |
Exp. Cell Res. |
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15-Deoxy-Delta12,14-prostaglandin J2 regulates endogenous Cot MAPK kinase kinase 1 activity induced by lipopolysaccharide. |
2003 |
J. Biol. Chem. |
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Possible involvement of small oligomers of amyloid-beta peptides in 15-deoxy-delta 12,14 prostaglandin J2-sensitive microglial activation. |
2003 |
J. Pharmacol. Sci. |
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Involvement of c-jun N-terminal kinase activation in 15-deoxy-delta12,14-prostaglandin J2-and prostaglandin A1-induced apoptosis in AGS gastric epithelial cells. |
2003 |
Mol. Carcinog. |
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Expression and molecular pharmacology of the mouse CRTH2 receptor. |
2003 |
J. Pharmacol. Exp. Ther. |
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The antiproliferative effects of PPARgamma ligands in normal human mammary epithelial cells. |
2003 |
Breast Cancer Res. Treat. |
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The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras. |
2003 |
Proc. Natl. Acad. Sci. U.S.A. |
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Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. |
2003 |
Biochemistry |
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GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells. |
2003 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:12615657
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Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells. |
2003 |
Cancer Res. |
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Role of cyclooxygenase activation and prostaglandins in antigen-induced excitability changes of bronchial parasympathetic ganglia neurons. |
2003 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
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Cytokine regulation by peroxisome proliferator-activated receptor gamma in human endometrial cells. |
2003 |
Fertil. Steril. |
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15R-methyl-prostaglandin D2 is a potent and selective CRTH2/DP2 receptor agonist in human eosinophils. |
2003 |
J. Pharmacol. Exp. Ther. |
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